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    METHOD FOR PREPARING OSTEOBLASTS AND OSTEOBLAST INDUCER
    6.
    发明申请
    METHOD FOR PREPARING OSTEOBLASTS AND OSTEOBLAST INDUCER 审中-公开
    制备OSTEOBLASTS和OSTEOBLAST电感的方法

    公开(公告)号：US20170037374A1

    公开(公告)日：2017-02-09

    申请号：US15304287

    申请日：2015-04-17

    申请人： KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION

    发明人： Kenta YAMAMOTO ,  Tsunao KISHIDA ,  Toshiro YAMAMOTO ,  Osam MAZDA

    IPC分类号： C12N5/077

    CPC分类号： C12N5/0654 ,  A61K35/32 ,  C12N2500/30 ,  C12N2501/01 ,  C12N2501/065 ,  C12N2501/36 ,  C12N2501/39 ,  C12N2501/72 ,  C12N2501/727 ,  C12N2506/1307

    摘要： An object of the present invention is to provide a method for preparing osteoblasts that are applicable, without causing risk of canceration, to bone defect repair or to the treatment of bone resorption, fracture, osteoporosis, or the like. To solve this problem, the present invention provides a method for preparing osteoblasts, the method comprising culturing mammal differentiated somatic cells in a medium in the presence of at least one compound selected from the group consisting of (1) statin compounds, (2) casein kinase 1 inhibitors, (3) cAMP inducers, and (4) histone methyltransferase inhibitors, to convert the somatic cells into osteoblasts.

    摘要翻译： 本发明的目的是提供一种制备可以不引起癌变风险的成骨细胞制备骨缺损修复或骨吸收，骨折，骨质疏松症等的治疗方法。 为了解决这个问题，本发明提供了一种制备成骨细胞的方法，该方法包括在至少一种选自（1）他汀类化合物，（2）酪蛋白的化合物的存在下，在培养基中培养哺乳动物分化的体细胞 激酶1抑制剂，（3）cAMP诱导剂和（4）组蛋白甲基转移酶抑制剂，将体细胞转化成成骨细胞。

    OSTEOBLAST AND METHOD FOR PREPARING SAME
    7.
    发明申请
    OSTEOBLAST AND METHOD FOR PREPARING SAME 审中-公开
    OSTEOBLAST及其制备方法

    公开(公告)号：US20160160180A1

    公开(公告)日：2016-06-09

    申请号：US14906948

    申请日：2014-07-24

    申请人： KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION

    发明人： Kenta YAMAMOTO ,  Tsunao KISHIDA ,  Toshiro YAMAMOTO ,  Osam MAZDA

    IPC分类号： C12N5/077 ,  C12N15/85

    CPC分类号： C12N5/0654 ,  C12N15/85 ,  C12N2501/60 ,  C12N2501/603 ,  C12N2506/1307 ,  C12N2510/00

    摘要： The present invention relates to: a method of preparing an osteoblast from a somatic cell of a mammal, the method including introducing a bone-related gene or an expression product thereof and a reprogramming-related gene or an expression product thereof, or introducing a reprogramming-related gene or an expression product thereof independently into the somatic cell, the bone-related gene including at least one kind selected from the group consisting of Runx2 (R), Osterix (O), and Dlx5 (D), the reprogramming-related gene including at least one kind selected from the group consisting of Oct family, c-Myc (M), L-Myc (L), Klf family, Lin-28, and Sox2; and an osteoblast prepared by the method.

    摘要翻译： 本发明涉及一种从哺乳动物体细胞制备成骨细胞的方法，所述方法包括引入骨相关基因或其表达产物和重编程相关基因或其表达产物，或引入重编程 相关基因或其表达产物独立地进入体细胞，所述骨相关基因包括选自Runx2（R），Osterix（O）和Dlx5（D）中的至少一种，重编程相关基因 包括选自Oct族，c-Myc（M），L-Myc（L），Klf家族，Lin-28和Sox2中的至少一种的基因; 和通过该方法制备的成骨细胞。