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    Silicone type cinnamic acid derivative, preparation method thereof, UV-ray absorber, and external skin treatment agent
    7.
    发明授权
    Silicone type cinnamic acid derivative, preparation method thereof, UV-ray absorber, and external skin treatment agent 失效
    硅酮型肉桂酸衍生物，其制备方法，紫外线吸收剂和外用皮肤处理剂

    公开(公告)号：US5315022A

    公开(公告)日：1994-05-24

    申请号：US676127

    申请日：1991-03-27

    申请人： Masashi Yoshida ,  Kenichi Umishio ,  Keiichi Uehara ,  Tomiyuki Nanba

    发明人： Masashi Yoshida ,  Kenichi Umishio ,  Keiichi Uehara ,  Tomiyuki Nanba

    IPC分类号： A61K8/58 ,  A61Q17/04 ,  C07F7/08

    CPC分类号： A61K8/585 ,  A61Q17/04 ,  C07F7/0852

    摘要： A silicone type cinnamic acid derivative which is a siloxane having at least one unit represented by the formula (I): ##STR1## and having the other units which may exist in the siloxane being represented by the formula:O.sub.(4-m)/2 SiR.sub.m.sup.3wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms, a phenyl group, or a trimethylsiloxy group, R.sup.2 is a divalent hydrocarbon group having at least two carbon atoms, which may include a heteroatom, O, X is an alkoxy group, n is an integer of 0 to 3, a is an integer of 2 or 3, R.sup.3 is an alkyl group having 1 to 4 carbon atoms, a phenyl group, or a trimethylsiloxy group, and m is an integer of 0 to 3.

    摘要翻译： 硅氧烷型肉桂酸衍生物，其是具有至少一个由式（I）表示的单元的硅氧烷：其中可能存在于硅氧烷中的其它单元由下式表示：O（4- m）/ 2SiRm3其中R 1表示具有1至4个碳原子的烷基，苯基或三甲基甲硅烷氧基，R 2是具有至少两个碳原子的二价烃基，其可以包括杂原子O，X是 烷氧基，n为0〜3的整数，a为2或3的整数，R3为碳原子数1〜4的烷基，苯基或三甲基甲硅烷氧基，m为0〜 3。

    1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same
    10.
    发明授权
    1,2-DI-substituted piperidine derivative, hair growth promoter and external composition for skin using the same 有权
    1,2-DI取代的哌啶衍生物，毛发生长促进剂和使用其的皮肤外用组合物

    公开(公告)号：US6057337A

    公开(公告)日：2000-05-02

    申请号：US239960

    申请日：1999-01-29

    申请人： Koji Kobayashi ,  Hirotada Fukunishi ,  Kenichi Umishio ,  Akihiro Ishino

    发明人： Koji Kobayashi ,  Hirotada Fukunishi ,  Kenichi Umishio ,  Akihiro Ishino

    IPC分类号： C07D211/22 ,  C07D211/26 ,  C07D401/12 ,  C07D521/00 ,  A61K7/06

    CPC分类号： C07D231/12 ,  C07D211/22 ,  C07D211/26 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12

    摘要： A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C.sub.1-30 expressed by R.sup.1 and the other is --(CH.sub.2)n-NR.sup.2 R.sup.3 ; Y is --CO--, --CONR.sup.5 -- or --COO--; Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --; R.sup.2 and R.sup.3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; --NR.sup.5 --(CH.sub.2)n-NR.sup.2 R.sup.3 and --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 of --(Y).sub.1 --A and --Z--B may be the following Group W: ##STR2## wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R.sup.2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R.sup.4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R.sup.5 and R.sup.6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

    摘要翻译： 由下式（I）表示的1,2-二取代的哌啶衍生物或其盐：其中A和B中的一个为由R1表示的C1-30的烃基，另一个为 - （CH 2）n - NR2R3; Y是-CO - ， - CONR 5 - 或-COO-; Z是-O - ， - OCO - ， - OCONR 6 - 或-NR 6 - ; R2和R3各自表示氢，低级烷基，苯基或苄基，或一起表示具有3-7个成员的杂环; - （Y）1-A和-ZB的-NR 5 - （CH 2）n -NR 2 R 3和-NR 6 - （CH 2）n -NR 2 R 3可以是以下W组：其中环E是6或7个成员的杂环，包括两个 氮原子，R 2为氢，低级烷基，苯基或苄基; R4是氢，卤素，低级烷基，低级酰基，硝基，氰基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基，低级烷基氨基，低级酰基氨基，低级烷氧基或低级酰氧基。 R5和R6各自为氢，低级烷基，低级酰基，低级烷基氨基甲酰基或所述环E的一部分; l为0或1; m为2-5的整数; n为0-5的整数。 1,2-二取代的哌啶衍生物或其盐具有优异的毛发生长和再生长促进效果，其可用于哺乳动物，特别是人的护发，改善或预防脱发。