公开(公告)号：US20070161897A1

公开(公告)日：2007-07-12

申请号：US10557237

申请日：2004-05-18

申请人： Kazuaki Sasaki ,  Takashi Azuma ,  Ken-ichi Kawabata ,  Shin-ichiro Umemura ,  Takashi Okai ,  Tetsuya Ishikawa

发明人： Kazuaki Sasaki ,  Takashi Azuma ,  Ken-ichi Kawabata ,  Shin-ichiro Umemura ,  Takashi Okai ,  Tetsuya Ishikawa

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/06 ,  A61B8/13 ,  A61B2090/378

摘要： Ultrasonic treatment equipment is provided which repeats therapeutic ultrasound exposure while measuring a degree of vessel constriction on a therapeutic ultrasound exposure basis. This equipment includes: a therapeutic ultrasonic transducer 2 which exposes a blood vessel of an affected part to a focused therapeutic ultrasonic wave for a specified period of exposure time; an imaging ultrasonic probe 3 which images an ultrasound tomographic image of the affected part; a display unit 24 which displays the ultrasound tomographic image; means 21 for detecting a blood flow signal from a signal received by the imaging ultrasonic probe and determining the blood flow velocity of the blood vessels of the affected part; means 21 for calculating a rate of change in blood flow velocity during the exposure to the therapeutic ultrasonic wave or before and after the exposure to the therapeutic ultrasonic wave; and means 23 for controlling exposure conditions of the therapeutic ultrasonic wave on the basis of the rate of change in blood flow velocity, and thereby controlling the therapeutic ultrasonic transducer.

摘要翻译： 提供超声波处理设备，其在治疗超声暴露基础上测量血管收缩程度时重复治疗性超声波暴露。 该设备包括：治疗超声波换能器2，其将受影响部分的血管暴露于聚焦的治疗超声波达指定的曝光时间; 成像超声波探头3，其对受影响部分的超声断层图像进行成像; 显示单元24，其显示超声断层图像; 用于从由成像超声波探头接收的信号中检测血流信号并确定受影响部分的血管的血流速度的装置21; 用于计算暴露于治疗超声波期间或暴露于治疗超声波之前和之后的血流速度变化率的装置21; 以及基于血流速度变化率来控制治疗超声波的暴露条件的装置23，由此控制治疗用超声波换能器。

公开(公告)号：US07699779B2

公开(公告)日：2010-04-20

申请号：US10557237

申请日：2004-05-18

申请人： Kazuaki Sasaki ,  Takashi Azuma ,  Ken-ichi Kawabata ,  Shin-ichiro Umemura ,  Takashi Okai ,  Tetsuya Ishikawa

发明人： Kazuaki Sasaki ,  Takashi Azuma ,  Ken-ichi Kawabata ,  Shin-ichiro Umemura ,  Takashi Okai ,  Tetsuya Ishikawa

IPC分类号： A61B8/00

CPC分类号： A61N7/02 ,  A61B8/06 ,  A61B8/13 ,  A61B2090/378

摘要： Ultrasonic treatment equipment is provided which repeats therapeutic ultrasound exposure while measuring a degree of vessel constriction on a therapeutic ultrasound exposure basis. This equipment includes: a therapeutic ultrasonic transducer 2 which exposes a blood vessel of an affected part to a focused therapeutic ultrasonic wave for a specified period of exposure time; an imaging ultrasonic probe 3 which images an ultrasound tomographic image of the affected part; a display unit 24 which displays the ultrasound tomographic image; means 21 for detecting a blood flow signal from a signal received by the imaging ultrasonic probe and determining the blood flow velocity of the blood vessels of the affected part; means 21 for calculating a rate of change in blood flow velocity during the exposure to the therapeutic ultrasonic wave or before and after the exposure to the therapeutic ultrasonic wave; and means 23 for controlling exposure conditions of the therapeutic ultrasonic wave on the basis of the rate of change in blood flow velocity, and thereby controlling the therapeutic ultrasonic transducer.

摘要翻译： 提供超声波处理设备，其在治疗超声暴露基础上测量血管收缩程度时重复治疗性超声波暴露。 该设备包括：治疗超声波换能器2，其将受影响部分的血管暴露于聚焦的治疗超声波达指定的曝光时间; 成像超声波探头3，其对受影响部分的超声断层图像进行成像; 显示单元24，其显示超声断层图像; 用于从由成像超声波探头接收的信号中检测血流信号并确定受影响部分的血管的血流速度的装置21; 用于计算暴露于治疗超声波期间或暴露于治疗超声波之前和之后的血流速度变化率的装置21; 以及基于血流速度变化率来控制治疗超声波的暴露条件的装置23，由此控制治疗用超声波换能器。

公开(公告)号：US07780598B2

公开(公告)日：2010-08-24

申请号：US11476866

申请日：2006-06-29

申请人： Nami Sugita ,  Ken-ichi Kawabata ,  Takashi Azuma ,  Shin-ichiro Umemura

发明人： Nami Sugita ,  Ken-ichi Kawabata ,  Takashi Azuma ,  Shin-ichiro Umemura

IPC分类号： A61B8/00

CPC分类号： A61B8/00 ,  A61M37/0092 ,  A61N7/00

摘要： In a sonodynamic treatment apparatus including: a first ultrasound radiating unit for radiating diagnostic ultrasound; a second ultrasound radiating unit for radiating treatment ultrasound; an echo detection unit for detecting an ultrasound echo; a diagnostic controller for radiating the diagnostic ultrasound with the first ultrasound radiating unit and detecting the ultrasound echo corresponding the diagnostic ultrasound; an echographic controller for processing an echographic image on the basis of the detected ultrasound echo; and a treatment controller for radiating the treatment ultrasound with the second ultrasound radiating unit, radiation of the treatment ultrasound with the second ultrasound radiating unit is controlled to have a predetermined exposure duration and a predetermined pause duration of the treatment ultrasound, and the echographic image is generated on the basis of the ultrasound echo during the pause duration of the treatment ultrasound exposure with the diagnostic image generator. The treatment ultrasound may be weakened after detection of a bubble generated by the treatment ultrasound.

摘要翻译： 一种声动治疗装置，包括：用于放射诊断超声的第一超声波辐射单元; 用于放射治疗超声波的第二超声波辐射单元; 用于检测超声回波的回波检测单元; 诊断控制器，用于利用所述第一超声波辐射单元辐射所述诊断超声波，并且检测对应于所述诊断超声的超声回波; 基于检测到的超声回波来处理回波图像的回波记录控制器; 以及处理控制器，用于利用所述第二超声波辐射单元照射所述处理超声波，将所述处理超声波与所述第二超声波辐射单元的放射线控制为具有预定的曝光持续时间和所述治疗超声波的预定暂停持续时间，并且所述回波图像为 在诊断图像生成器的处理超声波曝光的暂停时间期间，基于超声回波生成。 检测到由治疗超声波产生的气泡后，治疗超声可能会减弱。

公开(公告)号：US08562531B2

公开(公告)日：2013-10-22

申请号：US10583033

申请日：2004-11-16

申请人： Hideki Yoshikawa ,  Takashi Azuma ,  Shin-ichiro Umemura ,  Ken-ichi Kawabata

发明人： Hideki Yoshikawa ,  Takashi Azuma ,  Shin-ichiro Umemura ,  Ken-ichi Kawabata

IPC分类号： A61B8/00

CPC分类号： A61B8/08

摘要： There is provided a ultrasonic motion detecting device that detects a three-dimensional motion of an object. The ultrasonic motion detecting device, comprises first and second ultrasonic transducers 13 having piezoelectric elements arranged in an array, which transmit ultrasonic waves to an object and acquire reflection signals from the object, a motion detection unit 20 that extracts an estimation region which is used for estimating a motion of the object from the reflection signals that are acquired by the first and second ultrasonic transducers, and detects a three-dimensional motion within the estimation region, and an image display unit 19 that displays the three-dimensional motion within the estimation region, wherein ultrasonic wave scanning surfaces due to the first and second ultrasonic transducers cross over each other.

摘要翻译： 提供了一种检测物体的三维运动的超声波运动检测装置。 超声波运动检测装置包括具有排列成阵列的压电元件的第一和第二超声波换能器13，其将超声波向对象发送并从物体获取反射信号;运动检测单元20，其提取用于 根据由第一和第二超声换能器获取的反射信号估计物体的运动，并且检测估计区域内的三维运动;以及图像显示单元19，其在估计区域内显示三维运动 其中由于第一和第二超声波换能器引起的超声波扫描表面彼此交叉。

公开(公告)号：US20070078326A1

公开(公告)日：2007-04-05

申请号：US10583033

申请日：2004-11-16

申请人： Hideki Yoshikawa ,  Takashi Azuma ,  Shin-ichiro Umemura ,  Ken-ichi Kawabata

发明人： Hideki Yoshikawa ,  Takashi Azuma ,  Shin-ichiro Umemura ,  Ken-ichi Kawabata

IPC分类号： A61B5/05

CPC分类号： A61B8/08

摘要： There is provided a ultrasonic motion detecting device that detects a three-dimensional motion of an object. The ultrasonic motion detecting device, comprises first and second ultrasonic transducers 13 having piezoelectric elements arranged in an array, which transmit ultrasonic waves to an object and acquire reflection signals from the object, a motion detection unit 20 that extracts an estimation region which is used for estimating a motion of the object from the reflection signals that are acquired by the first and second ultrasonic transducers, and detects a three-dimensional motion within the estimation region; and an image display unit 19 that displays the three-dimensional motion within the estimation region, wherein ultrasonic wave scanning surfaces due to the first and second ultrasonic transducers cross over each other.

摘要翻译： 提供了一种检测物体的三维运动的超声波运动检测装置。 超声波运动检测装置包括具有排列成阵列的压电元件的第一和第二超声波换能器13，其将超声波向对象发送并从物体获取反射信号;运动检测单元20，其提取用于 根据由第一和第二超声换能器获取的反射信号估计物体的运动，并检测估计区域内的三维运动; 以及在估计区域内显示三维运动的图像显示单元19，其中由于第一和第二超声波换能器而引起的超声波扫描表面彼此交叉。

公开(公告)号：US20070038099A1

公开(公告)日：2007-02-15

申请号：US11476866

申请日：2006-06-29

申请人： Nami Sugita ,  Ken-ichi Kawabata ,  Takashi Azuma ,  Shin-ichiro Umemura

发明人： Nami Sugita ,  Ken-ichi Kawabata ,  Takashi Azuma ,  Shin-ichiro Umemura

IPC分类号： A61B8/00

CPC分类号： A61B8/00 ,  A61M37/0092 ,  A61N7/00

摘要： In a sonodynamic treatment apparatus including: a first ultrasound radiating unit for radiating diagnostic ultrasound; a second ultrasound radiating unit for radiating treatment ultrasound; an echo detection unit for detecting an ultrasound echo; a diagnostic controller for radiating the diagnostic ultrasound with the first ultrasound radiating unit and detecting the ultrasound echo corresponding the diagnostic ultrasound; an echographic controller for processing an echographic image on the basis of the detected ultrasound echo; and a treatment controller for radiating the treatment ultrasound with the second ultrasound radiating unit, radiation of the treatment ultrasound with the second ultrasound radiating unit is controlled to have a predetermined exposure duration and a predetermined pause duration of the treatment ultrasound, and the echographic image is generated on the basis of the ultrasound echo during the pause duration of the treatment ultrasound exposure with the diagnostic image generator. The treatment ultrasound may be weakened after detection of a bubble generated by the treatment ultrasound.

摘要翻译： 一种声动治疗装置，包括：用于放射诊断超声的第一超声波辐射单元; 用于放射治疗超声波的第二超声波辐射单元; 用于检测超声回波的回波检测单元; 诊断控制器，用于利用所述第一超声波辐射单元辐射所述诊断超声波，并且检测对应于所述诊断超声的超声回波; 基于检测到的超声回波来处理回波图像的回波记录控制器; 以及处理控制器，用于利用所述第二超声波辐射单元照射所述处理超声波，将所述处理超声波与所述第二超声波辐射单元的放射线控制为具有预定的曝光持续时间和所述治疗超声波的预定暂停持续时间，并且所述回波图像为 在诊断图像生成器的处理超声波曝光的暂停时间期间，基于超声回波生成。 检测到由治疗超声波产生的气泡后，治疗超声可能会减弱。

公开(公告)号：US08323197B2

公开(公告)日：2012-12-04

申请号：US12039344

申请日：2008-02-28

申请人： Miyuki Kono ,  Takashi Azuma ,  Shin-ichiro Umemura ,  Hiroki Tanaka

发明人： Miyuki Kono ,  Takashi Azuma ,  Shin-ichiro Umemura ,  Hiroki Tanaka

IPC分类号： A61B8/00

CPC分类号： A61B8/06 ,  A61B8/4472

摘要： Means for measuring and evaluating a dynamic property of a blood flow in a superficial blood vessel of a living body are constructed.A physical stimulus is given to the blood flow, and an ultrasonic response from the blood flow to the physical stimulus is measured and evaluated, which allows the blood property to be evaluated noninvasively and dynamically. Therefore, a medical check and a lifestyle-related diseases prevention effect are promising.

摘要翻译： 构建用于测量和评价生物体的浅表血管中的血液流动性的手段。 对血流进行物理刺激，并测量和评估从血流到物理刺激的超声波响应，从而可以非侵入性地和动态地评估血液性质。 因此，医疗检查和与生活方式有关的疾病预防效果是有希望的。

公开(公告)号：US07942821B2

公开(公告)日：2011-05-17

申请号：US10580225

申请日：2004-07-09

申请人： Shin-ichiro Umemura ,  Takashi Azuma ,  Tetsuya Hayashi

发明人： Shin-ichiro Umemura ,  Takashi Azuma ,  Tetsuya Hayashi

IPC分类号： A61B8/00

CPC分类号： G01S15/8981 ,  G01S15/8977

摘要： The present invention realizes a Doppler velocity detecting technique capable of performing velocity detection and analysis with a suppressed error while excellently distinguishing a clutter signal, and provides an ultrasonographic device using the technique. In a Doppler velocity detection device comprising means for transmitting/receiving pulse waves to/from a subject a plurality of times, and velocity analyzing means for analyzing a velocity of a moving reflector in the subject on the basis of a reception echo signal, the velocity analyzing means obtains a complex expansion coefficient by linearly connecting an expansion coefficient of an even-numbered degree term and an expansion coefficient of an odd-numbered degree term which is different from the even-numbered degree term by one degree, derived when reception echo time-series signals obtained by arranging reception echo signals of equal lapse time from pulse transmission times in order of the transmission times are expanded as components of a Legendre polynomial starting from the 0th degree, by using an imaginary unit as a coefficient, and obtains a signed velocity signal of a moving reflector in the subject on the basis of-the ratio between the magnitude of each complex expansion coefficient and the magnitude of an interval between the complex expansion coefficients.

摘要翻译： 本发明实现了一种多普勒速度检测技术，其能够在抑制误差的同时进行速度检测和分析，同时优异地区分杂波信号，并提供使用该技术的超声波装置。 在多普勒速度检测装置中，包括用于多次向对象发送/接收脉搏波的装置，以及速度分析装置，用于根据接收回波信号分析被检体内的移动反射器的速度，速度 分析装置通过将偶数度项的展开系数和与偶数度项不同的奇数项的展开系数线性连接一度获得复数展开系数，当接收回波时间 通过使用虚数单位作为系数，将从发送时间的顺序的脉冲发送时间的等待通过时间的接收回波信号作为从第0度开始的勒让德多项式的分量扩展得到的系列信号， 基于每个复合扩张系数的大小之间的比例，对象中的移动反射器的速度信号 有效率和复合扩张系数间隔的大小。

公开(公告)号：US07860258B2

公开(公告)日：2010-12-28

申请号：US11491198

申请日：2006-07-24

申请人： Takashi Azuma ,  Shin-ichiro Umemura ,  Tatsuya Nagata ,  Hiroshi Fukuda ,  Shuntaro Machida ,  Toshiyuki Mine

发明人： Takashi Azuma ,  Shin-ichiro Umemura ,  Tatsuya Nagata ,  Hiroshi Fukuda ,  Shuntaro Machida ,  Toshiyuki Mine

IPC分类号： H04R25/00

CPC分类号： B06B1/0292 ,  H04R19/005

摘要： A transducer for transmitting and receiving ultrasonic waves to a diaphragm-based ultrasonic transducer device using silicon as a base material. An electro-acoustic transducer device which can have a first electrode formed on top of, or inside, a substrate and having a thin film provided on top of the substrate. The device can also have a second electrode formed on top of, or inside, the thin film. A void layer can be provided between the first electrode and the second electrode. A charge-storage layer can be provided between the first electrode and the second electrode. A source electrode and a drain electrode can also be provided for measuring a quantity of electricity stored in the charge-storage layer.

摘要翻译： 一种用于将超声波发送和接收到使用硅作为基材的基于隔膜的超声波换能器装置的换能器。 一种电声换能器装置，其可以具有形成在基板的顶部或内部并且具有设置在基板顶部上的薄膜的第一电极。 该器件还可以具有形成在薄膜的顶部或内部的第二电极。 可以在第一电极和第二电极之间设置空隙层。 可以在第一电极和第二电极之间设置电荷存储层。 还可以提供源电极和漏电极来测量存储在电荷存储层中的电量。

公开(公告)号：US20080228076A1

公开(公告)日：2008-09-18

申请号：US10586665

申请日：2005-01-06

申请人： Takashi Azuma ,  Shin-ichiro Umemura ,  Hiroshi Kuribara ,  Tatsuya Hayashi

发明人： Takashi Azuma ,  Shin-ichiro Umemura ,  Hiroshi Kuribara ,  Tatsuya Hayashi

IPC分类号： A61B8/14

CPC分类号： G01S15/102 ,  A61B8/481 ,  G01S7/5202 ,  G01S7/52038 ,  G01S7/52039 ,  G01S15/8959 ,  G01S15/8963

摘要： This invention provides an ultrasonic imaging system that implements imaging by distinguishing sharply and definitely the echo components generated by scattering in a microbubble contrast medium, from the tissue harmonic components generated by nonlinear propagation of a transmitted pulse. This ultrasonic imaging system, constructed to transmit/receive ultrasonic pulses to/from a living body and form a contrast image of the inside of the living body by using the contrast-imaging microbubbles, repeats the transmitting/receiving operations four times in all, under the same transmitting/receiving focus conditions at different phase angles [(a)=0°, (b)=120°, (c)=−120°, (d)=180°] of the carrier of a transmitted pulse wave including a common envelope signal, sums up three time-series receive echo signals associated with (a), (b), (c), forms the contrast image, sums up two time-series receive echo signals associated with (a), (d), forms an image of the living body having a nonlinear pulse propagation property, and makes a superimposed display of the two kinds of images.

摘要翻译： 本发明提供了一种超声成像系统，其通过从由发射脉冲的非线性传播产生的组织谐波分量中清楚地和明确地区分由微泡造影剂中的散射产生的回波分量来实现成像。 该超声波成像系统被构造成通过使用对比度成像微泡将生物体的超声波脉冲发送/接收生物体内部的对比图像，全部重复发送/接收操作四次 发射脉冲波的载波的不同相位角[（a）= 0°，（b）= 120°，（c）= - 120°，（d）= 180°）的相同发射/接收对焦条件包括 共同的包络信号，与（a），（b），（c）相关联的三个时间序列接收回波信号相加形成对比度图像，将与（a），（d）相关联的两个时间序列接收回波信号相加 ），形成具有非线性脉冲传播特性的活体的图像，并且叠加显示两种图像。