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公开(公告)号:US4859769A
公开(公告)日:1989-08-22
申请号:US916542
申请日:1986-11-05
IPC分类号: A61K31/70 , A61K31/7028 , A61K39/12 , C07H3/06 , C07H15/04 , C07H15/10 , C12N7/02 , C12Q1/70 , G01N33/566 , G01N33/569
CPC分类号: C07H15/04 , C07H3/06 , C12N7/00 , C12Q1/70 , G01N33/566 , G01N33/56983 , C12N2760/18851
摘要: A second-step virus binding receptor is found in nature on the surface of animal and plant cells. This receptor is thought to be needed for virus penetration into target cells. The second-step receptor has been found to bind a wide variety of viruses belonging to a number of different families. The second-step receptor and natural or synthetic substances which correspond to or are analogous to the binding epitope of the second-step receptor in that they are able to bind to a site on the virus which recognizes the binding epitope of the natural second-step receptor, are therefore indicated for the diagnosis, prophylaxis or treatment of viral infections.
摘要翻译: PCT No.PCT / DK86 / 00007 Sec。 371日期:1986年11月5日 102(e)日期1986年11月5日PCT申请日1986年1月13日PCT公布。 出版物WO86 / 03971 日期1986年7月17日。在动物和植物细胞表面上发现自然界中的第二步病毒结合受体。 认为该受体是病毒渗入靶细胞所必需的。 已经发现第二步受体结合属于多个不同家族的各种病毒。 第二步受体和天然或合成物质对应于或类似于第二步受体的结合表位,因为它们能够结合识别天然第二步的结合表位的病毒位点 受体,因此被指示用于诊断,预防或治疗病毒感染。
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公开(公告)号:US4980462A
公开(公告)日:1990-12-25
申请号:US368188
申请日:1989-06-19
IPC分类号: A61K31/70 , A61K31/7028 , A61K39/12 , C07H3/06 , C07H15/04 , C07H15/10 , C12N7/02 , C12Q1/70 , G01N33/566 , G01N33/569
CPC分类号: C07H15/04 , C07H3/06 , C12N7/00 , C12Q1/70 , G01N33/566 , G01N33/56983 , C12N2760/18851
摘要: A second-step virus binding receptor is found in nature on the surface of animal and plant cells. This receptor is thought to be needed for virus penetration into target cells. The second-step receptor has been found to bind a wide variety of viruses belonging to a number of different families. The second-step receptor and natural or synthetic substances which correspond to or are analogous to the binding epitope of the second-step receptor in that they are able to bind to a site on the virus which recognizes the binding epitope of the natural second-step receptor, are therefore indicated for the diagnosis, prophylaxis or treatment of viral infections.
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公开(公告)号:US20120283318A1
公开(公告)日:2012-11-08
申请号:US13500300
申请日:2010-10-04
申请人: Ya-Fang Mei , Goran Wadell
发明人: Ya-Fang Mei , Goran Wadell
IPC分类号: A61K31/713 , A61P35/00 , C12N5/10 , C12P21/00 , A61P31/12 , A61N5/10 , A61P9/00 , A61P1/16 , A61P33/00 , A61P31/16 , A61P31/14 , C12N15/861 , A61P31/04
CPC分类号: C12N15/86 , C12N7/00 , C12N2710/10343
摘要: The present invention concerns the field of gene therapy and in particular the use of specific adenoviral vector systems for gene therapy, said vector systems offering enhanced efficiency and specificity for gene delivery. More specifically, the present invention provides replicating-competent adenoviral vector systems carrying one or more inserted heterologous gene. The adenoviral vectors system according to the invention are characterized by high binding efficiency and infectivity to cells of neural origin, endothelial cells, carcinoma cells and dendritic cells.
摘要翻译: 本发明涉及基因治疗领域,特别是使用特异性腺病毒载体系统进行基因治疗,所述载体系统提供增强的基因递送的效率和特异性。 更具体地,本发明提供携带一个或多个插入的异源基因的复制能力的腺病毒载体系统。 根据本发明的腺病毒载体系统的特征在于具有高的结合效率和对神经源,内皮细胞,癌细胞和树突状细胞的细胞的感染性。
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4.
公开(公告)号:US07528113B2
公开(公告)日:2009-05-05
申请号:US10997955
申请日:2004-11-29
申请人: Goran Wadell , Niklas Arnberg
发明人: Goran Wadell , Niklas Arnberg
IPC分类号: A61K31/1008 , A61K31/7012 , A61K31/7016 , A61K31/702 , C07H5/04 , C07H5/06 , C08B37/00
CPC分类号: A61K31/7012 , A61K31/00 , A61K31/726 , A61K31/727 , A61K31/737 , A61K38/1709
摘要: Adenoviral infections and in particular ocular adenoviral infections, e.g. keratoconjunctivitis, can be treated or alleviated by the administration of a substance, interfering with the interaction between the virus and the sialic acid receptor, in a therapeutically effective amount.
摘要翻译: 腺病毒感染,特别是眼部腺病毒感染,例如 可以以治疗有效量通过施用物质来干扰病毒和唾液酸受体之间的相互作用来治疗或缓解。
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5.
公开(公告)号:US20050080041A1
公开(公告)日:2005-04-14
申请号:US10997955
申请日:2004-11-29
申请人: Goran Wadell , Niklas Arnberg
发明人: Goran Wadell , Niklas Arnberg
IPC分类号: A61K45/00 , A61K31/00 , A61K31/7012 , A61K31/7016 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/737 , A61K38/17 , A61P15/00 , A61P27/02 , A61P31/14 , C12Q1/70 , A61K31/739
CPC分类号: A61K31/7012 , A61K31/00 , A61K31/726 , A61K31/727 , A61K31/737 , A61K38/1709
摘要: Adenoviral infections and in particular ocular adenoviral infections, e.g. kerato-conjunctivitis, can be treated or alleviated by the administration of a substance, interfering with the interaction between the virus and the sialic acid receptor, in a therapeutically effective amount.
摘要翻译: 腺病毒感染,特别是眼部腺病毒感染,例如 角膜结膜炎可以以治疗有效量通过施用物质来治疗或缓解,从而干扰病毒与唾液酸受体之间的相互作用。
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