公开(公告)号：US20170065764A1

公开(公告)日：2017-03-09

申请号：US15250469

申请日：2016-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo CHO ,  Eui Sung YOON ,  Hyogeun SHIN ,  Uikyu CHAE ,  Hyunjoo Jenny LEE

IPC: A61M5/14 ,  A61B5/04 ,  A61B5/00 ,  A61M5/168

CPC classification number: A61B5/4848 ,  A61B5/04001 ,  A61B5/6848 ,  A61B2562/028 ,  A61M5/158 ,  A61M39/105 ,  A61M2210/0693

Abstract: A neural probe structure has a probe having a microfluidic channel. The probe is inserted into an inside of a subject. A body to which the probe is fixed has a fluid entrance communicating with the microfluidic channel. A cover element is fixed to the body to cover the fluid entrance. The cover element has a connecting opening to which an external conduit is connected, and a fluid delivery channel extending such that the connecting opening and the fluid entrance are in fluid communication. A fluid fed from the external conduit flows along the fluid delivery channel, goes into the fluid entrance, and is delivered to the subject through the microfluidic channel.

Abstract translation: 神经探针结构具有具有微流体通道的探针。 探头插入到被检体的内部。 探针固定到的身体具有与微流体通道连通的流体入口。 盖元件固定到主体以覆盖流体入口。 盖元件具有连接外部导管的连接开口和延伸使得连接开口和流体入口流体连通的流体输送通道。 从外部导管供给的流体沿着流体输送通道流动，进入流体入口，并通过微流体通道输送到受试者。

公开(公告)号：US20150131034A1

公开(公告)日：2015-05-14

申请号：US14314202

申请日：2014-06-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo CHO ,  Eui Sung YOON ,  Hyunjoo Jenny LEE

IPC: G02F1/1333 ,  G02B27/22

CPC classification number: G02B3/0031 ,  G02B3/0018

Abstract: As an apparatus for manufacturing a micro lens array includes a first substrate having a plurality of cavities formed at locations corresponding to locations of the plurality of micro lenses, and a second substrate having a lower softening point than the first substrate and bonded on the first substrate to close the plurality of cavities, wherein a portion of the second substrate located on the cavities swells convexly by air trapped in the cavities expanding its volume in response to a temperature above the softening point of the second substrate being applied, to form domes corresponding to a shape of the micro lenses, and the micro lens array is cast using the second substrate having the formed domes as a mold.

Abstract translation: 作为微透镜阵列的制造装置，具有在与多个微透镜的位置对应的位置形成有多个空腔的第一基板和具有比第一基板软化点低的第二基板， 以闭合所述多个空腔，其中位于所述空腔上的所述第二基板的一部分由所述空腔中的空气膨胀而膨胀，以响应于高于所施加的第二基板的软化点的温度来扩张其体积，以形成对应于 微透镜的形状，并且使用具有形成的圆顶的第二基板作为模具来铸造微透镜阵列。

公开(公告)号：US20170253860A1

公开(公告)日：2017-09-07

申请号：US15438215

申请日：2017-02-21

Applicant: Korea Institute of Science and Technology

Inventor： Nakwon CHOI ,  Sohyun KIM ,  Sohyeon JEONG ,  Eui Sung YOON ,  Changjoon Justin LEE ,  Il-Joo CHO

IPC: C12N5/09 ,  B29C43/18 ,  C12M3/00 ,  C08J7/04 ,  C12N5/00 ,  C12M1/12

CPC classification number: C12N5/0693 ,  B29C43/02 ,  B29C43/18 ,  B29C43/36 ,  B29C2043/185 ,  B29K2995/0046 ,  C08J7/047 ,  C08J2383/04 ,  C08J2465/00 ,  C12M21/08 ,  C12M25/14 ,  C12N5/0068 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2535/00

Abstract: The present disclosure relates to an apparatus and a method for manufacturing a channel-coupled scaffold. The present disclosure provides a method for manufacturing a channel-coupled scaffold, which includes: (1) a step of compressing a first elastic substrate which includes a groove on the surface of the substrate to close the groove; (2) a step of loading a scaffold composition onto the closed groove; and (3) a step of restoring the elastic substrate. The present disclosure also provides an apparatus for manufacturing a channel-coupled scaffold, which includes: a first elastic substrate which includes a groove on the surface of the substrate and onto which a scaffold composition is loaded: and a compression module which compresses the width of the groove of the elastic substrate to close it. The apparatus or method may accumulate a microchannel controlling local mass transfer, and align a collagen fiber in the scaffold at the same time.

公开(公告)号：US20230110294A1

公开(公告)日：2023-04-13

申请号：US17962066

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo CHO ,  Nakwon CHOI ,  Hyogeun SHIN

IPC: G01N15/14 ,  F21V8/00 ,  G02B1/04

Abstract: A high resolution fluorescence imaging device includes a light guide plate having a fluid channel which allows a solution containing a fluorescent sample to pass; a light source disposed on a side of the light guide plate to irradiate light inward the light guide plate; an image sensor disposed under the light guide plate;
and a thin film interposed between the light guide plate and the image sensor, wherein the thin film has a first surface having a plurality of pillars and a second surface, the pillars separate the light guide plate and the image sensor apart from each other, and the second surface is bonded to the light guide plate. According to an embodiment, since the light guide plate acts in place of a filter element, it is possible to manufacture in ultrasmall size and achieve multiple fluorescence imaging without replacing a filter.

公开(公告)号：US20220330871A1

公开(公告)日：2022-10-20

申请号：US17721981

申请日：2022-04-15

Applicant: UIF (University Industry Foundation), Yonsei University ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungmok SEO ,  Yeontaek LEE ,  Il-Joo CHO ,  Hyogeun SHIN

IPC: A61B5/251 ,  A61B5/263 ,  C25D3/50 ,  C25D5/48 ,  C25D7/00

Abstract: The present invention relates to an electrode, which is an in vivo insertable electrode, including a substrate, an electrically conductive layer formed on the substrate, a platinum black layer formed on the electrically conductive layer, a self-assembled monolayer (SAM) formed on the platinum black layer, and a lubricant layer formed on the SAM, a method of manufacturing the electrode, and a medical device including the electrode. The in vivo insertable electrode according to the present invention provides excellent electrical properties such as low impedance. Further, it shows that friction with tissue occurring when the electrode is inserted is reduced, and trauma during insertion and an immune rejection response after insertion is suppressed. Further, in the long term, it is possible to detect signals with high sensitivity throughout the entire period by preventing bioadhesion of in vivo cells, such as immune cells, and other proteins.

公开(公告)号：US20210085996A1

公开(公告)日：2021-03-25

申请号：US16894887

申请日：2020-06-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Il-Joo CHO ,  Namsun CHOU

IPC: A61N5/06

Abstract: A neural probe structure includes a probe that is inserted into a subject, a body to support a rear end of the probe, at least one light source included in the body, a photo diode formed in the probe, and an optical waveguide extending from the at least one light source in the body to the photo diode of the probe, wherein the photo diode is formed at a smaller height than the optical waveguide.

公开(公告)号：US20150208963A1

公开(公告)日：2015-07-30

申请号：US14534378

申请日：2014-11-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunjoo Jenny LEE ,  Il-Joo CHO ,  Eui Sung YOON ,  Nakwon CHOI

IPC: A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14514 ,  A61B5/14503 ,  A61B5/4064 ,  A61B5/685

Abstract: A micro sensing system for real-time sensing a neurotrophic factor included in a body fluid includes a body, a neurotrophic factor channel formed in the body to allow a fluid flow therein, and a biosensor formed at the body to sense the neurotrophic factor, wherein the body fluid is extracted in a living body through the neurotrophic factor channel, and wherein the biosensor is disposed on a path of the neurotrophic factor channel to directly contact a body fluid flowing through the neurotrophic factor channel and senses a concentration of a neurotrophic factor in the body fluid.

Abstract translation: 用于实时感测包括在体液中的神经营养因子的微观感测系统包括身体，在体内形成的允许流体流动的神经营养因子通道，以及形成在身体的生物传感器以感测神经营养因子，其中 体液通过神经营养因子通道在生物体中提取，其中生物传感器设置在神经营养因子通道的路径上，以直接接触流过神经营养因子通道的体液，并感测神经营养因子的浓度 体液。