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    Intracranial monitoring and therapy delivery control device, system and method
    1.
    发明授权
    Intracranial monitoring and therapy delivery control device, system and method 有权
    颅内监测和治疗传递控制装置，系统和方法

    公开(公告)号：US06248080B1

    公开(公告)日：2001-06-19

    申请号：US09299774

    申请日：1999-04-26

    申请人： Keith A. Miesel ,  Lee Stylos

    发明人： Keith A. Miesel ,  Lee Stylos

    IPC分类号： A61B503

    CPC分类号： A61N1/36557 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/02154 ,  A61B5/031 ,  A61B5/076 ,  A61B5/14539 ,  A61B5/1459 ,  A61B5/6864 ,  A61N1/05 ,  A61N1/056 ,  A61N1/36585 ,  Y10S977/90

    摘要： An implantable medical device having an hermetically sealed enclosure housing electrical and electronic circuitry and a battery for powering such circuitry is connected to an intracranial lead or pigtail which measures or senses intracranial physiologic signals such as intracranial fluid pressure and/or temperature. The implantable medical device is preferably implanted subcutaneously beneath a patient's skin and telemeters stored data or real-time-sensed data to an external device which may be configured to combine barometric pressure data with intracranial pressure data to derive intracranial gage pressure. The implantable medical device and its associated lead reduce the risk of intracranial infections.

    摘要翻译： 具有容纳电气和电子电路的气密密封的壳体和用于为这种电路供电的电池的可植入医疗装置连接到测量或感测颅内生理信号如颅内流体压力和/或温度的颅内引线或尾纤。 优选将植入式医疗装置皮下植入患者皮肤下方，并将电能存储数据或实时检测数据传输到外部装置，外部装置可被配置为将大气压力数据与颅内压数据组合以导出颅内计量压力。 可植入医疗器械及其相关的导线可降低颅内感染的风险。

    Implantable medical device for sensing absolute blood pressure and barometric pressure
    3.
    发明授权
    Implantable medical device for sensing absolute blood pressure and barometric pressure 失效
    用于感测绝对血压和大气压力的植入式医疗装置

    公开(公告)号：US6024704A

    公开(公告)日：2000-02-15

    申请号：US70310

    申请日：1998-04-30

    申请人： John T. Meador ,  Keith A. Miesel ,  Louis E. Halperin ,  Robert T. Taepke, II ,  Lee Stylos

    发明人： John T. Meador ,  Keith A. Miesel ,  Louis E. Halperin ,  Robert T. Taepke, II ,  Lee Stylos

    IPC分类号： A61B5/0215 ,  A61B5/03 ,  A61B5/02

    CPC分类号： A61B5/0215 ,  A61B5/03 ,  A61B2560/0257 ,  A61M1/122 ,  A61M2205/702

    摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.

    摘要翻译： 与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。 在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。 在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。 在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室 压力传感器。 大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。 或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。

    Implantable medical device for sensing absolute blood pressure and barometric pressure
    5.
    发明授权
    Implantable medical device for sensing absolute blood pressure and barometric pressure 有权
    用于感测绝对血压和大气压力的植入式医疗装置

    公开(公告)号：US06234973B1

    公开(公告)日：2001-05-22

    申请号：US09442855

    申请日：1999-11-18

    申请人： John T. Meador ,  Keith A. Miesel ,  Louis E. Halperin ,  Robert T. Taepke, II ,  Lee Stylos

    发明人： John T. Meador ,  Keith A. Miesel ,  Louis E. Halperin ,  Robert T. Taepke, II ,  Lee Stylos

    IPC分类号： A61B502

    CPC分类号： A61B5/0215 ,  A61B5/03 ,  A61B2560/0257 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/122 ,  A61M2205/702

    摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.

    摘要翻译： 与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。 在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。 在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。 在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室 压力传感器。 大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。 或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。

    Non-invasive cardiac monitoring system and method with communications interface
    6.
    发明授权
    Non-invasive cardiac monitoring system and method with communications interface 失效
    非侵入性心脏监测系统及方法与通讯接口

    公开(公告)号：US6162180A

    公开(公告)日：2000-12-19

    申请号：US221038

    申请日：1998-12-28

    申请人： Keith A. Miesel ,  Lee Stylos

    发明人： Keith A. Miesel ,  Lee Stylos

    IPC分类号： A61B5/083 ,  A61N1/365 ,  A61B5/08 ,  A61B5/02

    CPC分类号： A61B5/083 ,  A61N1/36557

    摘要： A system and method for determining a patient's cardiac output in a non-invasive manner and transmitting cardiac output data to a remote host processor, a communications system, or a local output device is disclosed. A non-invasive cardiac monitoring approach utilizes an implantable medical device coupled to an oxygen sensor. The oxygen sensor provides venous oxygen saturation data to the implantable medical device. An oxygen consumption unit produces oxygen consumption data using air exhaled by a patient. A processing unit calculates a cardiac output result in real-time using the venous oxygen saturation data, the oxygen consumption data, and arterial oxygen saturation data assumed to be about 100% or acquired using a sensor external to the patient. The implantable medical device may transmit the venous oxygen saturation data to the processing unit using electromagnetic signals or acoustic signals. The implantable medical device may be a pacemaker, a pacemaker/cardioverter/defibrillator (PCD), an oxygen sensing device, or an implantable hemodynamic monitor. The processing unit may store the cardiac output data/result for a period of time and/or communicate the cardiac output result to the remote host processor substantially in real-time via a communications interface. The interface may include a modem, a computer interface, a network interface, or a communications system interface, for example. The processing unit may communicate the cardiac output result to the remote host processor in an analog, digital or optical form.

    摘要翻译： 公开了一种用于以非侵入性方式确定患者心输出量并将心输出量数据传送到远程主机处理器，通信系统或本地输出设备的系统和方法。 非侵入式心脏监测方法利用耦合到氧传感器的可植入医疗装置。 氧传感器向可植入医疗装置提供静脉氧饱和度数据。 耗氧单元使用患者呼出的空气产生氧气消耗数据。 处理单元使用假定为约100％的静脉血氧饱和度数据，氧耗数据和动脉血氧饱和度数据，使用患者外部的传感器获取，来实时计算心输出量结果。 可植入医疗装置可以使用电磁信号或声信号将静脉氧饱和度数据传送到处理单元。 可植入医疗装置可以是起搏器，起搏器/心律转复器/除颤器（PCD），氧气感测装置或可植入血液动力学监测器。 处理单元可以将心输出数据/结果存储一段时间和/或通过通信接口实时地将心输出结果传送到远程主机处理器。 该接口可以包括例如调制解调器，计算机接口，网络接口或通信系统接口。 处理单元可以以模拟，数字或光学形式将心输出结果传送到远程主机处理器。

    Implantable medical device with automatic ischemia threshold determination
    7.
    发明授权
    Implantable medical device with automatic ischemia threshold determination 有权
    具有自动缺血阈值测定的植入式医疗器械

    公开(公告)号：US07996084B2

    公开(公告)日：2011-08-09

    申请号：US11379290

    申请日：2006-04-19

    申请人： Lee Stylos ,  Todd J. Sheldon ,  Steven N. Lu ,  William J. Combs ,  Robert J. Nehls

    发明人： Lee Stylos ,  Todd J. Sheldon ,  Steven N. Lu ,  William J. Combs ,  Robert J. Nehls

    IPC分类号： A61N1/08

    CPC分类号： A61N1/3702 ,  A61N1/36514 ,  A61N1/36542 ,  A61N1/36557 ,  A61N1/37252

    摘要： An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.

    摘要翻译： 可植入医疗装置（IMD）执行患者的周期性测试以确定缺血阈值信息。 在患者静止时的选定时间，IMD随着时间的推移增加起搏速率，直到其从患者或缺血传感器接收到反馈。 IMD根据接收到反馈时的起搏速率来确定阈值。 阈值信息可以用于调整速率自适应起搏期间可以使用的上起搏速率，以确定药物治疗的效果，并提供患者冠状动脉疾病状态的一般指示。 对缺血区的起搏速率的周期性增加也提供心肌的预处理，以允许患者在没有心绞痛的情况下更大的运动益处。