公开(公告)号：US06337456B1

公开(公告)日：2002-01-08

申请号：US09458070

申请日：1999-12-10

申请人： Junichi Taniguchi ,  Hideo Tahara

发明人： Junichi Taniguchi ,  Hideo Tahara

IPC分类号： B23K1130

CPC分类号： B23K11/315 ,  B23K11/115

摘要： In a resistance welding machine, an arm including one electrode tip, a drive unit including a linear guide for driving another electrode tip corresponding to the one electrode tip, and a welding unit including a welding transformer for passing a secondary current through a gun bracket for supporting the present resistance welding machine on a robot and/or the present resistance welding machine, can be mounted and removed individually as a unit with a common base or a rail main body including the linear guide as the reference thereof.

摘要翻译： 在电阻焊机中，包括一个电极头的臂，包括用于驱动与一个电极尖端相对应的另一个电极尖端的线性引导件的驱动单元和包括用于使二次电流通过枪支架的焊接变压器的焊接单元， 将本电阻焊机支撑在机器人和/或本电阻焊机上，可以作为单元安装和拆卸为具有包括线性引导件的公共基座或轨道主体作为参考的单元。

公开(公告)号：US09275843B2

公开(公告)日：2016-03-01

申请号：US14007387

申请日：2012-02-06

申请人： Osamu Furuhashi ,  Junichi Taniguchi

发明人： Osamu Furuhashi ,  Junichi Taniguchi

IPC分类号： H01J49/06 ,  H01J49/40

CPC分类号： H01J49/067 ,  H01J49/401

摘要： An electrostatic lens (3), including five cylindrical electrodes (31-35) arrayed along an ion-optical axis (C) and an aperture plate (38) located on a common focal plane of two virtual convex lenses (L1 and L2) formed under an afocal condition, is used as an ion-injecting optical system for sending ions into an orthogonal acceleration unit. The diameter of a restriction aperture (39) formed in the aperture plate (38) determines the angular spread of an exit ion beam. When voltages for making the electrostatic lens (3) function as an afocal system are set, a measurement with high mass-resolving power can be performed at a slight sacrifice of the sensitivity. When voltages for making the lens function as a non-afocal system having the highest ion-passage efficiency are set, a measurement with high sensitivity can be performed at a slight sacrifice of the resolving power.

摘要翻译： 一个静电透镜（3），包括沿着离子光轴（C）排列的五个圆柱形电极（31-35）和位于两个虚拟凸透镜（L1和L2）的公共焦平面上的孔板（38），形成 在无焦状态下，被用作离子注入光学系统，用于将离子发送到正交加速单元。 形成在孔板（38）中的限制孔（39）的直径确定出射离子束的角扩展。 当使静电透镜（3）用作无焦点系统的电压被设定时，可以轻微地牺牲灵敏度来进行质量分辨率高的测量。 当将透镜用作具有最高离子通过效率的非焦点系统的电压被设置时，可以以分辨力的轻微牺牲来执行高灵敏度的测量。

公开(公告)号：US4656037A

公开(公告)日：1987-04-07

申请号：US746514

申请日：1985-06-19

申请人： Shigezo Udaka ,  Hideo Ueyama ,  Junichi Taniguchi ,  Keiji Adachi

发明人： Shigezo Udaka ,  Hideo Ueyama ,  Junichi Taniguchi ,  Keiji Adachi

IPC分类号： C12P1/04 ,  A61K35/74

CPC分类号： C12P1/04

摘要： Penicillin or related substances are added during the course of the cultivation of a streptococcus to recover SPF-100 from the culture broth. SPF-100 exhibits a broad range of molecular weight and may be classified into SPF-1 and SPF-2.SPF-100 has a direct cancericidal effect and an immunoactivation effect.

摘要翻译： 在培养链球菌的过程中加入青霉素或相关物质，从培养液中回收SPF-100。 SPF-100具有广泛的分子量，可分为SPF-1和SPF-2。 SPF-100具有直接的杀癌作用和免疫激活作用。

公开(公告)号：US08368014B2

公开(公告)日：2013-02-05

申请号：US13310377

申请日：2011-12-02

申请人： Junichi Taniguchi

发明人： Junichi Taniguchi

IPC分类号： H01J49/40 ,  H01J49/42

CPC分类号： H01J49/424 ,  H01J49/004 ,  H01J49/40

摘要： A technique for improving the mass-resolving power of an ion trap time-of-flight mass spectrometer is provided. At the final stage of a cooling process before the ejection of ions from an ion trap, the frequency of a rectangular-wave voltage applied to a ring electrode of the ion trap is increased for a few to several cycles. This operation reduces the confining potential depth of the ion trap and decelerates the captured ions. The turn-around time of the ions is shortened when the rectangular-wave voltage is halted and an accelerating electric field is created. Thus, the variation in the time of flight of the ions with the same mass-to-charge ratio is reduced. The time for increasing the frequency is determined so that a spread of the ions because of the depth reduction of the confining potential will fall within the range that can be corrected in the time-of-flight mass spectrometer.

摘要翻译： 提供了一种用于提高离子阱飞行时间质谱仪的质量分辨能力的技术。 在从离子阱排出离子之前的冷却过程的最后阶段，施加到离子阱的环形电极的矩形波电压的频率增加几个到几个周期。 该操作降低了离子阱的限制电位深度并使捕获的离子减速。 当矩形波电压停止并产生加速电场时，离子的周转时间被缩短。 因此，具有相同质荷比的离子的飞行时间的变化减小。 确定增加频率的时间，使得由于限制电位的深度降低而导致的离子扩散将落入可以在飞行时间质谱仪中校正的范围内。

公开(公告)号：US20110095180A1

公开(公告)日：2011-04-28

申请号：US12999957

申请日：2008-06-20

申请人： Junichi Taniguchi

发明人： Junichi Taniguchi

IPC分类号： H01J49/40

CPC分类号： H01J49/36 ,  H01J49/004 ,  H01J49/0481 ,  H01J49/40 ,  H01J49/424 ,  H01J49/426 ,  H01J49/427

摘要： In performing an isolation of specific ions or performing a dissociation operation by CID, ions are captured by applying a radio-frequency high voltage to a ring electrode 31 as before. In a cooling operation which is performed immediately before target ions are ejected toward a TOFMS unit 4 with the ions stored in an ion trap 3, a radio-frequency high voltage is not applied to the ring electrode 31 but to end cap electrodes 32 and 34 to capture the ions. In this operation, the frequency thereof is set to be higher than that of the voltage applied to the ring electrode 31 and the amplitude is also increased in order to assure a large pseudopotential and keep the low mass cutoff (LMC). This narrows the spatial distribution of the cooled ions, reducing the variation of the initial positions of the ions at the point in time when they are ejected, which increases the mass resolution. In addition, since an isolation of ions having a large m/z can be performed with a great qz value as is conventionally done, a high mass selectivity can be assured.

摘要翻译： 在执行特定离子的分离或通过CID进行解离操作时，如前所述通过向环形电极31施加射频高电压来捕获离子。 在将离子存储在离子阱3内的目标离子朝向TOFMS单元4喷射之前执行的冷却操作中，高频高压不施加到环形电极31而是端盖电极32和34 捕获离子。 在这种操作中，其频率被设置为高于施加到环形电极31的电压的频率，并且为了确保大的伪电位并保持低质量截止（LMC），振幅也增加。 这减小了冷却的离子的空间分布，减少了它们在喷射时的时间点上离子的初始位置的变化，这增加了质量分辨率。 此外，由于如以往那样以大的qz值进行具有大m / z的离子的分离，因此可以确保高的质量选择性。

公开(公告)号：US5229270A

公开(公告)日：1993-07-20

申请号：US713007

申请日：1991-06-10

申请人： Toshihiro Ono ,  Junichi Taniguchi

发明人： Toshihiro Ono ,  Junichi Taniguchi

IPC分类号： C12Q1/40 ,  G01N33/84

CPC分类号： G01N33/84 ,  C12Q1/40 ,  C12Q2334/10 ,  Y10S435/81

摘要： Quantitative assay and reagent for the determination of chlorine ion in body fluid. Body fluid is contacted with a reagent which includes deactivated .alpha.-amylase, a compound capable of chelating calcium ion, a calcium chelate compound, and an .alpha.-amylase activity-measuring substance; the amount of .alpha.-amylase activity is proportional to the amount of chlorine ion present in the body fluid. The assay is suitable for automation.

摘要翻译： 用于测定体液中氯离子的定量测定和试剂。 体液与包括失活的α-淀粉酶，能够螯合钙离子的化合物，钙螯合物和α-淀粉酶活性测量物质的试剂接触; α-淀粉酶活性的量与体液中存在的氯离子的量成比例。 该测定适用于自动化。

公开(公告)号：US08754368B2

公开(公告)日：2014-06-17

申请号：US12999957

申请日：2008-06-20

申请人： Junichi Taniguchi

发明人： Junichi Taniguchi

IPC分类号： H01J49/40 ,  H01J49/36 ,  H01J49/42

CPC分类号： H01J49/36 ,  H01J49/004 ,  H01J49/0481 ,  H01J49/40 ,  H01J49/424 ,  H01J49/426 ,  H01J49/427

摘要： In performing an isolation of specific ions or performing a dissociation operation by CID, ions are captured by applying a radio-frequency high voltage to a ring electrode 31 as before. In a cooling operation which is performed immediately before target ions are ejected toward a TOFMS unit 4 with the ions stored in an ion trap 3, a radio-frequency high voltage is not applied to the ring electrode 31 but to end cap electrodes 32 and 34 to capture the ions. In this operation, the frequency thereof is set to be higher than that of the voltage applied to the ring electrode 31 and the amplitude is also increased in order to assure a large pseudopotential and keep the low mass cutoff (LMC). This narrows the spatial distribution of the cooled ions, reducing the variation of the initial positions of the ions at the point in time when they are ejected, which increases the mass resolution. In addition, since an isolation of ions having a large m/z can be performed with a great qz value as is conventionally done, a high mass selectivity can be assured.

摘要翻译： 在执行特定离子的分离或通过CID进行解离操作时，如前所述通过向环形电极31施加射频高电压来捕获离子。 在将离子存储在离子阱3内的目标离子朝向TOFMS单元4喷射之前执行的冷却操作中，高频高压不施加到环形电极31而是端盖电极32和34 捕获离子。 在这种操作中，其频率被设置为高于施加到环形电极31的电压的频率，并且为了确保大的伪电位并保持低质量截止（LMC），振幅也增加。 这减小了冷却的离子的空间分布，减少了它们在喷射时的时间点上离子的初始位置的变化，这增加了质量分辨率。 此外，由于如以往那样以大的qz值进行具有大m / z的离子的分离，因此可以确保高的质量选择性。

公开(公告)号：US08288720B2

公开(公告)日：2012-10-16

申请号：US13219408

申请日：2011-08-26

申请人： Junichi Taniguchi

发明人： Junichi Taniguchi

IPC分类号： B01D59/44 ,  H01J49/42 ,  H01J49/40

CPC分类号： H01J49/424 ,  H01J49/428

摘要： A technique for performing precursor isolation with a desired mass-to-charge ratio (m/z) in a digital ion trap while maintaining the q value at a substantially constant value is provided. A data obtained by digitizing an FNF signal having a notch is stored beforehand in an FNF waveform memory 15. In the process of precursor isolation, a main voltage timing controller 7 and a main voltage generator 9 generate a rectangular-wave voltage based on a reference clock signal CK. An auxiliary signal generator 14 reads data from the FNF waveform memory 15 and generates an FNF signal by performing digital-to-analogue conversion of the data in accordance with a clock signal synchronized with the reference clock signal CK. Under the command of a controller 30, a reference clock generator 6 produces the reference clock signal CK having a frequency corresponding to the m/z value of a target ion. Accordingly, a change in the m/z of the target ion leads to a change in the frequency of the reference clock signal CK, which causes the frequency of the rectangular-wave voltage and the central frequency of the notch of the FNF signal to change in the same proportion.

摘要翻译： 提供了一种用于在数字离子阱中以期望的质荷比（m / z）进行前体隔离的技术，同时将q值保持在基本恒定的值。 通过数字化具有凹口的FNF信号获得的数据预先存储在FNF波形存储器15中。在前驱体隔离的过程中，主电压定时控制器7和主电压发生器9基于参考产生矩形波电压 时钟信号CK。 辅助信号发生器14从FNF波形存储器15读取数据，并且通过根据与参考时钟信号CK同步的时钟信号对数据进行数模转换来产生FNF信号。 在控制器30的指令下，参考时钟发生器6产生具有对应于目标离子的m / z值的频率的参考时钟信号CK。 因此，目标离子的m / z的变化导致参考时钟信号CK的频率的变化，这导致矩形波电压的频率和FNF信号的陷波的中心频率改变 以相同的比例。

公开(公告)号：US06621078B2

公开(公告)日：2003-09-16

申请号：US10166773

申请日：2002-06-12

申请人： Junichi Taniguchi ,  Eizo Kawato

发明人： Junichi Taniguchi ,  Eizo Kawato

IPC分类号： H01J4930

CPC分类号： H01J49/42

摘要： When ions are introduced from outside into the ion trap space, a static electric field having equi-voltage surfaces concave to the entrance hole is formed in the ion trap space. For ions obliquely entering the ion trap space, such a static electric field makes the ions cross the equi-voltage surfaces at almost perpendicular angles. Owing to such configuration, ions are effectively decelerated, and enough time can be secured until ions of larger mass-to-charge ratios assuredly enter the ion trap space.

公开(公告)号：US08742330B2

公开(公告)日：2014-06-03

申请号：US13458708

申请日：2012-04-27

申请人： Junichi Taniguchi

发明人： Junichi Taniguchi

IPC分类号： H01J49/42 ,  H01J49/36

CPC分类号： H01J49/424

摘要： When ions accumulated in the exit side end of ion guide are to be injected into ion trap as packets, the application of square wave high frequency voltage to ring electrode from main voltage generating unit is stopped. Once nearly all the ions have been injected into ion trap, the application of square wave high frequency voltage from main voltage generating unit to ring electrode is momentarily started, at which time the application of square wave high frequency voltage is started from a phase in the range of 90°±40° or 270°±40°. It is thereby possible to reduce the extent of spread of ions immediately after application of high frequency voltage and to improve the ion trapping efficiency.

摘要翻译： 当离子导管的出射侧端部积聚的离子以离子阱形式注入离子阱时，停止从主电压产生部向环形电极施加方波高频电压。 一旦几乎所有的离子都被注入到离子阱中，从主电压产生单元到环形电极的方波高频电压的施加暂时开始，此时方波高频电压的应用从 范围为90°±40°或270°±40°。 因此，可以在施加高频电压之后立即减少离子扩散的程度并提高离子捕获效率。