公开(公告)号：US11560540B2

公开(公告)日：2023-01-24

申请号：US16627154

申请日：2019-05-30

Applicant: KATAOKA CORPORATION

Inventor： Junichi Matsumoto ,  Shoichi Honda

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/36

Abstract: The present invention is intended to provide a cell treatment apparatus and a method for treating cells that can suppress a variation of a treatment time of treating cells using laser light. The cell treatment apparatus of the present invention includes: a cell treatment chamber in which cells in a cell culture vessel are treated; an observation unit that can observe the cells; a laser projection unit that can project a laser image onto the cells; a laser moving unit that can move the laser projection unit; and a control unit. The laser projection unit includes: a laser light source; and a laser image generation portion that generates the laser image to be projected onto the cells from laser light oscillated from the laser light source. The control unit controls generation of the laser image by the laser image generation portion. By moving the laser moving unit from a projection start position of the laser image at one end of the cell culture vessel to a projection end position of the laser image at the other end of the cell culture vessel, the laser projection unit projects the laser image from the projection start position of the laser image at one end of the cell culture vessel to the projection end position of the laser image at the other end of the cell culture vessel.

公开(公告)号：US11499133B2

公开(公告)日：2022-11-15

申请号：US16485367

申请日：2017-09-20

Applicant: KATAOKA CORPORATION

Inventor： Junichi Matsumoto ,  Shoichi Honda

IPC: C12M1/00 ,  C12M1/12 ,  C12M1/42 ,  C12M1/33 ,  C12N13/00 ,  C12N5/074 ,  C12N5/00 ,  C12N5/0735 ,  C12M1/34 ,  G01N21/64

Abstract: The present invention provides a cell treatment apparatus capable of treating cells in a cell culture vessel. The cell treatment apparatus 100 according to the present invention includes a first region 1, a second region 3, and a third region 5. The first region 1 and the second region 3 are placed in succession. The first region 1 is a cell treatment chamber for treating cells. The cell treatment chamber can be closed from the outside of the cell treatment chamber and includes a culture vessel placement portion for placing a cell culture vessel. The second region 3 includes: a laser irradiation device capable of irradiating the cell culture vessel placed in the culture vessel placement portion with a laser; and a spot diameter adjustment device that adjusts a spot diameter formed in a portion to be irradiated with the laser in an object to be irradiated. The third region 5 includes a control device that controls at least one device in the cell treatment apparatus 100 and a power supply device 52 that supplies electric power to at least one device in the cell treatment apparatus 100. The culture vessel placement portion is placed to be adjacent to the second region 3 in the cell treatment chamber. An adjacent portion to the second region 3 in the culture vessel placement portion is translucent.

公开(公告)号：US11977214B2

公开(公告)日：2024-05-07

申请号：US16648950

申请日：2018-08-17

Applicant: KATAOKA CORPORATION

Inventor： Shoichi Honda ,  Junichi Matsumoto ,  Tadao Morishita

IPC: G02B21/06 ,  G02B21/00 ,  G02B21/14 ,  G02B21/26 ,  G02B27/52

CPC classification number: G02B21/14 ,  G02B21/06 ,  G02B21/26 ,  G02B27/52

Abstract: A phase difference observation apparatus includes a light source; an illumination guide to guide illumination light from the light source to an observation target object in a cell culture vessel; an optical imager to form an optical image of the observation target object on an image sensor; and a controller. The illumination guide includes a spatial modulator to change an intensity distribution of the illumination light; the controller contains intensity distribution correction information associating a position of the imaging guide with respect to the cell culture vessel with an intensity distribution of illumination light at the position of the optical imager; the controller acquires imaging system position information, which is the position of the optical imager; and the controller changes an intensity distribution of illumination light in the spatial modulator on the basis of the imaging system position information and the intensity distribution correction information.