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1.N-(1-PHENYL-2-ARYLETHYL)-4,5-DIHYDRO-2H-PYRROL-5-AMINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B OR ALPHA2B AND ALPHA2C ADRENOCEPTORS 失效
标题翻译: 作为ALPHA2B或ALPHA2B和ALPHA2C ADRENOCEPTORS的亚型选择性调节剂的N-(1-苯基-2-芳基)-4,5-二氢-2H-吡喃-5-胺化合物公开(公告)号:US20100145061A1
公开(公告)日:2010-06-10
申请号:US12632494
申请日:2009-12-07
申请人: Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst
发明人: Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K. Fang , Santosh C. Sinha , Michael E. Garst
IPC分类号: C07D401/12 , C07D207/50
CPC分类号: C07D207/22 , C07D401/12
摘要: The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formula
摘要翻译: 本发明提供了N-(1-苯基-2-芳基乙基)-4,5-二氢-2H-吡咯-5-胺化合物的化合物,并且是α2B或α2B和α2C肾上腺素受体的亚型选择性调节剂,并且是 选自由式表示的化合物组
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2.N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds as subtype selective modulators of ALPHA2B or ALPHA2B and ALPHA2C adrenoceptors 失效
标题翻译: 作为ALPHA2B或ALPHA2B和ALPHA2C肾上腺素受体的亚型选择性调节剂的N-(1-苯基-2-芳基乙基)-4,5-二氢-2H-吡咯-5-胺化合物公开(公告)号:US08183414B2
公开(公告)日:2012-05-22
申请号:US12632494
申请日:2009-12-07
申请人: Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K Fang , Santosh C. Sinha , Michael E. Garst
发明人: Ken Chow , Janet A. Takeuchi , Ling Li , Todd M. Heidelbaugh , Phong X. Nguyen , Evelyn G. Corpuz , Wenkui K Fang , Santosh C. Sinha , Michael E. Garst
IPC分类号: C07C257/00 , A61K31/155
CPC分类号: C07D207/22 , C07D401/12
摘要: The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formula
摘要翻译: 本发明提供了N-(1-苯基-2-芳基乙基)-4,5-二氢-2H-吡咯-5-胺化合物的化合物,并且是α2B或α2B和α2C肾上腺素受体的亚型选择性调节剂,并且是 选自由式表示的化合物组
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公开(公告)号:US08492561B2
公开(公告)日:2013-07-23
申请号:US13305701
申请日:2011-11-28
申请人: Santosh C. Sinha , Smita S. Bhat , Evelyn G. Corpuz , Ken Chow , Wenkui K. Fang , Wha-Bin Im
发明人: Santosh C. Sinha , Smita S. Bhat , Evelyn G. Corpuz , Ken Chow , Wenkui K. Fang , Wha-Bin Im
IPC分类号: A61K31/397 , C07D205/04
CPC分类号: C07D205/04
摘要: The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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公开(公告)号:US20120208821A1
公开(公告)日:2012-08-16
申请号:US13500501
申请日:2010-10-06
申请人: Ken Chow , Liming Wang , Wenkui K. Fang , Evelyn G. Corpuz , Santosh C. Sinha , Daniel W. Gil , Mohammad I. Dibas , John E. Donello
发明人: Ken Chow , Liming Wang , Wenkui K. Fang , Evelyn G. Corpuz , Santosh C. Sinha , Daniel W. Gil , Mohammad I. Dibas , John E. Donello
IPC分类号: A61K31/40 , C07D403/12 , A61K31/4184 , C07D401/12 , A61K31/435 , A61K31/498 , A61K31/4709 , A61P25/00 , A61P17/00 , A61P29/00 , A61P17/10 , A61P17/06 , A61P27/06 , A61P27/02 , C07D207/22
CPC分类号: A61K31/498 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/4184 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4709 , C07D207/22 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , Y10S514/913
摘要: Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.
摘要翻译: 本文描述的化合物可用于通过调节一种或多种α-肾上腺素能受体来治疗疾病和病症。 化合物可以包括萘,喹啉,苯并咪唑或异喹啉作为核心结构。 描述制备,使用和配制这些化合物的方法。
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公开(公告)号:US09040532B2
公开(公告)日:2015-05-26
申请号:US13500501
申请日:2010-10-06
申请人: Ken Chow , Liming Wang , Wenkui K. Fang , Evelyn G. Corpuz , Santosh C. Sinha , Daniel W. Gil , Mohammad I. Dibas , John E. Donello
发明人: Ken Chow , Liming Wang , Wenkui K. Fang , Evelyn G. Corpuz , Santosh C. Sinha , Daniel W. Gil , Mohammad I. Dibas , John E. Donello
IPC分类号: A61K31/40 , A61K31/498 , A61K31/4184 , A61K31/4709 , C07D403/12 , C07D401/12 , C07D207/22 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
CPC分类号: A61K31/498 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/4184 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4709 , C07D207/22 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , Y10S514/913
摘要: Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.
摘要翻译: 本文描述的化合物可用于通过调节一种或多种α-肾上腺素能受体来治疗疾病和病症。 化合物可以包括萘,喹啉,苯并咪唑或异喹啉作为核心结构。 描述制备,使用和配制这些化合物的方法。
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6.ALKYNE AND ALKENE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE-1 RECEPTOR MODULATORS 失效
标题翻译: 亚磷酸和碱性衍生物作为磷酸酯1-磷酸酯-1受体调节剂公开(公告)号:US20120142640A1
公开(公告)日:2012-06-07
申请号:US13305398
申请日:2011-11-28
申请人: Santosh C. Sinha , Smita S. Bhat , Evelyn G. Corpuz , Ken Chow , Wenkui K. Fang , Wha-Bin Im
发明人: Santosh C. Sinha , Smita S. Bhat , Evelyn G. Corpuz , Ken Chow , Wenkui K. Fang , Wha-Bin Im
IPC分类号: A61K31/67 , A61K31/197 , C07F9/38 , A61K31/662 , C07F9/655 , A61K31/665 , C07F9/6553 , C07C43/23 , A61K31/085 , A61P27/02 , A61P9/10 , A61P27/06 , A61P29/00 , A61P9/00 , A61P11/00 , A61P35/04 , A61P37/06 , A61P37/04 , A61P1/00 , A61P25/00 , A61P17/06 , A61P13/12 , A61P17/00 , A61P37/08 , A61P11/06 , A61P17/02 , A61P19/08 , A61P19/10 , A61P19/02 , A61P19/04 , C07C229/14
CPC分类号: C07C229/14 , C07C43/23 , C07F9/3808 , C07F9/3834 , C07F9/65515 , C07F9/655345
摘要: The present invention relates to novel alkyne and alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译: 本发明涉及新的炔烃和烯烃衍生物,其制备方法,含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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公开(公告)号:US20110178143A1
公开(公告)日:2011-07-21
申请号:US12673301
申请日:2008-08-14
申请人: Ken Chow , Wenkui K. Fang , Evelyn G. Corpuz , Dario G. Gomez , Santosh N. Sinha , Smit S. Bhat , Todd M. Heidelbaugh , Daniel W. Gil
发明人: Ken Chow , Wenkui K. Fang , Evelyn G. Corpuz , Dario G. Gomez , Santosh N. Sinha , Smit S. Bhat , Todd M. Heidelbaugh , Daniel W. Gil
IPC分类号: A61K31/426 , C07D233/50 , C07D277/18 , C07D263/28 , A61K31/4168 , A61K31/421 , A61P27/02 , A61P29/00
CPC分类号: C07D233/50 , C07D263/28 , C07D277/18
摘要: Disclosed herein is a compound having a structure compositions, methods, and medicaments related thereto are also disclosed.
摘要翻译: 本文公开了具有与其有关的结构组成,方法和药物的化合物也被公开。
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8.Alkyne and alkene derivatives as sphingosine 1-phosphate-1 receptor modulators 失效
标题翻译: 炔基和烯烃衍生物作为鞘氨醇1-磷酸-1受体调节剂公开(公告)号:US08404663B2
公开(公告)日:2013-03-26
申请号:US13305398
申请日:2011-11-28
申请人: Santosh C. Sinha , Smita S. Bhat , Evelyn G. Corpuz , Ken Chow , Wenkui K. Fang , Wha-Bin Im
发明人: Santosh C. Sinha , Smita S. Bhat , Evelyn G. Corpuz , Ken Chow , Wenkui K. Fang , Wha-Bin Im
IPC分类号: A61K31/67 , A61K31/197 , A61K31/662 , A61K31/665 , A61K31/085 , C07F9/38 , C07F9/655 , C07F9/6553 , C07C43/23 , C07C229/14
CPC分类号: C07C229/14 , C07C43/23 , C07F9/3808 , C07F9/3834 , C07F9/65515 , C07F9/655345
摘要: The present invention relates to novel alkyne and alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
摘要翻译: 本发明涉及新的炔烃和烯烃衍生物,其制备方法,含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。
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公开(公告)号:US07709507B2
公开(公告)日:2010-05-04
申请号:US11747181
申请日:2007-05-10
申请人: Ken Chow , Wenkui K. Fang , Evelyn G. Corpuz , Daniel W. Gil , Michael E. Garst
发明人: Ken Chow , Wenkui K. Fang , Evelyn G. Corpuz , Daniel W. Gil , Michael E. Garst
IPC分类号: A61K31/381 , C07D213/02 , C07D333/10
CPC分类号: C07C275/24 , C07C2601/08 , C07C2601/14 , C07D213/40 , C07D307/52 , C07D333/20
摘要: Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.
摘要翻译: 下式的化合物或其药学上可接受的盐或其互变异构体,其中A和B如本文所述,可用于治疗哺乳动物的病症。
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10.SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS 审中-公开
标题翻译: 替代氟尿嘧啶作为ALPHA 2 ADRENERGIC AGENTS公开(公告)号:US20110028559A1
公开(公告)日:2011-02-03
申请号:US12667970
申请日:2008-06-20
申请人: Wenkui k. Fang , Ken Chow , Daniel W. Gil , Evelyn G. Corpuz , Michael E. Garst
发明人: Wenkui k. Fang , Ken Chow , Daniel W. Gil , Evelyn G. Corpuz , Michael E. Garst
IPC分类号: A61K31/17 , C07C275/26 , A61P29/00
CPC分类号: A61K31/17 , C07C275/18 , C07C275/26 , C07C2601/14
摘要: Treating pain in mammals with a compound having the formula (I) is disclosed herein.
摘要翻译: 本文公开了用具有式(I)的化合物治疗哺乳动物的疼痛。
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