公开(公告)号：US20050085537A1

公开(公告)日：2005-04-21

申请号：US10747671

申请日：2003-12-30

申请人： Kanury Rao ,  Mohan Wani ,  Venkatasamy Manivel ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa ,  Gyan Mishra ,  Anil Chatterji

发明人： Kanury Rao ,  Mohan Wani ,  Venkatasamy Manivel ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa ,  Gyan Mishra ,  Anil Chatterji

IPC分类号： A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  A61K31/255 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

CPC分类号： A61K31/255 ,  A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

摘要： This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.

摘要翻译： 本发明涉及可用作破骨细胞发生抑制剂的新型酸性氨基酸/二羧酸衍生物（天然氨基酸的磺酸/硫酸衍生物及其酰胺）。 本发明还提供了使用通式为ZOC-（CRR）m -COOH的新型酸性氨基酸/二羧酸衍生物的方法，其中：m = 2,3或4; Z是OH或NH 2; 该化合物中的一个R是由SO 3 H，OSO 3 H，CH 2 -SO 3， H，CH 2 -SO 2 SO 3，NHSO 3 H，剩余的R 5是H或NH 2， / SUB>，用于抑制破骨细胞发生。

公开(公告)号：US20050085547A1

公开(公告)日：2005-04-21

申请号：US10748844

申请日：2003-12-31

申请人： Anil Chatterji ,  Krishnamurthy Natarajan ,  Venkatasamy Manivel ,  Kanury Subba Rao ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa

发明人： Anil Chatterji ,  Krishnamurthy Natarajan ,  Venkatasamy Manivel ,  Kanury Subba Rao ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa

IPC分类号： A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  A61K31/255 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

CPC分类号： A61K31/255 ,  A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

摘要： The present invention is related to compounds having general formula Z-OC(CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, for modulation of immune response by differentiation dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—C(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1(NHR2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid/dicarboxylic acid derivatives or their pharmaceutically acceptable alkali/alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.

摘要翻译： 本发明涉及具有通式Z-OC（其中Z = OH或NH 2）的化合物（其中Z = OH或NH 2） 并且n1 = n2 = 1至8，用于通过分化树突状细胞调节免疫应答，所述分化树突细胞由通式ZOC-CR的新一类氨基酸衍生物（天然存在的氨基酸的磺酸/硫酸酯衍生物及其酰胺） （NHR 1） - COOH，ZOC-CR 5 > R 6 -CR 3 R 4 -C（NHR 2）-COOH，ZOC-CR _{7 R＆lt; 8＆gt;＆lt; 5＆gt;＆lt; 6＆gt;＆lt; 6＆lt; 3＆lt; 3＆lt; 其中Z = OH或NH 2;其中Z = OH或NH 2;其中Z = OH或NH 2。 R 1至R 8表示H，SO 3 H或OSO 3 H。 另外，二羧酸和它们的酰胺ZOC-（CH 2）n -OR 1 R 2 - COOH，其中Z = OH或NH 2; 基团R 1 / R 2 = H / SO 3 H或OSO 3， H或CH 2 -SO 3 H或CH 2 --OSO 3 H，反之亦然。 这些因素还含有不同的二价金属阳离子如Mg，Ca和Zn。 组合物由不同量的上述氨基酸/二羧酸衍生物或其药学上可接受的碱金属/碱土金属盐或其盐组成，用于制备用于树突状细胞分化和成熟的前述化合物的方法。}

公开(公告)号：US20050085546A1

公开(公告)日：2005-04-21

申请号：US10748843

申请日：2003-12-31

申请人： Anil Chatterji ,  Krishnamurthy Natarajan ,  Venkatasamy Manivel ,  Kanury Venkata Subba Rao ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa

发明人： Anil Chatterji ,  Krishnamurthy Natarajan ,  Venkatasamy Manivel ,  Kanury Venkata Subba Rao ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa

IPC分类号： A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  A61K31/255 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

CPC分类号： A61K31/255 ,  A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

摘要： The present invention is related to compounds having general formula Z-OC (CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—CR1(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1N2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid/dicarboxylic acid derivatives or their pharmaceutically acceptable alkali/alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.

公开(公告)号：US20050090480A1

公开(公告)日：2005-04-28

申请号：US10893531

申请日：2004-07-19

申请人： Pawan Malhotra ,  Palakodeti Venkata Dasaradhi ,  Asif Mohammed ,  Manzar Hossain ,  Sunil Mukherji ,  Manivel Venkatasamy ,  Kanury Rao ,  Gyan Mishra ,  Parameswaran Subrayan ,  Anil Chatterji

发明人： Pawan Malhotra ,  Palakodeti Venkata Dasaradhi ,  Asif Mohammed ,  Manzar Hossain ,  Sunil Mukherji ,  Manivel Venkatasamy ,  Kanury Rao ,  Gyan Mishra ,  Parameswaran Subrayan ,  Anil Chatterji

IPC分类号： A61K31/198 ,  A61K31/315 ,  A61K33/30 ,  A61K35/60 ,  A61K45/06 ,  A61K31/555 ,  A61K31/47

CPC分类号： A61K31/198 ,  A61K31/315 ,  A61K33/30 ,  A61K35/60 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

摘要： The invention provides the use of zinc complexes of selected amino acids from D or L isomers of proline, lysine, histidine, glycine, arginine and tryptophan or their various hydroxyl, amino, alkyl and carboxyl derivatives and zinc chloride, zinc acetate or other pharmacologically acceptable salts of zinc. The use of the compound comprises administering an effective amount of said compounds for inhibition of growth: of the malarial parasite, Plasmodium falciparum. The compound is lethal to the parasite in RBC cultures but have no effect on the RBCs. The compound has also displayed activity against, the chloroquine-resistant strain-W2Mef. The dose response curves for both 3D7 and W2Mef strains are identical which strongly suggested that the compound is equally effective against field isolates of chloroquine-resistant, P. falciparum. The compound acts on W2Mef strain through killing the target.

摘要翻译： 本发明提供了选自脯氨酸，赖氨酸，组氨酸，甘氨酸，精氨酸和色氨酸的D或L异构体的各种氨基酸的锌配合物或其各种羟基，氨基，烷基和羧基衍生物以及氯化锌，乙酸锌或其他药学上可接受的锌配合物 锌盐 化合物的使用包括施用有效量的所述化合物抑制生长：疟疾寄生虫恶性疟原虫。 该化合物对RBC培养物中的寄生虫是致死的，但对RBCs没有影响。 该化合物还显示出耐氯耐药菌株W2Mef的活性。 3D7和W2Mef菌株的剂量反应曲线是相同的，这强烈地表明该化合物对氯喹抗性恶性疟原虫的分离株同样有效。 该化合物通过杀死靶标而作用于W2Mef菌株。

公开(公告)号：US20050171063A1

公开(公告)日：2005-08-04

申请号：US10893474

申请日：2004-07-16

申请人： Pawan Malhotra ,  Palakodeti Dasaradhi ,  Asif Mohammed ,  Manzar Hossain ,  Sunil Mukherji ,  Venkatasamy Manivel ,  Kanury Subba Rao ,  Parameswaran Subrayan ,  Anil Chatterji

发明人： Pawan Malhotra ,  Palakodeti Dasaradhi ,  Asif Mohammed ,  Manzar Hossain ,  Sunil Mukherji ,  Venkatasamy Manivel ,  Kanury Subba Rao ,  Parameswaran Subrayan ,  Anil Chatterji

IPC分类号： A61K31/315 ,  A61K31/335 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/555 ,  A61K31/66 ,  A61K31/662 ,  A61K33/30

CPC分类号： A61K31/315 ,  A61K31/335 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/555 ,  A61K31/66 ,  A61K31/662 ,  A61K33/30 ,  Y02A50/411 ,  A61K2300/00

摘要： The invention provides the use of phosphono derivatives of selected aliphatic acids represented by the structural formulae R—COOH, R being PO3H2 or CR1R2—PO3H2 where R1/R2 are H, OH, COOH or alkyl groups for the treatment of malaria. The use of the compound comprises administering an effective amount of said compounds for in vitro and in vivo studies using malarial parasites (Plasmodium falciparum and Plasmodium berghei).

摘要翻译： 本发明提供了由结构式R-COOH表示的选择的脂族酸的膦酰基衍生物的用途，R是PO 3 H 2或CR 1 N 其中R 1 / R 2 2是R 2，R 2，R 3，R 3，R 2，R 2， H，OH，COOH或烷基用于治疗疟疾。 使用化合物包括施用有效量的所述化合物用于使用疟疾寄生虫（恶性疟原虫和疟原虫）的体外和体内研究。

公开(公告)号：US07335686B2

公开(公告)日：2008-02-26

申请号：US10747671

申请日：2003-12-30

申请人： Kanury Venkata Subba Rao ,  Mohan Ramachandran Wani ,  Venkatasamy Manivel ,  Parameswaran Perunninakulath Subrayan ,  Vinod Kumar Singh ,  Ramasamy Vijaya Anand ,  Ehrlich Desa ,  Gyan Chandra Mishra ,  Anil Chatterji

发明人： Kanury Venkata Subba Rao ,  Mohan Ramachandran Wani ,  Venkatasamy Manivel ,  Parameswaran Perunninakulath Subrayan ,  Vinod Kumar Singh ,  Ramasamy Vijaya Anand ,  Ehrlich Desa ,  Gyan Chandra Mishra ,  Anil Chatterji

IPC分类号： A61K31/195

CPC分类号： A61K31/255 ,  A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

摘要： This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.

摘要翻译： 本发明涉及可用作破骨细胞发生抑制剂的新型酸性氨基酸/二羧酸衍生物（天然氨基酸的磺酸/硫酸衍生物及其酰胺）。 本发明还提供了使用通式为ZOC-（CRR）m -COOH的新型酸性氨基酸/二羧酸衍生物的方法，其中：m = 2,3或4; Z是OH或NH 2; 该化合物中的一个R是由SO 3 H，OSO 3 H，CH 2 -SO 3， H，CH 2 -SO 2 SO 3，NHSO 3 H，剩余的R 5是H或NH 2， / SUB>，用于抑制破骨细胞发生。

公开(公告)号：US07074433B2

公开(公告)日：2006-07-11

申请号：US10112078

申请日：2002-03-29

申请人： Ramesh Ramchandra Bhonde ,  Anil Chatterji

发明人： Ramesh Ramchandra Bhonde ,  Anil Chatterji

IPC分类号： A61K35/56

CPC分类号： A61K35/618

摘要： The present invention relates to a process for the cure and control of Diabetes mellitus using natural products isolated from Perna viridis.

摘要翻译： 本发明涉及一种使用从白蛉分离的天然产物治疗和控制糖尿病的方法。

公开(公告)号：US06905710B2

公开(公告)日：2005-06-14

申请号：US09944497

申请日：2001-08-31

申请人： Mohan Ramachandra Wani ,  Pradeep Bhaskar Parab ,  Anil Chatterji

发明人： Mohan Ramachandra Wani ,  Pradeep Bhaskar Parab ,  Anil Chatterji

IPC分类号： A61K35/56 ,  A61K35/618 ,  C12P21/06

CPC分类号： A61K35/618

摘要： The invention provides a compositions comprising mussel hydrolysate from Indian green mussel, e.g., Perna viridis. The invention further provides methods of inhibiting or preventing osteoclast formation and/or bone resorption comprising administration of mussel hydrolysate from Indian Green to an animal or human. The compositions of the invention are non-toxic to other cells. Additionally, the invention provides processes for extracting mussel hydrolysate from Indian green mussel, e.g., Perna viridis.

摘要翻译： 本发明提供一种包含来自印度绿色贻贝的贻贝水解产物的组合物，例如白僵菌（Perna viridis）。 本发明还提供了抑制或预防破骨细胞形成和/或骨吸收的方法，包括将来自印度绿色的贻贝水解产物施用于动物或人。 本发明的组合物对其它细胞无毒性。 另外，本发明提供了从印度绿色贻贝（例如，白僵菌）提取贻贝水解产物的方法。

公开(公告)号：US07087429B2

公开(公告)日：2006-08-08

申请号：US10807682

申请日：2004-03-24

申请人： Pradeep Bhaskar Parab ,  Anil Chatterji

发明人： Pradeep Bhaskar Parab ,  Anil Chatterji

IPC分类号： C12N5/00

CPC分类号： C07K14/43509 ,  A61K35/63

摘要： A process for obtaining a substance with growth promoting activity that includes the step of isolating perivitelline fluid from a fertilized egg of a horseshoe crab. Also, a process for proliferating cells including the steps of isolating perivitelline fluid from a fertilized egg of a horseshoe crab and growing the cells in the presence of the isolated perivitelline fluid.

摘要翻译： 一种获得具有生长促进活性的物质的方法，其包括从马蹄蟹的受精卵中分离出奥维平原液体的步骤。 此外，增殖细胞的方法包括以下步骤：从马蹄蟹的受精卵中分离全氟代尿液，并在分离的维生素液存在下培养细胞。

公开(公告)号：US06790659B2

公开(公告)日：2004-09-14

申请号：US10109543

申请日：2002-03-28

申请人： Ramesh Ramchandra Bhonde ,  Anil Chatterji

发明人： Ramesh Ramchandra Bhonde ,  Anil Chatterji

IPC分类号： C12N500

CPC分类号： C12N5/0601 ,  C12N2500/82

摘要： The present invention provides a process for large scale in vitro production of amoebocytes of Indian Horseshoe Crab (Tachypleus gigas) (T. gigas) from dissected gill flaps of T. gigas, in Leibovitz L-15 culture medium concentration (2×), to provide enhanced generation of amoebocytes. The process comprises the steps of: dissecting gill flaps of T. gigas; washing the gill flaps with an antibiotic solution followed by alcohol; culturing the gill flaps in tissue culture plates of sterile saline on a Rocker platform; culturing further the gill flaps in Leibovitz L-15 culture medium (2×); purging the gill flaps with Tween 80 solution; and purging again the gill flaps with horseshoe crab serum, while keeping the gill flaps in the culture medium viable for 90 days by feeding with fresh medium at an interval of 10-15 days to enable the enhanced release of amoebocytes both within and outside the gill flaps.

摘要翻译： 本发明提供了一种在Leibovitz L-15培养基浓度（2x）中大规模体外生产印度马蹄蟹（Tachypleus gigas）（Tigigus gigas）（T.gigas））来自解剖的T.gigas鳃片的变形细胞的方法，以提供 增强的变形细胞生成。 该过程包括以下步骤：解剖T.gigas的鳃片; 用抗生素溶液洗涤鳃瓣，然后用酒精洗涤; 在Rocker平台上的无菌盐水组织培养板中培养鳃瓣; 在Leibovitz L-15培养基（2x）中进一步培养鳃瓣; 用吐温80溶液清洗鳃瓣; 并用马蹄蟹血清再次清除鳃瓣，同时通过以10-15天的间隔喂养新鲜培养基将鳃瓣保持在培养基中90天，以使得能够在鳃内和外部增强释放的变形细胞 襟翼