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    Circular Dichroic Thermal Lens Microscope
    5.
    发明申请
    Circular Dichroic Thermal Lens Microscope 审中-公开
    圆二色性热镜片显微镜

    公开(公告)号：US20100060981A1

    公开(公告)日：2010-03-11

    申请号：US11815976

    申请日：2006-02-10

    申请人： Masayo Yamauchi ,  Akihide Hibara ,  Takehiko Kitamori ,  Kazuma Mawatari ,  Manabu Tokeshi

    发明人： Masayo Yamauchi ,  Akihide Hibara ,  Takehiko Kitamori ,  Kazuma Mawatari ,  Manabu Tokeshi

    IPC分类号： G02B21/06

    CPC分类号： G01N21/171 ,  G01N21/19 ,  G01N2021/1712

    摘要： An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses.The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.

    摘要翻译： 本发明的目的是提供一种圆形二色性热透镜显微镜装置，其能够识别和定量超微量的光学活性样品，并且具有比常规装置更高的灵敏度。 目的是通过将激发光和检测光照射到光学显微镜中的圆二色性热透镜显微镜装置来实现，其中检测光进入通过用激发光照射样品而形成的热透镜，并且检测样品中的物质 通过确定通过热透镜的检测光的扩散，并且其中激发光被相位调制元件调制，以便识别或定量光学异构体。

    Microchemical system and method for calculating TLM output thereof
    6.
    发明申请
    Microchemical system and method for calculating TLM output thereof 审中-公开
    用于计算TLM输出的微化学系统和方法

    公开(公告)号：US20080123088A1

    公开(公告)日：2008-05-29

    申请号：US11985823

    申请日：2007-11-16

    申请人： Masatoshi Nara ,  Ryo Anraku ,  Takahiro Asai ,  Jun Yamaguchi ,  Akihiko Hattori ,  Takehiko Kitamori ,  Manabu Tokeshi ,  Akihide Hibara ,  Kazuma Mawatari

    发明人： Masatoshi Nara ,  Ryo Anraku ,  Takahiro Asai ,  Jun Yamaguchi ,  Akihiko Hattori ,  Takehiko Kitamori ,  Manabu Tokeshi ,  Akihide Hibara ,  Kazuma Mawatari

    IPC分类号： G01N21/41

    CPC分类号： G01N21/171 ,  G01N35/08

    摘要： There are provided a microchemical system capable of acquiring a highly accurate TLM output value and a method for calculating TLM output thereof. A microchemical system 1 comprises: a microchemical chip having a channel with a depth t in which a sample flows; an exciting light source 13 adapted to irradiate the sample with an exciting light through an objective lens 10 with a numerical aperture NA; a detecting light source 14 adapted to irradiate the sample with a detecting light coaxially with the exciting light through the objective lens 10; and a PD adapted to receive a transmitted light when the detecting light transmits the sample before and after formation of a thermal lens 12. When a TLM output is calculated in the microchemical system 1 on the basis of a received light amount of the PD, the depth t (μm) is set to the range of 75≦t≦300, the numerical aperture NA is set to the range of 0.04≦NA≦0.1 and chromatic aberrations df (nm) for the exciting light and the detecting light of the objective lens 10 is set to the range of 100≦df≦250.

    摘要翻译： 提供了能够获得高度精确的TLM输出值的微化学系统和用于计算TLM输出的方法。 微化学系统1包括：具有样品流过深度t的通道的微化学芯片; 激光光源13，其适于通过具有数值孔径NA的物镜10照射具有激发光的样品; 检测光源14，适于通过物镜10与激发光同轴地检测具有检测光的样品; 以及适于在检测光在形成热透镜12之前和之后透射样品时接收透射光的PD。当在微量化学系统1中基于PD的接收光量计算TLM输出时， 深度t（母体）设定为75 <= t <= 300的范围，数值孔径NA设定为0.04 <= NA <= 0.1的范围，激发光的色差df（nm） 物镜10的光被设定在100 <= df <= 250的范围内。

    Photothermal transducing spectroscopic analyzer
    7.
    发明授权
    Photothermal transducing spectroscopic analyzer 失效
    光热转换光谱分析仪

    公开(公告)号：US07036979B2

    公开(公告)日：2006-05-02

    申请号：US10181267

    申请日：2001-01-29

    申请人： Kazuma Mawatari

    发明人： Kazuma Mawatari

    IPC分类号： G01N21/63 ,  G01N21/71 ,  G01J5/08 ,  G01J1/04

    CPC分类号： G01N21/171

    摘要： In a photothermal spectroscopic analyzer in which a probe light is made to fall on a thermal lens produced in a sample by an input of an excitation light and the sample is analyzed in accordance with a change of the probe light which is caused by the thermal lens, a light source of excitation light is composed of semiconductor laser light emitting means, and a light source of the probe light is composed of another semiconductor laser light emitting means, and furthermore a condenser lens for focusing the excitation light upon the sample and a condenser lens for focusing the probe light upon the thermal lens are configured by a common condenser lens. Such a photothermal spectroscopic analyzer according to the present invention satisfies all the requirements of small size, low manufacturing cost, high sensitivity, high precision, maintenance free performance, short start-up time, and automatic measurement for such a device as to perform POC analysis.

    摘要翻译： 在通过激发光的输入使探针光落在样品中产生的热透镜的光热分析仪中，并且根据由热透镜引起的探测光的变化来分析样品 激发光的光源由半导体激光发光装置构成，探测光的光源由另一个半导体激光发光装置构成，另外还有用于将激发光聚焦在样品上的聚光透镜和冷凝器 用于将探测光聚焦在热透镜上的透镜由公共聚光透镜构成。 这样的本发明的光热分析装置能够满足小型化，低制造成本，高灵敏度，高精度，免维护性能，启动时间短，以及进行POC分析的装置的自动测定的要求 。