公开(公告)号：US08044206B2

公开(公告)日：2011-10-25

申请号：US10548197

申请日：2004-03-05

申请人： Kazumi Kikuchi ,  Makoto Oku ,  Jiro Fujiyasu ,  Norio Asai ,  Toshihiro Watanabe ,  Yukinori Nagakura ,  Hiroshi Tomiyama ,  Motoharu Sonegawa ,  Kazuo Tokuzaki ,  Yoshinori Iwai

发明人： Kazumi Kikuchi ,  Makoto Oku ,  Jiro Fujiyasu ,  Norio Asai ,  Toshihiro Watanabe ,  Yukinori Nagakura ,  Hiroshi Tomiyama ,  Motoharu Sonegawa ,  Kazuo Tokuzaki ,  Yoshinori Iwai

IPC分类号： C07D211/08 ,  A61K31/47

CPC分类号： C07D211/12

摘要： The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.

摘要翻译： 本发明提供了具有2,6-二取代苯乙烯基的新型含氮杂环衍生物及其药学上可接受的盐，以及包含含氮杂环衍生物及其药学上可接受的盐的药物组合物，特别是作为 钠通道抑制剂，具有优异的镇痛作用，特别是对神经性疼痛具有最小的副作用。

公开(公告)号：US20070099956A1

公开(公告)日：2007-05-03

申请号：US10548197

申请日：2004-03-05

申请人： Kazumi Kikuchi ,  Makoto Oku ,  Jiro Fujiyasu ,  Norio Asai ,  Toshihiro Watana ,  Yukinori Nagakura ,  Hiroshi Tomiyama ,  Motoharu Sonegawa ,  Kazuo Tokuzaki ,  Yoshinori Iwai

发明人： Kazumi Kikuchi ,  Makoto Oku ,  Jiro Fujiyasu ,  Norio Asai ,  Toshihiro Watana ,  Yukinori Nagakura ,  Hiroshi Tomiyama ,  Motoharu Sonegawa ,  Kazuo Tokuzaki ,  Yoshinori Iwai

IPC分类号： A61K31/47 ,  A61K31/44 ,  C07D215/12 ,  C07D213/81

CPC分类号： C07D211/12

摘要： The invention provides a novel nitrogen-containing heterocyclic derivative having 2,6-disubstituted styryl and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the nitrogen-containing heterocyclic derivative and a pharmaceutically acceptable salt thereof, in particular, a pharmaceutical composition effective as a sodium channel inhibitor, having an excellent analgesic action especially on neuropathic pain with minimized side effects.

摘要翻译： 本发明提供了具有2,6-二取代苯乙烯基的新型含氮杂环衍生物及其药学上可接受的盐，以及包含含氮杂环衍生物及其药学上可接受的盐的药物组合物，特别是作为 钠通道抑制剂，具有优异的镇痛作用，特别是对神经性疼痛具有最小的副作用。

公开(公告)号：US20080200551A1

公开(公告)日：2008-08-21

申请号：US10568684

申请日：2005-02-17

申请人： Hiroyoshi Yamada ,  Hirotsune Itahana ,  Ayako Moritomo ,  Takaho Matsuzawa ,  Koichiro Harada ,  Jiro Fujiyasu ,  Yuji Koga ,  Makoto Oku ,  Toshio Okazaki ,  Shinobu Akuzawa ,  Toshihiro Watanabe

发明人： Hiroyoshi Yamada ,  Hirotsune Itahana ,  Ayako Moritomo ,  Takaho Matsuzawa ,  Koichiro Harada ,  Jiro Fujiyasu ,  Yuji Koga ,  Makoto Oku ,  Toshio Okazaki ,  Shinobu Akuzawa ,  Toshihiro Watanabe

IPC分类号： A61K31/166 ,  C07C233/78 ,  A61P25/06

CPC分类号： C07D311/96 ,  A61K31/166 ,  A61K31/343 ,  A61K31/351 ,  A61K31/352 ,  A61K31/357 ,  A61K31/385 ,  A61K31/41 ,  A61K31/4168 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/426 ,  A61K31/438 ,  C07C279/22 ,  C07D207/20 ,  C07D209/54 ,  C07D209/96 ,  C07D211/70 ,  C07D221/20 ,  C07D233/50 ,  C07D249/14 ,  C07D257/06 ,  C07D263/28 ,  C07D277/18 ,  C07D303/06 ,  C07D305/14 ,  C07D307/94 ,  C07D309/06 ,  C07D309/20 ,  C07D317/12 ,  C07D319/14 ,  C07D327/04 ,  C07D335/04 ,  C07D339/06

摘要： This invention relates to a novel fluorene derivative having a characteristic structure in which guanidino group or the like functional group is linked to the fluorene structure via carbonyl group, or a salt thereof.The compound of the invention has an advantage in that it has high affinity for serotonin receptor subtypes, particularly for 5-HT2B receptor and 5-HT7 receptor, and shows excellent pharmacological effects in comparison with the conventional compounds which have only one of the antagonistic activities of 5-HT2B receptor and 5-HT7 receptor, this is useful as a prophylactic antimigraine agent having high safety and excellent effect.

摘要翻译： 本发明涉及具有胍基等官能团通过羰基与芴结构连接的特征结构的新型芴衍生物或其盐。 本发明的化合物具有的优点在于其对5-羟色胺受体亚型具有高亲和力，特别是对于5-HT 2B受体和5-HT 7受体，并且显示出优异的 与仅具有5-HT 2B受体和5-HT 7受体的拮抗活性的常规化合物相比，药理作用可用作预防性抗偏头痛 药剂安全性高，效果好。

公开(公告)号：US08153658B2

公开(公告)日：2012-04-10

申请号：US12514869

申请日：2007-11-14

申请人： Shunichiro Hachiya ,  Kazuhiro Ikegai ,  Ryotaro Ibuka ,  Taisuke Takahashi ,  Makoto Oku ,  Ryushi Seo ,  Yoh Terada ,  Masanao Sanagi

发明人： Shunichiro Hachiya ,  Kazuhiro Ikegai ,  Ryotaro Ibuka ,  Taisuke Takahashi ,  Makoto Oku ,  Ryushi Seo ,  Yoh Terada ,  Masanao Sanagi

IPC分类号： A61K31/4525 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  C07D409/12 ,  C07D405/04 ,  C07D413/04 ,  C07D411/04 ,  C07D401/04 ,  C07D401/12

CPC分类号： C07D211/26 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/06

摘要： To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism. It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).

摘要翻译： 提供可用于治疗钙感觉受体（CaSR）参与的疾病的化合物，特别是甲状旁腺功能亢进。 发现新的哌啶衍生物，其特征在于3-位和4-位中的一个被被芳基烷基等取代的氨基甲基取代，另一个位置被芳基，杂芳基或 或其盐具有优异的CaSR激动调节作用，并且与具有引起药物相互作用的可能性的CYP2D6抑制作用也具有优异的选择性。 基于上述，该新型哌啶衍生物可用作CaSR参与的疾病（甲状旁腺功能亢进，肾性骨营养不良，高钙血症等）的治疗剂。

公开(公告)号：US08477612B2

公开(公告)日：2013-07-02

申请号：US12934891

申请日：2009-04-01

申请人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

发明人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

IPC分类号： G01R31/08 ,  H04Q7/00

CPC分类号： H04W4/24 ,  H04L12/14 ,  H04L12/1439 ,  H04M15/00 ,  H04M15/8207 ,  H04M2215/204 ,  H04M2215/7813

摘要： An object of the invention is to provide a charging processing device and a charging processing method capable of performing an appropriate charging process even when a connectionless protocol, such as UDP, is used. Gateway units 101 and 106 transmit data transmitted between a mobile apparatus 300 and a server 400 to the mobile apparatus 300 or the server 400 as a transmission destination, and a charging processing unit 102 performs a charging process according to the amount of data transmitted by the gateway units 101 and 106. A detecting unit 103 detects whether response data is transmitted from the transmission destination. When the timer value of the time for which communication is not performed is more than a predetermined time and the detecting unit 103 does not detect the response data from the transmission destination, the control unit 104 may control the gateway unit 101 or 106 to stop the transmission process and control the charging processing unit 102 to stop the charging process.

摘要翻译： 本发明的目的是提供一种即使在使用诸如UDP之类的无连接协议的情况下也能够进行适当的计费处理的计费处理装置和计费处理方法。 网关单元101和106将在移动装置300和服务器400之间传送的数据作为发送目的地发送到移动装置300或服务器400，并且计费处理单元102根据由 网关单元101和106.检测单元103检测是否从发送目的地发送响应数据。 当不执行通信的时间的定时器值大于预定时间，并且检测单元103没有检测到来自发送目的地的响应数据时，控制单元104可以控制网关单元101或106停止 传输处理并控制充电处理单元102停止充电过程。

公开(公告)号：US20090062366A1

公开(公告)日：2009-03-05

申请号：US11662539

申请日：2006-05-18

申请人： Shunichiro Hachiya ,  Makoto Oku ,  Hana Mukai ,  Takashi Shin ,  Keisuke Matsuura ,  Ryushi Seo ,  Takashi Kamikubo ,  Yoh Terada ,  Masanao Sanagi ,  Kousei Yoshihara ,  Taisuke Takahashi

发明人： Shunichiro Hachiya ,  Makoto Oku ,  Hana Mukai ,  Takashi Shin ,  Keisuke Matsuura ,  Ryushi Seo ,  Takashi Kamikubo ,  Yoh Terada ,  Masanao Sanagi ,  Kousei Yoshihara ,  Taisuke Takahashi

IPC分类号： A61K31/40 ,  C07D207/04

CPC分类号： C07D207/09 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/10 ,  C07D417/06 ,  C07D417/10

摘要： [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism.[Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).

公开(公告)号：US20100029687A1

公开(公告)日：2010-02-04

申请号：US12514869

申请日：2007-11-14

申请人： Shunichiro Hachiya ,  Kazuhiro Ikegai ,  Ryotaro Ibuka ,  Taisuke Takahashi ,  Makoto Oku ,  Ryushi Seo ,  Yoh Terada ,  Masanao Sanagi

发明人： Shunichiro Hachiya ,  Kazuhiro Ikegai ,  Ryotaro Ibuka ,  Taisuke Takahashi ,  Makoto Oku ,  Ryushi Seo ,  Yoh Terada ,  Masanao Sanagi

IPC分类号： A61K31/497 ,  C07D211/30 ,  C07D413/12 ,  C07D401/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/445 ,  A61P5/18

CPC分类号： C07D211/26 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/06

摘要： [Problem] To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism.[Means for Resolution] It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).

摘要翻译： [问题]提供可用于治疗钙感觉受体（CaSR）参与的疾病的化合物，特别是甲状旁腺功能亢进。 [解决方法]发现一种新的哌啶衍生物，其特征在于3-位和4-位中的一个被被芳基烷基等取代的氨基甲基取代，另一个位置被 芳基，杂芳基等，或其盐具有优异的CaSR激动调节作用，并且与具有引起药物相互作用的可能性的CYP2D6抑制作用也具有优异的选择性。 基于上述，该新型哌啶衍生物可用作CaSR参与的疾病（甲状旁腺功能亢进，肾性骨营养不良，高钙血症等）的治疗剂。

公开(公告)号：US08572259B2

公开(公告)日：2013-10-29

申请号：US12936105

申请日：2009-04-01

申请人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

发明人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

IPC分类号： H04L12/66 ,  G06F15/16

CPC分类号： H04L29/12509 ,  H04L12/14 ,  H04L29/12528 ,  H04L29/12547 ,  H04L61/2567 ,  H04L61/2575 ,  H04L61/2582 ,  H04L67/02 ,  H04L67/14 ,  H04L67/18 ,  H04L69/16 ,  H04L69/18 ,  H04L69/326 ,  H04W4/02 ,  H04W4/50

摘要： A technique for easily realizing data communication without limiting the application layer protocol during data communication while maintaining the proxy function. A mobile communication terminal (2) includes a control protocol processing section (203) which transmits an address request to a proxy device (5) to acquire global address information using the HTTP that is preset so as to be used by the mobile communication terminal (2) and the proxy device (5), a TCP/UDP data transmitter/receiver section (205) which establishes a connection with the proxy device (5), and an application section (201) which transmits data via a communication path between the proxy device (5) and a server device (6) using the global address information as the transmitter address. The control protocol processing section (203) transmits information relating to the connection destination of the server device (6) to the proxy device (5) using the HTTP, and requests a connection between the proxy device (5) and the server device (6) using a predetermined transport layer protocol.

摘要翻译： 一种在保持代理功能的同时在数据通信期间不限制应用层协议的轻松实现数据通信的技术。 移动通信终端（2）包括：控制协议处理部（203），其向代理装置（5）发送地址请求，以使用预先设定为由移动通信终端使用的HTTP获取全局地址信息 2）和代理设备（5），建立与代理设备（5）的连接的TCP / UDP数据发送器/接收器部分（205），以及应用部分（201），其经由通信路径 代理设备（5）和使用全局地址信息作为发送器地址的服务器设备（6）。 控制协议处理部（203）使用HTTP将与服务器装置（6）的连接目的地有关的信息发送给代理装置（5），并请求代理装置（5）与服务器装置（6）之间的连接 ）使用预定的传输层协议。

公开(公告)号：US20110106955A1

公开(公告)日：2011-05-05

申请号：US12936105

申请日：2009-04-01

申请人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

发明人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

IPC分类号： G06F15/16

CPC分类号： H04L29/12509 ,  H04L12/14 ,  H04L29/12528 ,  H04L29/12547 ,  H04L61/2567 ,  H04L61/2575 ,  H04L61/2582 ,  H04L67/02 ,  H04L67/14 ,  H04L67/18 ,  H04L69/16 ,  H04L69/18 ,  H04L69/326 ,  H04W4/02 ,  H04W4/50

摘要： A technique for easily realizing data communication without limiting the application layer protocol during data communication while maintaining the proxy function. A mobile communication terminal (2) includes a control protocol processing section (203) which transmits an address request to a proxy device (5) to acquire global address information using the HTTP that is preset so as to be used by the mobile communication terminal (2) and the proxy device (5), a TCP/UDP data transmitter/receiver section (205) which establishes a connection with the proxy device (5), and an application section (201) which transmits data via a communication path between the proxy device (5) and a server device (6) using the global address information as the transmitter address. The control protocol processing section (203) transmits information relating to the connection destination of the server device (6) to the proxy device (5) using the HTTP, and requests a connection between the proxy device (5) and the server device (6) using a predetermined transport layer protocol.

摘要翻译： 一种在保持代理功能的同时在数据通信期间不限制应用层协议的轻松实现数据通信的技术。 移动通信终端（2）包括：控制协议处理部（203），其向代理装置（5）发送地址请求，以使用预先设定为由移动通信终端使用的HTTP获取全局地址信息 2）和代理设备（5），建立与代理设备（5）的连接的TCP / UDP数据发送器/接收器部分（205），以及应用部分（201），其经由通信路径 代理设备（5）和使用全局地址信息作为发送器地址的服务器设备（6）。 控制协议处理部（203）使用HTTP将与服务器装置（6）的连接目的地有关的信息发送给代理装置（5），并请求代理装置（5）与服务器装置（6）之间的连接 ）使用预定的传输层协议。

公开(公告)号：US20110090801A1

公开(公告)日：2011-04-21

申请号：US12934891

申请日：2009-04-01

申请人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

发明人： Makoto Oku ,  Noriko Mizuguchi ,  Masayuki Tsuda

IPC分类号： H04B7/14 ,  H04L12/26

CPC分类号： H04W4/24 ,  H04L12/14 ,  H04L12/1439 ,  H04M15/00 ,  H04M15/8207 ,  H04M2215/204 ,  H04M2215/7813

摘要： An object of the invention is to provide a charging processing device and a charging processing method capable of performing an appropriate charging process even when a connectionless protocol, such as UDP, is used. Gateway units 101 and 106 transmit data transmitted between a mobile apparatus 300 and a server 400 to the mobile apparatus 300 or the server 400 as a transmission destination, and a charging processing unit 102 performs a charging process according to the amount of data transmitted by the gateway units 101 and 106. A detecting unit 103 detects whether response data is transmitted from the transmission destination. When the timer value of the time for which communication is not performed is more than a predetermined time and the detecting unit 103 does not detect the response data from the transmission destination, the control unit 104 may control the gateway unit 101 or 106 to stop the transmission process and control the charging processing unit 102 to stop the charging process.

摘要翻译： 本发明的目的是提供一种即使在使用诸如UDP之类的无连接协议的情况下也能够进行适当的计费处理的计费处理装置和计费处理方法。 网关单元101和106将在移动装置300和服务器400之间传送的数据作为发送目的地发送到移动装置300或服务器400，并且计费处理单元102根据由 网关单元101和106.检测单元103检测是否从发送目的地发送响应数据。 当不执行通信的时间的定时器值大于预定时间，并且检测单元103没有检测到来自发送目的地的响应数据时，控制单元104可以控制网关单元101或106停止 传输处理并控制充电处理单元102停止充电过程。