公开(公告)号：US09803167B2

公开(公告)日：2017-10-31

申请号：US14950710

申请日：2015-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Nakwon Choi ,  Eun-Mi Hur ,  Sohyun Kim ,  Sun-Kyoung Im ,  Eui Sung Yoon ,  Changjoon Justin Lee

IPC: B29C55/00 ,  C12M1/42 ,  B29C55/02 ,  B29C55/20 ,  B29C55/12 ,  C08J5/00 ,  A61L27/16 ,  A61L27/38 ,  A61L27/50

CPC classification number: C12M35/04 ,  A61L27/165 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L2430/32 ,  B29C55/02 ,  B29C55/023 ,  B29C55/12 ,  B29C55/20 ,  C08J5/00

Abstract: The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.