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1.发明公开公开(公告)号：US20240117389A1
公开(公告)日：2024-04-11
申请号：US18470284
申请日：2023-09-19
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Youngsoon UM , Deurim YUN , Sun Mi LEE , Gyeongtaek GONG , Ja Kyong KO , Jung Ho AHN
Abstract: The present disclosure is to provide a method capable of producing an organic acid in high yield from an acetic acid strain using synthesis gas as a substrate. According to the present disclosure, the productivity of metabolites with C2 to C6 carbon atoms derived from synthesis gas and the selectivity of hexanoic acid production among metabolites can be improved through a first fermentation step of simultaneously providing a substrate comprising synthesis gas and sugar; and a second fermentation step of semi-mixotrophic fermentation of providing only the substrate comprising the synthesis gas. Therefore, the disclosure can contribute to sustainable chemical production using synthesis gas.
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公开(公告)号：US20230383317A1
公开(公告)日：2023-11-30
申请号：US18249379
申请日：2020-11-24
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Hyunju OH , Youngsoon UM , Sun Mi LEE , Gyeongtaek GONG , Ja Kyong KO
Abstract: The present invention relates to a composition for producing 2,3-butanediol by using ethanol and synthetic gas and a 2,3-butanediol production method. A composition according to an aspect of the present invention includes ethanol as an active ingredient. In the case where a 2,3-butanediol production strain is inoculated into a medium containing the composition and cultured and a synthetic gas is added thereto, 2,3-butanediol, which is a biofuel and a chemical substance, can be economically produced with ethanol serving as a substrate. In the metabolism process, the carbon flux can be concentrated on the production route of the target material, whereby the composition has an excellent effect of increasing the production efficiency of 2,3-butanediol and enhancing the productivity of 2,3-butanediol by controlling only fermentation conditions such as amounts of the synthetic gas or ethanol and stirring speeds of the medium.
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公开(公告)号：US20230093685A1
公开(公告)日：2023-03-23
申请号：US17849571
申请日：2022-06-24
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Hyun Ju OH , Youngsoon UM , Sun Mi LEE , Gyeongtaek GONG , Ja Kyong KO
Abstract: The present disclosure relates to a composition for preparing hexanol or butanol and a method for preparing hexanol or butanol using ethanol and synthesis gas, wherein the composition according to an aspect of the present disclosure is a medium composition containing ethanol as an active ingredient, and by culturing a strain producing hexanol or butanol after inoculating with a medium containing the composition and supplying synthesis gas, hexanol or butanol can be prepared economically using inexpensive synthesis gas, and hexanol or butanol can be prepared with high efficiency by focusing the flow of a carbon source consumed in a fermentation process to the production of hexanol or butanol.
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公开(公告)号：US20230313241A1
公开(公告)日：2023-10-05
申请号：US18059330
申请日：2022-11-28
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Ja Kyong KO , Youngyun JO , Gyeongtaek GONG , Jung Ho AHN , Sun Mi LEE , Youngsoon UM
CPC classification number: C12P7/625 , C12N15/74 , C12N9/1022 , C12Y202/01006 , C12N9/1029 , C12Y203/01009 , C12Y203/01182
Abstract: The present disclosure provides a recombinant microorganism for producing PHBV, a method for preparing the same, and a method for producing PHBV using the microorganism. The present disclosure may provide a recombinant microorganism capable of producing PHBV, which is a biodegradable plastic material with superior physical properties, directly from an inexpensive single carbon source with high efficiency without supplementation of organic acid. The present disclosure can enhance the utilization of PHA, which is expensive and has limited physical properties, and can also provide a technology more effective for industrialization using an inexpensive single carbon source. The PHBV produced according to an exemplary embodiment of the present disclosure can be used not only for general-purpose inexpensive products such as ecofriendly packing materials but also as a high-value-added medical biopolymer.
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公开(公告)号：US20220113243A1
公开(公告)日：2022-04-14
申请号：US17083299
申请日：2020-10-29
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Myung-Suk CHUN , Sun Mi LEE , Jae Hun KIM , Chansung PARK
Abstract: Provided is an apparatus for cell particle sorting based on microfluidic-chip flow, by using a design in which Dean flow focusing occurring in a spiral channel and hydrodynamic filtration are coupled. The apparatus comprises a first substrate including a spiral channel having an inner surface and an outer surface based on a radius of curvature, a sample solution inlet, a medium inlet, and a spiral inner-outlet and a spiral outer-outlet both for discharging the particles, and a second substrate including a main channel in which the sample solution discharged from the first substrate and passing through an inter-substrate way flows and a cut-off width WC is set, a side channel allowing a medium introduced into the medium inlet to flow to focus the sample solution on a sidewall of the main channel, a plurality of branch channels connected to the sidewall of main channel and configured to receive the particles from the main channel, a main channel outlet, and at least one branch channel outlet.
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Patent Agency Ranking
公开(公告)号：US20240352401A1
公开(公告)日：2024-10-24
申请号：US18521797
申请日：2023-11-28
Applicant: Korea Institute of Science and Technology
Inventor： Sun Mi LEE , Jiwon Kim , Hyeoncheol Son , Ja Kyong Ko , Gyeongtaek Gong , Jung Ho Ahn , Youngsoon Um
CPC classification number: C12N1/165 , C12N9/0008 , C12N15/815 , C12R2001/645 , C12Y102/01003
Abstract: The present disclosure discloses a strain having resistance by neutralizing furfural, an inhibitor derived from lignocellulosic biomass, based on a technique using aldehyde dehydrogenase and a method of using the same. According to the present disclosure, furfural, an inhibitor derived from lignocellulosic biomass, is neutralized based on a technique using aldehyde dehydrogenase, so that a resistant strain overexpresses aldehyde dehydrogenase (EcAldH) in Yarrowia lipolytica, which has the ability to produce yeast oil, and has resistance to furfural, a biomass-derived inhibitor. Accordingly, even in the medium containing furfural, it can provide excellent strain growth and yeast oil production ability.
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7.发明公开公开(公告)号：US20230242948A1
公开(公告)日：2023-08-03
申请号：US17823034
申请日：2022-08-29
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Sun Mi LEE , Yeon-Ho CHOI , Gyeongtaek GONG , Ja Kyoung KO , Jung Ho AHN , Youngsoon UM
IPC: C12P7/6409 , C12N9/10 , C12N1/16
CPC classification number: C12P7/6409 , C12N9/1029 , C12Y203/0102 , C12N1/16
Abstract: The present specification describes a culture of a microorganism, which comprises an increased content of oleic acid, or a microbial oil comprising the same. In addition, the present specification describes a method for producing oleic acid and lipids comprising the same by culturing a microorganism. Since the present disclosure enables the production of lipids comprising oleic acid at a high concentration without genetic manipulation of a lipid-producing microorganism, it may be utilized in various industrial fields requiring oleic acid, such as foods, cosmetic materials, biofuels, etc.
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公开(公告)号：US20170283832A1
公开(公告)日：2017-10-05
申请号：US15357815
申请日：2016-11-21
Applicant: Korea Institute of Science and Technology
Inventor： Han Min WOO , Sun-young CHOI , Youngsoon UM , Gyeong Taek GONG , Sun Mi LEE , Yunje KIM
CPC classification number: C12P5/007 , C12N9/0006 , C12N9/1022 , C12N9/1085 , C12N9/90 , C12N15/52 , C12Y101/01267 , C12Y202/01007 , C12Y205/0101 , C12Y205/01021 , C12Y503/03002
Abstract: The present specification discloses a transformed Synechococcus elongatus strain which may directly produce squalene from carbon dioxide, and a method for producing squalene and a method for removing carbon dioxide, using the same. In an aspect, the strain may produce squalene using carbon dioxide as a carbon source. The Synechococcus elongatus strain is economically efficient because a high-value added squalene is produced using light and carbon dioxide present in the atmosphere as a carbon source, and the method for producing squalene is eco-friendly because the strain may be utilized to remove or reduce carbon dioxide in the atmosphere by using microorganisms. The strain of the present disclosure may produce only squalene, which is a desired target material with high purity, and has an advantage in that squalene may be continuously mass-produced.
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公开(公告)号：US20170114375A1
公开(公告)日：2017-04-27
申请号：US15299188
申请日：2016-10-20
Applicant: Korea Institute of Science and Technology
Inventor： Han Min WOO , Hyun Jeong LEE , Youngsoon UM , Gyeong Taek GONG , Sun Mi LEE , Yunje KIM
CPC classification number: C12P7/649 , C12N9/0006 , C12N9/1029 , C12N9/16 , C12N9/88 , C12N15/52 , C12Y101/01001 , C12Y401/01001
Abstract: The present disclosure discloses a transformed Synechococcus elongatus strain capable of producing biodiesel directly from carbon dioxide and a method for producing biodiesel and a method for removing carbon dioxide using the same. In an aspect, the transformed Synechococcus elongatus strain of the present disclosure can produce biodiesel in large scale using carbon dioxide as a carbon source. The Synechococcus elongatus strain is environment-friendly because it can be used to remove or reduce carbon dioxide in the atmosphere. The strain of the present disclosure is advantageous in that it can produce biodiesel in large scale because it grows faster and exhibits excellent carbon dioxide fixation capability as compared to other photosynthetic microorganisms.
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10.发明申请VECTORS AND STRAINS FOR PRODUCING MYRCENE AND METHOD OF PRODUCING MYRCENE USING THE SAME 有权用于生产MYRCENE的产品和生产方法以及使用该方法生产MYRCENE的方法公开(公告)号：US20170009240A1
公开(公告)日：2017-01-12
申请号：US14950425
申请日：2015-11-24
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Han Min WOO , Eun Mi KIM , Youngsoon UM , Gyeongtaek GONG , Sun Mi LEE , Yunje KIM
CPC classification number: C12N15/52 , C12N9/0006 , C12N9/1029 , C12N9/1085 , C12N9/1205 , C12N9/1229 , C12N9/88 , C12N9/90 , C12N15/70 , C12N15/71 , C12N15/72 , C12Y101/01034 , C12Y203/01026 , C12Y205/01 , C12Y207/01036 , C12Y207/04002 , C12Y401/01033 , C12Y401/03 , C12Y503/03002
Abstract: Disclosed herein are an expression vector capable of expressing myrcene, an Escherichia coli strain transformed with the vector and having improved capability of producing myrcene and a method for producing myrcene and a method for recycling glycerol using the same. In an aspect, the transformed Escherichia coli strain of the present disclosure can produce myrcene with high purity on a large scale using glycerol or glucose as a carbon source. Also, the Escherichia coli strain of the present disclosure is economical and environment-friendly because it can produce high value-added myrcene using waste glycerol as a carbon source. In addition, the strongly volatile myrcene can be produced and isolated at the same time.
Abstract translation: 本文公开了能够表达月桂烯的表达载体，用载体转化的大肠杆菌菌株，并且具有改进的生产月桂烯的能力和用于制备月桂烯的方法和使用该方法回收甘油的方法。 在一方面，本公开的转化的大肠杆菌菌株可以使用甘油或葡萄糖作为碳源大量生产高纯度的月桂烯。 此外，本公开的大肠杆菌菌株是经济和环境友好的，因为它可以使用废甘油作为碳源产生高附加值的月桂烯。 此外，强烈挥发性月桂烯可以同时生产和分离。
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