公开(公告)号：US20190070435A1

公开(公告)日：2019-03-07

申请号：US16083596

申请日：2017-04-01

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Gipson JOE ANTO ,  Sivaramakrishnan KRISHNAIYER RAMAN ,  Vaitheeswaran RANGANATHAN

IPC: A61N5/10

Abstract: A radiation therapy system (100) includes a radiation therapy (RT) optimizer unit (102) and an interactive planning interface unit (120). The RT optimizer unit (102) receives at least one target structure and at least one organ-at-risk (OAR) structure segmented from a volumetric image (108), and generates an optimized RT plan (140) based on dose objectives (200-204, 210-222, 320), at least one dose objective of the dose objectives corresponding to each of the at least one target structure (210-222) and the at least one OAR structure (200-204). The optimized RT plan includes a planned radiation dose for each voxel of the volumetric image using external beam radiation therapy, wherein the RT optimizer unit operates iteratively. The interactive planning interface unit (120) interactively controls each of the dose objectives through controls (300) displayed on a single display (126) of a display device (124), operates the RT optimizer unit to iteratively compute the planned radiation dose according to the controls, and provide visual feedback (310, 134) on the single display according to progress of the RT optimizer unit after each trial.

公开(公告)号：US20180111005A1

公开(公告)日：2018-04-26

申请号：US15571294

申请日：2016-05-11

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Prashant KUMAR ,  Gipson JOE ANTO

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1045 ,  A61N5/1048 ,  A61N2005/1092

Abstract: The invention relates to a method of selecting a set of beam geometries for use in radiation therapy. The method (10) comprises providing (12) a plurality of candidate beam geometries; optimizing (1) a radiation treatment plan with all candidate beam geometries; and computing (14) a cost function value based on all candidate beam geometries. A first beam geometry from the plurality of candidate beam geometries is removed (15) and a first modified cost function value based on the candidate beam geometries without the removed first beam geometry computed (16). The first beam geometry is restored (17). The steps of removing a beam geometry, computing of a modified cost function value and restoring of the removed beam geometry are repeated (R) for all other candidate beam geometries. One or more beam geometries from the plurality of candidate beam geometries based on the modified cost function values are chosen (19).

公开(公告)号：US20160030767A1

公开(公告)日：2016-02-04

申请号：US14772441

申请日：2014-03-11

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Prashant KUMAR ,  Vaitheeswaran RANGANATHAN ,  Karl Antonin BZDUSEK

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/103 ,  A61N5/1071 ,  A61N2005/1074

Abstract: A method for reviewing a treatment plan (24) for delivering radiation therapy to a patient. The treatment plan (24) includes geometric analysis data, dose distribution analysis data, dose volume histogram data, parametric analysis data or deliverability analysis data of a patient. First, for the treatment plan (24), a plurality of clinical and delivery goals are identified (20, 22). Next, goal data points are extracted (26) from the treatment plan (24). Then, data points are correlated (28) to identify deficiencies in the treatment plan (24). A report is generated (30) to display on a display (10) the correlated data points using visual markings (84) to highlight identified deficiencies. Text and audio notations can be attached to the report to explain the correlations and warn a user of plan deficiencies.

Abstract translation: 一种用于检查将辐射治疗递送给患者的治疗计划（24）的方法。 治疗计划（24）包括患者的几何分析数据，剂量分布分析数据，剂量体积直方图数据，参数分析数据或递送能力分析数据。 首先，对于治疗计划（24），确定了多个临床和递送目标（20,22）。 接下来，从处理计划（24）提取目标数据点（26）。 然后，数据点是相关的（28）来识别治疗计划中的缺陷（24）。 生成报告（30），使用视觉标记（84）在显示器（10）上显示相关数据点，以突出识别缺陷。 文本和音频符号可以附加到报告中，以解释相关性，并向用户警告计划缺陷。

公开(公告)号：US20210031054A1

公开(公告)日：2021-02-04

申请号：US17040920

申请日：2019-03-18

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Bojarajan PERUMAL ,  Rohinee NUGGEHALLI ASHWINEE KUMAR ,  Saravanan KARUNANITHI

IPC: A61N5/10 ,  G16H20/40 ,  G16H30/40

Abstract: A radiation therapy delivery device console (50) controls a radiation therapy delivery device (36) and an imaging device (40, 42), and further performs adaptive radiotherapy (ART) recommendation as follows. The imaging device is controlled to acquire a current image (44) of a patient. At least one perturbation of the current image is determined compared with a radiation therapy planning image (1) from which a radiation therapy plan (22) for the patient has been generated. An ART recommendation score is computed, indicating whether ART should be performed, based on the determined at least one perturbation. A recommendation is displayed as to whether ART should be performed based on the computed ART recommendation score, or an alarm is displayed conditional upon the computed ART recommendation score satisfying an ART recommendation criterion.

公开(公告)号：US20200261743A1

公开(公告)日：2020-08-20

申请号：US16061443

申请日：2016-12-12

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Gipson JOE ANTO ,  Vaitheeswaran RANGANATHAN ,  Ajesh KUMAR

IPC: A61N5/10

Abstract: A method includes generating a nominal dose distribution based on an image and clinical goals. The method further includes generating a setup error dose distribution based on range and setup uncertainties. The method further includes generating a dose distribution for a parameter of an internal organ. The method further includes optimizing a planned dose distribution of an intensity modulated proton therapy plan by minimizing a total objective value including the nominal dose distribution, the setup error dose distribution dose distribution, and the dose distribution for the internal organ. The method further includes generating a final dose distribution for the intensity modulated proton therapy plan based on beam parameters of the optimized planned dose distribution. The method further includes controlling a proton therapy apparatus configured to deliver proton therapy based on the intensity modulated proton therapy plan with the optimized planned dose distribution.

公开(公告)号：US20150141733A1

公开(公告)日：2015-05-21

申请号：US14600474

申请日：2015-01-20

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Prashant KUMAR ,  Karl Antonin BZDUSEK ,  Vaitheeswaran RANGANATHAN ,  Matthew PALMER ,  Michael KANTOR

IPC: A61N5/10

CPC classification number: A61N5/1039 ,  A61N5/1031 ,  A61N5/1038 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  G06F19/3481 ,  G16H20/40

Abstract: A therapy planning system and method generate an optimal treatment plan accounting for changes in anatomy. Therapy is delivered to the subject according to a first auto-planned optimal treatment plan based on a first image of a subject. A second image of the subject is received after a period of time. The second image is registered with the first image to generate a deformation map accounting for physiological changes. The second image is segmented into regions of interest using the deformation map. A mapped delivered dose is computed for each region of interest using the dose delivery goals and the deformation map. The first treatment plan is merged with the segmented regions of the second image and the mapped delivered dose during optimization.

Abstract translation: 治疗计划系统和方法产生解释解剖变化的最佳治疗方案。 根据受试者的第一个图像，根据第一个自动计划的最佳治疗计划，将治疗传递给该受试者。 在一段时间后收到主题的第二张图像。 将第二图像与第一图像一起登记，以生成考虑生理变化的变形图。 使用变形图将第二图像分割成感兴趣区域。 使用剂量递送目标和变形图计算每个感兴趣区域的映射递送剂量。 在优化过程中，第一个处理计划与第二个图像的分割区域和映射的递送剂量合并。

公开(公告)号：US20220257977A1

公开(公告)日：2022-08-18

申请号：US17613528

申请日：2020-05-25

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Bojarajan PERUMAL ,  Natarajan RAMAR

IPC: A61N5/10

Abstract: A method and system for normalizing an IMPT plan are provided as well as an arrangement for planning IMPT and a computer program product comprising instructions to perform the method. The method comprises the steps of: receiving an IMPT plan for a subject to be treated, receiving anatomical image data of the subject comprising at least one ROI, and receiving at least one clinical goal associated with the ROI. The method further comprises identifying one or more deficiency areas of the IMPT plan within the ROI where the clinical goal is not met, and identifying the particle spots of the IMPT plan that are associated with the identified deficiency areas as critical particle spots. When the critical spots have been identified, the method comprises normalizing at least one of the deficiency areas by adjusting the intensity of the critical particle spots.

公开(公告)号：US20200054895A1

公开(公告)日：2020-02-20

申请号：US16344854

申请日：2017-10-30

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN

IPC: A61N5/10 ,  G16H20/40

Abstract: In a continuous arc radiation therapy planning method for planning a radiation therapy session parameterized by a set parameters for control points (CPs) along at least one radiation source arc, a geometric optimization (40) is performed that does not include calculating radiation absorption profiles to generate optimized values for a sub-set of the parameters. After the geometric optimization, a main optimization (42) is performed that includes calculating radiation absorption profiles. The main optimization is performed with the sub-set of parameters initialized to the optimized values from the geometric optimization. The sub-set of parameters optimized by the geometric optimization may include collimator angle parameters for a multileaf collimator (MLC) (58). The geometric optimization may optimize a cost function comprising a sum over the CPs of a per-CP cost function dependent on a target-only region (62) defined as a planning target volume excluding any portion overlapping an organ at risk.

公开(公告)号：US20190290931A1

公开(公告)日：2019-09-26

申请号：US16301747

申请日：2017-06-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Gipson JOE ANTO ,  Murali BALASUBRAMANIAN ,  Bojarajan PERUMAL ,  Reshmi BHATTACHARJEE

IPC: A61N5/10 ,  G21K5/04

Abstract: A robustness optimization is disclosed for a broad beam proton therapy plan. A nominal dose distribution (62) is computed, to be delivered to a volume by performing proton therapy on the volume according to a proton therapy plan (50) having parameters (52) defining a range compensator shape and a range band. The parameters of the proton therapy plan are adjusted to reduce a difference between the nominal dose distribution (62) and a perturbed dose distribution calculated to be delivered to the volume modified by an error scenario (64) by performing proton therapy on the volume modified by the error scenario in accordance with the proton therapy plan with the parameters adjusted by the adjusting operation. The adjusting may be repeated serially for each error scenario of a set of error scenarios (44) to produce a proton therapy plan that is robust for any of these error scenarios.

公开(公告)号：US20160089549A1

公开(公告)日：2016-03-31

申请号：US14785751

申请日：2014-04-17

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Gipson JOE ANTO ,  Prashant KUMAR ,  Sivaramakrishnan KRISHNAIYER RAMAN ,  Deepak Uddhavrao MAHAJAN

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1077 ,  A61N2005/1074 ,  G06F19/00

Abstract: A method for dose-gradient based optimization of an intensity modulated radiation therapy plan. First, an optimizer (6) performs a first optimization (40) of the plan to generate dose distributions corresponding to the plan. Next, the optimizer (6) generates a beam specific dose gradient map (42) for each beam of the plan. Then, new dose gradients are specified (44) for the plan. Last, the optimizer (6) performs a final optimization (46) using the new dose gradients. The final optimization is given the new dose gradients as soft constraints into an objective function. The optimizer (3) applies a limiting factor to the objective function such that a first dose gradient is limited by the optimizer only if the first dose gradient exceeds the new dose gradient for a specific beamlet.

Abstract translation: 一种强度调制放射治疗计划的剂量梯度优化方法。 首先，优化器（6）执行计划的第一优化（40）以产生对应于该计划的剂量分布。 接下来，优化器（6）针对该计划的每个波束产生波束特定剂量梯度图（42）。 然后，规定新剂量梯度（44）。 最后，优化器（6）使用新的剂量梯度进行最终优化（46）。 最终优化给出了新的剂量梯度作为目标函数的软约束。 优化器（3）对目标函数应用限制因子，使得仅当第一剂量梯度超过特定子束的新剂量梯度时，优化器才限制第一剂量梯度。