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1.发明申请Sulfated Depolymerized Derivatives of Expolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing the Same, and Uses Thereof in Tissue Regeneration 有权来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20110245199A1
公开(公告)日：2011-10-06
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图示出了根据本发明的多糖衍生物GY 785 DRS如何可以以10μg（m）g / ml的浓度刺激网状或重建的结缔组织中的成纤维细胞增殖。
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2.发明申请公开(公告)号：US20080317860A1
公开(公告)日：2008-12-25
申请号：US12096596
申请日：2006-12-06
申请人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
发明人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the engineering of non-mineralised connective tissues, in particular for skin and cartilage engineering.
摘要翻译： 本发明涉及由异形弧菌物种排泄的多糖用于非矿化结缔组织的工程，特别是用于皮肤和软骨工程。
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3.发明授权Sulfated depolymerized derivatives of expolysaccharides (EPS) from mesophilic marine bacteria, method for preparing the same, and uses thereof in tissue regeneration 有权嗜温海洋细菌的多糖（EPS）的硫酸化解聚衍生物及其制备方法及其在组织再生中的应用公开(公告)号：US08598142B2
公开(公告)日：2013-12-03
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/715 , A61P17/02
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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4.发明申请公开(公告)号：US20110305647A1
公开(公告)日：2011-12-15
申请号：US13162804
申请日：2011-06-17
申请人： Karim SENNI , Corinne SINQUIN , Sylvia COLLIEC-JOUAULT , Gaston-Jacques GODEAU , Jean GUEZENNEC
发明人： Karim SENNI , Corinne SINQUIN , Sylvia COLLIEC-JOUAULT , Gaston-Jacques GODEAU , Jean GUEZENNEC
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the regeneration and protection of the non-mineralised connective tissue of the periodontium.
摘要翻译： 本发明涉及由异形弧菌物种排泄的多糖用于牙周膜的非矿化结缔组织的再生和保护的用途。
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公开(公告)号：US20080292645A1
公开(公告)日：2008-11-27
申请号：US11915341
申请日：2006-05-24
申请人： Anthony Courtois , Christian Berthou , Anne Loussouarn , Jean Guezennec , Claire Boisset , Stephanie Gac-Breton
发明人： Anthony Courtois , Christian Berthou , Anne Loussouarn , Jean Guezennec , Claire Boisset , Stephanie Gac-Breton
IPC分类号： A61K39/395 , C07K16/18 , A61P31/00 , C07K1/00
CPC分类号： B82Y5/00 , A61K47/549 , A61K47/6807 , A61K47/6891 , C07K2317/41
摘要： An immunogenic conjugate includes a target cell-specific circulating molecule and at least one immunogenic agent, the immunogenic agent being coupled by any appropriate means with the circulating molecule. Also described is a method for preparing the immunogenic conjugate and its use for treating cancers or autoimmune diseases.
摘要翻译： 免疫原性缀合物包括靶细胞特异性循环分子和至少一种免疫原性试剂，所述免疫原性试剂通过任何合适的方式与循环分子偶联。 还描述了制备免疫原性缀合物的方法及其用于治疗癌症或自身免疫疾病的用途。
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6.发明申请公开(公告)号：US20130108819A1
公开(公告)日：2013-05-02
申请号：US13806908
申请日：2011-07-01
申请人： Jean Guezennec
发明人： Jean Guezennec
IPC分类号： C09D5/00
CPC分类号： C09D5/00 , A01N43/16 , A01N63/02 , C09D5/1637 , C09D105/00 , Y10T428/139 , Y10T428/31678 , Y10T428/31685 , Y10T428/31725 , Y10T428/31971
摘要： Exopolysaccharides, preferably obtained by fermenting bacteria from deep hydrothermal ecosystems, serve as agents for preventing the formation of unwanted biofilms on a surface. A method for protecting a surface by preventing the formation of the primary film leading to unwanted biofilms, includes placing the surface in contact with at least one exopolysaccharide, or grafting the exopolysaccharide onto the surface. A method for modifying the physical properties of a surface such that the adhesion of an unwanted bacterial biofilm to the surface is reduced is also described.
摘要翻译： 优选通过从深水热生态系统发酵细菌获得的多糖，用作防止在表面上形成不想要的生物膜的试剂。 通过防止导致不想要的生物膜的初级膜的形成来保护表面的方法包括将表面与至少一种外多糖接触或将外多糖接枝到表面上。 还描述了一种用于改变表面的物理性质使得不期望的细菌生物膜与表面的粘附减小的方法。
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7.发明申请公开(公告)号：US20090028924A1
公开(公告)日：2009-01-29
申请号：US12096588
申请日：2007-12-06
申请人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
发明人： Karim Senni , Corinne Sinquin , Sylvia Colliec-Jouault , Gaston-Jacques Godeau , Jean Guezennec
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the re-generation and protection of the non-mineralised connective tissue of the periodontium.
摘要翻译： 本发明涉及由弧菌弧菌排泄的多糖用于重新产生和保护牙周组织的非矿化结缔组织的用途。
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公开(公告)号：US06545145B1
公开(公告)日：2003-04-08
申请号：US09720238
申请日：2001-03-02
申请人： Hèlène Rougeaux , Jean Guezennec
发明人： Hèlène Rougeaux , Jean Guezennec
IPC分类号： C08B3700
CPC分类号： C12H1/02 , A23L29/269 , C08B37/006
摘要： The invention concerns a purified polysaccharide consisting of glucose, galactose, glucuronic acid, galacturonic acid, and pyruvate mannose, combined in a repeat hexasaccharide unit of formula (1), said polysaccharide comprising a saccharide units of formula (1), n being not less than 1. Said polysaccharide is useful in particular in the agri-foodstuff sector.
摘要翻译： 本发明涉及由式（1）的重复六糖单元组合的由葡萄糖，半乳糖，葡萄糖醛酸，半乳糖醛酸和丙酮酸甘露糖组成的纯化多糖，所述多糖包含式（1）的糖单元，n不少于 所述多糖特别在农业食品领域是有用的。
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9.发明申请Sulfated Depolymerized Derivatives of Exopolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing Same, and Uses Thereof in Tissue Regeneration 审中-公开来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20080131472A1
公开(公告)日：2008-06-05
申请号：US11629579
申请日：2005-06-06
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/737 , A01N1/00 , A61K9/00 , A61Q19/00 , C12P19/04
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg(m)g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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公开(公告)号：US20130263793A1
公开(公告)日：2013-10-10
申请号：US13993863
申请日：2011-12-14
IPC分类号： A01K61/00
CPC分类号： A01K61/56 , A01K61/54 , Y02A40/822
摘要： The present invention relates to a nucleus covered or coated with a film including one or more PHA. The invention also relates to a PHA, characterized in that it is of the type PHB-V, a film and a composition including the PHA. The invention further relates to a film or a composition including a PHA and zosteric acid or a bioactive molecule. The invention moreover relates to a surface, preferably a nucleus, covered with the film of PHA, a method for production thereof, and methods for grafting a pearl oyster and producing a pearl using this nucleus. Finally, the present invention relates to a method for reducing graft failure and/or for improving the quality of the pearl using the nucleus according to the invention.
摘要翻译： 本发明涉及覆盖或涂覆有包含一种或多种PHA的膜的核。 本发明还涉及一种PHA，其特征在于，其类型为PHB-V，膜和包含PHA的组合物。 本发明还涉及包含PHA和带状疱疹或生物活性分子的膜或组合物。 此外，本发明涉及用PHA膜覆盖的表面，优选细胞核，其制备方法，以及使用该核接枝珍珠牡蛎并生产珍珠的方法。 最后，本发明涉及使用本发明的细胞核减少移植物衰竭和/或改善珍珠质量的方法。
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