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1.发明申请Sulfated Depolymerized Derivatives of Exopolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing Same, and Uses Thereof in Tissue Regeneration 审中-公开来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20080131472A1
公开(公告)日：2008-06-05
申请号：US11629579
申请日：2005-06-06
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/737 , A01N1/00 , A61K9/00 , A61Q19/00 , C12P19/04
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg(m)g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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2.发明申请Sulfated Depolymerized Derivatives of Expolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing the Same, and Uses Thereof in Tissue Regeneration 有权来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20110245199A1
公开(公告)日：2011-10-06
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图示出了根据本发明的多糖衍生物GY 785 DRS如何可以以10μg（m）g / ml的浓度刺激网状或重建的结缔组织中的成纤维细胞增殖。
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3.发明授权Sulfated depolymerized derivatives of expolysaccharides (EPS) from mesophilic marine bacteria, method for preparing the same, and uses thereof in tissue regeneration 有权嗜温海洋细菌的多糖（EPS）的硫酸化解聚衍生物及其制备方法及其在组织再生中的应用公开(公告)号：US08598142B2
公开(公告)日：2013-12-03
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/715 , A61P17/02
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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4.发明申请公开(公告)号：US20140050773A1
公开(公告)日：2014-02-20
申请号：US13990004
申请日：2010-11-26
CPC分类号： A61K38/22 , A61K6/0035 , A61K6/0067 , A61K9/0063 , A61K9/7007 , A61K38/34 , A61K47/645
摘要： The present invention concerns a compound comprising an α-MSH peptide, coupled to a polypeptide consisting of a chain of about 15 to about 400 amino acids, for use in endodontic regeneration and/or for the treatment of dental inflammatory diseases. The invention further concerns pharmaceutical compositions, in particular nanostructured compositions, comprising such a compound.
摘要翻译： 本发明涉及一种化合物，其包含偶联至由约15至约400个氨基酸的链组成的多肽的α-MSH肽，用于牙髓根管再生和/或治疗牙齿炎性疾病。 本发明还涉及包含这种化合物的药物组合物，特别是纳米结构组合物。
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