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1.发明申请3-ETHYLIDENEHYDRAZINO SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS 失效作为血栓素受体激活剂的3-乙酰基乙酰胺取代的杂环化合物公开(公告)号：US20090281317A1
公开(公告)日：2009-11-12
申请号：US11721252
申请日：2005-12-07
申请人： Katsuaki Miyaji , Yukihiro Shigeta , Satoshi Nakano , Shunuske Iwamoto , Yutaka Hirokawa , Hirofumi Ota , Kazufumi Yanagihara , Shingo Owada , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Yukihiro Shigeta , Satoshi Nakano , Shunuske Iwamoto , Yutaka Hirokawa , Hirofumi Ota , Kazufumi Yanagihara , Shingo Owada , Norihisa Ishiwata
IPC分类号： C07D409/12 , C07D333/32
CPC分类号： C07D409/12 , C07D333/32 , C07D401/12
摘要： A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐 化合物或其溶剂合物。
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2.发明授权3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators 失效3-亚乙基肼基取代的杂环化合物作为血小板生成素受体激活剂公开(公告)号：US08552031B2
公开(公告)日：2013-10-08
申请号：US11721252
申请日：2005-12-07
申请人： Katsuaki Miyaji , Yukihiro Shigeta , Satoshi Nakano , Shunuske Iwamoto , Yutaka Hirokawa , Hirofumi Ota , Kazufumi Yanagihara , Shingo Owada , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Yukihiro Shigeta , Satoshi Nakano , Shunuske Iwamoto , Yutaka Hirokawa , Hirofumi Ota , Kazufumi Yanagihara , Shingo Owada , Norihisa Ishiwata
IPC分类号： A01N43/40 , A61K31/445 , C07D211/68 , C07D211/80 , C07D213/02 , C07D401/00 , C07D409/00
CPC分类号： C07D409/12 , C07D333/32 , C07D401/12
摘要： A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐 化合物或其溶剂合物。
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公开(公告)号：US07968542B2
公开(公告)日：2011-06-28
申请号：US11994502
申请日：2006-07-13
申请人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , A61K31/381 , A61P7/00
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。
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公开(公告)号：US20110092496A1
公开(公告)日：2011-04-21
申请号：US12955477
申请日：2010-11-29
申请人： Katsuaki MIYAJI , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki MIYAJI , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： A61K31/5377 , C07D405/12 , C07D409/12 , C07D233/96 , C07D231/10 , C07D333/22 , C07D261/08 , C07D411/12 , A61K31/497 , A61K31/4436 , A61K31/4178 , A61K31/4155 , A61K31/422 , A61K31/4025 , A61K31/381 , A61P7/00
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。
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公开(公告)号：US20090131659A1
公开(公告)日：2009-05-21
申请号：US11721786
申请日：2005-12-14
申请人： Katsuaki Miyaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
IPC分类号： C07D413/12 , C07D409/14
CPC分类号： C07D231/18
摘要： The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective.A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 本发明提供了可用于预防，治疗或缓解血小板生成素受体活化有效的疾病的化合物。 由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐 化合物或其溶剂合物。
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公开(公告)号：US20090118500A1
公开(公告)日：2009-05-07
申请号：US11994502
申请日：2006-07-13
申请人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
发明人： Katsuaki Miyaji , Kazufumi Yanagihara , Yukihiro Shigeta , Shunsuke Iwamoto , Masato Horikawa , Yutaka Hirokawa , Shingo Owada , Satoshi Nakano , Hirofumi Ota , Norihisa Ishiwata
IPC分类号： C07D495/04 , C07D409/12 , C07D409/02
CPC分类号： C07D409/14 , C07D333/32 , C07D333/38 , C07D413/14
摘要： A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3和R4如说明书中所定义），互变异构体，前药或药学上可接受的盐。
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公开(公告)号：US08134013B2
公开(公告)日：2012-03-13
申请号：US11721786
申请日：2005-12-14
申请人： Katsuaki Myaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
发明人： Katsuaki Myaji , Shunsuke Iwamoto , Satoshi Nakano , Hirofumi Ota , Yukihiro Shigeta , Yutaka Hirokawa , Kazufumi Yanagihara , Koji Toyama , Shingo Owada , Masato Horikawa , Norihisa Ishiwata
IPC分类号： C07D409/02 , A61K31/40
CPC分类号： C07D231/18
摘要： The present invention provides compounds useful for prevention, treatment or alleviation of diseases against which activation of the thrombopoietin receptor is effective.A compound represented by the formula (1): wherein A, B, R1, L1, R2, L2, L3, Y, L4, R3 and X are the same as defined in the description, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 本发明提供了可用于预防，治疗或缓解血小板生成素受体活化有效的疾病的化合物。 由式（1）表示的化合物：其中A，B，R1，L1，R2，L2，L3，Y，L4，R3和X与说明书中定义的相同，互变异构体，前药或药学上可接受的盐 化合物或其溶剂合物。
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公开(公告)号：US08026368B2
公开(公告)日：2011-09-27
申请号：US12092834
申请日：2006-11-07
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D409/12 , C07D409/14
摘要： Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided.A compound represented by the formula (I) (wherein R1, R2, R3, L1, L2, X and Y are defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 提供了有效预防，治疗或改善血小板生成素受体激活有效的疾病的化合物。 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3，L1，L2，X和Y在说明书中定义），互变异构体，前药或药学上可接受的盐。
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公开(公告)号：US20090253751A1
公开(公告)日：2009-10-08
申请号：US12092834
申请日：2006-11-07
IPC分类号： A61K31/4439 , C07D409/12 , C07D409/14 , A61K31/415
CPC分类号： C07D409/12 , C07D409/14
摘要： Compounds effective for preventing, treatment or improving diseases against which activation of the thrombopoietin receptor is effective are provided.A compound represented by the formula (I) (wherein R1, R2, R3, L1, L2, X and Y are defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.
摘要翻译： 提供了有效预防，治疗或改善血小板生成素受体激活有效的疾病的化合物。 由式（I）表示的化合物或其溶剂化物，其中R1，R2，R3，L1，L2，X和Y在说明书中定义），互变异构体，前药或药学上可接受的盐。
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公开(公告)号：US09102602B2
公开(公告)日：2015-08-11
申请号：US13990312
申请日：2010-11-29
申请人： Junko Takada , Shunsuke Iwamoto , Satoshi Nakano
发明人： Junko Takada , Shunsuke Iwamoto , Satoshi Nakano
IPC分类号： C07C331/28
CPC分类号： C07C331/28
摘要： The object of the present invention is to provide a novel method for producing an isothiocyanate compound having a carboxyl group(s) by a reaction of the corresponding amino compound having a carboxyl group(s), thiocarbonyldiimidazole and a base, in one step with high purity. An amino compound having a carboxyl group(s) is reacted with thiocarbonyldiimidazole in a solvent in the presence of a base to obtain an isothiocyanate compound having a carboxyl group(s).
摘要翻译： 本发明的目的是提供一种具有羧基的具有羧基的相应氨基化合物，硫代羰基二咪唑和碱的具有羧基的异硫氰酸酯化合物的新方法，其中一步具有高的 纯度。 具有羧基的氨基化合物与硫代羰基二咪唑在溶剂中在碱存在下反应，得到具有羧基的异硫氰酸酯化合物。
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