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1.发明授权Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use 有权酰基-4-羧基苯基脲衍生物，其制备方法及其用途公开(公告)号：US07223796B2
公开(公告)日：2007-05-29
申请号：US10410601
申请日：2003-04-10
申请人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen , Joerg Rieke-Zapp
发明人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen , Joerg Rieke-Zapp
IPC分类号： A61K31/24 , C07C265/30 , C07C275/06 , C07D207/04 , C07D263/34
CPC分类号： C07D295/155 , C07C275/54
摘要： The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.The invention particularly relates to compounds of formula I, in which the radicals have the given meanings described herein, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.
摘要翻译： 本发明涉及酰基-4-羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。 本发明特别涉及式I化合物，其中基团具有本文所述的给定含义，以及其生理学上耐受的盐及其制备方法。 化合物例如适合用作抗糖尿病药。
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2.发明授权Heterocyclically substituted benzoylureas, process for their preparation and their use as pharmaceuticals 有权杂环取代的苯甲酰脲，其制备方法及其作为药物的用途公开(公告)号：US07138414B2
公开(公告)日：2006-11-21
申请号：US10617498
申请日：2003-07-11
申请人： Karl Schoenafinger , Elisabeth Defossa , Dieter Kadereit , Erich Von Roedern , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt
发明人： Karl Schoenafinger , Elisabeth Defossa , Dieter Kadereit , Erich Von Roedern , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt
IPC分类号： C07D235/02 , C07D251/00 , A61K31/395 , A61K31/445
CPC分类号： C07D211/60 , C07D211/62 , C07D231/12 , C07D231/26 , C07D233/56 , C07D235/18 , C07D249/08 , C07D249/12 , C07D253/07 , C07D257/04 , C07D271/10 , C07D271/113 , C07D307/68
摘要： The invention relates to heterocyclically substituted benzoylureas and also to their physiologically tolerated salts and physiologically functional derivatives.Compounds are described of the formula I where the radicals are defined as specified, and also their pharmaceutically acceptable salts and processes for their preparation. The compounds are suitable, for example, for treating type 2 diabetes.
摘要翻译： 本发明涉及杂环取代的苯甲酰脲，也涉及其生理上耐受的盐和生理功能衍生物。 化合物描述为其中基团被定义为特定的式I，以及它们的药学上可接受的盐及其制备方法。 该化合物适用于例如治疗2型糖尿病。
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公开(公告)号：US07078404B2
公开(公告)日：2006-07-18
申请号：US10410892
申请日：2003-04-10
申请人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Karl Schoenafinger , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Alfons Enhsen
IPC分类号： A61K31/50 , C07D241/04 , C07D263/32 , C07D307/06 , C07C243/09
CPC分类号： C07C275/54
摘要： The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.The invention relates to compounds of formula I, in which the radicals have the given meanings, and to their physiologically tolerated salts and processes for preparing them. The compounds are, for example, suitable for use as antidiabetics.
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4.发明申请Substituted benzoylureido-o-benzoylamides, process for their preparation and their use 有权取代的苯甲酰脲基 - 邻苯甲酰胺，其制备方法及其用途公开(公告)号：US20050065142A1
公开(公告)日：2005-03-24
申请号：US10899868
申请日：2004-07-27
IPC分类号： A61K31/397 , A61K31/401 , A61K31/404 , A61K31/445 , A61P3/06 , A61P3/08 , A61P3/10 , C07D205/04 , C07D207/10 , C07D207/16 , C07D209/42 , C07D211/60
CPC分类号： C07D207/16 , C07D205/04 , C07D209/42 , C07D211/60
摘要： The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
摘要翻译： 本发明涉及取代的苯甲酰脲基 - 邻苯甲酰胺及其生理上耐受的盐和生理功能衍生物。 本发明涉及其中基团具有所述含义的式I化合物及其生理上耐受的盐。 该化合物适用于例如用于预防和治疗2型糖尿病的药物。
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5.发明授权Carboxyalkoxy-substituted acyl-carboxyphenylurea derivatives and their use as medicaments 有权羧甲氧基取代的酰基 - 羧基苯基脲衍生物及其作为药物的用途公开(公告)号：US07781459B2
公开(公告)日：2010-08-24
申请号：US11613433
申请日：2006-12-20
申请人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： C07C275/54
摘要： The invention relates to acyl-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives.Compounds of the formula I, in which the radicals have the stated meanings, and the physiological tolerated salts thereof and processes for preparing them are described. The compounds are suitable for example for the treatment of type II diabetes.
摘要翻译： 本发明涉及酰基羧基苯基脲衍生物及其生理上耐受的盐和生理功能衍生物。 描述了其中基团具有所述含义的式I化合物及其生理耐受盐及其制备方法。 该化合物适用于例如治疗II型糖尿病。
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6.发明申请UREA-AND URETHANE-SUBSTITUTED ACYLUREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE 有权尿素和尿素取代的精油，其制备方法及其使用公开(公告)号：US20080033042A1
公开(公告)日：2008-02-07
申请号：US11845242
申请日：2007-08-27
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： A61K31/16 , A61K31/24 , A61P3/00 , A61P5/00 , C07C229/38 , C07C233/37
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。 特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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7.发明授权Urea- and urethane-substituted acylureas, process for their preparation and their use 有权尿素和氨基甲酸酯取代的酰基脲，其制备方法及其用途公开(公告)号：US07262220B2
公开(公告)日：2007-08-28
申请号：US10616959
申请日：2003-07-11
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： C07C275/24 , A61K31/277
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。 特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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8.发明授权Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use 有权取代的3-（苯甲酰基脲基）噻吩衍生物，其制备方法及其应用公开(公告)号：US07196114B2
公开(公告)日：2007-03-27
申请号：US10780344
申请日：2004-02-17
申请人： Karl Schoenafinger , Elisabeth Defossa , Erich Von Roedern , Dieter Kadereit , Andreas Herling , Hans-Joerg Burger , Thomas Klabunde , Karl-Ulrich Wendt
发明人： Karl Schoenafinger , Elisabeth Defossa , Erich Von Roedern , Dieter Kadereit , Andreas Herling , Hans-Joerg Burger , Thomas Klabunde , Karl-Ulrich Wendt
IPC分类号： A61K31/38 , C07D333/36
CPC分类号： C07D409/04 , C07D333/36 , C07D333/38 , C07D333/44 , C07D413/04
摘要： Substituted 3-(benzoylureido)thiophene derivatives, processes for preparing them and their useThe invention relates to compounds of the formula I where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译： 取代的3-（苯甲酰基脲基）噻吩衍生物，其制备方法及其应用
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9.发明申请Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use 有权羰基氨基取代的酰基苯基脲衍生物，其制备方法及其应用公开(公告)号：US20050014822A1
公开(公告)日：2005-01-20
申请号：US10763877
申请日：2004-01-23
申请人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
发明人： Elisabeth Defossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger , Alfons Enhsen
IPC分类号： C07C275/54 , C07D209/12 , C07D213/82 , C07D295/02 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38 , A61K31/325 , A61K31/17 , A61K31/195 , C07C275/52
CPC分类号： C07D213/82 , C07C275/54 , C07C2601/04 , C07D209/12 , C07D295/033 , C07D307/68 , C07D307/85 , C07D333/38
摘要： The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for preventing and treating type 2 diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中基团按照规定定义，也涉及其生理上耐受的盐。 该化合物例如可用作预防和治疗2型糖尿病的药物。
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10.发明授权Urea- and urethane-substituted acylureas, process for their preparation and their use 有权尿素和氨基甲酸酯取代的酰基脲，其制备方法及其用途公开(公告)号：US08247452B2
公开(公告)日：2012-08-21
申请号：US11845242
申请日：2007-08-27
申请人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
发明人： Elisabeth DeFossa , Dieter Kadereit , Thomas Klabunde , Hans-Joerg Burger , Andreas Herling , Karl-Ulrich Wendt , Erich Von Roedern , Karl Schoenafinger
IPC分类号： C07C275/24 , A61K31/277
CPC分类号： C07C275/54 , C07D213/75 , C07D239/96 , C07D295/135
摘要： The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I wherein the radicals have meanings described herein, and to their physiologically tolerated salts and to processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 本发明涉及脲和氨基甲酸酯取代的酰基脲及其生理上耐受的盐和生理功能衍生物。 特别地，本发明涉及式I化合物，其中基团具有本文所述的含义及其生理学耐受的盐及其制备方法。 该化合物例如适用于抗糖尿病药。
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