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    Composition for application to hair or scalp
    1.
    发明授权
    Composition for application to hair or scalp 失效
    用于头发或头皮的组合物

    公开(公告)号：US5017368A

    公开(公告)日：1991-05-21

    申请号：US472438

    申请日：1990-01-31

    申请人： Keikichi Sugiyama ,  Koji Takada ,  Akira Fukushima ,  Makoto Egawa

    发明人： Keikichi Sugiyama ,  Koji Takada ,  Akira Fukushima ,  Makoto Egawa

    IPC分类号： A61K8/00 ,  A61K8/34 ,  A61K8/36 ,  A61K8/49 ,  A61K8/64 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q7/00

    CPC分类号： A61K8/498 ,  A61K8/64 ,  A61Q5/10 ,  A61Q7/00

    摘要： A composition for application to hair or scalp comprises (A) at least one compound selected from the group consisting of (i) forskolin and derivatives thereof and (ii) peptides having a basic skeletal structure represented by the following general formula (I):-P-Glu-His-Q-Arg-Trp-Gly-Lys- (I)(wherein P represents an L-norleucine or L-methionine residue; Q represents a D- or L-phenylalamine residue; and Glu, His, Arg, Trp, Gly and Lys are L-glutamic acid, L-histidine, L-arginine, L-tryptophan, glycine and L-lysine residues respectively); or the component A and (B) at least one compound selected from the group consisting of aliphatic acids, alcohols and derivatives thereof having an odd number of carbon atoms. The composition for hair or scalp exhibits excellent effect of preventing graying of the hair and restoring grayed hair to its natural color upon externally applied to the scalp and is highly safe as regards to the possibility of causing skin damage. Therefore, the composition can be widely used in various forms capable of being externally applied to the scalp.

    Composition for application to hair
    2.
    发明授权
    Composition for application to hair 失效
    适用于头发的成分

    公开(公告)号：US5376643A

    公开(公告)日：1994-12-27

    申请号：US684461

    申请日：1990-09-20

    申请人： Keikichi Sugiyama ,  Koji Takada ,  Ikuo Yamamoto

    发明人： Keikichi Sugiyama ,  Koji Takada ,  Ikuo Yamamoto

    IPC分类号： A61K8/36 ,  A61K8/362 ,  A61K8/37 ,  A61K8/42 ,  A61K8/55 ,  A61K8/60 ,  A61K8/63 ,  A61K8/68 ,  A61Q5/00 ,  A61Q5/06 ,  A61K31/52

    CPC分类号： A61Q5/00 ,  A61K8/361 ,  A61K8/362 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61K8/553 ,  A61K8/606 ,  A61K8/63 ,  A61K8/68 ,  A61Q5/065 ,  A61Q5/10 ,  Y10S514/88

    摘要： Methods and compositions for restoring grayed hair to its natural color comprising at least one compound of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 may be the same or different and each represents a hydrogen atom, an acyl group having 5 to 15 carbon atoms derived from a monocarboxylic acid having 5 to 15 carbon atoms or an acyl group having 2 to 15 carbon atoms derived from a dicarboxylic acid having 2 to 15 carbon atoms or an alkyl group having 1 to 2 carbon atoms; X.sub.1 and X.sub.2, respectively, represent a hydrogen atom, a halogen, or a mercapto group; with the proviso that when R.sub.1, R.sub.2 and R.sub.3 and X.sub.1 are hydrogen atoms at the same time, X.sub.2 is not a halogen atom or a mercapto group, and M.sub.1 represents a hydrogen atom, an alkali metal or tris(hydroxymethyl)aminomethane.

    摘要翻译： 用于将灰白色毛发恢复至其天然色的方法和组合物，其包含至少一种下式化合物：其中R 1，R 2和R 3可以相同或不同，并且各自表示氢原子，具有5至15个碳原子的酰基 衍生自碳原子数5〜15的一元羧酸或碳原子数2〜15的二羧酸或碳原子数1〜2的烷基的碳原子数2〜15的酰基的原子; X1和X2分别表示氢原子，卤素或巯基; 条件是当R1，R2和R3和X1同时为氢原子时，X2不是卤原子或巯基，M1表示氢原子，碱金属或三（羟甲基）氨基甲烷。

    Composition for preventing graying of the hair
    3.
    发明授权
    Composition for preventing graying of the hair 失效
    用于防止头发变灰的组合物

    公开(公告)号：US5318776A

    公开(公告)日：1994-06-07

    申请号：US53325

    申请日：1993-04-27

    申请人： Keikichi Sugiyama ,  Koji Takada ,  Ikuo Yamamoto

    发明人： Keikichi Sugiyama ,  Koji Takada ,  Ikuo Yamamoto

    IPC分类号： A61K8/00 ,  A61K8/60 ,  A61K31/675 ,  A61P17/00 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q7/00 ,  A61K7/06

    CPC分类号： A61K8/606 ,  A61Q5/10 ,  Y10S514/88 ,  Y10S514/881

    摘要： A composition for preventing graying of the hair and restoring grayed hair to its natural color comprises an effective amount of one member selected from the group consisting of cAMP compounds such as 8-butylthio cAMP-Na or 8-methoxy cAMP-Na and water. The composition can prevent graying of the hair and restoring grayed hair to its natural color upon application to the scalp, the effective component is very stable even in the form of compositions containing water and the composition does not cause quality deteriorations such as giving out of bad smell.

    摘要翻译： 用于防止毛发变灰并将灰白色毛发恢复为其天然色彩的组合物包含有效量的选自由c-cAMP化合物如8-丁硫基cAMP-Na或8-甲氧基cAMP-Na和水组成的组中的一种。 该组合物可以防止头发变灰，并将灰头发恢复到其头皮上的自然颜色，即使以含有水的组合物的形式，有效成分也非常稳定，并且组合物不会引起质量恶化，例如不良 闻。

    Composition for preventing graying of the hair and restoring grayed hair to its natural color
    4.
    发明授权
    Composition for preventing graying of the hair and restoring grayed hair to its natural color 失效
    用于防止头发变灰并将灰色头发恢复为其自然颜色的组合物

    公开(公告)号：US5378453A

    公开(公告)日：1995-01-03

    申请号：US206675

    申请日：1994-03-07

    申请人： Keikichi Sugiyama ,  Koji Takada ,  Ikuo Yamamoto

    发明人： Keikichi Sugiyama ,  Koji Takada ,  Ikuo Yamamoto

    IPC分类号： A61K8/00 ,  A61K8/60 ,  A61K31/675 ,  A61P17/00 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q7/00 ,  A61K7/06

    CPC分类号： A61K8/606 ,  A61Q5/10 ,  Y10S514/88 ,  Y10S514/881

    摘要： A composition for preventing graying of the hair and restoring grayed hair to its natural color comprises an effective amount of one member selected from the group consisting of cAMP compounds such as 8-butylthio cAMP-Na or 8-methoxy cAMP-Na and water. The composition can prevent graying of the hair and restoring grayed hair to its natural color upon application to the scalp, the effective component is very stable even in the form of compositions containing water and the composition does not cause quality deteriorations such as giving out of bad smell.

    摘要翻译： 用于防止毛发变灰并将灰白色毛发恢复为其天然色彩的组合物包含有效量的选自由c-cAMP化合物如8-丁硫基cAMP-Na或8-甲氧基cAMP-Na和水组成的组中的一种。 该组合物可以防止头发变灰，并将灰头发恢复到其头皮上的自然颜色，即使以含有水的组合物的形式，有效成分也非常稳定，并且组合物不会引起质量恶化，例如不良 闻。