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公开(公告)号：US20210363475A1
公开(公告)日：2021-11-25
申请号：US16627108
申请日：2019-05-30
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO , Norihiro YAMAGISHI
Abstract: The present invention provides a cell treatment apparatus that can improve the operating rates of an observation unit and a laser irradiation unit in the case of treating a plurality of cell culture vessels. The cell treatment apparatus of the present invention includes: a cell treatment chamber in which cells in a cell culture vessel are treated; an observation unit that can observe the cells in the cell culture vessel; a laser irradiation unit that can irradiate the cells with lasers; a first moving unit that can move the observation unit; and a second moving unit that can move the laser irradiation unit, wherein the cell treatment chamber includes a plurality of regions in which the cells can be treated, each region includes a first cell culture vessel placement unit and a second cell culture vessel placement unit, in the first cell culture vessel placement unit, the cells in the cell culture vessel are observed by the observation unit, in the second cell culture vessel placement unit, the cells in the cell culture vessel are irradiated with lasers by the laser irradiation unit, the observation unit is moved by the first moving unit in a state of being able to observe the cells in the cell culture vessel in the first cell culture vessel placement unit of each region, and the laser irradiation unit is moved by the second moving unit in a state of being able to irradiate the cells in the cell culture vessel in the second cell culture vessel placement unit of each region with lasers.
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公开(公告)号：US20230242862A1
公开(公告)日：2023-08-03
申请号：US18011911
申请日：2021-05-21
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO , Tadao MORISHITA , Chiharu TABEI
Abstract: The cell treatment apparatus of the present disclosure is a cell treatment apparatus including: an observation unit; a laser emitter; and a controller. The controller includes at least one processor that is configured to detect, using image data that includes the cell captured by an observation unit and a learned model capable of detecting a target cell or a non-target cell, a target cell or a non-target cell in the image data; set a region where the target cell is present or a region where the non-target cell is not present as a laser irradiation region to be subjected to laser irradiation by the laser emitter, and apply a laser emitted from the laser emitter to the laser irradiation region in the cell culture tool to treat the target cell.
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公开(公告)号：US20220025336A1
公开(公告)日：2022-01-27
申请号：US17288636
申请日：2019-11-11
Inventor： Ping DAI , Yukimasa TAKEDA , Yoshinori HARADA , Junichi MATSUMOTO , Ayumi KUSAKA
IPC: C12N5/071
Abstract: It is a main object of the present invention to provide a new producing method capable of efficiently performing direct conversion or induction from a somatic cell to an insulin-producing cell. The present invention can include, for example, a process for producing an insulin-producing cell by direct differentiation induction from a somatic cell, comprising a step of culturing a somatic cell in a serum-free differentiation induction medium, or a step of culturing a somatic cell in a differentiation induction medium containing 5 μg/mL or more of insulin. According to the present invention, insulin-producing cells having a high insulin secretion ability can be produced directly and efficiently from a somatic cell. The insulin-producing cells obtained according to the present invention are useful in regenerative medicine and the like.
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公开(公告)号：US20210062155A1
公开(公告)日：2021-03-04
申请号：US16962190
申请日：2019-01-24
Inventor： Ping DAI , Yukimasa TAKEDA , Yoshinori HARADA , Junichi MATSUMOTO , Ayumi KUSAKA
IPC: C12N5/071
Abstract: The present invention chiefly aims to provide a process for directly inducing insulin-producing cells from somatic cells without performing artificial gene transfer. The present invention can include a process for producing an insulin-producing cell by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a cAMP inducer, and six members selected from the group consisting of a GSK3 inhibitor, a TGF-β inhibitor, a BMP inhibitor, a p53 inhibitor, a PI3K inhibitor, a Notch inhibitor and a RAR agonist, or all members thereof. The insulin-producing cells obtained by the present invention are useful in regenerative medicine and the like.
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公开(公告)号：US20190352594A1
公开(公告)日：2019-11-21
申请号：US16347788
申请日：2017-10-27
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO , Norihiro YAMAGISHI
Abstract: In order to perform a process of emitting a laser beam toward a cell culture vessel while maintaining the atmosphere around the cell culture vessel in a desired condition, a culture vessel housing apparatus 1 is configured to include surrounding walls 312 and 322 that surround an internal space 10 in which a cell culture vessel 9 is to be housed, a transparent top panel 4 that closes an upper part of the internal space 10 surrounded by the surrounding walls 312 and 322, a heater 5 that is provided at the top panel 4 to keep the internal space 10 warm, and a transparent bottom panel 6 that closes a lower part of the internal space 10 surrounded by the surrounding walls 312 and 322 and allows a laser beam emitted toward the cell culture vessel 9 housed in the internal space 10 to pass through.
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Patent Agency Ranking
公开(公告)号：US20220073862A1
公开(公告)日：2022-03-10
申请号：US17312620
申请日：2019-12-13
Inventor： Kimio SUMARU , Toshiyuki TAKAGI , Toshiyuki KANAMORI , Kana MORISHITA , Junichi MATSUMOTO
Abstract: A cell culture instrument configured to detach cells at a desired position and a cell processing method using the cell culture instrument. The cell culture instrument includes: a substrate; and a photoreactive layer having a photosolubility and a photothermal convertibility, wherein the photoreactive layer is laminated on the substrate, and the photoreactive layer includes a polymer having a photosolubility and a photothermal convertibility.
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公开(公告)号：US20210395689A1
公开(公告)日：2021-12-23
申请号：US17288674
申请日：2019-11-11
Inventor： Ping DAI , Yukimasa TAKEDA , Yoshinori HARADA , Junichi MATSUMOTO , Ayumi KUSAKA
IPC: C12N5/077 , C12N5/0775
Abstract: It is a main object of the present invention to provide a process for producing an insulin-producing cell from a somatic cell without performing artificial gene transfer, an insulin-producing cell obtained from the process, or a composition comprising a combination of chemical substances that can be used for the process. The present invention can include, for example: a process for producing an insulin-producing cell from a somatic cell by direct differentiation induction, comprising a step of culturing a somatic cell in the presence of an RSK inhibitor; an insulin-producing cell obtained from the process; and a composition for producing an insulin-producing cell from a somatic cell by directly inducing differentiation, comprising an RSK inhibitor. The insulin-producing cells obtained according to the present invention are useful in regenerative medicine and the like.
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公开(公告)号：US20210340482A1
公开(公告)日：2021-11-04
申请号：US17282065
申请日：2019-09-30
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO
Abstract: A cell culture tool configured to be produced in a simple facility to obtain a cell mass having a desired shape. The cell culture tool includes a cell culture base layer that contains a cell culture base. The cell culture base layer has a cell adhesive area to which a cell is adherable and a cell adhesion inhibitory area where cell adhesion is inhibited. The cell adhesion inhibitory area includes a modified product of the cell culture base.
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公开(公告)号：US20210079324A1
公开(公告)日：2021-03-18
申请号：US17103539
申请日：2020-11-24
Inventor： Masami SUZUKI , Norio NISHI , Junichi MATSUMOTO , Kimio SUMARU , Toshiyuki KANAMORI
IPC: C12M1/42 , C12N1/00 , C12M1/00 , C12M1/34 , C12M1/12 , C12M1/32 , C12M1/26 , C12N1/02 , C12N5/00 , C12N13/00
Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5 W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.
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公开(公告)号：US20210071121A1
公开(公告)日：2021-03-11
申请号：US17103597
申请日：2020-11-24
Inventor： Masami SUZUKI , Norio NISHI , Junichi MATSUMOTO , Kimio SUMARU , Toshiyuki KANAMORI
IPC: C12M1/42 , C12N1/00 , C12M1/00 , C12M1/34 , C12M1/12 , C12M1/32 , C12M1/26 , C12N1/02 , C12N5/00 , C12N13/00
Abstract: A cell culture vessel for use with a laser processing machine, including: a layer containing an ingredient that generates heat upon laser irradiation; the layer kills specific cells from among a group of cells cultured on a first surface of the layer when a second surface of the layer is irradiated with laser light having an output of 5W or less at a wavelength of 380 nm or greater and a relative movement between a second area on the second surface where the laser light is applied and the layer is at a rate of 2000 mm/sec or less such that the second area absorbs energy of the laser light to generate heat that kills the specific cells that are present on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation with the laser light.
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