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公开(公告)号：US08951964B2
公开(公告)日：2015-02-10
申请号：US13339448
申请日：2011-12-29
申请人： Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
发明人： Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
IPC分类号： A61K38/00 , A01N37/18 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US20120295842A1
公开(公告)日：2012-11-22
申请号：US13339448
申请日：2011-12-29
申请人： Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
发明人： Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , David J. Grampovnik , Brian Green , Timothy Middleton , Todd Hopkins , Yat Sun Or
CPC分类号： C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US20120196792A1
公开(公告)日：2012-08-02
申请号：US13439551
申请日：2012-04-04
申请人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Ken Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
发明人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Ken Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
CPC分类号： C07K1/113 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US20100144608A1
公开(公告)日：2010-06-10
申请号：US12584716
申请日：2009-09-10
申请人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Ken Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
发明人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik , Ying Sun , Dong Liu , Yonghua Gai , Yat Sun Or , Seble H. Wagaw , Ken Engstrom , Tim Grieme , Ahmad Sheikh , Jianzhang Mei
IPC分类号： A61K38/12 , C07D487/04 , A61P31/12
CPC分类号： C07K1/113 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US08748374B2
公开(公告)日：2014-06-10
申请号：US13154721
申请日：2011-06-07
申请人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarllla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
发明人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarllla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
IPC分类号： A61K38/00
CPC分类号： C07K5/081 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US20120101031A1
公开(公告)日：2012-04-26
申请号：US13154721
申请日：2011-06-07
申请人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
发明人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
CPC分类号： C07K5/081 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US08420596B2
公开(公告)日：2013-04-16
申请号：US12584716
申请日：2009-09-10
申请人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik
发明人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik
IPC分类号： A61K38/00
CPC分类号： C07K1/113 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US08642538B2
公开(公告)日：2014-02-04
申请号：US13439551
申请日：2012-04-04
申请人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik
发明人： Yiyin Ku , Keith F. McDaniel , Hui-Ju Chen , Jason P. Shanley , Dale J. Kempf , David J. Grampovnik
CPC分类号： C07K1/113 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
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公开(公告)号：US07910595B2
公开(公告)日：2011-03-22
申请号：US11613810
申请日：2006-12-20
申请人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
发明人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC分类号： C07D471/04 , A01N31/519 , A61P31/12
CPC分类号： C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译： 公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。 本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。
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公开(公告)号：US07915411B2
公开(公告)日：2011-03-29
申请号：US11613825
申请日：2006-12-20
申请人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
发明人： David A. Betebenner , David A. DeGoey , Clarence J. Maring , Allan C. Krueger , Nobuhiko Iwasaki , Todd W. Rockway , Curt S. Cooper , David D. Anderson , Pamela L. Donner , Brian E. Green , Dale J. Kempf , Dachun Liu , Keith F. McDaniel , Darold L. Madigan , Christopher E. Motter , John K. Pratt , Jason P. Shanley , Michael D. Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami J. Pilot-Matias , Sherie V L. Masse , Robert J. Carrick , Wenping He , Liangjun Lu , David J. Grampovnik
IPC分类号： C07D471/04 , A61P1/16
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
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