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1.发明授权公开(公告)号：US06770488B1
公开(公告)日：2004-08-03
申请号：US09527226
申请日：2000-03-16
IPC分类号： G01N33553
CPC分类号： G01N21/658 , G01N33/54313 , G01N2021/651 , G01N2201/101 , G01N2201/102 , G01N2201/129 , Y10S435/968 , Y10S435/973 , Y10S436/805
摘要： A colloidal system for detection of a variety of analytes involves techniques which permit reconstitution of a desiccated substance such as for surface enhanced Raman spectroscopic analysis and multiple sensors at once, each having different spectra through the use of markers or the like. Competitive assay techniques and a variety of substances are explained to permit a practical an versatile system which can also be used for immunological assays and can include antibodies tagged to provide spectroscopic indicia.
摘要翻译： 用于检测各种分析物的胶体系统涉及允许重新构建干燥物质的技术，例如用于表面增强拉曼光谱分析和多个传感器，每个传感器通过使用标记物等具有不同的光谱。 解释竞争性测定技术和各种物质以允许实用的通用系统，其也可用于免疫测定，并且可以包括标记以提供光谱标记的抗体。
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公开(公告)号：US06558956B1
公开(公告)日：2003-05-06
申请号：US09446168
申请日：1999-12-17
IPC分类号： G01N2165
CPC分类号： G01N21/658 , Y10S436/815 , Y10S436/816 , Y10S436/901 , Y10T436/14 , Y10T436/141111 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/163333 , Y10T436/170769
摘要： Techniques and devices for detecting and analyzing controlled substances and the like are discussed including highly reactive sensor molecules which are coated on a spectroscopic sample surface (4) and which may chemically react with a given analyte to form a covalently bonded adduct with spectral characteristics unique to the new adduct. The techniques provide the basis of a detection system with high sensitivity and high specificity in which the surface can even be washed to remove interfering or nonreactive compounds. The sensor molecules which comprise the coating (8) may have three major components: a central molecular scaffold (“CMS”), a “tether” terminated by a surface attachment group “SAG,” and a reactive functional group “RFG” which may be highly reactive towards certain classes of molecules. One or more modifiers or modifier groups “Z” which may serve to increase or decrease the reactivity of the RFG towards target analytes, or to modify the spectral characteristics of the adduct may also be included. Some sensor molecules include diazonium compounds, activated acyls, and nitrosos.
摘要翻译： 讨论了用于检测和分析受控物质等的技术和装置，其包括涂覆在光谱样品表面（4）上的高反应性传感器分子，并且其可以与给定的分析物发生化学反应，以形成共价键合的加合物， 新加入。 该技术提供了具有高灵敏度和高特异性的检测系统的基础，其中表面甚至可以被洗涤以除去干扰或非反应性化合物。 包含涂层（8）的传感器分子可以具有三个主要组分：中心分子支架（“CMS”），由表面附着基团“SAG”终止的“连接臂”和可能的表面附着基团“RFG”的反应性官能团“RFG” 对某些类别的分子具有高反应性。 还可以包括一种或多种改性剂或修饰基团“Z”，其可用于增加或降低RFG对靶分析物的反应性，或修饰加合物的光谱特征。 一些传感器分子包括重氮化合物，活化的酰基和亚硝基。
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公开(公告)号：US20100291701A1
公开(公告)日：2010-11-18
申请号：US12843997
申请日：2010-07-27
IPC分类号： B01L3/00
CPC分类号： G01N21/658
摘要： An assay method and kit for detecting a chemical. The method and kit utilize a metal surface capable of surface enhanced Raman Scattering. The metal surface may be provided in the form of one or more nanoparticles, to increase the surface enhanced Raman Scattering capability of the metal surface. The nanoparticles may be treated with one or more additives to further enhance or maintain the surface enhanced Raman Scattering capability of the nanoparticles.
摘要翻译： 用于检测化学物质的测定方法和试剂盒。 该方法和试剂盒利用能够进行表面增强拉曼散射的金属表面。 金属表面可以以一种或多种纳米颗粒的形式提供，以增加金属表面的表面增强的拉曼散射能力。 可以用一种或多种添加剂处理纳米颗粒以进一步增强或维持纳米颗粒的表面增强的拉曼散射能力。
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4.发明授权
公开(公告)号：US5327211A
公开(公告)日：1994-07-05
申请号：US788900
申请日：1991-11-07
申请人： Keith T. Carron , Kenneth I. Mullen
发明人： Keith T. Carron , Kenneth I. Mullen
CPC分类号： G01N21/658 , C03C25/102 , G01N21/7703 , G01N2021/656 , G01N2021/772
摘要： A process for indicator coating of SERS fiber-optic probes comprising selecting a potentially roughened probe which is enhanced with a deposited silver film and then treated by chemisorption on said probe to form a molecular-specific coating, such as by employing Eriochrome Black T for metal ions, octadecyl mercaptan for organics, or Cresol Red for pH.
摘要翻译： 一种用于SERS光纤探针的指示剂涂覆的方法，包括选择潜在的粗糙化的探针，其被沉积的银膜增强，然后通过所述探针上的化学吸附进行处理以形成分子特异性涂层，例如通过将Eriochrome Black T用于金属 离子，有机物的十八烷基硫醇，或pH值的甲酚红。
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公开(公告)号：US20090135417A1
公开(公告)日：2009-05-28
申请号：US12268419
申请日：2008-11-10
申请人： Keith T. Carron , Mark Watson , Shane Buller
发明人： Keith T. Carron , Mark Watson , Shane Buller
IPC分类号： G01J3/44
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0272 , G01J3/44
摘要： A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.
摘要翻译： 描述了一种分光系统，其将激发光束的焦点中的至少一个提供到样本上，用于收集分光信号的光谱系统的光学系统的自动聚焦和/或样品的表面积上的激发强度的平均值 。
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公开(公告)号：US07776610B2
公开(公告)日：2010-08-17
申请号：US10840090
申请日：2004-05-06
CPC分类号： G01N21/658
摘要： An assay method and kit for detecting a chemical. The method and kit utilize a metal surface capable of surface enhanced Raman Scattering. The metal surface may be provided in the form of one or more nanoparticles, to increase the surface enhanced Raman Scattering capability of the metal surface. The nanoparticles may be treated with one or more additives to further enhance or maintain the surface enhanced Raman Scattering capability of the nanoparticles.
摘要翻译： 用于检测化学物质的测定方法和试剂盒。 该方法和试剂盒利用能够进行表面增强拉曼散射的金属表面。 金属表面可以以一种或多种纳米颗粒的形式提供，以增加金属表面的表面增强的拉曼散射能力。 可以用一种或多种添加剂处理纳米颗粒以进一步增强或维持纳米颗粒的表面增强的拉曼散射能力。
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公开(公告)号：US09097675B2
公开(公告)日：2015-08-04
申请号：US13160985
申请日：2011-06-15
IPC分类号： G01N33/553 , G01N21/65 , G01N33/543
CPC分类号： G01N21/658 , G01N33/54373 , G01N33/54393 , Y10T436/25
摘要： An assay and method of making same for use in SERS spectroscopy. The assay includes colloidal particles of a metal, which have been lyophilized. The lyophilized particles of metal produce a SERS active solution when reconstituted. The lyophilized particles of metal may be provided in a container in an assay system.
摘要翻译： 一种用于SERS光谱法的测定方法和制备方法。 该测定法包括已经被冻干的金属的胶体颗粒。 重新配制时，冻干的金属颗粒产生SERS活性溶液。 冻干的金属颗粒可以提供在测定系统的容器中。
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公开(公告)号：US08125637B2
公开(公告)日：2012-02-28
申请号：US12268419
申请日：2008-11-10
申请人： Keith T. Carron , Mark Watson , Shane Buller
发明人： Keith T. Carron , Mark Watson , Shane Buller
CPC分类号： G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0272 , G01J3/44
摘要： A spectroscopic system is described that provides at least one of focus of an excitation beam onto a sample, automatic focus of an optical system of the spectroscopic system for collecting a spectroscopic signal, and/or averaging of excitation intensity over a surface area of the sample.
摘要翻译： 描述了一种分光系统，其将激发光束的焦点中的至少一个提供到样本上，用于收集分光信号的光谱系统的光学系统的自动聚焦和/或样品的表面积上的激发强度的平均值 。
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9.发明申请公开(公告)号：US20110294230A1
公开(公告)日：2011-12-01
申请号：US13160985
申请日：2011-06-15
IPC分类号： G01N33/553
CPC分类号： G01N21/658 , G01N33/54373 , G01N33/54393 , Y10T436/25
摘要： An assay and method of making same for use in SERS spectroscopy. The assay includes colloidal particles of a metal, which have been lyophilized. The lyophilized particles of metal produce a SERS active solution when reconstituted. The lyophilized particles of metal may be provided in a container in an assay system.
摘要翻译： 一种用于SERS光谱法的测定方法和制备方法。 该测定法包括已经被冻干的金属的胶体颗粒。 重新配制时，冻干的金属颗粒产生SERS活性溶液。 冻干的金属颗粒可以提供在测定系统的容器中。
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公开(公告)号：US07993933B2
公开(公告)日：2011-08-09
申请号：US12843997
申请日：2010-07-27
IPC分类号： B01L3/00
CPC分类号： G01N21/658
摘要： An assay method and kit for detecting a chemical. The method and kit utilize a metal surface capable of surface enhanced Raman Scattering. The metal surface may be provided in the form of one or more nanoparticles, to increase the surface enhanced Raman Scattering capability of the metal surface. The nanoparticles may be treated with one or more additives to further enhance or maintain the surface enhanced Raman Scattering capability of the nanoparticles.
摘要翻译： 用于检测化学物质的测定方法和试剂盒。 该方法和试剂盒利用能够进行表面增强拉曼散射的金属表面。 金属表面可以以一种或多种纳米颗粒的形式提供，以增加金属表面的表面增强的拉曼散射能力。 可以用一种或多种添加剂处理纳米颗粒以进一步增强或维持纳米颗粒的表面增强的拉曼散射能力。
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