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公开(公告)号：US4510129A
公开(公告)日：1985-04-09
申请号：US406531
申请日：1982-08-09
IPC分类号： A61K38/46 , A61K38/47 , A61K39/39 , A61P37/04 , C12N9/24 , A61K39/42 , A61K39/02 , A61K39/12 , A61K39/40
CPC分类号： A61K38/47 , A61K39/39 , A61K2039/55516
摘要： The invention relates to an agent for stimulating the immunologic reactivity, comprising a mixture of an antigen and neuraminidase.
摘要翻译： 本发明涉及用于刺激免疫反应性的试剂，其包含抗原和神经氨酸酶的混合物。
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公开(公告)号：US4479934A
公开(公告)日：1984-10-30
申请号：US101645
申请日：1979-12-10
摘要： What is disclosed is a method for the therapy of immunocomplex diseases with an agent which contains Fc-reagents that react with the Fc-part of the antibody contained in the immunocomplex, but which themselves do not posses an immunologically active Fc-part or an Fc-part capable of being activated.
摘要翻译： 所公开的是使用含有与免疫复合物中所含的抗体的Fc部分反应但与本发明不具有免疫活性Fc部分或Fc的Fc试剂反应的试剂来治疗免疫复合物疾病的方法 - 能够被激活。
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3.发明授权公开(公告)号：US07838637B2
公开(公告)日：2010-11-23
申请号：US10883472
申请日：2004-06-30
CPC分类号： C07K16/468 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/3007 , C07K16/40 , C07K2317/34 , C07K2317/626 , C07K2319/00 , Y02A50/412
摘要： The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid.
摘要翻译： 本发明涉及具有不同可变结构域的单链多重抗原结合分子，其具有以VH-VL构建体形式连接的免疫球蛋白的重链和轻链，其又连接在一起 通过肽，以及其作为药物或诊断助剂的制备和使用。
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4.发明申请Pharmaceutical composition for the prophylaxis and/or treatment of virus diseases 审中-公开用于预防和/或治疗病毒病的药物组合物公开(公告)号：US20050129694A1
公开(公告)日：2005-06-16
申请号：US10486313
申请日：2002-07-26
IPC分类号： C12N15/09 , A61K31/00 , A61K31/13 , A61K31/136 , A61K31/275 , A61K31/4439 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61P43/00 , C12Q1/02 , C12Q1/70 , A61K39/395 , A61K31/551 , A61K31/553
CPC分类号： A61K31/00 , A61K31/136 , A61K31/4439 , A61K2300/00
摘要： The invention relates to the use of at least one active substance for producing a pharmaceutical composition for the prophylaxis and/or treatment of at least one viral disease. It is characterized by active substance(s) which inhibit(s) either at least two kinases or at least one SEK kinase of a cellular signal transmission path such that virus multiplication is inhibited.
摘要翻译： 本发明涉及至少一种活性物质用于制备用于预防和/或治疗至少一种病毒性疾病的药物组合物的用途。 其特征在于抑制至少两种激酶或至少一种细胞信号传递途径的SEK激酶的活性物质，使得病毒繁殖被抑制。
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5.发明授权Nucleic acid construct for expressing active substances which can be activated by proteases, and preparation and use 失效用于表达可由蛋白酶活化的活性物质的核酸构建体，以及制备和使用公开(公告)号：US06670147B1
公开(公告)日：2003-12-30
申请号：US09256237
申请日：1999-02-24
IPC分类号： C12P2106
CPC分类号： C12N9/6432 , A61K48/00 , C12N15/63 , C12N15/85 , C12N2830/007 , C12N2830/008 , C12N2840/20 , C12Y304/21006
摘要： The invention relates to a nucleic acid construct for expressing an active substance which is activated by an enzyme which is released from mammalian cells, which construct comprises the following components: a) at least one promoter element, b) at least one DNA sequence which encodes an active compound (protein B), c) a least one DNA sequence which encodes an amino acid sequence (part structure C) which can be cleaved specifically by an enzyme which is released from a mammalian cell, and d) at least one DNA sequence which encodes a peptide or protein (part structure D) which is bound to the active compound (protein B) by way of the cleavable amino acid sequence (part structure C) and inhibits the activity of the active compound (protein B), and also to the use of the nucleic acid construct for preparing a drug for treating diseases.
摘要翻译： 本发明涉及用于表达由哺乳动物细胞释放的酶活化的活性物质的核酸构建物，该构建体包含以下组分：a）至少一个启动子元件，b）至少一个编码 活性化合物（蛋白B），c）至少一个DNA序列，其编码可以被从哺乳动物细胞释放的酶特异性切割的氨基酸序列（部分结构C），和d）至少一个DNA序列 其编码通过可切割氨基酸序列（部分结构C）与活性化合物（蛋白B）结合并抑制活性化合物（蛋白B）的活性的肽或蛋白质（部分结构D），并且还 涉及使用核酸构建体来制备用于治疗疾病的药物。
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公开(公告)号：US4713371A
公开(公告)日：1987-12-15
申请号：US824939
申请日：1986-02-03
申请人： Werner Aretz , Hans G. Berscheid , Gerhard Huber , Hans-Wolfram Fehlhaber , Hans P. Kraemer , Hans-Harald Sedlacek , Bimal N. Ganguli , Ratan S. Sood , Julia Gandhi , Gauknapalli C. Reddy
发明人： Werner Aretz , Hans G. Berscheid , Gerhard Huber , Hans-Wolfram Fehlhaber , Hans P. Kraemer , Hans-Harald Sedlacek , Bimal N. Ganguli , Ratan S. Sood , Julia Gandhi , Gauknapalli C. Reddy
IPC分类号： A61K31/12 , A61K31/215 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P35/00 , C07C45/00 , C07C50/36 , C07C67/00 , C07H15/252 , C12P19/56 , C12R1/465 , A61K31/71 , C07H15/24
CPC分类号： C07H15/252 , C12P19/56
摘要： The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of these cultures and to the anthracycline derivatives themselves. The new compounds are distinguished by antibacterial activity and, in addition, they act against various types of tumors.
摘要翻译： 本发明涉及微生物链霉菌紫球菌（DSM 2658），其突变体和变体，通过这些培养物的发酵和蒽环类衍生物本身制备蒽环类衍生物的方法。 新化合物的特征在于抗菌活性，另外它们还可以抵抗各种类型的肿瘤。
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公开(公告)号：US4699912A
公开(公告)日：1987-10-13
申请号：US754269
申请日：1985-07-12
IPC分类号： C07D491/16 , A61K31/435 , A61K31/47 , A61P37/00 , A61K31/44
CPC分类号： A61K31/47 , Y10S514/885
摘要： The fact that Lycorine can be used for suppression of the immune system of mammals is described. Lycorine is therefore suitable for the therapy of autoimmune diseases, immune complex diseases and allergic and rheumatic conditions and for prophylaxis against transplant rejections.
摘要翻译： 描述了Lycorine可用于抑制哺乳动物免疫系统的事实。 因此，Lycorine适用于治疗自身免疫性疾病，免疫复合物疾病和过敏性和风湿性疾病，并适用于预防移植排斥反应。
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公开(公告)号：US4296201A
公开(公告)日：1981-10-20
申请号：US67003
申请日：1979-08-16
IPC分类号： G01N33/554 , G01N33/564 , G01N33/54
CPC分类号： G01N33/554 , G01N33/564 , Y10S436/80
摘要： What is disclosed are methods for the detection of antimitochondrial and antinuclear antibodies employing hypernephroma cells as a diagnostic agent.
摘要翻译： 公开的是用于检测使用hypernephroma细胞作为诊断剂的抗线粒体和抗核抗体的方法。
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9.发明申请公开(公告)号：US20090326206A1
公开(公告)日：2009-12-31
申请号：US12545247
申请日：2009-08-21
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K48/00 , A61K2039/505 , C07K16/00 , C07K16/3007 , C07K16/40 , C07K2317/34 , C07K2317/626 , C07K2319/00 , Y02A50/412
摘要： The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid.
摘要翻译： 本发明涉及具有不同可变结构域的单链多重抗原结合分子，其具有以VH-VL构建体形式连接的免疫球蛋白的重链和轻链，其又连接在一起 通过肽，以及其作为药物或诊断助剂的制备和使用。
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10.发明申请CASPASE INHIBITORS, ESPECIALLY CASPASE 3 INHIBITORS, FOR THE TREATMENT OF INFLUENZA 审中-公开CASPASE INHIBITORS，特别是CASPASE 3抑制剂，用于治疗流感公开(公告)号：US20090155270A1
公开(公告)日：2009-06-18
申请号：US12331864
申请日：2008-12-10
IPC分类号： A61K39/395 , A61K38/16 , C12N5/10 , C12Q1/68 , A61P37/04
CPC分类号： C07K14/81
摘要： The invention relates to the use of at least one caspase inhibitor, in particular a caspase-3 inhibitor, for preparing a pharmaceutical composition for the prophylaxis or therapy of a viral infection, in particular an infection with an RNA negative-strand virus, preferably an influenza infection, and to a test system for identifying suitable active substances.
摘要翻译： 本发明涉及至少一种半胱天冬酶抑制剂，特别是胱天蛋白酶-3抑制剂用于制备用于预防或治疗病毒感染的药物组合物的用途，特别是RNA负链病毒的感染，优选为 流感感染，以及用于鉴定合适活性物质的测试系统。
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