公开(公告)号：US10351538B2

公开(公告)日：2019-07-16

申请号：US15758807

申请日：2016-09-01

Applicant: KANEKA CORPORATION

Inventor： Koji Machida ,  Akira Nishiyama

IPC: C07D251/24 ,  C07D251/28 ,  G02B1/14 ,  B32B7/02 ,  G02B5/30

Abstract: The present invention provides methods respectively for producing a 2,4,6-tris(2-hydroxy-3-methyl-4-alkoxyphenyl)-1,3,5-triazine compound and 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine, both of which are improved in yield and quality. The methods according to the present invention are characterized in that a reaction of 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine with an alkylating agent is carried out using a base in the presence of an alcohol or water, and are also characterized in that an ester compound is used as an additive in a reaction of cyanuric chloride with 2-methylresorcinol.

公开(公告)号：US10919829B2

公开(公告)日：2021-02-16

申请号：US16445264

申请日：2019-06-19

Applicant: KANEKA CORPORATION

Inventor： Koji Machida ,  Hiroaki Yasukouchi ,  Akira Nishiyama

IPC: C07C37/74 ,  B01D3/14 ,  B01D15/36 ,  B01J41/12 ,  C07C37/56 ,  C07H1/06 ,  C07D249/08 ,  C07C69/12 ,  C07C33/22 ,  C07C67/03 ,  C07B61/00

Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.

公开(公告)号：US10202337B2

公开(公告)日：2019-02-12

申请号：US15129927

申请日：2015-03-23

Applicant: KANEKA CORPORATION

Inventor： Koji Machida ,  Kohei Mori ,  Narumi Kishimoto ,  Toshihiro Takeda

IPC: C07C277/08

Abstract: A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride and a base in a water/organic solvent bilayer system to an arginine or arginine derivative (1) represented by the formula (1), or a salt thereof.

公开(公告)号：US11161820B2

公开(公告)日：2021-11-02

申请号：US16810050

申请日：2020-03-05

Applicant: KANEKA CORPORATION

Inventor： Hiroaki Yasukouchi ,  Akira Nishiyama ,  Koji Machida

IPC: C07D217/06 ,  B01J19/18 ,  C01B32/80 ,  B01J19/00

Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.

公开(公告)号：US20200207717A1

公开(公告)日：2020-07-02

申请号：US16810050

申请日：2020-03-05

Applicant: KANEKA CORPORATION

Inventor： Hiroaki Yasukouchi ,  Akira Nishiyama ,  Koji Machida

IPC: C07D217/06 ,  C01B32/80 ,  B01J19/18 ,  B01J19/00

Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.

公开(公告)号：US12134600B2

公开(公告)日：2024-11-05

申请号：US17605408

申请日：2020-03-05

Applicant: KANEKA CORPORATION

Inventor： Koji Machida ,  Hiroaki Yasukouchi ,  Akira Nishiyama

IPC: C07D213/81

Abstract: A method for producing a first vadadustat intermediate represented by the following formula (3) comprising reacting a compound represented by the following formula (1) with glycine or a glycine derivative represented by the following formula (2) or a salt of the glycine or the glycine derivative in the presence of carbon monoxide. The method produces a vadadustat intermediate through a clean reaction with high atom conversion efficiency.