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136 条记录 (耗时 0.028 秒)

    Mutant alpha-amylases
    1.
    发明申请
    Mutant alpha-amylases 审中-公开
    突变型α-淀粉酶

    公开(公告)号：US20050181493A1

    公开(公告)日：2005-08-18

    申请号：US10988529

    申请日：2004-11-16

    申请人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    发明人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    IPC分类号： C11D3/386 ,  C12N1/21 ,  C12N9/28 ,  C12N15/56 ,  C11D7/42

    CPC分类号： C12N9/2417 ,  C11D3/386

    摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase. The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.

    摘要翻译： 本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶 具有所述氨基酸序列的淀粉酶或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，用于产生突变型α-淀粉酶的方法， 包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。 本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

    Mutant α-amylases
    2.
    发明授权
    Mutant α-amylases 失效
    突变型α-淀粉酶

    公开(公告)号：US07078212B1

    公开(公告)日：2006-07-18

    申请号：US09590375

    申请日：2000-06-09

    申请人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    发明人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    IPC分类号： C12N9/26 ,  C12N9/28 ,  C07H21/04

    CPC分类号： C12N9/2417 ,  C11D3/386

    摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase.The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.

    摘要翻译： 本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶 具有所述氨基酸序列的淀粉酶或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，用于产生突变型α-淀粉酶的方法， 包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。 本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

    MUTANT ALPHA-AMYLASES
    6.
    发明申请
    MUTANT ALPHA-AMYLASES 审中-公开
    突变型ALPHA-AMYLASES

    公开(公告)号：US20090226961A1

    公开(公告)日：2009-09-10

    申请号：US11864245

    申请日：2007-09-28

    申请人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    发明人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    IPC分类号： C12P21/00 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00

    CPC分类号： C12N9/2417 ,  C11D3/386

    摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase.The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.

    摘要翻译： 本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶 具有所述氨基酸序列的淀粉酶，或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，产生突变型α-淀粉酶的方法， 包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。 本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

    Mutant &agr;-amylases
    9.
    发明授权
    Mutant &agr;-amylases 失效
    突变型α-淀粉酶

    公开(公告)号：US06486113B1

    公开(公告)日：2002-11-26

    申请号：US09381687

    申请日：1999-09-23

    申请人： Yuji Hatada ,  Kaori Ikawa ,  Susumu Ito ,  Kazuaki Igarashi ,  Hiroshi Hagihara ,  Yasuhiro Hayashi ,  Hiroyuki Araki ,  Katsuya Ozaki

    发明人： Yuji Hatada ,  Kaori Ikawa ,  Susumu Ito ,  Kazuaki Igarashi ,  Hiroshi Hagihara ,  Yasuhiro Hayashi ,  Hiroyuki Araki ,  Katsuya Ozaki

    IPC分类号： C11D3386

    CPC分类号： C12N9/2417 ,  C11D3/386

    摘要： The invention relates to a mutant &agr;-amylase having an amino acid sequence obtained by making deletion or replacement by another arbitrary amino acid residue of at least a methionine residue at the 202-position or a position homologous thereto among amino acid residues set forth in SEQ ID NO:1, which constitute a liquefying alkaline &agr;-amylase, a gene thereof, and a detergent composition comprising the mutant &agr;-amylase. The mutant &agr;-amylase has the optimum pH in an alkaline range, an excellent &agr;-amylase activity, and high and lasting resistance to oxidizing agents, and is hence particularly useful as a component of detergent compositions containing a bleaching agent and an oxidizing agent.

    摘要翻译： 本发明涉及一种具有氨基酸序列的突变型α-淀粉酶，该氨基酸序列是通过在SEQ ID NO：1所示的氨基酸残基之间至少含有202位的甲硫氨酸残基或其同源位置的另外任意氨基酸残基进行缺失或替换而获得的 ID NO：1，其构成液化碱性α-淀粉酶，其基因和包含突变型α-淀粉酶的洗涤剂组合物。 突变型α-淀粉酶在碱性范围内具有最佳pH，优异的α-淀粉酶活性和对氧化剂的高持久耐受性，因此特别可用作含有漂白剂和氧化剂的洗涤剂组合物的组分。

    THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY
    10.
    发明申请
    THIENOPYRAZOLE DERIVATIVE HAVING PDE7 INHIBITORY ACTIVITY 审中-公开
    具有PDE7抑制活性的噻吩衍生物

    公开(公告)号：US20110166343A1

    公开(公告)日：2011-07-07

    申请号：US13047660

    申请日：2011-03-14

    申请人： Hidekazu Inoue ,  Hidenobu Murafuji ,  Yasuhiro Hayashi

    发明人： Hidekazu Inoue ,  Hidenobu Murafuji ,  Yasuhiro Hayashi

    IPC分类号： C07D403/14 ,  C07D231/20 ,  C07D231/16 ,  C07D231/18 ,  C07D487/04 ,  C07D413/14 ,  C07D401/14 ,  C07D471/10

    CPC分类号： C07D231/18 ,  C07D495/04

    摘要： To provide thienopyrazole derivatives inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic diseases, inflammatory diseases or immunologic diseases. The compound is thienopyrazole compound represented by the following formula (I): [wherein, especially, R1 is a cyclohexyl, a cycloheptyl group or a tetrahydropyranyl group; R2 is methyl; R3 is a hydrogen atom; and R4 is a group: —CONR5R6 (in which any one of R5 and R6 is a hydrogen atom)].

    摘要翻译： 提供抑制PDE 7的噻吩并吡唑衍生物，从而提高细胞cAMP水平。 因此，该化合物可用于治疗各种疾病如过敏性疾病，炎性疾病或免疫疾病。 该化合物是由下式（I）表示的噻吩并吡唑化合物：[其中，特别是R 1是环己基，环庚基或四氢吡喃基; R2是甲基; R3是氢原子; 和R 4是基团-CONR 5 R 6（其中R 5和R 6中的任一个是氢原子）]。