公开(公告)号：US20230313241A1

公开(公告)日：2023-10-05

申请号：US18059330

申请日：2022-11-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ja Kyong KO ,  Youngyun JO ,  Gyeongtaek GONG ,  Jung Ho AHN ,  Sun Mi LEE ,  Youngsoon UM

IPC: C12P7/625 ,  C12N15/74 ,  C12N9/10

CPC classification number: C12P7/625 ,  C12N15/74 ,  C12N9/1022 ,  C12Y202/01006 ,  C12N9/1029 ,  C12Y203/01009 ,  C12Y203/01182

Abstract: The present disclosure provides a recombinant microorganism for producing PHBV, a method for preparing the same, and a method for producing PHBV using the microorganism. The present disclosure may provide a recombinant microorganism capable of producing PHBV, which is a biodegradable plastic material with superior physical properties, directly from an inexpensive single carbon source with high efficiency without supplementation of organic acid. The present disclosure can enhance the utilization of PHA, which is expensive and has limited physical properties, and can also provide a technology more effective for industrialization using an inexpensive single carbon source. The PHBV produced according to an exemplary embodiment of the present disclosure can be used not only for general-purpose inexpensive products such as ecofriendly packing materials but also as a high-value-added medical biopolymer.

公开(公告)号：US20240117389A1

公开(公告)日：2024-04-11

申请号：US18470284

申请日：2023-09-19

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Youngsoon UM ,  Deurim YUN ,  Sun Mi LEE ,  Gyeongtaek GONG ,  Ja Kyong KO ,  Jung Ho AHN

IPC: C12P7/40 ,  C12P7/02 ,  C12P7/16 ,  C12P7/52

CPC classification number: C12P7/40 ,  C12P7/02 ,  C12P7/16 ,  C12P7/52

Abstract: The present disclosure is to provide a method capable of producing an organic acid in high yield from an acetic acid strain using synthesis gas as a substrate. According to the present disclosure, the productivity of metabolites with C2 to C6 carbon atoms derived from synthesis gas and the selectivity of hexanoic acid production among metabolites can be improved through a first fermentation step of simultaneously providing a substrate comprising synthesis gas and sugar; and a second fermentation step of semi-mixotrophic fermentation of providing only the substrate comprising the synthesis gas. Therefore, the disclosure can contribute to sustainable chemical production using synthesis gas.

公开(公告)号：US20230383317A1

公开(公告)日：2023-11-30

申请号：US18249379

申请日：2020-11-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyunju OH ,  Youngsoon UM ,  Sun Mi LEE ,  Gyeongtaek GONG ,  Ja Kyong KO

IPC: C12P7/16 ,  C12N1/20

CPC classification number: C12P7/16 ,  C12N1/20

Abstract: The present invention relates to a composition for producing 2,3-butanediol by using ethanol and synthetic gas and a 2,3-butanediol production method. A composition according to an aspect of the present invention includes ethanol as an active ingredient. In the case where a 2,3-butanediol production strain is inoculated into a medium containing the composition and cultured and a synthetic gas is added thereto, 2,3-butanediol, which is a biofuel and a chemical substance, can be economically produced with ethanol serving as a substrate. In the metabolism process, the carbon flux can be concentrated on the production route of the target material, whereby the composition has an excellent effect of increasing the production efficiency of 2,3-butanediol and enhancing the productivity of 2,3-butanediol by controlling only fermentation conditions such as amounts of the synthetic gas or ethanol and stirring speeds of the medium.

公开(公告)号：US20230093685A1

公开(公告)日：2023-03-23

申请号：US17849571

申请日：2022-06-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ju OH ,  Youngsoon UM ,  Sun Mi LEE ,  Gyeongtaek GONG ,  Ja Kyong KO

IPC: C12P7/06 ,  C12P7/16

Abstract: The present disclosure relates to a composition for preparing hexanol or butanol and a method for preparing hexanol or butanol using ethanol and synthesis gas, wherein the composition according to an aspect of the present disclosure is a medium composition containing ethanol as an active ingredient, and by culturing a strain producing hexanol or butanol after inoculating with a medium containing the composition and supplying synthesis gas, hexanol or butanol can be prepared economically using inexpensive synthesis gas, and hexanol or butanol can be prepared with high efficiency by focusing the flow of a carbon source consumed in a fermentation process to the production of hexanol or butanol.