公开(公告)号：US6072083A

公开(公告)日：2000-06-06

申请号：US30955

申请日：1998-02-26

申请人： Kazuhiro Hasegawa ,  Yutaka Okamoto ,  Toru Nakamura ,  Tetsuya Kaneko ,  Chiaki Sano ,  Kinzo Iitani

发明人： Kazuhiro Hasegawa ,  Yutaka Okamoto ,  Toru Nakamura ,  Tetsuya Kaneko ,  Chiaki Sano ,  Kinzo Iitani

IPC分类号： C07C227/42 ,  C07C229/08 ,  C09C227/00

CPC分类号： C07C227/42 ,  C07C229/08

摘要： A method for purifying an amino acid selected from the group consisting of valine, leucine and isoleucine easily in high yield and with high purity using an inexpensive precipitant, comprising allowing p-ethylbenzenesulfonic acid or its water-soluble salt to act on an aqueous solution containing an amino acid to form crystals of the amino acid p-ethylbenzenesulfonate and then separating and decomposing the crystals to purify and obtain the amino acid. The p-ethylbenzenesulfonic acid may be used as the free acid, an alkali metal salt and an ammonium salt.

摘要翻译： 一种使用廉价的沉淀剂，以高产率和高纯度容易地纯化选自缬氨酸，亮氨酸和异亮氨酸的氨基酸的方法，包括使对乙基苯磺酸或其水溶性盐作用于含有 氨基酸形成对乙基苯磺酸氨基酸的晶体，然后分离和分解晶体进行纯化并获得氨基酸。 对乙基苯磺酸可以用作游离酸，碱金属盐和铵盐。

公开(公告)号：US5689001A

公开(公告)日：1997-11-18

申请号：US661117

申请日：1996-06-10

申请人： Kazuhiro Hasegawa ,  Tetsuya Kaneko ,  Noriko Takahashi ,  Chiaki Sano

发明人： Kazuhiro Hasegawa ,  Tetsuya Kaneko ,  Noriko Takahashi ,  Chiaki Sano

IPC分类号： C07C227/40 ,  C07C227/42 ,  C07C229/08 ,  C07C309/31 ,  C07C227/00

CPC分类号： C07C229/08 ,  C07C227/40

摘要： A process is provided for obtaining high-purity valine in high yield by a simple method using an inexpensive precipitant of p-isopropylbenzene sulfonic acid or a water-soluble salt thereof.

摘要翻译： 提供了通过使用廉价的对异丙基苯磺酸沉淀剂或其水溶性盐的简单方法以高产率获得高纯度缬氨酸的方法。

公开(公告)号：US4584400A

公开(公告)日：1986-04-22

申请号：US678809

申请日：1984-12-06

申请人： Masaru Otani ,  Chiaki Sano ,  Isao Kusumoto

发明人： Masaru Otani ,  Chiaki Sano ,  Isao Kusumoto

IPC分类号： C07C227/40 ,  C07C67/00 ,  C07C227/00 ,  C07C227/28 ,  C07C229/30 ,  C07C229/36 ,  C12P13/22 ,  C07C45/79

CPC分类号： C12P13/222

摘要： A process for refining phenylalanine, in which a phenylalanine solution containing tyrosine as the main impurity and other impurities is contacted with a non-polar, highly porous synthetic adsorbent, adsorbing phenylalanine on the adsorbent selectively, and eluting and recovering the adsorbed phenylalanine, is disclosed.

摘要翻译： 公开了一种用于精制苯丙氨酸的方法，其中将含有酪氨酸作为主要杂质的苯丙氨酸溶液和其它杂质与非极性，高度多孔的合成吸附剂接触，选择性地吸附苯丙氨酸，并洗脱和回收吸附的苯丙氨酸 。

公开(公告)号：US4778808A

公开(公告)日：1988-10-18

申请号：US839041

申请日：1986-03-12

申请人： Chiaki Sano ,  Yoshimi Nagano ,  Kiyoshi Tanaka ,  Shigeho Ikeda ,  Masayoshi Naruse

发明人： Chiaki Sano ,  Yoshimi Nagano ,  Kiyoshi Tanaka ,  Shigeho Ikeda ,  Masayoshi Naruse

IPC分类号： A23K1/00 ,  A23K1/16 ,  A23K1/18 ,  C07D207/20 ,  C12P13/22 ,  C07D209/20 ,  A61K31/405

CPC分类号： C12P13/227 ,  A23K20/142 ,  A23K50/30 ,  C07D207/20

摘要： A feed additive produced by concentrating an aqueous solution containing tryptophan and impurities both originating in the culture broth of a tryptophan-producing microorganism, with the pH of the aqueous solution being maintained in the range of 4 to 6 and the temperature thereof being maintained in the range of 20.degree. to 80.degree. C. during the process of concentrating.

摘要翻译： 通过将含有色氨酸的水溶液和源自色氨酸生产微生物的培养液的杂质浓缩，将水溶液的pH保持在4至6的范围内并将其温度保持在 在浓缩过程中为20〜80℃。

公开(公告)号：US5616786A

公开(公告)日：1997-04-01

申请号：US533943

申请日：1995-09-26

申请人： Takeru Sato ,  Chiaki Sano

发明人： Takeru Sato ,  Chiaki Sano

IPC分类号： C07C227/42 ,  C07C227/44 ,  C07C229/36 ,  C07C229/28

CPC分类号： C07C227/42

摘要： A method of obtaining optically active anhydrous phenylalanine crystals from an aqueous solution containing optically active phenylalanine, which involves crystallizing and precipitating optically active phenylalanine from an optically active phenylalanine super-saturated solution at a temperature, T, wherein the super-saturated solution is required to have an osmotic pressure .pi. (mOsm/kg.H.sub.2 O) which is related to said temperature T in accordance with the following formula (I):.pi..gtoreq.10,500-450T+4.4T.sup.2 (I),wherein the method provides anhydrous crystals having excellent handleability.

摘要翻译： 从含有光学活性苯丙氨酸的水溶液中获得光学活性无水苯丙氨酸晶体的方法，该方法涉及在温度T下从光学活性苯丙氨酸超饱和溶液中结晶并沉淀光学活性苯丙氨酸，其中超饱和溶液需要 具有根据下式（I）与所述温度T相关的渗透压力pI（mOsm / kg·H 2 O）：其中该方法提供无水晶体，其具有 优良的操作性。

公开(公告)号：US20060276674A1

公开(公告)日：2006-12-07

申请号：US11391327

申请日：2006-03-29

申请人： Takeshi Kushiku ,  Kenji Fujiwara ,  Takeru Satou ,  Chiaki Sano

发明人： Takeshi Kushiku ,  Kenji Fujiwara ,  Takeru Satou ,  Chiaki Sano

IPC分类号： C07C229/00

CPC分类号： C12P7/46 ,  C07C51/47 ,  C07C55/10

摘要： Succinic acid is produced by bringing a succinic acid-containing liquid containing succinic acid and cation which is obtained by fermentation or an enzymatic method into contact with an H-type strongly acidic cation-exchange resin in an amount equivalent to or more than the amount of cation other than hydrogen ion contained in the succinic acid-containing liquid, and precipitating a crystal of succinic acid from the obtained ion-exchange-treated liquid to obtain purified succinic acid.

摘要翻译： 通过将含有琥珀酸和阳离子的含琥珀酸的液体通过发酵或酶法与H型强酸性阳离子交换树脂接触，生成琥珀酸，其量等于或大于 从含有琥珀酸的液体中含有的氢离子以外的阳离子，从得到的离子交换处理液中析出琥珀酸的结晶，得到纯化的琥珀酸。