公开(公告)号：US20120243369A1

公开(公告)日：2012-09-27

申请号：US13513341

申请日：2011-01-26

申请人： Yoshiaki Sudo ,  Kazuhiko Fukutani ,  Takao Nakajima ,  Yoshitaka Baba

发明人： Yoshiaki Sudo ,  Kazuhiko Fukutani ,  Takao Nakajima ,  Yoshitaka Baba

IPC分类号： H04B17/00

CPC分类号： A61B5/0095 ,  A61B5/0059 ,  A61B8/0825 ,  A61B8/0833 ,  G01N21/1702 ,  G01N29/0663 ,  G01N29/2418 ,  G01N2021/1706 ,  G01N2291/02475

摘要： A subject information acquisition apparatus includes: an acoustic wave detector which detects an acoustic wave which is generated from a subject by irradiating light and outputs a detection signal; an amplifier which amplifies the detection signal which is output from the acoustic wave detector; a gain control unit which changes a gain of the amplifier as time elapses, according to a gain control table, in order to correct a drop in intensity of the acoustic wave caused by attenuation of fluence inside the subject; and a signal processing unit which obtains information inside the subject based on the signal amplified by the amplifier. Measurement under a plurality of measurement conditions, where at least fluence distribution inside the subject or a position of the acoustic wave detector differs, is possible, and the gain control unit changes the gain control table according to the measurement conditions.

摘要翻译： 对象信息获取装置包括：声波检测器，其通过照射光检测从对象产生的声波并输出检测信号; 放大器，其放大从声波检测器输出的检测信号; 增益控制单元，用于根据增益控制表改变放大器的增益随时间的变化，以便校正由对象内的注量衰减引起的声波强度的下降; 以及信号处理单元，其基于由放大器放大的信号来获取对象内的信息。 在多个测量条件下进行测量，其中至少对象内的注量分布或声波检测器的位置不同，并且增益控制单元根据测量条件改变增益控制表。

公开(公告)号：US20100191109A1

公开(公告)日：2010-07-29

申请号：US12750836

申请日：2010-03-31

申请人： Kazuhiko Fukutani ,  Takao Nakajima ,  Yoshitaka Baba

发明人： Kazuhiko Fukutani ,  Takao Nakajima ,  Yoshitaka Baba

IPC分类号： A61B8/00

CPC分类号： A61B5/0059 ,  A61B5/0095 ,  A61B8/00 ,  A61B8/0833 ,  G01N21/1702 ,  G01N2021/1706

摘要： A biological information processing apparatus includes: a light source 11 that irradiates light 12 to a light irradiation region 13A on a test object 13; an acoustic wave detector 17 that detects an acoustic wave 16 generated by a light absorber 15 in the test object upon its absorption of the light, and outputs a detection signal; and an electronic control system 18 having an amplifier that amplifies the detection signal outputted from the acoustic wave detector 17. The electronic control system controls a gain of the amplifier in such a manner that a gain for a detection signal of an acoustic wave generated at a first location in the test object becomes larger as compared with a gain for a detection signal of an acoustic wave generated at a second location which exists nearer to the light irradiation region than the first location does.

摘要翻译： 一种生物信息处理设备包括：将光12照射到测试对象13上的光照射区域13A的光源11; 声波检测器17，其在吸收光时检测由被测物中的光吸收体15产生的声波16，并输出检测信号; 以及具有放大从声波检测器17输出的检测信号的放大器的电子控制系统18.电子控制系统以这样的方式控制放大器的增益，使得在 与在比第一位置更靠近光照射区域的第二位置处产生的声波的检测信号的增益相比，测试对象中的第一位置变大。

公开(公告)号：US20110128816A1

公开(公告)日：2011-06-02

申请号：US13055632

申请日：2009-09-03

申请人： Yoshitaka Baba ,  Haruo Yoda ,  Kazuhiko Fukutani

发明人： Yoshitaka Baba ,  Haruo Yoda ,  Kazuhiko Fukutani

IPC分类号： G03B42/06

CPC分类号： A61B5/0095 ,  A61B5/0073 ,  A61B5/7225 ,  A61B5/7278 ,  A61B8/13 ,  A61B8/483

摘要： There is provided a received data processing apparatus of photoacoustic tomography including a minimum constitution unit data composition unit that sequentially reads receiving digital signals from first storage units and composes minimum constitution unit data of the acoustic wave of the minimum constitution units by performing a delay-and-sum process; a second storage unit that stores the minimum constitution unit data of the entire region of the specimen; an image construction unit that constructs an image of the specimen based on the minimum constitution unit data stored in the second storage unit; and a control unit that sequentially stores the minimum constitution unit data calculated by the minimum constitution unit data composition unit in the second storage unit and reads the stored minimum constitution unit data of the entire region of the specimen to transmit the minimum constitution unit data to the image construction unit.

摘要翻译： 提供了一种光声层析成像的接收数据处理装置，包括：最小构成单元数据合成单元，其顺序地从第一存储单元读取接收数字信号，并通过执行延迟来构成最小构成单元的声波的最小构成单位数据; -sum过程 第二存储单元，其存储所述检体的整个区域的最小构成单位数据; 图像构造单元，其基于存储在第二存储单元中的最小构成单位数据构建样本的图像; 以及控制单元，其将由最小构成单位数据构成单元计算出的最小构成单位数据顺序地存储在第二存储单元中，并读取所存储的样本的整个区域的最小构成单位数据，以将最小构成单位数据发送到 形象建设单位。

公开(公告)号：US09247923B2

公开(公告)日：2016-02-02

申请号：US13055632

申请日：2009-09-03

申请人： Yoshitaka Baba ,  Haruo Yoda ,  Kazuhiko Fukutani

发明人： Yoshitaka Baba ,  Haruo Yoda ,  Kazuhiko Fukutani

IPC分类号： A61B13/00 ,  A61B8/13 ,  A61B5/00 ,  A61B8/08

CPC分类号： A61B5/0095 ,  A61B5/0073 ,  A61B5/7225 ,  A61B5/7278 ,  A61B8/13 ,  A61B8/483

摘要： There is provided a received data processing apparatus of photoacoustic tomography including a minimum constitution unit data composition unit that sequentially reads receiving digital signals from first storage units and composes minimum constitution unit data of the acoustic wave of the minimum constitution units by performing a delay-and-sum processing. A second storage unit stores the minimum constitution unit data of the entire region of the specimen, and an image construction unit constructs an image of the specimen based on the minimum constitution unit data stored in the second storage unit. A control unit sequentially stores the minimum constitution unit data calculated by the minimum constitution unit data composition unit in the second storage unit and reads the stored minimum constitution unit data of the entire region of the specimen to transmit the minimum constitution unit data to the image construction unit.

摘要翻译： 提供了一种光声层析成像的接收数据处理装置，包括：最小构成单元数据合成单元，其顺序地从第一存储单元读取接收数字信号，并通过执行延迟来构成最小构成单元的声波的最小构成单位数据; -sum处理。 第二存储单元存储样本的整个区域的最小构成单位数据，图像构造单元基于存储在第二存储单元中的最小构成单位数据构建样本的图像。 控制单元将由最小构成单位数据构成单元计算出的最小构成单位数据顺序地存储在第二存储单元中，并读取所存储的样本的整个区域的最小构成单位数据，将最小构成单位数据发送到图像构造 单元。

公开(公告)号：US10041876B2

公开(公告)日：2018-08-07

申请号：US13003503

申请日：2009-07-09

申请人： Hiroshi Nishihara ,  Kazuhiko Fukutani ,  Takao Nakajima

发明人： Hiroshi Nishihara ,  Kazuhiko Fukutani ,  Takao Nakajima

IPC分类号： A61B5/05 ,  G01N21/17 ,  A61B5/00 ,  A61B5/145

摘要： A measurement apparatus capable of measuring a position and a size of an absorber with high accuracy, which includes: a light source unit for emitting a pulse beam; an illumination optical unit for leading the pulse beam emitted by the light source unit to an inside of an inspection object; and an acoustic signal detection unit for detecting a photoacoustic signal generated by the pulse beam in which the illumination optical unit includes a first and second illumination optical units that are arranged so that the inspection object is irradiated with the pulse beam from both sides thereof opposingly; and the acoustic signal detection unit is provided so that a detection surface of the acoustic signal detection unit is positioned on the same side as that of one of irradiation surfaces of the inspection object which the first and second illumination optical units irradiate with the pulse beam.

公开(公告)号：US08540637B2

公开(公告)日：2013-09-24

申请号：US13140816

申请日：2009-12-16

申请人： Toshinobu Tokita ,  Kazuhiko Fukutani ,  Takao Nakajima ,  Katsumi Nakagawa

发明人： Toshinobu Tokita ,  Kazuhiko Fukutani ,  Takao Nakajima ,  Katsumi Nakagawa

IPC分类号： A61B8/00

CPC分类号： A61B5/0095 ,  A61B5/0091 ,  A61B5/4312 ,  A61B8/0825 ,  A61B8/5207

摘要： When a subject is pressed by a plate and an acoustic wave is received by a probe via the plate, the acoustic wave is refracted because of the difference between a sound velocity in the subject and a sound velocity in the plate. When the refraction is not considered, a reduction in resolution occurs. Weights for signals or virtual wavefronts corresponding to the signals to be added to one another are determined using a thickness of the plate, the sound velocity in the plate, the sound velocity in the subject, positions of image elements (pixels or voxels) for image information, and arrival times of the acoustic wave from an object that is a sound source. The signals or the virtual wavefronts corresponding to the signals are added to one another, thereby acquiring the image information.

摘要翻译： 当受试者被板按压并且通过探针经由板接收声波时，由于被检体中的声速和板中的声速之间的差异，声波被折射。 当不考虑折射时，会发生分辨率降低。 使用板的厚度，板中的声速，被摄体中的声速，图像的像素（像素或体素）的位置来确定对应于要添加到彼此的信号的信号或虚拟波前的权重 信息和来自作为声源的物体的声波的到达时间。 对应于信号的信号或虚拟波前相互添加，从而获取图像信息。

公开(公告)号：US08300224B2

公开(公告)日：2012-10-30

申请号：US13367894

申请日：2012-02-07

申请人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

发明人： Takao Nakajima ,  Kazuhiko Fukutani ,  Yasufumi Asao ,  Ryuichi Nanaumi

IPC分类号： G01N21/00

CPC分类号： G01N21/1702 ,  A61B5/0059 ,  A61B5/0095 ,  A61B8/4281 ,  G01N2021/1706

摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.

摘要翻译： 光声设备通过接收由照射到样本的光产生的样本产生的光声来获得关于样本的信息。 该装置包括用于向样本照射光的光源，用于接收光声波的声波接收器，以及光反射构件，其用于使得通过其进入其内部的光学扩散而从样本中辐射出的光 来自光源的样本，重新进入样本的内部，其中光反射构件允许弹性波通过。 结果，提供了一种光声装置和探针，其可以将来自样本的散射光限制在样本中，并且可以可靠地防止通过散射光从探测器的接收元件区域产生光声波。

公开(公告)号：US09131851B2

公开(公告)日：2015-09-15

申请号：US12365237

申请日：2009-02-04

申请人： Kazuhiko Fukutani ,  Takao Nakajima ,  Yasufumi Asao

发明人： Kazuhiko Fukutani ,  Takao Nakajima ,  Yasufumi Asao

IPC分类号： A61B5/00 ,  G01N29/24 ,  A61B8/08

CPC分类号： A61B5/0095 ,  A61B5/0091 ,  A61B5/4312 ,  A61B5/4887 ,  A61B5/489 ,  A61B8/0825 ,  A61B8/4416 ,  A61B8/5223 ,  G01N29/2418

摘要： There are provided a biological information imaging apparatus that can measure ultrasound generated from an optical absorber in a deep part of a subject living body with high sensitivity, and a method for analyzing biological information using the biological information imaging apparatus. The biological information imaging apparatus that detects ultrasound and images biological information, includes: a light source that irradiates the subject with light for generating ultrasound from an optical absorber existing in the subject; an ultrasound transmission unit that transmits focused ultrasound to a specific region where the optical absorber exists; and an ultrasound detection unit that detects an ultrasound synthesized signal due to interaction between ultrasound generated from the optical absorber that absorbs the light and the focused ultrasound transmitted to the specific region.

摘要翻译： 本发明提供一种生物信息成像装置，其能够高灵敏度地测量本体体内深部的光吸收体产生的超声波，以及使用该生物体信息成像装置分析生物信息的方法。 检测超声波和图像生物信息的生物信息成像装置包括：从存在于被检体内的光吸收体照射被检体的光用于产生超声的光源; 超声波发送单元，其将聚焦超声波发送到存在光吸收体的特定区域; 以及超声波检测单元，其检测由吸收光的光吸收体产生的超声波与发送到特定区域的聚焦超声波之间的相互作用引起的超声合成信号。

公开(公告)号：US08396534B2

公开(公告)日：2013-03-12

申请号：US12130331

申请日：2008-05-30

申请人： Kazuhiko Fukutani ,  Takao Nakajima ,  Kenichi Nagae ,  Yasuhiro Someda ,  Yasufumi Asao

发明人： Kazuhiko Fukutani ,  Takao Nakajima ,  Kenichi Nagae ,  Yasuhiro Someda ,  Yasufumi Asao

IPC分类号： A61B6/00

CPC分类号： A61B5/0059 ,  A61B5/0095 ,  A61B8/08 ,  G01N21/1702

摘要： An intravital-information imaging apparatus includes light sources for irradiating a living body with light, and acoustic-wave detectors that detect acoustic waves generated from a light absorber having absorbed part of energy of the light from the light sources, the light absorber existing in the living body. Furthermore, the intravital-information imaging apparatus includes signal processors that calculate information representing a distribution of optical characteristic values of the living body using sound pressures of the acoustic waves generated from the light absorber.

摘要翻译： 活体信息成像装置包括用于对生物体照射光的光源，以及声波检测器，其检测由吸收了来自光源的光的能量的光吸收体产生的声波，存在于 活体。 此外，活体内信息成像装置包括使用从光吸收体产生的声波的声压来计算表示生物体的光学特性值的分布的信息的信号处理器。

公开(公告)号：US08260403B2

公开(公告)日：2012-09-04

申请号：US12816556

申请日：2010-06-16

申请人： Kazuhiko Fukutani ,  Takao Nakajima

发明人： Kazuhiko Fukutani ,  Takao Nakajima

IPC分类号： A61B6/00

CPC分类号： A61B5/0059 ,  A61B5/0073 ,  A61B5/0095 ,  G01N21/1702

摘要： A photoacoustic wave detector detects a photoacoustic wave generated inside a specimen by light irradiated thereto. A signal processing device: forms first volume data from a first signal, the first signal being the detection signal acquired from the detector or a signal obtained by adjusting an amplitude of the detection signal; forms second volume data from a second signal, the second signal being a signal obtained by changing a phase of the first signal; forms third volume data from the first and second volume data; and generates and outputs image data representing information on an interior of the specimen from the third volume data.

摘要翻译： 光声波检测器通过照射到其上的光检测检测体内的光声波。 信号处理装置：从第一信号形成第一体积数据，第一信号是从检测器获取的检测信号或通过调整检测信号的幅度而获得的信号; 从第二信号形成第二音量数据，第二信号是通过改变第一信号的相位而获得的信号; 从第一和第二卷数据形成第三卷数据; 并从第三体积数据生成并输出表示样本内部的信息的图像数据。