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1.发明申请公开(公告)号：US20090318455A1
公开(公告)日：2009-12-24
申请号：US12477715
申请日：2009-06-03
申请人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca F. Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
发明人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca F. Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
IPC分类号： A61K31/50 , A61K31/497 , A61K31/437 , A61K31/44 , C07D237/02 , C07D241/02 , C07D471/02 , C07D213/63
CPC分类号： C07D213/63 , C07D213/22 , C07D213/64 , C07D213/69 , C07D213/71 , C07D213/85 , C07D237/14 , C07D239/36 , C07D239/54 , C07D241/18 , C07D251/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
摘要翻译： 公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。 还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。
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2.发明授权公开(公告)号：US08304413B2
公开(公告)日：2012-11-06
申请号：US12477715
申请日：2009-06-03
申请人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca Francesco Mario Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
发明人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca Francesco Mario Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
IPC分类号： A61K31/50 , A61K31/497 , A61K31/437 , A61K31/44
CPC分类号： C07D213/63 , C07D213/22 , C07D213/64 , C07D213/69 , C07D213/71 , C07D213/85 , C07D237/14 , C07D239/36 , C07D239/54 , C07D241/18 , C07D251/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
摘要翻译： 公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。 还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。
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公开(公告)号：US08412560B1
公开(公告)日：2013-04-02
申请号：US12718032
申请日：2010-03-05
申请人： Faisal Masud , Stacy Saal , Paul D. Ohlhaut , Josiah P. Olivieri , Umair Bashir , Xiao Yu , Tao Hu
发明人： Faisal Masud , Stacy Saal , Paul D. Ohlhaut , Josiah P. Olivieri , Umair Bashir , Xiao Yu , Tao Hu
IPC分类号： G06Q30/00
CPC分类号： G06Q30/00
摘要： Disclosed are various embodiments for optimizing prices of items using current offers. Numerous current offers to sell an item are determined from a subset of sellers in an electronic marketplace. Each one of the subset of sellers is associated with a respective reputational score that meets a minimum threshold. A competitive price is generated for the item based at least in part on an average marketplace price determined from the current offers.
摘要翻译： 公开了使用当前报价来优化物品价格的各种实施例。 许多当前的出售物品的出售是从电子市场中的卖家的一部分确定的。 卖方子集中的每一个都与符合最低门槛值的相应声誉评分相关联。 至少部分基于从当前报价确定的平均市场价格，为该项目生成有竞争力的价格。
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公开(公告)号：US6022983A
公开(公告)日：2000-02-08
申请号：US2541
申请日：1998-01-02
IPC分类号： C07D309/38 , A61K31/351 , A61K31/366 , A61P31/04 , C07C45/29 , C07C45/30 , C07C45/38 , C07C47/21 , C07C49/203 , C07C57/66 , C07D309/36 , C07F7/08 , C07F7/18 , C07C33/03 , C07C45/26 , C07C67/30 , C07D309/32
CPC分类号： C07D309/36 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07C57/66 , C07D309/38 , C07F7/0812 , C07F7/1856
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
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公开(公告)号：US10002593B2
公开(公告)日：2018-06-19
申请号：US15616932
申请日：2017-06-08
申请人： Tao Hu
发明人： Tao Hu
IPC分类号： G10D3/04
CPC分类号： G10D3/043
摘要： A guitar capo applicable to different kinds of guitars, having upper shell silica gel fixed onto an upper shell; lower shell silica gel fixed onto a lower shell; a groove provided at a center position of each of the upper shell silica gel and the lower shell silica gel; a raised platform positioned at a periphery of each groove; a connecting end of the upper shell sleeving a connecting end of the lower shell; the connecting ends of the upper shell and the lower shell connected and fixed via the double rivet; a spring mounted on the double rivet; an end of an arm of the lower shell connecting to the upper shell being connected with the screw. The upper shell silica gel is applicable to an acoustic guitar. The lower shell silica gel is applicable to a classical guitar.
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公开(公告)号：US20130285673A1
公开(公告)日：2013-10-31
申请号：US13548080
申请日：2012-07-12
申请人： Xiaodong Han , Yi Zhou , Tao Hu , Ching Brendon Chau
发明人： Xiaodong Han , Yi Zhou , Tao Hu , Ching Brendon Chau
IPC分类号： G01R29/00
CPC分类号： G01R19/04 , G01R31/2851
摘要： A test system and method for low voltage differential signaling (LVDS) is provided. The system comprises: an input module for the user to input the information needed by the test; a communication module for connecting the control device 110 and the oscilloscope 120 using the communication means selected by the user; a measurement module for measure the parameters of the LVDS signal thought controlling a oscilloscope; an assessment module for assessing whether the obtained parameters of the LVDS signal comply with relevant LVDS specifications; and an output module for outputting the parameters of the LVDS signal and the assessment result of the parameters from the assessment module. The test system and method for LVDS provided by the present invention can advantageously meet the competitive needs in fast mass production and efficient engineering qualification.
摘要翻译： 提供了一种用于低压差分信号（LVDS）的测试系统和方法。 该系统包括：输入模块，供用户输入测试所需的信息; 通信模块，用于使用由用户选择的通信装置来连接控制装置110和示波器120; 用于测量控制示波器的LVDS信号的参数的测量模块; 用于评估所获得的LVDS信号的参数是否符合相关的LVDS规范的评估模块; 以及输出模块，用于从评估模块输出LVDS信号的参数和参数的评估结果。 本发明提供的用于LVDS的测试系统和方法可以有利地满足快速批量生产和高效工程鉴定中的竞争需求。
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公开(公告)号：US06239291B1
公开(公告)日：2001-05-29
申请号：US09574134
申请日：2000-05-18
IPC分类号： C07D30932
CPC分类号： C07C57/66 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07D309/36 , C07D309/38 , C07F7/0812 , C07F7/1804
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
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公开(公告)号：US6090953A
公开(公告)日：2000-07-18
申请号：US370533
申请日：1999-08-09
IPC分类号： C07D309/30 , A61K31/366 , C07C45/29 , C07C45/30 , C07C45/38 , C07C47/21 , C07C49/227 , C07C49/258 , C07C57/66 , C07D309/36 , C07D309/38 , C07F7/08 , C07F7/18 , C07D309/32
CPC分类号： C07F7/1856 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07C57/66 , C07D309/36 , C07D309/38 , C07F7/0812
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.
摘要翻译： 本发明提供了用于制备myxopyronins和珊瑚绿素的收敛过程，其用作抗菌治疗剂。 本发明还提供了可用于制备pyronin抗生素的新物质组合物。
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