公开(公告)号：US20110020943A1

公开(公告)日：2011-01-27

申请号：US12933794

申请日：2009-03-23

申请人： Kazuhiro Okamoto ,  Isao Fukuta ,  Hisashi Sakamoto ,  Hideko Kosaka ,  Atsushi Nakao

发明人： Kazuhiro Okamoto ,  Isao Fukuta ,  Hisashi Sakamoto ,  Hideko Kosaka ,  Atsushi Nakao

IPC分类号： G01N33/20 ,  G01N31/22

CPC分类号： G01N21/78 ,  G01N31/22 ,  G01N33/583 ,  G01N33/84

摘要： The present invention provides a dry testing tool with which a metal in the various types of samples such as biological samples, food, and the like can be measured very easily, rapidly, high sensitively, and specifically by a simple colorimetric method and a method for measuring the metal. The dry testing tool of the present invention is a dry testing tool for measuring a metal in a sample, including a porous support and a chelate dye, wherein the chelate dye is bound to the porous support by a hydrophobic bond. The measuring method of the present invention is a method for measuring a metal in a sample, including the steps of: forming a composite of the chelate dye and the metal in the sample by supplying the sample to the porous support to which a chelate dye is bound by a hydrophobic bond; and detecting the metal in the sample using a developed color of the composite.

摘要翻译： 本发明提供了一种干式检测工具，其可以非常容易，快速，高灵敏度地测量各种类型的样品中的金属，例如生物样品，食品等，特别是通过简单的比色法和 测量金属。 本发明的干式测试工具是用于测量样品中的金属的干燥测试工具，其包括多孔载体和螯合染料，其中螯合染料通过疏水键与多孔载体结合。 本发明的测定方法是测定样品中的金属的方法，包括以下步骤：通过将样品供给到螯合染料的多孔载体上，形成螯合染料与金属的复合物 受到疏水键的约束; 并使用显影的复合材料的颜色来检测样品中的金属。

公开(公告)号：US08460877B2

公开(公告)日：2013-06-11

申请号：US10586774

申请日：2005-01-21

申请人： Hideko Kosaka ,  Hisashi Sakamoto

发明人： Hideko Kosaka ,  Hisashi Sakamoto

IPC分类号： G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N21/76

CPC分类号： G01N21/78 ,  G01N33/6827 ,  G01N33/70

摘要： The present invention relates to a technique of measuring a protein based on a degree of coloring in a liquid sample mixed with a protein measurement indicator. In the present invention, information reflecting creatinine concentration in the liquid sample is obtained, and then an influence quantity caused by creatinine to the protein concentration measurement is eliminated based on the information.

摘要翻译： 本发明涉及一种基于与蛋白质测量指示剂混合的液体样品中的着色程度来测量蛋白质的技术。 在本发明中，获得反映肌酸酐浓度的信息，根据该信息，消除肌酸酐对蛋白质浓度测定引起的影响量。

公开(公告)号：US20080241850A1

公开(公告)日：2008-10-02

申请号：US10586774

申请日：2005-01-21

申请人： Hideko Kosaka ,  Hisashi Sakamoto

发明人： Hideko Kosaka ,  Hisashi Sakamoto

IPC分类号： G01N33/53 ,  G01N33/00

CPC分类号： G01N21/78 ,  G01N33/6827 ,  G01N33/70

摘要： The present invention relates to a technique of measuring a protein based on a degree of coloring in a liquid sample mixed with a protein measurement indicator. In the present invention, information reflecting creatinine concentration in the liquid sample is obtained, and then an influence quantity caused by creatinine to the protein concentration measurement is eliminated based on the information.

摘要翻译： 本发明涉及一种基于与蛋白质测量指示剂混合的液体样品中的着色程度来测量蛋白质的技术。 在本发明中，获得反映肌酸酐浓度的信息，根据该信息，消除肌酸酐对蛋白质浓度测定引起的影响量。

公开(公告)号：US20110217207A1

公开(公告)日：2011-09-08

申请号：US13039235

申请日：2011-03-02

申请人： Koji Fujimoto ,  Noriaki Furusato ,  Hideko Kosaka

发明人： Koji Fujimoto ,  Noriaki Furusato ,  Hideko Kosaka

IPC分类号： G01N21/64 ,  G01N33/00 ,  G01N21/00

CPC分类号： G01N21/00 ,  G01N21/64 ,  G01N33/00

摘要： A technique is provided, which makes it possible to easily judge whether or not an analysis tool to be used for an analysis process for a sample is authentic and which makes it possible to secure the reliability of an analysis result thereby. An identification apparatus for identifying an analysis tool having a reagent portion to be used for an analysis process for a sample is provided, wherein the analysis tool further includes an identifying marker portion which is formed by using an invisible substance, the identification apparatus comprising a light emitter which emits a light toward the identifying marker portion, a light receiver which receives a light emitted by the invisible substance for forming the identifying marker portion exposed with the emitted light emitted by the light emitter, and an identification unit which identifies the analysis tool on the basis of a light-receiving result obtained by the light receiver.

摘要翻译： 提供了一种技术，其使得可以容易地判断用于样品的分析处理的分析工具是否可靠，并且由此可以确保分析结果的可靠性。 提供一种用于识别具有用于样品的分析处理的试剂部分的分析工具的识别装置，其中所述分析工具还包括通过使用不可见物质形成的识别标记部分，所述识别装置包括光 向识别标记部分发射光的发射器，接收由不可见物质发射的光的光接收器，用于形成由光发射器发射的发射光暴露的识别标记部分;以及识别单元，其识别分析工具 光接收器获得的光接收结果的基础。

公开(公告)号：US20060057735A1

公开(公告)日：2006-03-16

申请号：US10523853

申请日：2003-08-04

申请人： Hideko Kosaka

发明人： Hideko Kosaka

IPC分类号： G01N33/50

CPC分类号： G01N33/84

摘要： The present invention relates to a test piece for protein assay that is used for quantifying or semi-quantifying a protein and that contains an acidic pH indicator. This test piece for protein assay contains a surfactant as a sensitizer for increasing coloration sensitivity with respect to protein. A triphenylmethane-based indicator is used as the acidic pH indicator, for example. The present invention also provides a method for manufacturing a test piece for protein assay. With this method, a test piece for protein assay is manufactured by impregnating an absorbent carrier with an impregnant containing an acidic pH indicator and a sensitizer, and then drying this product. A surfactant is used as the sensitizer.

摘要翻译： 本发明涉及用于蛋白质测定的测试片，其用于定量或半定量蛋白质并含有酸性pH指示剂。 用于蛋白质测定的该测试片含有作为敏化剂的表面活性剂，用于增加相对于蛋白质的着色敏感性。 例如，使用三苯基甲烷类指示剂作为酸性pH指示剂。 本发明还提供了一种用于制造用于蛋白质测定的试片的方法。 使用该方法，通过用含有酸性pH指示剂和敏化剂的浸渍剂浸渍吸收剂制造用于蛋白质测定的试验片，然后干燥该产品。 使用表面活性剂作为敏化剂。

公开(公告)号：US5955027A

公开(公告)日：1999-09-21

申请号：US862676

申请日：1997-05-23

申请人： Hideko Kosaka

发明人： Hideko Kosaka

IPC分类号： G01N31/00 ,  G01N33/52 ,  G01N33/48

CPC分类号： G01N33/52

摘要： A reagent composition for detecting an analyte in a liquid sample, comprising an iron (III) complex of a tetrakis (N-hydroxyalkyl) ethylenediamine represented by the general formula (1): ##STR1## wherein n, m, p, and q are each independently integers of 1 to 3.

摘要翻译： 一种用于检测液体样品中的分析物的试剂组合物，其包含由通式（1）表示的四（N-羟烷基）乙二胺的铁（III）络合物：其中n，m，p和q各自独立地为整数 为1至3。

公开(公告)号：US07820449B2

公开(公告)日：2010-10-26

申请号：US10530790

申请日：2003-10-15

申请人： Hideko Kosaka

发明人： Hideko Kosaka

IPC分类号： G01N33/00

CPC分类号： G01N33/526 ,  G01N33/523 ,  G01N33/70 ,  G01N2800/347 ,  Y10T436/147777

摘要： The present invention provides a novel test piece for creatinine measurement. The test piece includes a compound expressed by the following formula (1), a metal that forms a colored complex with the compound, and a buffer agent in a porous material. The amount of creatinine is determined by optically measuring a colored complex of the compound and the metal and evaluating the degree of inhibition of the colored complex formation by creatinine. In the formula (1), R1 represents H, SO3X, or COOX. R4 and R6 represent OH, SO3X, or COOX and may be either the same or different. R2, R3, R5, and R7 represent H, OH, Cl, Br, I, NO2, NO, or CH3 and may be either the same or different. Xs in the R1, R4, and R6 represent H, Na, K, or NH4 and may be either the same or different.

摘要翻译： 本发明提供一种用于肌酐测定的新型试片。 测试件包括由下式（1）表示的化合物，与该化合物形成着色络合物的金属和多孔材料中的缓冲剂。 通过光学测量化合物和金属的有色复合物并评估肌酸酐对着色复合体形成的抑制程度来测定肌酸酐的量。 在式（1）中，R 1表示H，SO 3 X或COOX。 R4和R6表示OH，SO3X或COOX，可以相同或不同。 R2，R3，R5和R7表示H，OH，Cl，Br，I，NO2，NO或CH3，可以相同或不同。 R1，R4和R6中的Xs表示H，Na，K或NH4，可以相同或不同。

公开(公告)号：US20050266574A1

公开(公告)日：2005-12-01

申请号：US10530790

申请日：2003-10-15

申请人： Hideko Kosaka

发明人： Hideko Kosaka

IPC分类号： G01N21/78 ,  G01N33/52 ,  G01N33/70 ,  G01N33/00

CPC分类号： G01N33/526 ,  G01N33/523 ,  G01N33/70 ,  G01N2800/347 ,  Y10T436/147777

摘要： The present invention provides a novel test piece for creatinine measurement. The test piece includes a compound expressed by the following formula (1), a metal that forms a colored complex with the compound, and a buffer agent in a porous material. The amount of creatinine is determined by optically measuring a colored complex of the compound and the metal and evaluating the degree of inhibition of the colored complex formation by creatinine. In the formula (1), R1 represents H, SO3X, or COOX. R4 and R6 represent OH, SO3X, or COOX and may be either the same or different. R2, R3, R5, and R7 represent H, OH, Cl, Br, I, NO2, NO, or CH3 and may be either the same or different. Xs in the R1, R4, and R6 represent H, Na, K, or NH4 and may be either the same or different.

摘要翻译： 本发明提供一种用于肌酐测定的新型试片。 测试件包括由下式（1）表示的化合物，与该化合物形成着色络合物的金属和多孔材料中的缓冲剂。 通过光学测量化合物和金属的有色复合物并评估肌酸酐对着色复合体形成的抑制程度来测定肌酸酐的量。 在式（1）中，R 1表示H，SO 3 X或COOX。 R 4和R 6表示OH，SO 3 X或COOX，并且可以相同或不同。 R 2，R 3，R 5和R 7表示H，OH，Cl，Br，I ，NO 2，NO或CH 3，并且可以相同或不同。 R 1，R 4和R 6中的X 1表示H，Na，K或NH 4， 并且可以相同或不同。

公开(公告)号：US20060057730A1

公开(公告)日：2006-03-16

申请号：US10523865

申请日：2003-08-04

申请人： Hideko Kosaka

发明人： Hideko Kosaka

IPC分类号： G01N33/48

CPC分类号： G01N33/84 ,  G01N33/6839

摘要： The present invention relates to a technique for assaying a protein. With the present invention, a compound having a chemical structure expressed by the following Chemical Formula (1) is used as a protein assay indicator. In Chemical Formula (1), X1 is a halogen, a nitro group, or a nitroso group; X2 is a halogen; X3 is a halogen or hydrogen; X4 is a hydroxyl group or a salt thereof, and X5 is a carboxyl group or a salt thereof.

摘要翻译： 本发明涉及一种测定蛋白质的技术。 使用本发明，可以使用具有以下化学式（1）表示的化学结构的化合物作为蛋白质测定指标。 在化学式（1）中，X 1是卤素，硝基或亚硝基; X2是卤素; X3是卤素或氢; X 4为羟基或其盐，X 5为羧基或其盐。

公开(公告)号：US06797520B2

公开(公告)日：2004-09-28

申请号：US09967975

申请日：2001-10-02

申请人： Hideko Kosaka

发明人： Hideko Kosaka

IPC分类号： G01N3100

CPC分类号： G01N33/683 ,  Y10S436/815

摘要： A composition capable of showing a color change sufficient for indicating the presence and/or concentration of a protein in a protein-containing liquid sample by contacting with the sample, comprising: indium or an indium compound, and a dye or pigment capable of forming a complex with indium.

摘要翻译： 能够显示足够的颜色变化的组合物，该颜色变化足以通过与样品接触来指示含蛋白质的液体样品中的蛋白质的存在和/或浓度，包括：铟或铟化合物，以及能够形成 与铟复合。