公开(公告)号：US5430171A

公开(公告)日：1995-07-04

申请号：US272623

申请日：1994-07-11

申请人： Shigeru Mitsuhashi ,  Kazutoshi Sakurai ,  Hidenori Kumobayashi

发明人： Shigeru Mitsuhashi ,  Kazutoshi Sakurai ,  Hidenori Kumobayashi

IPC分类号： C07C253/14 ,  C07C255/20 ,  C07C255/23 ,  C07C255/12

CPC分类号： C07C255/23

摘要： T-butyl (R)-(-)-4-cyano-3-hydroxybutyrate having an optical purity of 99%ee or higher and a process for producing the same are disclosed, the process comprising cyanogenation of a t-butyl (S)-(-)-4-halogeno-3-hydroxybutyrate obtained by enantioselective hydrogenation of a t-butyl 4-halogenoacetoacetate. Recrystallization of the resulting crude product gives the optically active compound with high optical purity.

摘要翻译： 公开了光学纯度为99％ee以上的（R） - （ - ） - 4-氰基-3-羟基丁酸叔丁酯及其制备方法，该方法包括将（S） - （ - ） - 4-卤代-3-羟基丁酸酯，通过4-卤代乙酰乙酸叔丁酯的对映选择性氢化得到。 所得粗产物的重结晶得到具有高光学纯度的光学活性化合物。

公开(公告)号：US5286883A

公开(公告)日：1994-02-15

申请号：US976498

申请日：1992-11-13

申请人： Kazutoshi Sakurai ,  Shigeru Mitsuhashi ,  Hidenori Kumobayashi

发明人： Kazutoshi Sakurai ,  Shigeru Mitsuhashi ,  Hidenori Kumobayashi

IPC分类号： B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07D309/12 ,  C07D319/06

CPC分类号： C07D319/06 ,  C07D309/12

摘要： A (3R,5S)-3,5,6-trihydroxyhexanoic acid derivative and a process of producing the (3R,5S)-3,5,6-trihydroxyhexanoic acid derivative which comprises the step of enantioselectively hydrogenating an (S)-5,6-dihydroxy-3-oxohexanoic acid derivative with a specific ruthenium-optically active phosphine complex represented as a catalyst are disclosed. The (3R,5S)-3,5,6-trihydroxyhexanoic acid derivative which is a useful compound capable of being easily converted into a lactone moiety, which is the active part of an inhibitor on HMG-CoA reductase, can be easily and efficiently obtained under a mild reaction condition with a high selectivity for the syn-diol form.

摘要翻译： A（3R，5S）-3,5,6-三羟基己酸衍生物和（3R，5S）-3,5,6-三羟基己酸衍生物的制备方法，其包括以下步骤：对（S）-5 公开了以表示为催化剂的特定钌光学活性膦配合物的6-二羟基-3-氧代己酸衍生物。 作为HMG-CoA还原酶抑制剂的活性成分的能够容易地转化为内酯部分的有用化合物的（3R，5S）-3,5,6-三羟基己酸衍生物可以容易且有效地 在温和的反应条件下以对顺式二醇形式的高选择性获得。

公开(公告)号：US07030070B2

公开(公告)日：2006-04-18

申请号：US10634915

申请日：2003-08-06

申请人： Kazutoshi Sakurai ,  Hideaki Ohta

发明人： Kazutoshi Sakurai ,  Hideaki Ohta

IPC分类号： C11D3/50

CPC分类号： C11D3/2075 ,  C11D3/50

摘要： A fragrant compound or fragrant composition stable for a long period of time in an acidic hard article surface cleaning liquid adjusted so as to be acidic, particularly to pH 2.0 to 3.0 with an organic acid. One or more of fragrant compounds selected from the group consisting of 2,6-dimethyl-2-heptanol, 3,3-dimethylcyclohexyl methyl ketone, o-tert-butylcyclohexanol, α-amylcinnamic aldehyde, α-damascone, γ-octalactone, γ-nonalactone, γ-decalactone, anethole, ethyl benzoate, ethyl 2,2,6-trimethylcyclohexanecarboxylate, 2,2,6-trimethyl-1-crotonylcyclohexane, 6-acetyl-1,1,2,4,4,7-hexamethyltetrahydronaphthalene, isoamyl phenylethyl ether, methyl octin carbonate, 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone, tricyclodecenyl acetate, undecyl aldehyde, fenchyl acetate, dihydrojasmone, cedryl methyl ether, p-cresol, hexyl aldehyde, and rosephenone are stable.

摘要翻译： 在酸性硬的制品表面清洗液中长时间稳定的芳香化合物或芳香组合物被调节至酸性，特别是用有机酸调至pH2.0至3.0。 一种或多种选自2,6-二甲基-2-庚醇，3,3-二甲基环己基甲基酮，邻叔丁基环己醇，α-戊基肉桂醛，α-大黄酮，γ-八聚内酯，γ- 壬内酯，γ-癸内酯，茴香脑，苯甲酸乙酯，2,2,6-三甲基环己烷羧酸乙酯，2,2,6-三甲基-1-丁烯基环己烷，6-乙酰基-1,1,2,4,4,7-六甲基四氢化萘 ，异戊基苯基乙基醚，甲基辛烯碳酸酯，6,7-二氢-1,1,2,3,3-五甲基-4（5H） - 茚满酮，乙酸三环癸酯，十一烷基醛，乙酸戊酯，二氢茉莉酮，柏木甲基醚， - 甲酚，己醛和rosephenone是稳定的。

公开(公告)号：US06811789B2

公开(公告)日：2004-11-02

申请号：US10282156

申请日：2002-10-29

申请人： Kazutoshi Sakurai ,  Masataka Miyasaka ,  Yasutaka Mishima

发明人： Kazutoshi Sakurai ,  Masataka Miyasaka ,  Yasutaka Mishima

IPC分类号： A01N2502

CPC分类号： A01N31/02 ,  A01N35/06 ,  Y10S424/10 ,  Y10S514/919 ,  A01N2300/00

摘要： A mosquito-repelling agent which is gentle to human and environment and safe, and has an excellent mosquito-repelling effect almost equal to the effect of DEET and also an excellent persistency of the effect. The mosquito-repelling agent comprises a mixture of isomenthone, linalool, geraniol, citral and citronellol as an effective ingredient for a mosquito-repelling effect, which may be contained in a fragrant composition.

摘要翻译： 一种对人体和环境温和，安全的防蚊剂，具有与DEET效果几乎相当的极好的驱蚊效果，并且效果优异。 灭蚊剂包括异麦芽酮醇，芳樟醇，香叶醇，柠檬醛和香茅醇的混合物，作为可以包含在香料组合物中的驱蚊效果的有效成分。

公开(公告)号：US5831125A

公开(公告)日：1998-11-03

申请号：US843838

申请日：1997-04-17

申请人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

发明人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

IPC分类号： C07C231/16 ,  C07C231/02 ,  C07C233/18 ,  C07C233/20 ,  C07C235/08 ,  C07C231/08 ,  C07C231/10

CPC分类号： C07C231/02

摘要： A method of selective N-acylation of an aminodiol having a primary alcoholic hydroxyl group and a secondary alcoholic hydroxyl group, in which the objective product can be prepared in high yield and without troublesome extraction and purification operations. More particularly, a method of making a primary amide derivative represented by the following general formula (3) is disclosed: ##STR1## wherein R.sup.1 represents a linear saturated aliphatic hydrocarbon group having 11 to 19 carbon atoms, R.sup.2 represents a linear saturated or unsaturated aliphatic hydrocarbon group having 9 to 19 carbon atoms which may have a hydroxyl group at the 1-position, which includes the steps of reacting an aminodiol represented by the following general formula (1): ##STR2## wherein R.sup.1 is the same as R.sup.1 in general formula (3) with a fatty acid alkyl ester represented by the following general formula (2): R.sup.2 --COO--R.sup.3 (2) wherein R.sup.2 is the same as R.sup.2 in general formula (3) and R.sup.3 represents a lower alkyl group, in a reaction system comprising an alcoholic solvent and in the presence of a basic catalyst, said reacting step forming a lower alcohol as a by-product; and removing the lower alcohol formed during the reaction from the reaction system.

摘要翻译： 具有初级醇羟基和仲醇羟基的氨基二醇的选择性N-酰化的方法，其中可以高产率制备目标产物并且不需要麻烦的提取和纯化操作。 更具体地说，公开了制备由以下通式（3）表示的伯酰胺衍生物的方法：其中R1表示具有11至19个碳原子的直链饱和脂族烃基，R2表示直链饱和 或可以在1位具有羟基的碳原子数9〜19的不饱和脂肪族烃基，其包括使下述通式（1）表示的氨基二醇反应的步骤：其中R1为 与通式（3）中的R 1与由以下通式（2）表示的脂肪酸烷基酯相同：R2-COO-R3（2）其中R2与通式（3）中的R2相同，R3表示 在含有醇溶剂的反应体系中，在碱性催化剂的存在下，所述反应步骤形成作为副产物的低级醇; 并从反应体系中除去反应期间形成的低级醇。

公开(公告)号：US5786386A

公开(公告)日：1998-07-28

申请号：US678598

申请日：1996-07-15

申请人： Kenya Ishida ,  Kazutoshi Sakurai

发明人： Kenya Ishida ,  Kazutoshi Sakurai

IPC分类号： A01N33/04 ,  A01N33/06 ,  A01N33/10 ,  A01N43/30 ,  A01N43/50 ,  C07C217/58 ,  C07D233/54 ,  C07D317/58

CPC分类号： C07D233/64 ,  A01N33/04 ,  A01N33/06 ,  A01N33/10 ,  A01N43/30 ,  A01N43/50 ,  C07C217/58 ,  C07D317/58

摘要： The present invention provides an antibacterial and fungicidal agent containing an amino compound of formula (1) or a salt thereof. The invention also provides a method for imparting antibacterial and fungicidal properties to a variety of objects using the compound. ##STR1## wherein .phi. represents a phenyl group, a substituted phenyl group (wherein the substituents are 1-5 members arbitrarily selected from the group consisting of a hydroxyl group, halogen atoms, lower alkoxyl groups, trifluoromethyl group, an amino group, and a methylenedioxy group), or an imidazolyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; and R.sup.2 represents a C6-C12 alkyl group. The amino compound of formula (1) or a salt thereof exhibits excellent antibacterial effects and fungicidal effects, and when it is applied to a variety of articles used in industry, commodities, etc., enhanced antibacterial effects and fungicidal effects are obtained.

摘要翻译： 本发明提供含有式（1）的氨基化合物或其盐的抗细菌剂和杀真菌剂。 本发明还提供了使用该化合物赋予各种物体抗菌和杀真菌性能的方法。 （1）其中phi表示苯基，取代的苯基（其中取代基任选地选自羟基，卤素原子，低级烷氧基，三氟甲基，氨基 ，和亚甲二氧基）或咪唑基; R1表示氢原子或低级烷基; R2代表C6-C12烷基。 式（1）的氨基化合物或其盐具有优异的抗菌效果和杀真菌效果，并且当其应用于工业，商品等中使用的各种制品时，获得了增强的抗菌效果和杀真菌效果。

公开(公告)号：US5317770A

公开(公告)日：1994-06-07

申请号：US969781

申请日：1992-10-30

申请人： Kazutoshi Sakurai

发明人： Kazutoshi Sakurai

IPC分类号： A61G1/00 ,  A61G1/01 ,  A61G7/05

CPC分类号： A61G7/0504 ,  A61G1/01

摘要： An object of the present invention is to provide a collapsible stretcher. The stretcher comprises: a mattress section having a rectangular shape, the mattress section being made of a material, which is capable of absorbing air, the mattress section being capable of spreading by absorbing air and being wound from a longitudinal end when air is discharged; a cover section for accommodating the mattress section, the cover section having a rectangular shape; belt holders being provided on both longitudinal edges of the cover section; and a belt being run through the belt holders, the belt being formed into a loop. Having the windable and light mattress section and no long shafts, the stretcher can be easily and rapidly managed even in narrow places.

摘要翻译： 本发明的目的是提供一种可折叠担架。 担架包括：具有矩形形状的床垫部分，床垫部分由能够吸收空气的材料制成，床垫部分能够通过吸收空气扩散并且当空气排放时从纵向端部卷绕; 用于容纳床垫部分的盖部分，盖部分具有矩形形状; 皮带保持器设置在盖部分的两个纵向边缘上; 并且带子穿过所述带保持器，所述带形成为环。 具有可收放轻便的床垫部分并且没有长轴，担架即使在狭窄的地方也能轻松快速地进行管理。

公开(公告)号：US20080112910A1

公开(公告)日：2008-05-15

申请号：US12003609

申请日：2007-12-28

申请人： Kenya Ishida ,  Kazutoshi Sakurai

发明人： Kenya Ishida ,  Kazutoshi Sakurai

IPC分类号： A61K8/37 ,  A61K8/31

CPC分类号： A61Q19/00 ,  A23L27/204 ,  A61K8/34 ,  A61K8/345 ,  A61K8/37 ,  A61K8/42 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q11/02 ,  A61Q13/00 ,  C09K5/00

摘要： The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-1-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N,2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

摘要翻译： 通过将含有至少一种选自1-薄荷醇，异铃兰，3-（1-薄荷氧基）丙烷-1,2-二醇，2-（1-薄荷氧基）丙烷-1,2-二醇的化合物的冷却物质组合得到的本发明的凉爽感觉组合物， 乙-1-醇，3-（1-薄荷氧基）丙-1-醇，2-甲基-3-（1-薄荷氧基）丙烷-1,2-二醇，N-乙基-1-薄荷基甲酰胺，对薄荷烷 - 3,5-二醇，1-薄荷酸乳酸酯和2-异丙基-N，2,3-三甲基丁酰胺与下列通式（I）表示的水杨酸酯如水杨酸2-羟乙酯提高了强度和持久性 特别是含有1-薄荷醇作为凉爽感觉物质的感觉效果可以减轻由1-薄荷醇引起的刺激性香味。 混合含有食品和饮料，化妆品，化妆品，浴剂和药物的产品的凉爽感觉组合物或香料组合物可以得到有效发挥本发明的凉爽感觉组合物的上述特征的产品。 其中R表示可具有取代基的碳原子数1〜18的烃基。

公开(公告)号：US06723501B2

公开(公告)日：2004-04-20

申请号：US10041455

申请日：2002-01-10

申请人： Kazutoshi Sakurai ,  Sadahiko Yamazaki ,  Minoru Hanada ,  Kiyohito Sawano

发明人： Kazutoshi Sakurai ,  Sadahiko Yamazaki ,  Minoru Hanada ,  Kiyohito Sawano

IPC分类号： C02Q100

CPC分类号： C12Q1/04 ,  G01N33/487

摘要： Convenient methods for judging mouth odor with the use of an artificial mouth odor prepared by a convenient method which load any burdens neither on the operator nor on the subjects. Saliva collected immediately after wake-up is cultured under anaerobic conditions and head space components of the thus cultured saliva are analyzed, or anaerobic bacteria contained in the collected saliva are counted.

摘要翻译： 使用通过方便的方法制备的人造口腔气味来判断口腔气味的方便方法，既不对操作者也不对受试者负担任何负担。 唤醒后立即收集的唾液在厌氧条件下进行培养，分析由此培养的唾液的头部空间组分，或计数收集的唾液中含有的厌氧菌。

公开(公告)号：US5998668A

公开(公告)日：1999-12-07

申请号：US17239

申请日：1998-02-02

申请人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

发明人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

IPC分类号： C07C231/16 ,  C07C231/18 ,  C07C235/08 ,  C07C233/05 ,  C07C231/02

CPC分类号： C07C231/18 ,  C07C235/08 ,  C07B2200/07

摘要： An optically active (2S,3R)-2-(3'-hydroxyacyl)aminoalkane-1,3-diol and a process for producing the same are disclosed. The compound is represented by the following general formula (1): ##STR1## wherein R.sup.1 represents a linear or branched, saturated aliphatic hydrocarbon group having 9 to 19 carbon atoms; R.sup.2 represents a linear or branched, saturated aliphatic hydrocarbon group having 1 to 19 carbon atoms; and symbol * means that the carbon atom is an asymmetric carbon atom of the S or R configuration. The optically active compound is a ceramide in which the fatty acid moiety has an optically active hydroxyl group in the 3-position.

摘要翻译： 公开了光学活性（2S，3R）-2-（3'-羟基酰基）氨基烷-1,3-二醇及其制备方法。 该化合物由以下通式（1）表示：其中R1表示具有9至19个碳原子的直链或支链饱和脂族烃基; R2表示碳原子数为1〜19的直链或支链饱和脂肪族烃基; 符号*表示碳原子是S或R构型的不对称碳原子。 光学活性化合物是其中脂肪酸部分在3-位具有光学活性羟基的神经酰胺。