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    SUBSTITUTED AMINE DERIVATIVE AND MEDICINAL COMPOSITION COMPRISING SAME AS THE ACTIVE INGREDIENT
    4.
    发明申请
    SUBSTITUTED AMINE DERIVATIVE AND MEDICINAL COMPOSITION COMPRISING SAME AS THE ACTIVE INGREDIENT 审中-公开
    取代的胺衍生物和药物组合物作为活性成分包含

    公开(公告)号：US20110171192A1

    公开(公告)日：2011-07-14

    申请号：US12737925

    申请日：2009-08-27

    申请人： Hiroshi Tomiyama ,  Kazuo Tokuzaki ,  Yoshinori Iwai

    发明人： Hiroshi Tomiyama ,  Kazuo Tokuzaki ,  Yoshinori Iwai

    IPC分类号： A61K31/7064 ,  C07H19/14 ,  A61K38/44 ,  A61P3/00 ,  A61P13/00 ,  A61P13/12 ,  A61P29/00 ,  A61P3/06 ,  A61P3/04 ,  A61P3/10 ,  A61P7/00 ,  A61P37/06 ,  A61P9/12 ,  A61P11/00

    CPC分类号： C07D239/70 ,  A61K31/517 ,  A61K31/519 ,  A61K31/7042 ,  A61K45/06 ,  C07D409/04 ,  C07D487/04 ,  C07H19/14 ,  A61K2300/00

    摘要： A compound represented by following general formula (I): wherein, represents a single bond or a double bond; L represents —NH— or the like; X1 represents N or C, provided that in the case where X1 is N, X2 represents C—R and in the case where X1 is C, X2 represents N—R1 or the like; Y's may be either the same or different and represent CH2 or the like; A represents a non-natural sugar residue represented by following general formula: wherein, m represents 0 to 1; represents a single bond or a double bond; X represents O or the like; R3 to R8 may be either the same or different and represent hydroxy group or the like; and B represents a group represented by following general formula: wherein, n and k represent 0 to 5; represents a single bond or a double bond; Z1 to Z16 may be either the same or different and represent CH or the like; R10 and R11 may be either the same or different and represent a lower alkoxy group having 1 to 5 carbon atoms or the like; and R15 represents a hydrogen atom or the like, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or solvate thereof. Because of having an excellent CNT2 inhibitory activity and showing a high in vivo stability and stable physicochemical properties, the aforesaid compound is useful as a remedy for hyperuricemia.

    摘要翻译： 由以下通式（I）表示的化合物：其中，表示单键或双键; L表示-NH-等; X1表示N或C，条件是在X1为N的情况下，X2表示C-R，在X1为C的情况下，X2表示N-R1等; Y可以相同或不同，表示CH2等; A表示由以下通式表示的非天然糖残基：其中，m表示0至1; 代表单键或双键; X表示O等; R3至R8可以相同或不同，表示羟基等; 并且B表示由以下通式表示的基团：其中，n和k表示0至5; 代表单键或双键; Z1至Z16可以相同或不同，表示CH等; R 10和R 11可以相同或不同，表示具有1〜5个碳原子的低级烷氧基等; R 15表示氢原子等，其药学上可接受的盐，前药，其水合物或其溶剂合物。 由于具有优异的CNT2抑制活性并且具有高的体内稳定性和稳定的物理化学性质，上述化合物可用作高尿酸血症的补救剂。