公开(公告)号：US5471615A

公开(公告)日：1995-11-28

申请号：US263954

申请日：1994-06-22

申请人： Keiji Amatsu ,  Zenhachiroh Butoh ,  Hiroshi Hirai ,  Minoru Massaki ,  Hirofumi Morita ,  Takeo Nakajima ,  Nobuo Nomura ,  Mikio Sakaki ,  Stephen J. Schmandt ,  Katsuhiro Tanaka

发明人： Keiji Amatsu ,  Zenhachiroh Butoh ,  Hiroshi Hirai ,  Minoru Massaki ,  Hirofumi Morita ,  Takeo Nakajima ,  Nobuo Nomura ,  Mikio Sakaki ,  Stephen J. Schmandt ,  Katsuhiro Tanaka

IPC分类号： G06F9/46 ,  G06F9/455 ,  G06F9/50 ,  G06F15/16 ,  G06F13/00

CPC分类号： G06F15/161

摘要： A distributed data processing system is provided in which two computers, each running under a different operating system, are coupled so that jobs initiated by a first one of the computers can be executed on a second computer by using the resources of the second computer. This enables the user of the first computer to use the second computer under the environment of the first computer. The first computer acts as the interface between the user and the data processing system. Service programs running on the system can handle or provide for input/output operations during the execution of jobs on the second computer so that the jobs seem to the user of the first computer to be executed on the first computer. The system has means for creating a dummy file in the file system of one operating system which is used as a place holder for a corresponding file in a storage device attached to the other operating system, and accessed by programs controlled by that other operating system.

摘要翻译： 提供了一种分布式数据处理系统，其中每个运行在不同操作系统下的两台计算机被耦合，使得由第一计算机启动的作业可以通过使用第二计算机的资源在第二计算机上执行。 这使得第一计算机的用户能够在第一计算机的环境下使用第二计算机。 第一台计算机充当用户和数据处理系统之间的接口。 在第二计算机上执行作业期间，在系统上运行的服务程序可以处理或提供输入/输出操作，使得第一计算机的用户似乎在第一计算机上执行作业。 该系统具有用于在一个操作系统的文件系统中创建虚拟文件的装置，该操作系统被用作连接到另一个操作系统的存储设备中的对应文件的占位符，并由该另一个操作系统控制的程序访问。

公开(公告)号：US20060019959A1

公开(公告)日：2006-01-26

申请号：US10532677

申请日：2003-10-27

申请人： Hiroshi Hirai ,  Nobuhiko Kawanishi ,  Masaaki Hirose ,  Tetsuya Sugimoto ,  Kaori Kamijyo ,  Jun Shibata ,  Kouta Masutani

发明人： Hiroshi Hirai ,  Nobuhiko Kawanishi ,  Masaaki Hirose ,  Tetsuya Sugimoto ,  Kaori Kamijyo ,  Jun Shibata ,  Kouta Masutani

IPC分类号： A61K31/498 ,  C07D498/14 ,  C07D491/14

CPC分类号： C07D487/18 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/55 ,  C07D498/18 ,  C07D498/22 ,  C07D515/18 ,  C07D515/22

摘要： A quinoxalinone derivative of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein; X is NH, S or the like; Y is O or the like; the partial structure is, for example, the formula: B1, B2, . . . , Bn-1 and Bn, (in which n is 4, 5 or 6) are each independently CH, N or the like; B′1, B′2, . . . , B′n-1 and B′n (in which n is 4, 5 or 6) are each independently hydrogen or the like; and R is hydrogen, lower alkyl or the like.

摘要翻译： 式（I）的喹喔啉酮衍生物或其药学上可接受的盐或酯，其中： X是NH，S等; Y为O等; 该部分结构例如是以下公式：B 1，B 2，...。 。 。 （其中n为4,5或6）各自独立地为CH，N等;其中n为4或5或6。 B'1，B'2，...， 。 。 ，其中n为4,5或6个，各自独立地为氢等;其中n为4或5或6。 和R是氢，低级烷基等。

公开(公告)号：US06627914B1

公开(公告)日：2003-09-30

申请号：US09763603

申请日：2001-02-26

申请人： Susumu Komiyama ,  Astafiev Oleg ,  Antonov Vladimir ,  Hiroshi Hirai ,  Takeshi Kutsuwa

发明人： Susumu Komiyama ,  Astafiev Oleg ,  Antonov Vladimir ,  Hiroshi Hirai ,  Takeshi Kutsuwa

IPC分类号： H01L2906

CPC分类号： H01Q9/28 ,  B82Y10/00 ,  H01L31/02325 ,  H01L31/03046 ,  H01L31/0352 ,  H01L31/101

摘要： An MR/FIR light detector is disclosed herein that has extraordinarily high degree of sensitivity and a high speed of response. The detector includes an MR/FIR light introducing section (1) for guiding an incident MR/FIR light (2), a semiconductor substrate (14) formed with a single-electron transistor (14) for controlling electric current passing through a semiconductor quantum dot (12) formed therein, and a BOTAI antenna (6, 6a, 6b, 6c) for concentrating the MW/FIR light (2) into a small special zone of sub-micron size occupied by the semiconductor quantum dot (12) in the single-electron transistor (14). The quantum dot (12) forming a two-dimensional electron system absorbs the electromagnetic wave concentrated efficiently, and retains an excitation state created therein for 10 nanoseconds or more, thus permitting electrons of as many as one millions in number or more to be transferred with respect to a single photon absorbed.

摘要翻译： 本文公开了具有非常高的灵敏度和高响应速度的MR / FIR光检测器。 检测器包括用于引导入射MR / FIR光（2）的MR / FIR光导入部（1），形成有用于控制通过半导体量子的电流的单电子晶体管（14）的半导体衬底（14） 形成在其中的点（12）和用于将MW / FIR光（2）聚集成由半导体量子点（12）占据的亚微米尺寸的小特殊区域的BOTAI天线（6,6a，6b，6c） 单电子晶体管（14）。 形成二维电子系统的量子点（12）吸收有效集中的电磁波，并且将其中产生的激发态保持10纳秒以上，从而允许多达一百万数以上的电子与 尊重单个光子吸收。

公开(公告)号：US06180763B2

公开(公告)日：2001-01-30

申请号：US08928941

申请日：1997-09-12

申请人： Charles J. Sherr ,  Hiroshi Hirai ,  Kazushi Inoue ,  Sara M. Bodner

发明人： Charles J. Sherr ,  Hiroshi Hirai ,  Kazushi Inoue ,  Sara M. Bodner

IPC分类号： C07K122

CPC分类号： C07K14/4705 ,  A01K2217/05 ,  A01K2217/075 ,  C07K2319/00

摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

摘要翻译： 本发明公开了D型细胞周期蛋白与与细胞周期蛋白D2特异性相互作用的新型myb样转录因子DMP1之间的直接相互作用。 本发明还提供了D型细胞周期蛋白以不依赖RB的方式调节基因表达的证据。 还包括DMP1，转录因子由包含三个非典型myb重复的中心DNA结合结构域组成，其侧翼为位于其氨基末端和羧基末端的高度酸性的片段。 本发明包括编码DMP1的氨基酸序列，以及编码氨基酸序列的DNA和RNA核苷酸序列。 公开了DMP1作为转录因子的用途，因为它在与含有非标记共有序列CCCG（G / T）ATGT的寡核苷酸的结合中具有特异性。 在本发明的这个方面，当转染到哺乳动物细胞中时，DMP1激活由含有连接的DMP1结合位点的最小启动子驱动的报道基因的转录。

公开(公告)号：US20110319354A1

公开(公告)日：2011-12-29

申请号：US13254108

申请日：2010-02-23

申请人： Mark E. Layton ,  Hiroshi Hirai ,  Hidehito Kotani

发明人： Mark E. Layton ,  Hiroshi Hirai ,  Hidehito Kotani

IPC分类号： A61K31/704 ,  A61K31/7068 ,  A61P35/00 ,  A61K31/513 ,  A61K31/517 ,  A61K31/4375 ,  A61K31/4745

CPC分类号： A61K31/495 ,  A61K31/4196 ,  A61K31/50 ,  A61K2300/00

摘要： The invention relates to combination anticancer therapy with certain Akt inhibitor and other anticancer agents such as anticancer antimetabolites, anticancer antibiotics, plant-derived anticancer agents, anticancer platinum-coordinated complex compounds, anticancer camptothecin derivatives and anticancer tyrosine kinase inhibitors.

摘要翻译： 本发明涉及与某些Akt抑制剂和其它抗癌剂如抗癌抗代谢剂，抗癌抗生素，植物衍生抗癌剂，抗癌铂配位化合物，抗癌喜树碱衍生物和抗癌酪氨酸激酶抑制剂的组合抗癌治疗。

公开(公告)号：US20100063024A1

公开(公告)日：2010-03-11

申请号：US12226707

申请日：2007-04-25

申请人： Toshihiro Sakamoto ,  Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Toshihiro Sakamoto ,  Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/397 ,  C07D487/04 ,  C07D413/14 ,  C07D417/14 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc.The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US07388010B2

公开(公告)日：2008-06-17

申请号：US10532677

申请日：2003-10-27

申请人： Hiroshi Hirai ,  Nobuhiko Kawanishi ,  Masaaki Hirose ,  Tetsuya Sugimoto ,  Kaori Kamijyo ,  Jun Shibata ,  Kouta Masutani

发明人： Hiroshi Hirai ,  Nobuhiko Kawanishi ,  Masaaki Hirose ,  Tetsuya Sugimoto ,  Kaori Kamijyo ,  Jun Shibata ,  Kouta Masutani

IPC分类号： A61K31/498 ,  A61P35/00 ,  C07D487/00

CPC分类号： C07D487/18 ,  A61K31/4995 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/55 ,  C07D498/18 ,  C07D498/22 ,  C07D515/18 ,  C07D515/22

摘要： A quinoxalinone derivative of the formula (I): or a pharmaceutically acceptable salt or ester thereof, wherein; X is NH, S or the like; Y is O or the like; the partial structure is, for example, the formula: B1, B2, . . . , Bn−1 and Bn, (in which n is 4, 5 or 6) are each independently CH, N or the like; B′1, B′2, . . . , B′n−1 and B′n (in which n is 4, 5 or 6) are each independently hydrogen or the like; and R is hydrogen, lower alkyl or the like.

摘要翻译： 式（I）的喹喔啉酮衍生物或其药学上可接受的盐或酯，其中： X是NH，S等; Y为O等; 该部分结构例如是以下公式：B 1，B 2，...。 。 。 （其中n为4,5或6）各自独立地为CH，N等;其中n为4或5或6。 B'1，B'2，...， 。 。 ，其中n为4,5或6个，各自独立地为氢等;其中n为4或5或6。 和R是氢，低级烷基等。

公开(公告)号：US06673902B2

公开(公告)日：2004-01-06

申请号：US09892398

申请日：2001-06-27

申请人： Charles J. Sherr ,  Hiroshi Hirai ,  Sara M. Bodner ,  Kazushi Inoue

发明人： Charles J. Sherr ,  Hiroshi Hirai ,  Sara M. Bodner ,  Kazushi Inoue

IPC分类号： C07K1600

CPC分类号： C07K14/4705 ,  A01K2217/05 ,  A01K2217/075 ,  C07K2319/00

摘要： The invention discloses a direct interaction between D-type cyclins and a novel myb-like transcription factor, DMP1, which specifically interacts with cyclin D2. The present invention also provides evidence that D-type cyclins regulate gene expression in an RB-independent manner. Also included is DMP1, the transcription factor composed of a central DNA-binding domain containing three atypical myb repeats flanked by highly acidic segments located at its amino- and carboxyterminal ends. The invention includes amino acid sequences coding for DMP1, and DNA and RNA nucleotide sequences that encode the amino acid sequences. A use of DMP1 as a transcription factor is disclosed due to its specificity in binding to oligonucleotides containing the nonamer consensus sequence CCCG(G/T)ATGT. In this aspect of the invention, DMP1 when transfected into mammalian cells, activates the transcription of a reporter gene driven by a minimal promoter containing concatamerized DMP1 binding sites.

摘要翻译： 本发明公开了D型细胞周期蛋白与与细胞周期蛋白D2特异性相互作用的新型myb样转录因子DMP1之间的直接相互作用。 本发明还提供了D型细胞周期蛋白以不依赖RB的方式调节基因表达的证据。 还包括DMP1，转录因子由包含三个非典型myb重复的中心DNA结合结构域组成，其侧翼为位于其氨基末端和羧基末端的高度酸性的片段。 本发明包括编码DMP1的氨基酸序列，以及编码氨基酸序列的DNA和RNA核苷酸序列。 公开了DMP1作为转录因子的用途，因为它在与含有非标记共有序列CCCG（G / T）ATGT的寡核苷酸的结合中具有特异性。 在本发明的这个方面，当转染到哺乳动物细胞中时，DMP1激活由含有连接的DMP1结合位点的最小启动子驱动的报道基因的转录。

公开(公告)号：US07834019B2

公开(公告)日：2010-11-16

申请号：US11789548

申请日：2007-04-25

申请人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

发明人： Takeshi Sagara ,  Sachie Otsuki ,  Satoshi Sunami ,  Toshihiro Sakamoto ,  Kenji Niiyama ,  Fuyuki Yamamoto ,  Takashi Yoshizumi ,  Hidetomo Furuyama ,  Yasuhiro Goto ,  Makoto Bamba ,  Keiji Takahashi ,  Hiroshi Hirai ,  Toshihide Nishibata

IPC分类号： A61K31/519 ,  A61K31/497 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/519

摘要： The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

摘要翻译： 本发明涉及通式（I）的化合物：其中Ar1是任选取代的芳基或杂芳基; R 1是任选取代的低级烷基，低级烯基，低级炔基或环低级烷基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R2是氢原子，低级烷基，低级烯基或低级炔基，或者是任选具有取代基的芳基，芳烷基或杂芳基; R3是氢原子或低级烷基; R4是氢原子，卤素原子，羟基，低级烷基或-N（R1k）R1m基团; T和U是氮原子或次甲基等。本发明的化合物具有优异的韦尔激酶抑制作用，因此可用于药物领域，特别是治疗各种癌症。

公开(公告)号：US20080081811A1

公开(公告)日：2008-04-03

申请号：US11596735

申请日：2005-05-19

申请人： Yoshikazu Iwasawa ,  Jun Shibata ,  Tadashi Shimamura ,  Hideki Kurihara ,  Takashi Mita ,  Nobuhiko Kawanishi ,  Takashi Hashihayata ,  Mikako Kawamura ,  Takeshi Sagara ,  Sachie Arai ,  Hiroshi Hirai

发明人： Yoshikazu Iwasawa ,  Jun Shibata ,  Tadashi Shimamura ,  Hideki Kurihara ,  Takashi Mita ,  Nobuhiko Kawanishi ,  Takashi Hashihayata ,  Mikako Kawamura ,  Takeshi Sagara ,  Sachie Arai ,  Hiroshi Hirai

IPC分类号： A61K31/496 ,  A61K31/497 ,  A61K31/505 ,  A61K31/5377 ,  A61P35/00 ,  C07D239/32 ,  C07D403/14 ,  C07D413/14

CPC分类号： C07D417/14 ,  C07D417/12 ,  C07D491/08

摘要： The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.

摘要翻译： 本发明涉及由式[I]表示的化合物：其中X是O，S，NH或CH 2; Y 1，Y 2，Y 3，Y 4和Y 5， 其可以相同或不同，各自为CH或N; 然而，Y 1，Y 2，Y 3，Y 4和Y 3中的至少一个， 5 是N; Z 1和Z 2可以相同或不同，各自为CH或N; n为1〜3的整数， R 1是C 3 -C 8环烷基，C 6 -C 10环烷基，C 6 -C 15环烷基， 芳基，脂族杂环或芳族杂环，或双环脂族饱和烃基; R 2和R 3可以相同或不同，分别为氢原子，低级烷基，低级烯基，C 3， C 1 -C 8环烷基，C 6 -C 10芳基，芳族杂环等; 和R 4是氢原子，低级烷基，C 3 -C 6环烷基等，或药学上可接受的 盐或酯，以及对Cdk4和/或Cdk6的选择性抑制剂或含有该化合物或其药学上可接受的盐或酯的抗癌剂。