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1.发明申请NEURAL PROBE STRUCTURE COMPRISING COVER ELEMENT WHERE FLUID DELIVERY CHANNEL IS FORMED 有权形成流体输送通道的封套元件的神经探测结构公开(公告)号：US20170065764A1
公开(公告)日：2017-03-09
申请号：US15250469
申请日：2016-08-29
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Il-Joo CHO , Eui Sung YOON , Hyogeun SHIN , Uikyu CHAE , Hyunjoo Jenny LEE
CPC classification number: A61B5/4848 , A61B5/04001 , A61B5/6848 , A61B2562/028 , A61M5/158 , A61M39/105 , A61M2210/0693
Abstract: A neural probe structure has a probe having a microfluidic channel. The probe is inserted into an inside of a subject. A body to which the probe is fixed has a fluid entrance communicating with the microfluidic channel. A cover element is fixed to the body to cover the fluid entrance. The cover element has a connecting opening to which an external conduit is connected, and a fluid delivery channel extending such that the connecting opening and the fluid entrance are in fluid communication. A fluid fed from the external conduit flows along the fluid delivery channel, goes into the fluid entrance, and is delivered to the subject through the microfluidic channel.
Abstract translation: 神经探针结构具有具有微流体通道的探针。 探头插入到被检体的内部。 探针固定到的身体具有与微流体通道连通的流体入口。 盖元件固定到主体以覆盖流体入口。 盖元件具有连接外部导管的连接开口和延伸使得连接开口和流体入口流体连通的流体输送通道。 从外部导管供给的流体沿着流体输送通道流动，进入流体入口，并通过微流体通道输送到受试者。
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公开(公告)号：US20230110294A1
公开(公告)日：2023-04-13
申请号：US17962066
申请日：2022-10-07
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Il-Joo CHO , Nakwon CHOI , Hyogeun SHIN
Abstract: A high resolution fluorescence imaging device includes a light guide plate having a fluid channel which allows a solution containing a fluorescent sample to pass; a light source disposed on a side of the light guide plate to irradiate light inward the light guide plate; an image sensor disposed under the light guide plate;
and a thin film interposed between the light guide plate and the image sensor, wherein the thin film has a first surface having a plurality of pillars and a second surface, the pillars separate the light guide plate and the image sensor apart from each other, and the second surface is bonded to the light guide plate. According to an embodiment, since the light guide plate acts in place of a filter element, it is possible to manufacture in ultrasmall size and achieve multiple fluorescence imaging without replacing a filter.-
公开(公告)号：US20220330871A1
公开(公告)日：2022-10-20
申请号：US17721981
申请日：2022-04-15
Applicant: UIF (University Industry Foundation), Yonsei University , KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Jungmok SEO , Yeontaek LEE , Il-Joo CHO , Hyogeun SHIN
Abstract: The present invention relates to an electrode, which is an in vivo insertable electrode, including a substrate, an electrically conductive layer formed on the substrate, a platinum black layer formed on the electrically conductive layer, a self-assembled monolayer (SAM) formed on the platinum black layer, and a lubricant layer formed on the SAM, a method of manufacturing the electrode, and a medical device including the electrode. The in vivo insertable electrode according to the present invention provides excellent electrical properties such as low impedance. Further, it shows that friction with tissue occurring when the electrode is inserted is reduced, and trauma during insertion and an immune rejection response after insertion is suppressed. Further, in the long term, it is possible to detect signals with high sensitivity throughout the entire period by preventing bioadhesion of in vivo cells, such as immune cells, and other proteins.
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