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    Peptides for Treatment of Autoimmune Disease
    3.
    发明申请
    Peptides for Treatment of Autoimmune Disease 审中-公开
    用于治疗自身免疫性疾病的肽

    公开(公告)号：US20070264229A1

    公开(公告)日：2007-11-15

    申请号：US11662697

    申请日：2005-09-13

    申请人： Jack Strominger

    发明人： Jack Strominger

    IPC分类号： A61K38/00 ,  A61K38/21 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61P21/00 ,  C07K14/00

    CPC分类号： A61K45/06 ,  A61K38/00 ,  A61K39/0008 ,  A61K2039/55566 ,  C07K7/08 ,  C07K14/4713

    摘要： Peptides are provided that both inhibit more strongly than synthetic amino acid polymers the binding of MBP85-99 to HLA-DR2 (DRA/DRB1*1501), and inhibit interleukin-2 production by two MBP85-99-specific HLA-DR2-restricted T cells. Peptide 15mers J5, J3, and J2 suppress MBP85-99-induced EAE in humanized mice and proteolipid protein 139-151-induced EAE in SJL/J mice. Spleen and lymph node cultures stimulated with these peptides produced large amounts of Th2 cytokines (IL-4 and IL-10), and adoptive transfer of T cell lines established from those cultures suppressed disease induction. These peptides provide specific, non-random sequences that are as effective as random copolymers in suppressing EAE in several murine models, and may be useful in treatment of MS.

    摘要翻译： 提供的肽比合成氨基酸聚合物比MBP85-99与HLA-DR2（DRA / DRB1 * 1501）的结合更强烈地抑制，并且通过两种MBP85-99特异性HLA-DR2限制性T抑制白细胞介素-2产生 细胞。 肽15mg J5，J3和J2抑制人源化小鼠中的MBP85-99诱导的EAE和SJL / J小鼠中的蛋白脂蛋白139-151诱导的EAE。 用这些肽刺激的脾和淋巴结培养物产生大量的Th2细胞因子（IL-4和IL-10），并且由这些培养物建立的T细胞系的过继转移抑制疾病诱导。 这些肽提供了在几种鼠模型中抑制EAE中无规共聚物有效的特异性非随意序列，并且可用于治疗MS。

    Treatment of autoimmune conditions with Copolymer 1 and related Copolymers
    5.
    发明申请
    Treatment of autoimmune conditions with Copolymer 1 and related Copolymers 有权
    用共聚物1和相关共聚物治疗自身免疫病症

    公开(公告)号：US20070021341A1

    公开(公告)日：2007-01-25

    申请号：US11528894

    申请日：2006-09-27

    申请人： Michael Sela ,  Masha Fridkis-Hareli ,  Jack Strominger ,  Rina Aharoni ,  Dvora Teitelbaum ,  Ruth Arnon

    发明人： Michael Sela ,  Masha Fridkis-Hareli ,  Jack Strominger ,  Rina Aharoni ,  Dvora Teitelbaum ,  Ruth Arnon

    IPC分类号： C07K14/47 ,  A61K38/16

    CPC分类号： A61K31/785 ,  A61K38/16 ,  C08G73/02 ,  G01N33/6842 ,  Y10S424/81 ,  Y10S514/866 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/903

    摘要： The present invention is directed to polypeptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three amino acids is a charged amino acid and at least one amino acid is an aliphatic amino acid. In a preferred embodiment the polypeptide contains three or four of the following amino acids: tyrosine, alanine, glutamic acid or lysine. According to the present invention, the present polypeptides bind to antigen presenting cells, purified human lymphocyte antigens (HLA) and/or Copolymer 1-specific T cells. Moreover, according to the present invention, these polypeptides can be formulated into pharmaceutical compositions for treating autoimmune disease. The present invention further contemplates methods of treating an autoimmune disease in a mammal by administering a pharmaceutically effective amount of any one of the present polypeptides to the mammal.

    摘要翻译： 本发明涉及含有以线性阵列随机连接的至少三个氨基酸的多肽; 其中所述三个氨基酸中的至少一个是芳族氨基酸，所述三个氨基酸中的至少一个是带电荷的氨基酸，并且至少一个氨基酸是脂族氨基酸。 在优选的实施方式中，多肽含有三个或四个以下氨基酸：酪氨酸，丙氨酸，谷氨酸或赖氨酸。 根据本发明，本发明的多肽与抗原呈递细胞，纯化的人淋巴细胞抗原（HLA）和/或共聚物1-特异性T细胞结合。 此外，根据本发明，这些多肽可以配制成用于治疗自身免疫疾病的药物组合物。 本发明进一步考虑了通过向哺乳动物施用药学上有效量的本发明多肽的任何一种来治疗哺乳动物自身免疫性疾病的方法。