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    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS
    5.
    发明申请
    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
    聚合，可降解药水和涂层

    公开(公告)号：US20110190866A1

    公开(公告)日：2011-08-04

    申请号：US13057974

    申请日：2009-07-17

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    IPC分类号： A61F2/84 ,  A61F2/82 ,  B05D7/00

    CPC分类号： A61L31/18 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或脱胶的情况下扩展，并且可以用作药物掺入的涂层基质。

    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS
    6.
    发明申请
    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
    聚合，可降解药水和涂层

    公开(公告)号：US20090012604A1

    公开(公告)日：2009-01-08

    申请号：US12188113

    申请日：2008-08-07

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    IPC分类号： A61F2/06

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS
    9.
    发明申请
    POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
    聚合，可降解药水和涂层

    公开(公告)号：US20090093872A1

    公开(公告)日：2009-04-09

    申请号：US12251173

    申请日：2008-10-14

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David P. Martin ,  Simon F. Williams

    IPC分类号： A61L27/54 ,  A61F2/82 ,  A61F2/84

    CPC分类号： A61L31/18 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally polylactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包括生物相容性共聚物或4-羟基丁酸酯的均聚物，以及任选的聚乳酸和其它可吸收的聚合物和添加剂。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。

    Polymeric, degradable drug-eluting stents and coatings
    10.
    发明授权
    Polymeric, degradable drug-eluting stents and coatings 有权
    聚合，可降解的药物洗脱支架和涂层

    公开(公告)号：US09592325B2

    公开(公告)日：2017-03-14

    申请号：US12188113

    申请日：2008-08-07

    申请人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    发明人： Klaus-Peter Schmitz ,  Detlef Behrend ,  Katrin Sternberg ,  Niels Grabow ,  David Martin ,  Simon Williams

    IPC分类号： A61F2/82 ,  A61L31/18 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16

    CPC分类号： A61L31/18 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/606 ,  A61L2420/08 ,  C08L67/04

    摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

    摘要翻译： 可吸收支架和可吸收支架涂层已经开发出具有改进的性能。 这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。 这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。 衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或分层的情况下扩展，并且可以用作药物掺入的涂层基质。