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公开(公告)号：US08729264B2
公开(公告)日：2014-05-20
申请号：US12680484
申请日：2008-09-26
申请人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
IPC分类号： C07D487/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
摘要翻译： 本发明提供含有式（I）表示的吡唑并嘧啶衍生物（其中各符号如说明书中的定义）作为活性成分的皮肤病的预防和/或治疗药剂或其药理学上可接受的盐 ，等等。
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公开(公告)号：US20100256134A1
公开(公告)日：2010-10-07
申请号：US12680484
申请日：2008-09-26
申请人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Daisuke Nakashima , Kimihisa Ueno , Mirai Mizutani , Daisuke Harada , Katsuya Kobayashi , Kazuki Hemmi
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/497 , A61P17/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
摘要： Provided is an agent for the prevention and/or treatment of a skin disease containing, as an active ingredient, a pyrazolopyrimidine derivative represented by the formula (I) (wherein each symbol is as defined in the specification), or a pharmacologically acceptable salt thereof, and the like.
摘要翻译： 本发明提供含有式（I）表示的吡唑并嘧啶衍生物（其中各符号如说明书中的定义）作为活性成分的皮肤病的预防和/或治疗药剂或其药理学上可接受的盐 ，等等。
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公开(公告)号：US20140221340A1
公开(公告)日：2014-08-07
申请号：US14241065
申请日：2012-08-31
申请人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi , Mirai Mizutani , Yuko Seno
发明人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi , Mirai Mizutani , Yuko Seno
IPC分类号： C07D491/107 , C07D487/10 , C07D487/04
CPC分类号： C07D491/107 , A61K31/519 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention provides a chemokine receptor activity modulator containing a pyrazolopyrimidine derivative represented by the formula (I) wherein R1, R2, R3, and R4 are as described herein.
摘要翻译： 本发明提供含有式（I）表示的吡唑并嘧啶衍生物的趋化因子受体活性调节剂，其中R 1，R 2，R 3和R 4如本文所述。
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公开(公告)号：US20130102620A1
公开(公告)日：2013-04-25
申请号：US13582992
申请日：2011-03-04
申请人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
IPC分类号： C07D487/04 , C07D487/10 , C07D491/107
CPC分类号： C07D487/04 , C07D487/10 , C07D491/107 , C07D519/00
摘要： The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom or aralkyl), R2 represents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, R5 represents halogen, R6 represents aryl, X represents —CR8 (wherein R8 represents a hydrogen atom), and R7 represents a hydrogen], R3 represents —SO2R13a [wherein R13a represents lower alkoxy, —NR13dC(═O)R13e (wherein R13d represents a hydrogen atom, and R13e represents lower alkyl)], and R4 represents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases.
摘要翻译： 本发明提供式（I）的吡唑并嘧啶衍生物，其中，例如，R1表示-NR1aR1b（其中R1a和R1b相同或不同，各自为氢原子或芳烷基），R2表示式（Ya）[其中k m表示0-2的整数，n表示0-4的整数，L表示单键，R5表示卤素，R6表示芳基，X表示-CR8（其中R8表示氢原子），R7表示 氢]，R3表示-SO2R13a [其中R13a表示低级烷氧基，-NR13dC（= O）R13e（其中R13d表示氢原子，R13e表示低级烷基）]，R4表示氢原子或药学上可接受的盐 其中。 本发明还提供含有吡唑并嘧啶衍生物的药物，以及使用吡唑并嘧啶衍生物预防和/或治疗皮肤病的方法。
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公开(公告)号：US08815874B2
公开(公告)日：2014-08-26
申请号：US13582992
申请日：2011-03-04
申请人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
发明人： Keisuke Yamamoto , Seiji Aratake , Kazuki Hemmi
IPC分类号： A01N43/90 , A61K31/519 , A61K38/00 , A61P17/00 , C07D491/107 , C07D487/04 , C07D519/00 , C07D487/10
CPC分类号： C07D487/04 , C07D487/10 , C07D491/107 , C07D519/00
摘要： The invention provides a pyrazolopyrimidine derivative of formula (I), wherein, for example, R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each is a hydrogen atom or aralkyl), R2 represents formula (Ya) [wherein k and m each represents an integer of 0-2, n represents an integer of 0-4, L represents a single bond, R5 represents halogen, R6 represents aryl, X represents —CR8 (wherein R8 represents a hydrogen atom), and R7 represents a hydrogen], R3 represents —SO2R13a [wherein R13a represents lower alkoxy, —NR13dC(═O)R13e (wherein R13d represents a hydrogen atom, and R13e represents lower alkyl)], and R4 represents a hydrogen atom, or a pharmaceutically acceptable salt thereof. The invention also provides a medicament containing the pyrazolopyrimidine derivative, as well as a method of using the pyrazolopyrimidine derivative to prevent and/or treat skin diseases.
摘要翻译： 本发明提供式（I）的吡唑并嘧啶衍生物，其中，例如，R1表示-NR1aR1b（其中R1a和R1b相同或不同，各自为氢原子或芳烷基），R2表示式（Ya）[其中k m表示0-2的整数，n表示0-4的整数，L表示单键，R5表示卤素，R6表示芳基，X表示-CR8（其中R8表示氢原子），R7表示 氢]，R 3表示-SO 2 R 13 a [其中R 13a表示低级烷氧基，-NR 13 d C（= O）R 13e（其中R 13d表示氢原子，R 13e表示低级烷基）]，R 4表示氢原子或其药学上可接受的盐 其中。 本发明还提供含有吡唑并嘧啶衍生物的药物，以及使用吡唑并嘧啶衍生物预防和/或治疗皮肤病的方法。
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公开(公告)号：US08486980B2
公开(公告)日：2013-07-16
申请号：US13057599
申请日：2009-08-06
申请人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
发明人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
IPC分类号： A61K31/4245 , A61K31/335 , A61K31/4184 , A61K31/4188 , C07D271/07 , C07D313/10 , C07D235/00 , C07D235/04
CPC分类号： C07D471/04 , A61K31/335 , A61K31/4184 , A61K31/422 , A61K31/4353 , A61K31/4409 , C07C255/34 , C07C255/44 , C07D235/08 , C07D235/16 , C07D257/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14
摘要： Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
摘要翻译： 本发明提供具有PPARγ激动剂活性的三环化合物，其通式（I）表示，其中Z表示单键等，Y表示氢原子，任选具有取代基的低级烷基等， X表示氢原子等，A表示芳基等，B和C相同或不同，各自表示芳香族碳环等，R4-R9相同或不同，表示氢等， V表示单键等，R 10和R 11相同或不同，各自表示氢等，或其药学上可接受的盐等：
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公开(公告)号：US20140163008A1
公开(公告)日：2014-06-12
申请号：US14236545
申请日：2011-08-03
IPC分类号： C07D495/04 , C07D471/04 , C07D487/04 , C07D413/14
CPC分类号： C07D495/04 , A61K31/335 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D413/14 , C07D471/04 , C07D487/04
摘要： A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPARγ agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.
摘要翻译： 由以下通式（I）表示的二苯并氧杂环己烷衍生物，其中Y为氢原子等，RA为氢原子等，X为式（b3），其中RB为氢原子等， A是式（a18），其中R1是氢原子等，RC和RD相同或不同，各自是具有PPARγ激动剂活性的氢原子等，以及 作为2型糖尿病等的治疗剂和/或预防剂等，或其药学上可接受的盐等有用。
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公开(公告)号：US08969345B2
公开(公告)日：2015-03-03
申请号：US14236545
申请日：2012-08-03
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/5025 , A61K31/519
CPC分类号： C07D495/04 , A61K31/335 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D413/14 , C07D471/04 , C07D487/04
摘要： A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPARγ agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.
摘要翻译： 由以下通式（I）表示的二苯并氧杂环己烷衍生物，其中Y为氢原子等，RA为氢原子等，X为式（b3），其中RB为氢原子等， A是式（a18），其中R1是氢原子等，RC和RD相同或不同，各自是具有PPARγ激动剂活性的氢原子等，以及 作为2型糖尿病等的治疗剂和/或预防剂等，或其药学上可接受的盐等有用。
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公开(公告)号：US20110201640A1
公开(公告)日：2011-08-18
申请号：US13057599
申请日：2009-08-06
申请人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
发明人： Arata Yanagisawa , Keiji Uehara , Masahiro Matsubara , Kimihisa Ueno , Michihiko Suzuki , Takeshi Kuboyama , Keisuke Yamamoto , Tomohiro Tamura
IPC分类号： A61K31/4184 , C07D235/16 , C07D403/06 , C07D413/10 , A61K31/4245 , C07D471/04 , A61K31/437 , C07D413/14 , A61K31/41 , C07D405/14 , A61K31/422 , C07D491/044 , A61K31/4353 , A61P3/10 , A61P9/12 , A61P3/04 , A61P35/00
CPC分类号： C07D471/04 , A61K31/335 , A61K31/4184 , A61K31/422 , A61K31/4353 , A61K31/4409 , C07C255/34 , C07C255/44 , C07D235/08 , C07D235/16 , C07D257/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14
摘要： Provided is a tricyclic compound having a PPAR γ agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:
摘要翻译： 本发明提供具有PPARγ激动剂活性的三环化合物，其通式（I）表示，其中Z表示单键等，Y表示氢原子，任选具有取代基的低级烷基等， X表示氢原子等，A表示芳基等，B和C相同或不同，各自表示芳香族碳环等，R4-R9相同或不同，表示氢等， V表示单键等，R 10和R 11相同或不同，各自表示氢等，或其药学上可接受的盐等：
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10.发明授权公开(公告)号：US09337894B2
公开(公告)日：2016-05-10
申请号：US13811944
申请日：2011-07-29
摘要： The disclosed electromagnetic wave transmission medium prevents electromagnetic leakage during high-power electromagnetic wave transmission. The sheet-form electromagnetic wave transmission medium is configured from a first mesh conductor used in transmission of electromagnetic waves having a first power; and a second mesh conductor used in transmission of electromagnetic waves having a second power. By using two mesh conductors, when said sheet-form electromagnetic wave transmission medium is used, the conduction density of the surface region where electromagnetic waves are extracted to be used for power supply assumes a coarser state than that of the other surface region.
摘要翻译： 所公开的电磁波传输介质防止在大功率电磁波传输期间的电磁泄漏。 片状电磁波传输介质由用于传输具有第一功率的电磁波的第一网状导体构成; 以及用于传输具有第二功率的电磁波的第二网状导体。 通过使用两个网状导体，当使用所述片状电磁波传输介质时，提取电磁波的表面区域的导电密度用于供电，呈现比其他表面区域更粗糙的状态。
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