公开(公告)号：US06379659B1

公开(公告)日：2002-04-30

申请号：US09193731

申请日：1998-11-17

申请人： Kenya Ishida ,  Kazutoshi Sakurai ,  Miharu Ogura ,  Tetsuro Yamasaki ,  Kenichiro Shiroyama

发明人： Kenya Ishida ,  Kazutoshi Sakurai ,  Miharu Ogura ,  Tetsuro Yamasaki ,  Kenichiro Shiroyama

IPC分类号： A61K706

CPC分类号： A61K8/68 ,  A61Q5/04

摘要： A keratin fiber strengthening agent comprising 0.001 to 20% by weight of at least one (2S,3R)-2-acylaminoalkane-1,3-diol represented by formula (I): wherein R1 represents a straight-chain alkyl group having 9 to 17 carbon atoms; and R2 represents an acyl group having 2 to 24 carbon atoms which may contain at least one hydroxy group or unsaturated bond is disclosed. A method for improving physical properties, such as breaking strength, of keratin fiber such as hair comprising applying the keratin fiber strengthening agent to keratin fiber by adhesion, coating or impregnation is also disclosed.

摘要翻译： 一种角蛋白纤维增强剂，其包含0.001至20重量％的由式（I）表示的至少一种（2S，3R）-2-酰基氨基烷-1,3-二醇：其中R1表示直链烷基，其具有9至 17个碳原子; 并且R 2表示可以含有至少一个羟基或不饱和键的碳原子数为2〜24的酰基。 还公开了用于改善角蛋白纤维如头发的物理性能如断裂强度的方法，其包括通过粘附，涂覆或浸渍将角蛋白纤维增强剂施用于角蛋白纤维。

公开(公告)号：US5998668A

公开(公告)日：1999-12-07

申请号：US17239

申请日：1998-02-02

申请人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

发明人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

IPC分类号： C07C231/16 ,  C07C231/18 ,  C07C235/08 ,  C07C233/05 ,  C07C231/02

CPC分类号： C07C231/18 ,  C07C235/08 ,  C07B2200/07

摘要： An optically active (2S,3R)-2-(3'-hydroxyacyl)aminoalkane-1,3-diol and a process for producing the same are disclosed. The compound is represented by the following general formula (1): ##STR1## wherein R.sup.1 represents a linear or branched, saturated aliphatic hydrocarbon group having 9 to 19 carbon atoms; R.sup.2 represents a linear or branched, saturated aliphatic hydrocarbon group having 1 to 19 carbon atoms; and symbol * means that the carbon atom is an asymmetric carbon atom of the S or R configuration. The optically active compound is a ceramide in which the fatty acid moiety has an optically active hydroxyl group in the 3-position.

摘要翻译： 公开了光学活性（2S，3R）-2-（3'-羟基酰基）氨基烷-1,3-二醇及其制备方法。 该化合物由以下通式（1）表示：其中R1表示具有9至19个碳原子的直链或支链饱和脂族烃基; R2表示碳原子数为1〜19的直链或支链饱和脂肪族烃基; 符号*表示碳原子是S或R构型的不对称碳原子。 光学活性化合物是其中脂肪酸部分在3-位具有光学活性羟基的神经酰胺。

公开(公告)号：US5831125A

公开(公告)日：1998-11-03

申请号：US843838

申请日：1997-04-17

申请人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

发明人： Kazutoshi Sakurai ,  Kenya Ishida ,  Miharu Ogura

IPC分类号： C07C231/16 ,  C07C231/02 ,  C07C233/18 ,  C07C233/20 ,  C07C235/08 ,  C07C231/08 ,  C07C231/10

CPC分类号： C07C231/02

摘要： A method of selective N-acylation of an aminodiol having a primary alcoholic hydroxyl group and a secondary alcoholic hydroxyl group, in which the objective product can be prepared in high yield and without troublesome extraction and purification operations. More particularly, a method of making a primary amide derivative represented by the following general formula (3) is disclosed: ##STR1## wherein R.sup.1 represents a linear saturated aliphatic hydrocarbon group having 11 to 19 carbon atoms, R.sup.2 represents a linear saturated or unsaturated aliphatic hydrocarbon group having 9 to 19 carbon atoms which may have a hydroxyl group at the 1-position, which includes the steps of reacting an aminodiol represented by the following general formula (1): ##STR2## wherein R.sup.1 is the same as R.sup.1 in general formula (3) with a fatty acid alkyl ester represented by the following general formula (2): R.sup.2 --COO--R.sup.3 (2) wherein R.sup.2 is the same as R.sup.2 in general formula (3) and R.sup.3 represents a lower alkyl group, in a reaction system comprising an alcoholic solvent and in the presence of a basic catalyst, said reacting step forming a lower alcohol as a by-product; and removing the lower alcohol formed during the reaction from the reaction system.

摘要翻译： 具有初级醇羟基和仲醇羟基的氨基二醇的选择性N-酰化的方法，其中可以高产率制备目标产物并且不需要麻烦的提取和纯化操作。 更具体地说，公开了制备由以下通式（3）表示的伯酰胺衍生物的方法：其中R1表示具有11至19个碳原子的直链饱和脂族烃基，R2表示直链饱和 或可以在1位具有羟基的碳原子数9〜19的不饱和脂肪族烃基，其包括使下述通式（1）表示的氨基二醇反应的步骤：其中R1为 与通式（3）中的R 1与由以下通式（2）表示的脂肪酸烷基酯相同：R2-COO-R3（2）其中R2与通式（3）中的R2相同，R3表示 在含有醇溶剂的反应体系中，在碱性催化剂的存在下，所述反应步骤形成作为副产物的低级醇; 并从反应体系中除去反应期间形成的低级醇。

公开(公告)号：US20050129721A1

公开(公告)日：2005-06-16

申请号：US10506187

申请日：2003-02-28

申请人： Kenya Ishida ,  Kazutoshi Sakurai

发明人： Kenya Ishida ,  Kazutoshi Sakurai

IPC分类号： A23L27/20 ,  A23L29/00 ,  A61K8/34 ,  A61K8/37 ,  A61K8/42 ,  A61K9/00 ,  A61K47/10 ,  A61K47/14 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q11/02 ,  A61Q13/00 ,  A61Q90/00 ,  C09K5/00 ,  A61K7/00 ,  A61K31/045 ,  A61K31/16 ,  A61K31/22 ,  A61K31/60

CPC分类号： A61Q19/00 ,  A23L27/204 ,  A61K8/34 ,  A61K8/345 ,  A61K8/37 ,  A61K8/42 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q11/02 ,  A61Q13/00 ,  C09K5/00

摘要： The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-l-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N, 2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

摘要翻译： 通过将含有至少一种选自1-薄荷醇，异铃兰，3-（1-薄荷氧基）丙烷-1,2-二醇，2-（1-薄荷氧基）丙烷-1,2-二醇的化合物的冷却物质组合得到的本发明的凉爽感觉组合物， 乙-1-醇，3-（1-薄荷氧基）丙-1-醇，2-甲基-3-（1-薄荷氧基）丙烷-1,2-二醇，N-乙基-1-薄荷基甲酰胺，对薄荷烷 - 3,5-二醇，1-薄荷酸乳酸酯和2-异丙基-N，2,3-三甲基丁酰胺与下列通式（I）表示的水杨酸酯如水杨酸2-羟乙酯提高了强度和持久性 特别是含有1-薄荷醇作为凉爽感觉物质的感觉效果可以减轻由1-薄荷醇引起的刺激性香味。 混合含有食品和饮料，化妆品，化妆品，浴剂和药物的产品的凉爽感觉组合物或香料组合物可以得到有效发挥本发明的凉爽感觉组合物的上述特征的产品。 其中R表示可具有取代基的碳原子数1〜18的烃基。

公开(公告)号：US06355627B1

公开(公告)日：2002-03-12

申请号：US09244106

申请日：1999-02-04

申请人： Kenya Ishida ,  Kazutoshi Sakurai

发明人： Kenya Ishida ,  Kazutoshi Sakurai

IPC分类号： A61K31715

CPC分类号： C08B37/0015 ,  A61K8/35 ,  A61K8/738 ,  A61K2800/56 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/10

摘要： The invention has an object of providing a hinokitiol which is not damaged in the antibacterial activity and improved in the water solubility, heat stability (anti-sublimation characteristics) and corrosion to metals and also providing a composition comprising a hinokitiol. The invention resides in a clathrate compound comprising clathration of hinokitiols by using a branched cyclodextrin such as a branched &bgr;-cyclodextrin. The clathrate compound can be used in various applications requiring an antibacterial activity, such as hair cosmetics, bath agents, skin cosmetics and oral compositions.

摘要翻译： 本发明的目的是提供一种在抗菌活性中不受损害并提高水溶性，热稳定性（抗升华特性）和对金属的腐蚀并且还提供包含扁柏酚的组合物的桧醇。 本发明涉及一种包合化合物，其包括通过使用支链环糊精如支链β-环糊精来包合桧醇醇。 包合化合物可以用于需要抗菌活性的各种应用中，例如头发化妆品，浴剂，皮肤化妆品和口服组合物。

公开(公告)号：US20080112910A1

公开(公告)日：2008-05-15

申请号：US12003609

申请日：2007-12-28

申请人： Kenya Ishida ,  Kazutoshi Sakurai

发明人： Kenya Ishida ,  Kazutoshi Sakurai

IPC分类号： A61K8/37 ,  A61K8/31

CPC分类号： A61Q19/00 ,  A23L27/204 ,  A61K8/34 ,  A61K8/345 ,  A61K8/37 ,  A61K8/42 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/14 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q11/02 ,  A61Q13/00 ,  C09K5/00

摘要： The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-1-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N,2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

摘要翻译： 通过将含有至少一种选自1-薄荷醇，异铃兰，3-（1-薄荷氧基）丙烷-1,2-二醇，2-（1-薄荷氧基）丙烷-1,2-二醇的化合物的冷却物质组合得到的本发明的凉爽感觉组合物， 乙-1-醇，3-（1-薄荷氧基）丙-1-醇，2-甲基-3-（1-薄荷氧基）丙烷-1,2-二醇，N-乙基-1-薄荷基甲酰胺，对薄荷烷 - 3,5-二醇，1-薄荷酸乳酸酯和2-异丙基-N，2,3-三甲基丁酰胺与下列通式（I）表示的水杨酸酯如水杨酸2-羟乙酯提高了强度和持久性 特别是含有1-薄荷醇作为凉爽感觉物质的感觉效果可以减轻由1-薄荷醇引起的刺激性香味。 混合含有食品和饮料，化妆品，化妆品，浴剂和药物的产品的凉爽感觉组合物或香料组合物可以得到有效发挥本发明的凉爽感觉组合物的上述特征的产品。 其中R表示可具有取代基的碳原子数1〜18的烃基。

公开(公告)号：US5925792A

公开(公告)日：1999-07-20

申请号：US696161

申请日：1996-08-13

申请人： Kazutoshi Sakurai ,  Kenya Ishida

发明人： Kazutoshi Sakurai ,  Kenya Ishida

IPC分类号： C07B53/00 ,  C07B61/00 ,  C07C213/00 ,  C07C213/08 ,  C07C215/10 ,  C07C229/22 ,  C07D303/48 ,  C07C209/00

CPC分类号： C07D303/48 ,  C07C213/08 ,  C07C229/22 ,  Y02P20/55

摘要： A process for preparing an optically active dihydrosphingosine derivative is disclosed, comprising reducing a (2R,3R)-2-amino-3-hydroxyalkanoic acid derivative represented by formula (III): ##STR1## wherein R.sup.3 represents a straight-chain alkyl group having 7 to 21 carbon atoms; and R.sup.4 represents an amino group protecting group, (e.g., (2R,3R)-2-benzylamino-3-hydroxyoctadecanoic acid) with sodium tetrahydroborate in the presence of an acid. The process makes it feasible to produce an optically active dihydrosphingosine at high optical purity and through a simple process that is safe and easy to industrialize.

摘要翻译： 公开了一种制备光学活性二氢鞘氨醇衍生物的方法，包括还原由式（III）表示的（2R，3R）-2-氨基-3-羟基链烷酸衍生物：其中R 3表示具有7-21个碳原子的直链烷基 碳原子 和R4代表氨基保护基团（例如（2R，3R）-2-苄基氨基-3-羟基十八烷酸）与四氢硼酸钠在酸存在下反应。 该方法使得生产具有高光学纯度的光学活性二氢鞘氨醇和通过安全且容易工业化的简单方法是可行的。

公开(公告)号：US5786386A

公开(公告)日：1998-07-28

申请号：US678598

申请日：1996-07-15

申请人： Kenya Ishida ,  Kazutoshi Sakurai

发明人： Kenya Ishida ,  Kazutoshi Sakurai

IPC分类号： A01N33/04 ,  A01N33/06 ,  A01N33/10 ,  A01N43/30 ,  A01N43/50 ,  C07C217/58 ,  C07D233/54 ,  C07D317/58

CPC分类号： C07D233/64 ,  A01N33/04 ,  A01N33/06 ,  A01N33/10 ,  A01N43/30 ,  A01N43/50 ,  C07C217/58 ,  C07D317/58

摘要： The present invention provides an antibacterial and fungicidal agent containing an amino compound of formula (1) or a salt thereof. The invention also provides a method for imparting antibacterial and fungicidal properties to a variety of objects using the compound. ##STR1## wherein .phi. represents a phenyl group, a substituted phenyl group (wherein the substituents are 1-5 members arbitrarily selected from the group consisting of a hydroxyl group, halogen atoms, lower alkoxyl groups, trifluoromethyl group, an amino group, and a methylenedioxy group), or an imidazolyl group; R.sup.1 represents a hydrogen atom or a lower alkyl group; and R.sup.2 represents a C6-C12 alkyl group. The amino compound of formula (1) or a salt thereof exhibits excellent antibacterial effects and fungicidal effects, and when it is applied to a variety of articles used in industry, commodities, etc., enhanced antibacterial effects and fungicidal effects are obtained.

摘要翻译： 本发明提供含有式（1）的氨基化合物或其盐的抗细菌剂和杀真菌剂。 本发明还提供了使用该化合物赋予各种物体抗菌和杀真菌性能的方法。 （1）其中phi表示苯基，取代的苯基（其中取代基任选地选自羟基，卤素原子，低级烷氧基，三氟甲基，氨基 ，和亚甲二氧基）或咪唑基; R1表示氢原子或低级烷基; R2代表C6-C12烷基。 式（1）的氨基化合物或其盐具有优异的抗菌效果和杀真菌效果，并且当其应用于工业，商品等中使用的各种制品时，获得了增强的抗菌效果和杀真菌效果。

公开(公告)号：US08586009B2

公开(公告)日：2013-11-19

申请号：US13601434

申请日：2012-08-31

申请人： Kazuma Hojo ,  Takashi Aida ,  Kenya Ishida

发明人： Kazuma Hojo ,  Takashi Aida ,  Kenya Ishida

IPC分类号： A23L1/226 ,  A61K8/37 ,  A61Q19/00

CPC分类号： A61K8/37 ,  A23G4/06 ,  A23L27/203 ,  A23L27/88 ,  A61K2800/244 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/00 ,  C07B2200/07 ,  C07C67/31 ,  C07C2601/14 ,  C11B9/0034 ,  C07C69/675

摘要： Disclosed is a method for producing (3S)-l-menthyl 3-hydroxybutyrate of the following formula (I) by subjecting l-menthyl acetoacetate to asymmetric hydrogenation. The compound may be used as a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling.

摘要翻译： 公开了通过使1-薄荷酰乙酰乙酸酯进行不对称氢化制备下式（I）的（3S）-1-薄荷基-3-羟基丁酸酯的方法。 该化合物可以用作不具有不期望的刺激感，苦味等的冷却组分或感觉组分，并且具有优异的刷新感和凉爽感。

公开(公告)号：US08377458B2

公开(公告)日：2013-02-19

申请号：US12898939

申请日：2010-10-06

申请人： Yasuhiro Komatsuki ,  Tomoko Yamamoto ,  Takashi Aida ,  Kenya Ishida

发明人： Yasuhiro Komatsuki ,  Tomoko Yamamoto ,  Takashi Aida ,  Kenya Ishida

IPC分类号： A61Q5/02 ,  A61Q15/00 ,  A61Q13/10

CPC分类号： C07C69/34 ,  A61K8/37 ,  A61K31/225 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q19/00 ,  C07C69/40 ,  C07C69/42 ,  C07C2601/14

摘要： Disclosed is a cooling sensation agent composition or sensory stimulation agent composition which contains at least one of diester compounds of dicarboxylic acid represented by the formula (1) wherein A represents CH2 or CH═CH, n represents an integer of 0 to 4 when A is CH2, or 1 when A is CH═CH, B is an alcohol residue having 10 to 18 carbon atoms and containing a para-menthane skeleton, which may have a substituent, and C is an alcohol residue having 6 to 18 carbon atoms, which may have a substituent as well as a flavor or fragrance composition, a beverage, a food product, a perfume or cosmetic product, a toiletry product, daily utensil products or groceries, a fiber, a fiber product, clothes, clothing or a medicine, wherein the cooling sensation agent composition or the sensory stimulation agent composition is compounded.

摘要翻译： 公开了一种冷却感觉剂组合物或感觉刺激剂组合物，其含有由式（1）表示的二羧酸二酯化合物中的至少一种，其中A表示CH 2或CH = CH，n表示0至4的整数，当A为 CH 2或1，当A为CH = CH时，B为具有10至18个碳原子的醇残基，并含有可具有取代基的对位薄荷烷骨架，C为具有6至18个碳原子的醇残基， 可以具有取代基以及香料或香料组合物，饮料，食品，香料或化妆品，化妆品，日用具产品或杂货，纤维，纤维制品，衣服，衣服或药物， 其中所述冷却感觉剂组合物或所述感觉刺激剂组合物复合。