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    STRETCHING APPARATUS AND METHOD FOR ALIGNING MICROFIBRILS
    2.
    发明申请
    STRETCHING APPARATUS AND METHOD FOR ALIGNING MICROFIBRILS 有权
    拉伸装置和微阵列的方法

    公开(公告)号：US20160152946A1

    公开(公告)日：2016-06-02

    申请号：US14950710

    申请日：2015-11-24

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Nakwon CHOI ,  Eun-Mi HUR ,  Sohyun KIM ,  Sun-Kyoung IM ,  Eui Sung YOON ,  Changjoon Justin LEE

    IPC分类号： C12N5/00

    CPC分类号： C12M35/04 ,  A61L27/165 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L2430/32 ,  B29C55/02 ,  B29C55/023 ,  B29C55/12 ,  B29C55/20 ,  C08J5/00

    摘要： The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.

    摘要翻译： 本发明涉及用于对准微纤丝的拉伸装置和方法。 具体地说，本公开内容提供了一种沿着单一方向对准微原纤维的装置，其包括：第一弹性基材，其上装载有微原纤维的组合物; 以及延伸弹性基板的宽度的拉伸模块。 根据本公开的装置，微原纤维或细胞可以简单地通过拉动然后释放弹性基底沿着特定方向排列。 本公开也可用于培养对准的细胞，因为可以保持细胞的生理活性并且可以防止细胞毒性。

    MICRO SENSING SYSTEM FOR DETECTING NEUROTROPHIC FACTORS
    3.
    发明申请
    MICRO SENSING SYSTEM FOR DETECTING NEUROTROPHIC FACTORS 审中-公开
    用于检测神经营养因子的微观传感系统

    公开(公告)号：US20150208963A1

    公开(公告)日：2015-07-30

    申请号：US14534378

    申请日：2014-11-06

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Hyunjoo Jenny LEE ,  Il-Joo CHO ,  Eui Sung YOON ,  Nakwon CHOI

    IPC分类号： A61B5/145 ,  A61B5/00

    CPC分类号： A61B5/14514 ,  A61B5/14503 ,  A61B5/4064 ,  A61B5/685

    摘要： A micro sensing system for real-time sensing a neurotrophic factor included in a body fluid includes a body, a neurotrophic factor channel formed in the body to allow a fluid flow therein, and a biosensor formed at the body to sense the neurotrophic factor, wherein the body fluid is extracted in a living body through the neurotrophic factor channel, and wherein the biosensor is disposed on a path of the neurotrophic factor channel to directly contact a body fluid flowing through the neurotrophic factor channel and senses a concentration of a neurotrophic factor in the body fluid.

    摘要翻译： 用于实时感测包括在体液中的神经营养因子的微观感测系统包括身体，在体内形成的允许流体流动的神经营养因子通道，以及形成在身体的生物传感器以感测神经营养因子，其中 体液通过神经营养因子通道在生物体中提取，其中生物传感器设置在神经营养因子通道的路径上，以直接接触流过神经营养因子通道的体液，并感测神经营养因子的浓度 体液。

    NEURAL PROBE STRUCTURE COMPRISING COVER ELEMENT WHERE FLUID DELIVERY CHANNEL IS FORMED
    4.
    发明申请
    NEURAL PROBE STRUCTURE COMPRISING COVER ELEMENT WHERE FLUID DELIVERY CHANNEL IS FORMED 有权
    形成流体输送通道的封套元件的神经探测结构

    公开(公告)号：US20170065764A1

    公开(公告)日：2017-03-09

    申请号：US15250469

    申请日：2016-08-29

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Il-Joo CHO ,  Eui Sung YOON ,  Hyogeun SHIN ,  Uikyu CHAE ,  Hyunjoo Jenny LEE

    IPC分类号： A61M5/14 ,  A61B5/04 ,  A61B5/00 ,  A61M5/168

    CPC分类号： A61B5/4848 ,  A61B5/04001 ,  A61B5/6848 ,  A61B2562/028 ,  A61M5/158 ,  A61M39/105 ,  A61M2210/0693

    摘要： A neural probe structure has a probe having a microfluidic channel. The probe is inserted into an inside of a subject. A body to which the probe is fixed has a fluid entrance communicating with the microfluidic channel. A cover element is fixed to the body to cover the fluid entrance. The cover element has a connecting opening to which an external conduit is connected, and a fluid delivery channel extending such that the connecting opening and the fluid entrance are in fluid communication. A fluid fed from the external conduit flows along the fluid delivery channel, goes into the fluid entrance, and is delivered to the subject through the microfluidic channel.

    摘要翻译： 神经探针结构具有具有微流体通道的探针。 探头插入到被检体的内部。 探针固定到的身体具有与微流体通道连通的流体入口。 盖元件固定到主体以覆盖流体入口。 盖元件具有连接外部导管的连接开口和延伸使得连接开口和流体入口流体连通的流体输送通道。 从外部导管供给的流体沿着流体输送通道流动，进入流体入口，并通过微流体通道输送到受试者。

    APPARATUS AND METHOD FOR MANUFACTURING MICRO LENS ARRAY, AND MICRO LENS ARRAY MANUFACTURED USING THE SAME
    5.
    发明申请
    APPARATUS AND METHOD FOR MANUFACTURING MICRO LENS ARRAY, AND MICRO LENS ARRAY MANUFACTURED USING THE SAME 审中-公开
    用于制造微透镜阵列的装置和方法以及使用其制造的微透镜阵列

    公开(公告)号：US20150131034A1

    公开(公告)日：2015-05-14

    申请号：US14314202

    申请日：2014-06-25

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Il-Joo CHO ,  Eui Sung YOON ,  Hyunjoo Jenny LEE

    IPC分类号： G02F1/1333 ,  G02B27/22

    CPC分类号： G02B3/0031 ,  G02B3/0018

    摘要： As an apparatus for manufacturing a micro lens array includes a first substrate having a plurality of cavities formed at locations corresponding to locations of the plurality of micro lenses, and a second substrate having a lower softening point than the first substrate and bonded on the first substrate to close the plurality of cavities, wherein a portion of the second substrate located on the cavities swells convexly by air trapped in the cavities expanding its volume in response to a temperature above the softening point of the second substrate being applied, to form domes corresponding to a shape of the micro lenses, and the micro lens array is cast using the second substrate having the formed domes as a mold.

    摘要翻译： 作为微透镜阵列的制造装置，具有在与多个微透镜的位置对应的位置形成有多个空腔的第一基板和具有比第一基板软化点低的第二基板， 以闭合所述多个空腔，其中位于所述空腔上的所述第二基板的一部分由所述空腔中的空气膨胀而膨胀，以响应于高于所施加的第二基板的软化点的温度来扩张其体积，以形成对应于 微透镜的形状，并且使用具有形成的圆顶的第二基板作为模具来铸造微透镜阵列。

    MICRO PROBE AND MANUFACTURING METHOD THEREOF
    6.
    发明申请
    MICRO PROBE AND MANUFACTURING METHOD THEREOF 有权
    微探针及其制造方法

    公开(公告)号：US20130123599A1

    公开(公告)日：2013-05-16

    申请号：US13670957

    申请日：2012-11-07

    申请人： Korea Institute of Science and Technology

    发明人： Il Joo CHO ,  Eui Sung YOON ,  Jei Won CHO ,  Myoung Gun JEON ,  Yun Kyung KIM

    IPC分类号： A61B5/0478

    CPC分类号： A61B5/0478 ,  A61B5/6868 ,  A61B2503/40 ,  A61B2503/42 ,  A61B2562/125 ,  A61B2562/18

    摘要： The micro probe according to an embodiment of the present disclosure includes: a probe portion made of a rigid material and serving as a portion inserted into the brain; a flexible portion connected to a distal end of the probe portion and made of a flexible material; a soluble portion coated on at least one surface of the flexible portion and made of a material which is dissolved by a solution in the cranium; and a body portion connected to the other end of the flexible portion whose one end is connected to the probe portion.

    摘要翻译： 根据本公开的实施例的微型探针包括：由刚性材料制成并用作插入脑中的部分的探针部分; 柔性部分，其连接到探针部分的远端并由柔性材料制成; 所述可溶部分涂覆在所述柔性部分的至少一个表面上，并且由溶液溶解在所述颅骨中的材料制成; 以及主体部分，其连接到柔性部分的另一端，其一端连接到探针部分。