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1.发明申请Sulfated Depolymerized Derivatives of Exopolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing Same, and Uses Thereof in Tissue Regeneration 审中-公开来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20080131472A1
公开(公告)日：2008-06-05
申请号：US11629579
申请日：2005-06-06
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/737 , A01N1/00 , A61K9/00 , A61Q19/00 , C12P19/04
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg(m)g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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2.发明申请Sulfated Depolymerized Derivatives of Expolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing the Same, and Uses Thereof in Tissue Regeneration 有权来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20110245199A1
公开(公告)日：2011-10-06
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图示出了根据本发明的多糖衍生物GY 785 DRS如何可以以10μg（m）g / ml的浓度刺激网状或重建的结缔组织中的成纤维细胞增殖。
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3.发明授权Sulfated depolymerized derivatives of expolysaccharides (EPS) from mesophilic marine bacteria, method for preparing the same, and uses thereof in tissue regeneration 有权嗜温海洋细菌的多糖（EPS）的硫酸化解聚衍生物及其制备方法及其在组织再生中的应用公开(公告)号：US08598142B2
公开(公告)日：2013-12-03
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/715 , A61P17/02
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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4.发明申请公开(公告)号：US20080317860A1
公开(公告)日：2008-12-25
申请号：US12096596
申请日：2006-12-06
申请人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
发明人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the engineering of non-mineralised connective tissues, in particular for skin and cartilage engineering.
摘要翻译： 本发明涉及由异形弧菌物种排泄的多糖用于非矿化结缔组织的工程，特别是用于皮肤和软骨工程。
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5.发明申请公开(公告)号：US20090028924A1
公开(公告)日：2009-01-29
申请号：US12096588
申请日：2007-12-06
申请人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
发明人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the re-generation and protection of the non-mineralised connective tissue of the periodontium.
摘要翻译： 本发明涉及由弧菌弧菌排泄的多糖用于重新产生和保护牙周组织的非矿化结缔组织的用途。
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6.发明授权公开(公告)号：US07951391B2
公开(公告)日：2011-05-31
申请号：US12280352
申请日：2007-02-21
申请人： Sylvie Igondjo-Tchen Changotade , Karim Senni , Alexandrine Foucault-Bertaud , Grégory Korb , Maya Brigitte Baroukh , Jean-Louis Saffar , Gaston-Jacques Godeau , Corinne Sinquin , Sylvia Colliec-Jouault , Patrick Durand
发明人： Sylvie Igondjo-Tchen Changotade , Karim Senni , Alexandrine Foucault-Bertaud , Grégory Korb , Maya Brigitte Baroukh , Jean-Louis Saffar , Gaston-Jacques Godeau , Corinne Sinquin , Sylvia Colliec-Jouault , Patrick Durand
CPC分类号： A61L27/34 , A61L2430/02 , C12N5/0654 , C12N2533/70 , C08L5/00
摘要： The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.
摘要翻译： 本发明涉及用于骨移植，工程和再生的重量平均摩尔质量在5000和100000g / mol之间的岩藻石的用途。
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7.发明申请USE OF FUCANS FOR THE PURPOSE OF BONE GRAFTING, ENGINEERING AND REGENERATION 有权使用FUCANS作为骨牵引，工程和再生的目的公开(公告)号：US20090043399A1
公开(公告)日：2009-02-12
申请号：US12280352
申请日：2007-02-21
申请人： Sylvie Igondjo-Tchen Changotade , Karim Senni , Alexandrine Foucault-Bertaud , Gregory Korb , Maya Brigitte Baroukh , Jean-Louis Saffar , Gaston-Jacques Godeau , Corinne Sinquin , Sylvia Colliec-Jouault , Patrick Durand
发明人： Sylvie Igondjo-Tchen Changotade , Karim Senni , Alexandrine Foucault-Bertaud , Gregory Korb , Maya Brigitte Baroukh , Jean-Louis Saffar , Gaston-Jacques Godeau , Corinne Sinquin , Sylvia Colliec-Jouault , Patrick Durand
CPC分类号： A61L27/34 , A61L2430/02 , C12N5/0654 , C12N2533/70 , C08L5/00
摘要： The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.
摘要翻译： 本发明涉及用于骨移植，工程和再生的重量平均摩尔质量在5000和100000g / mol之间的岩藻石的用途。
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公开(公告)号：US06559131B1
公开(公告)日：2003-05-06
申请号：US09581810
申请日：2000-11-06
申请人： Karim Senni , Bernard Pellat , Bruno Gogly , Catherine Blondin , Didier Letourneur , Jacqueline Jozefonvicz , Corinne Sinquin , Sylvia Colliec-Jouault , Patrick Durand
发明人： Karim Senni , Bernard Pellat , Bruno Gogly , Catherine Blondin , Didier Letourneur , Jacqueline Jozefonvicz , Corinne Sinquin , Sylvia Colliec-Jouault , Patrick Durand
IPC分类号： A61K31715
CPC分类号： A61K31/737
摘要： The invention concerns the use of fucanes for obtaining medicines for modulating metalloprotease and inhibiting leukocytic elastase. Said medicines help activate collagen synthesis inhibit proliferation of gingival fibroblasts, and activate proliferation of dermal fibroblasts. They are useful in particular for treating periodontal pathologies and dermal lesions.
摘要翻译： 本发明涉及使用石蜡来获得用于调节金属蛋白酶和抑制白细胞弹性蛋白酶的药物。 所述药物有助于激活胶原合成抑制牙龈成纤维细胞的增殖，并激活真皮成纤维细胞的增殖。 它们特别用于治疗牙周病变和真皮病变。
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