公开(公告)号：US20090041875A1

公开(公告)日：2009-02-12

申请号：US11918424

申请日：2006-04-12

申请人： Keiko Takada ,  Shinji Inomata ,  Yuki Ogura ,  Kenichi Umishio

发明人： Keiko Takada ,  Shinji Inomata ,  Yuki Ogura ,  Kenichi Umishio

IPC分类号： A61K36/31 ,  A61K36/13 ,  A61K36/00 ,  A61P17/00

CPC分类号： A61K8/97 ,  A61Q19/08

摘要： There is provided a novel anti-wrinkle composition comprising one or more from among watercress, juniper, baizhu and coltsfoot extracts as active ingredients.

摘要翻译： 本发明提供了一种新颖的抗皱组合物，其包含以水田芥，杜松子，白芷和ts foot提取物中的一种或多种作为活性成分。

公开(公告)号：US20120253064A1

公开(公告)日：2012-10-04

申请号：US13467254

申请日：2012-05-09

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

IPC分类号： C07C309/26

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了一种角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，其各自包含至少一种选自指定的甘氨酸衍生物及其盐的化合物和指定的氨基硫酸衍生物及其盐。 此外，提供了包含这些化合物的外用皮肤制剂。

公开(公告)号：US20070225380A1

公开(公告)日：2007-09-27

申请号：US10580471

申请日：2004-11-22

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

IPC分类号： A61K47/12

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了角化不全抑制剂和孔还原剂，其各自包含至少一种选自甘氨酸衍生物，氨基二羧酸衍生物，酰氨基二羧酸衍生物，吡咯烷羧酸衍生物，哌啶羧酸衍生物，六亚甲基亚氨基羧酸 ，β-丙氨酸衍生物和这些衍生物的盐。 此外，提供了分别含有选自特定的甘氨酸衍生物及其盐的化合物和规定的氨基硫酸衍生物及其盐中的至少一种化合物的角化不全抑制剂，减孔剂和皮肤粗糙度防止改善剂。 此外，提供了包含这些化合物的外用皮肤制剂。

公开(公告)号：US20070134265A1

公开(公告)日：2007-06-14

申请号：US10588780

申请日：2004-05-18

申请人： Keiko Takada ,  Rikako Suzuki ,  Miki Guentert ,  Shinji Inomata ,  Chika Hamada ,  Takayuki Sakiguchi

发明人： Keiko Takada ,  Rikako Suzuki ,  Miki Guentert ,  Shinji Inomata ,  Chika Hamada ,  Takayuki Sakiguchi

IPC分类号： A61K36/06 ,  A61K31/737

CPC分类号： A61K8/99 ,  A61Q19/08

摘要： There are provided an anti-aging composition, a collagen production promoting composition, a collagen gel contraction promoting composition, and an integrin production promoting composition for promoting integrin production in fibroblasts/epidermal cell, which have improved collagen production promotion effect and are effective for preventing or reducing wrinkle and/or sagging caused by aging. These anti-aging composition and promoting composition comprise, as an active ingredient, a hydrogen peroxide-treated yeast hydrolysate.

摘要翻译： 提供抗老化组合物，胶原蛋白生成促进组合物，胶原凝胶收缩促进组合物和用于促进成纤维细胞/表皮细胞中整联蛋白产生的整联蛋白生产促进组合物，其具有改善的胶原蛋白生产促进作用并且有效预防 或减少由老化引起的皱纹和/或松弛。 这些抗衰老组合物和促进组合物包含作为活性成分的过氧化氢处理的酵母水解物。

公开(公告)号：US08586638B2

公开(公告)日：2013-11-19

申请号：US10580471

申请日：2004-11-22

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

IPC分类号： A61K47/12

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了角化不全抑制剂和孔还原剂，其各自包含至少一种选自甘氨酸衍生物，氨基二羧酸衍生物，酰氨基二羧酸衍生物，吡咯烷羧酸衍生物，哌啶羧酸衍生物，六亚甲基亚氨基羧酸 ，β-丙氨酸衍生物和这些衍生物的盐。 此外，提供了分别含有选自特定的甘氨酸衍生物及其盐的化合物和规定的氨基硫酸衍生物及其盐中的至少一种化合物的角化不全抑制剂，减孔剂和皮肤粗糙度防止改善剂。 此外，提供了包含这些化合物的外用皮肤制剂。

公开(公告)号：US20120053243A1

公开(公告)日：2012-03-01

申请号：US13290309

申请日：2011-11-07

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Toshii Iida ,  Shinji Inomata ,  Keiko Takada ,  Yuji Katsuta

IPC分类号： A61K31/197 ,  C07C233/83 ,  C07C235/52 ,  A61K8/44 ,  A61Q19/00 ,  C07C309/19 ,  A61K31/185 ,  A61K8/46 ,  A61P17/00 ,  C07C311/19 ,  C07C309/15

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/466 ,  A61Q1/02 ,  A61Q19/00

摘要： To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provide a parakeratosis inhibitor and a pore reducing agent each comprising at least one compound selected from the group consisting of a glycine derivative, an aminodicarboxylic acid derivative, an acylaminodicarboxylic acid derivative, a pyrrolidinecarboxylic acid derivative, a piperidinecarboxylic acid derivative, a hexamethyleneiminecarboxylic acid, a beta-alanine derivative and salts of these derivatives. Further, there are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing/ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

摘要翻译： 提供表现角化不全抑制，减孔，皮肤粗糙度防止/改善等的角化不全抑制剂，减孔剂和皮肤粗糙度防止/改善剂，进一步提供具有这些能力的外用皮肤制剂。 提供了角化不全抑制剂和孔还原剂，其各自包含至少一种选自甘氨酸衍生物，氨基二羧酸衍生物，酰氨基二羧酸衍生物，吡咯烷羧酸衍生物，哌啶羧酸衍生物，六亚甲基亚氨基羧酸 ，β-丙氨酸衍生物和这些衍生物的盐。 此外，提供了分别含有选自特定的甘氨酸衍生物及其盐的化合物和规定的氨基硫酸衍生物及其盐中的至少一种化合物的角化不全抑制剂，减孔剂和皮肤粗糙度防止改善剂。 此外，提供了包含这些化合物的外用皮肤制剂。

公开(公告)号：US20110065794A1

公开(公告)日：2011-03-17

申请号：US12926351

申请日：2010-11-12

申请人： Makoto Tsunenaga ,  Haruhi Iwaki ,  Toshii Iida ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Keiko Takada ,  Shinji Inomata

发明人： Makoto Tsunenaga ,  Haruhi Iwaki ,  Toshii Iida ,  Mikiko Kaminuma ,  Masaru Suetsugu ,  Keiko Takada ,  Shinji Inomata

IPC分类号： A61K31/197 ,  A61Q19/08

CPC分类号： A61K8/44 ,  A61K8/445 ,  A61Q19/08

摘要： A wrinkle-preventing and -improving composition comprising one or more than one compound selected from the group consisting of α-amino acid derivatives represented by the following general formula (1) and salts thereof: wherein, R1 represents hydrogen atom, CH3 group or CH2OH group, R2 and R3 each independently represent hydrogen atom, alkyl group having 1 to 4 carbons, provided that R2 and R3 cannot be hydrogen atom at the same time, or R2 and R3 together with N atom to which they are bound may form a ring structure having a total carbon number of 4 to 6, in which case said ring structure may optionally contain an oxygen atom as a heteroatom, R4 represents hydrogen atom, alkyl group having 1 to 18 carbons, wherein when R1 and R4 are hydrogen atom, it cannot be that one of R2 and R3 is benzyloxycarbonyl group and the other is hydrogen atom.

摘要翻译： 一种防皱和改善组合物，其包含一种或多于一种选自下列通式（1）表示的α-氨基酸衍生物及其盐的化合物：其中，R 1表示氢原子，CH 3基或CH 2 OH 基团，R 2和R 3各自独立地表示氢原子，具有1至4个碳的烷基，条件是R 2和R 3不能同时为氢原子，或者R 2和R 3与它们所连接的N原子可以形成环 总碳数为4〜6的结构，在这种情况下，所述环结构可任选地含有氧原子作为杂原子，R4表示氢原子，具有1至18个碳原子的烷基，其中当R 1和R 4为氢原子时， 不能是R2和R3之一是苄氧基羰基，另一个是氢原子。

公开(公告)号：US20090136540A1

公开(公告)日：2009-05-28

申请号：US12320088

申请日：2009-01-16

申请人： Keiko Takada ,  Rikako Suzuki ,  Miki Guentert ,  Shinji Inomata ,  Chika Hamada ,  Takayuki Sakiguchi

发明人： Keiko Takada ,  Rikako Suzuki ,  Miki Guentert ,  Shinji Inomata ,  Chika Hamada ,  Takayuki Sakiguchi

IPC分类号： A61K36/06

CPC分类号： A61K8/99 ,  A61Q19/08

摘要： There are provided an anti-aging composition, a collagen production promoting composition, a collagen gel contraction promoting composition, and an integrin production promoting composition for promoting integrin production in fibroblasts/epidermal cell, which have improved collagen production promotion effect and are effective for preventing or reducing wrinkle and/or sagging caused by aging. These anti-aging composition and promoting composition comprise, as an active ingredient, a hydrogen peroxide-treated yeast hydrolysate.

摘要翻译： 提供抗老化组合物，胶原蛋白生成促进组合物，胶原凝胶收缩促进组合物和用于促进成纤维细胞/表皮细胞中整联蛋白产生的整联蛋白生产促进组合物，其具有改善的胶原蛋白生产促进作用并且有效预防 或减少由老化引起的皱纹和/或松弛。 这些抗衰老组合物和促进组合物包含作为活性成分的过氧化氢处理的酵母水解物。

公开(公告)号：US20070254052A1

公开(公告)日：2007-11-01

申请号：US11819890

申请日：2007-06-29

申请人： Keiko Takada ,  Satoshi Amano ,  Toshio Nishiyama

发明人： Keiko Takada ,  Satoshi Amano ,  Toshio Nishiyama

IPC分类号： A61K36/00 ,  A61K36/482 ,  A61K36/488 ,  A61Q19/08

CPC分类号： A61Q19/08 ,  A61K8/97 ,  A61K35/20 ,  A61K36/24 ,  A61K36/48 ,  A61K36/482 ,  A61K36/484 ,  A61K36/488 ,  A61K36/59 ,  A61K36/66 ,  A61K36/896 ,  A61K2800/70 ,  A61K2300/00

摘要： The invention provides cosmetics or dermatological compositions comprising plant extract or whey extract having an action to potentiate laminin 5 productivity in the epidermal cells. They have mainly the action and efficacy to prevent or improve aging in the skin.

摘要翻译： 本发明提供了包含具有增强表皮细胞中层粘连蛋白5生产力的作用的植物提取物或乳清提取物的化妆品或皮肤病学组合物。 它们主要具有预防或改善皮肤老化的作用和功效。

公开(公告)号：US20120190745A1

公开(公告)日：2012-07-26

申请号：US13393410

申请日：2010-08-31

申请人： Yutaka Ashida ,  Keiko Takada ,  Mihoshi Yokoo ,  Yosuke Tojo

发明人： Yutaka Ashida ,  Keiko Takada ,  Mihoshi Yokoo ,  Yosuke Tojo

IPC分类号： A61K31/198 ,  A61P17/00

CPC分类号： A23C9/1322 ,  A21D2/245 ,  A23G3/44 ,  A23L7/20 ,  A23L11/09 ,  A23L27/50 ,  A23L27/60 ,  A23L33/175 ,  A23V2002/00 ,  A61K31/198 ,  A23V2200/302 ,  A23V2250/0618 ,  A23V2200/318

摘要： Provided is a novel composition that acts to inhibit and/or ameliorate wrinkle formation, does not have adverse effects like those of retinoids, and is highly photostable. An oral composition for reducing wrinkle formation and an oral composition for preventing wrinkle formation are provided, the compositions containing at least one compound selected from the group consisting of D-glutamic acid and derivatives and/or salts thereof. Also provided are a pharmaceutical composition and a food composition containing the oral composition for reducing wrinkle formation or the oral composition for preventing wrinkle formation.

摘要翻译： 提供了用于抑制和/或改善皱纹形成的新型组合物，不具有类似类维生素A的不利影响，并且是高度光稳定的。 提供了用于减少皱纹形成的口腔组合物和用于防止皱纹形成的口腔组合物，所述组合物含有至少一种选自D-谷氨酸及其衍生物和/或盐的化合物。 还提供了含有用于减少皱纹形成的口腔组合物的药物组合物和食品组合物或用于防止皱纹形成的口腔组合物。