公开(公告)号：US20090248001A1

公开(公告)日：2009-10-01

申请号：US12271013

申请日：2008-11-14

申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61F7/12 ,  A61B18/0218 ,  A61B2018/00452 ,  A61B2018/0293 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0087 ,  A61F2007/0094 ,  A61F2007/0285 ,  A61F2007/126

摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

摘要翻译： 用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。 替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。 在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

公开(公告)号：US20080154254A1

公开(公告)日：2008-06-26

申请号：US11614887

申请日：2006-12-21

申请人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

发明人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00747 ,  A61B2018/00452 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.

摘要翻译： 医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。 实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。 治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量 冷却液。 可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

公开(公告)号：US08715275B2

公开(公告)日：2014-05-06

申请号：US13615059

申请日：2012-09-13

申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/18

CPC分类号： A61F7/12 ,  A61B18/0218 ,  A61B2018/00452 ,  A61B2018/0293 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0087 ,  A61F2007/0094 ,  A61F2007/0285 ,  A61F2007/126

摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

摘要翻译： 用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。 替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。 在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

公开(公告)号：US20080200910A1

公开(公告)日：2008-08-21

申请号：US11675886

申请日：2007-02-16

申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02 ,  A61M5/31

CPC分类号： A61B18/0218 ,  A61B18/02 ,  A61B2017/00747 ,  A61B2018/00023 ,  A61B2018/00458 ,  A61B2018/0262 ,  A61B2018/0293

摘要： The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion. Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be controlled through depletion of liquid from an evaporating cryogenic cooling flow. Hence, even needles having similar external structures may provide differing lengths of an iceball along the needle axis. Surprisingly, small cryogenic cooling needles and/or other cryogenic cooling probes having a lubricious coating will allow safe removal of the probe from the treatment region while at a least a portion of the tissue remains frozen, significantly decreasing the overall time for a procedure involving many insertion/freeze/removal cycles.

摘要翻译： 本发明通常提供改进的医疗装置，系统和方法。 实施方案可以特别适用于治疗皮肤病和/或美容缺陷，并且替代实施方案可以被配置用于治疗大范围的靶组织。 本发明的一些实施方案用至少一个小的穿透组织的探针进行冷却，所述探针通常包括适于穿过患者皮肤的暴露表面插入的尺寸的针，而不留下可见的瘢痕。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 示例性实施例使用由探针主体手柄支撑的可替换的针探针，在单个患者的治疗期间经常更换小的针头探针。 与过去的大型低温冷却系统不同，小型低温冷却针探针可能会沉没或被插入而损坏。 将低温冷却液控制到针头探针中的仔细控制可以通过从蒸发的低温冷却流中消耗液体来控制主动冷却的长度。 因此，即使具有相似外部结构的针也可以沿针轴提供不同长度的冰球。 令人惊讶的是，具有光滑涂层的小型低温冷却针和/或其它低温冷却探针将允许从处理区域安全地移除探针，同时在组织的至少一部分保持冷冻，显着降低涉及许多方法的程序的总体时间 插入/冻结/去除循环。

公开(公告)号：US09254162B2

公开(公告)日：2016-02-09

申请号：US11614887

申请日：2006-12-21

申请人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

发明人： Keith Burger ,  Ronald Williams ,  Lisa Elkins

IPC分类号： A61B18/02 ,  A61B17/00 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B2017/00747 ,  A61B2018/00452 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Medical devices, systems, and methods optionally treat dermatological and/or cosmetic defects, and/or a wide range of additional target tissues. Embodiments apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. Treatment may be applied along most or all of the insertable length of an elongate needle, optionally by introducing cryogenic cooling fluid into the needle lumen through a small, tightly-toleranced lumen of a fused silica fluid supply tube, with the supply tube lumen often metering the cooling fluid. Treatment temperature and/or time control may be enhanced using a simple pressure relief valve coupled to the needle lumen via a limited total exhaust volume space.

摘要翻译： 医疗装置，系统和方法可任选地治疗皮肤病和/或美容缺陷，和/或广泛的其它靶组织。 实施例用至少一个小的组织穿透探针进行冷却，所述探针通常包括具有适合于穿过患者皮肤的暴露表面插入的尺寸的针而不留下可见的瘢痕。 治疗可以沿着细长针的大部分或全部可插入长度施加，任选地通过将低温冷却流体通过熔融二氧化硅流体供应管的小的，紧密公差的管腔引入针内腔，供应管内腔经常计量 冷却液。 可以通过经由有限的总排气量空间耦合到针内腔的简单的压力释放阀来增强治疗温度和/或时间控制。

公开(公告)号：US20130218148A1

公开(公告)日：2013-08-22

申请号：US13615059

申请日：2012-09-13

申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61F7/12 ,  A61B18/0218 ,  A61B2018/00452 ,  A61B2018/0293 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0087 ,  A61F2007/0094 ,  A61F2007/0285 ,  A61F2007/126

摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

摘要翻译： 用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。 替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。 在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

公开(公告)号：US08409185B2

公开(公告)日：2013-04-02

申请号：US11675886

申请日：2007-02-16

申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/18

CPC分类号： A61B18/0218 ,  A61B18/02 ,  A61B2017/00747 ,  A61B2018/00023 ,  A61B2018/00458 ,  A61B2018/0262 ,  A61B2018/0293

摘要： The present invention generally provides improved medical devices, systems, and methods. Embodiments may be particularly well suited for the treatment of dermatological and/or cosmetic defects, and alternative embodiments may be configured for treatment of a wide range of target tissues. Some embodiments of the present invention apply cooling with at least one small, tissue-penetrating probe, the probe often comprising a needle having a size suitable for inserting through an exposed surface of the skin of a patient without leaving a visible scar. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments make use of replaceable needle probes supported by a probe body handle, with small needle probes often being replaced during treatment of a single patient. Unlike the large format cryogenic cooling systems of the past, small cryogenic cooling needle probes may dull or be damaged by insertion. Careful control over the control of cryogenic cooling fluid into a needle probe can allow the length of the active cooling to be controlled through depletion of liquid from an evaporating cryogenic cooling flow. Hence, even needles having similar external structures may provide differing lengths of an iceball along the needle axis. Surprisingly, small cryogenic cooling needles and/or other cryogenic cooling probes having a lubricious coating will allow safe removal of the probe from the treatment region while at a least a portion of the tissue remains frozen, significantly decreasing the overall time for a procedure involving many insertion/freeze/removal cycles.

摘要翻译： 本发明通常提供改进的医疗装置，系统和方法。 实施方案可以特别适用于治疗皮肤病和/或美容缺陷，并且替代实施方案可以被配置用于治疗大范围的靶组织。 本发明的一些实施方案用至少一个小的穿透组织的探针进行冷却，所述探针通常包括适于穿过患者皮肤的暴露表面插入的尺寸的针，而不留下可见的瘢痕。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 示例性实施例使用由探针主体手柄支撑的可替换的针探针，在单个患者的治疗期间经常更换小的针头探针。 与过去的大型低温冷却系统不同，小型低温冷却针探针可能会沉没或被插入而损坏。 将低温冷却液控制到针头探针中的仔细控制可以通过从蒸发的低温冷却流中消耗液体来控制主动冷却的长度。 因此，即使具有相似外部结构的针也可以沿针轴提供不同长度的冰球。 令人惊讶的是，具有光滑涂层的小型低温冷却针和/或其它低温冷却探针将允许从处理区域安全地移除探针，同时在组织的至少一部分保持冷冻，显着降低涉及许多方法的程序的总体时间 插入/冻结/去除循环。

公开(公告)号：US08298216B2

公开(公告)日：2012-10-30

申请号：US12271013

申请日：2008-11-14

申请人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

发明人： Keith Burger ,  Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61F7/12 ,  A61B18/0218 ,  A61B2018/00452 ,  A61B2018/0293 ,  A61F7/00 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0087 ,  A61F2007/0094 ,  A61F2007/0285 ,  A61F2007/126

摘要： Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

摘要翻译： 用于疼痛管理和其它应用的医疗装置，系统和方法可以用至少一个穿过皮肤暴露的皮肤表面插入的探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现目标组织的组成所需的改变和/或其行为的变化，经常干扰沿着感觉神经传递疼痛信号。 替代实施例可能干扰运动神经的功能，收缩肌肉的功能，和/或包含在收缩功能链中的一些其他组织，以便抑制肌肉收缩，从而减轻相关的疼痛。 在一些实施例中，可以治疗其他疼痛源，例如脊柱的部件（可选地包括突出的椎间盘）。

公开(公告)号：US07850683B2

公开(公告)日：2010-12-14

申请号：US11770185

申请日：2007-06-28

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

公开(公告)号：US09072498B2

公开(公告)日：2015-07-07

申请号：US12948659

申请日：2010-11-17

申请人： Lisa Elkins ,  Ronald Williams

发明人： Lisa Elkins ,  Ronald Williams

IPC分类号： A61B18/02 ,  A61B5/15 ,  A61B18/14 ,  A61B17/00 ,  A61B18/00

CPC分类号： A61B18/02 ,  A61B18/14 ,  A61B2017/00747 ,  A61B2018/00041 ,  A61B2018/0262 ,  A61B2018/0293

摘要： Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and/or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve/muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

摘要翻译： 装置，系统和方法处理化妆品缺陷，并且经常使用插入穿过患者皮肤的至少一个组织穿透探针施加冷却。 冷却可以改变一个或多个靶组织，以便实现靶组织的组合物的期望变化和/或其行为的改变。 冷却处理的示例性实施方案将干扰神经/肌肉收缩功能链，以减轻皮肤的皱纹。 相关治疗可用于治疗背部和其它肌肉痉挛，慢性疼痛等。 一些实施方案可改变皮下脂肪组织以改变皮肤表面的形状或外观。