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    Pressure Regulator and Vibration Isolator
    1.
    发明申请
    Pressure Regulator and Vibration Isolator 有权
    压力调节器和隔振器

    公开(公告)号：US20100030386A1

    公开(公告)日：2010-02-04

    申请号：US12445196

    申请日：2007-10-10

    申请人： Kenji Kawashima ,  Toshiharu Kagawa ,  Tomonori Kato

    发明人： Kenji Kawashima ,  Toshiharu Kagawa ,  Tomonori Kato

    IPC分类号： G05D16/02 ,  G05D7/06 ,  G06F17/10 ,  G06G7/57

    CPC分类号： F16F15/027 ,  G05D16/2013

    摘要： A pressure regulator for controlling pressure with high response and high accuracy even a flow change occurs on the downstream side. The pressure regulator (1) regulates the rate of inflow into an isothermal pressure vessel (13) for the gas supplied from a gas supply source (10) by means of a servo valve (11) to maintain the constant pressure in the isothermal pressure vessel (13). Pressure control means (a computer (16)) operating the servo valve (11) has as a main loop a pressure control system for feedback-controlling the pressure in the isothermal pressure vessel (13) measured by a pressure gauge (14) and has therein a rate-of-inflow-control system for feedback-controlling the rate of flow measured by a flow meter (12), an observer for estimating the rate of outflow from the isothermal pressure vessel (13) according to the rate of inflow and the derivative of the pressure in the isothermal pressure vessel (13) measured by a pressure differentiator (15), and a model follow-up control system for feed-backing the estimated rate of outflow to the rate-of-inflow control system.

    摘要翻译： 在下游侧发生用于控制压力高的压力调节器，甚至具有高精度，甚至流量变化。 压力调节器（1）调节通过伺服阀（11）从气体供应源（10）供应的气体流入等温压力容器（13）的速率，以保持恒温压力容器 （13）。 操作伺服阀（11）的压力控制装置（计算机（16））具有作为主回路的压力控制系统，用于反馈控制由压力​​表（14）测量的等温压力容器（13）中的压力，并具有 其中具有用于反馈控制由流量计（12）测量的流量的流入速率控制系统，用于根据流入速率估计来自等温压力容器（13）的流出速率的观测器，以及 通过压力微分器（15）测量的等温压力容器（13）中的压力的​​导数，以及用于将流出量的估计流量提供给流入速率控制系统的模型跟踪控制系统。

    Pressure regulator
    2.
    发明授权
    Pressure regulator 有权
    压力调节器

    公开(公告)号：US08195336B2

    公开(公告)日：2012-06-05

    申请号：US12445196

    申请日：2007-10-10

    申请人： Kenji Kawashima ,  Toshiharu Kagawa ,  Tomonori Kato

    发明人： Kenji Kawashima ,  Toshiharu Kagawa ,  Tomonori Kato

    IPC分类号： G05D7/00 ,  G05D11/00 ,  G06F17/00 ,  G05B21/00

    CPC分类号： F16F15/027 ,  G05D16/2013

    摘要： A pressure regulator for controlling pressure with high response and high accuracy even a flow change occurs on the downstream side. The pressure regulator (1) regulates the rate of inflow into an isothermal pressure vessel (13) for the gas supplied from a gas supply source (10) by means of a servo valve (11) to maintain the constant pressure in the isothermal pressure vessel (13). Pressure control means (a computer (16)) operating the servo valve (11) has as a main loop a pressure control system for feedback-controlling the pressure in the isothermal pressure vessel (13) measured by a pressure gauge (14) and has therein a rate-of-inflow-control system for feedback-controlling the rate of flow measured by a flow meter (12), an observer for estimating the rate of outflow from the isothermal pressure vessel (13) according to the rate of inflow and the derivative of the pressure in the isothermal pressure vessel (13) measured by a pressure differentiator (15), and a model follow-up control system for feed-backing the estimated rate of outflow to the rate-of-inflow control system.

    摘要翻译： 在下游侧发生用于控制压力高的压力调节器，甚至具有高精度，甚至流量变化。 压力调节器（1）调节通过伺服阀（11）从气体供应源（10）供应的气体流入等温压力容器（13）的速率，以保持恒温压力容器 （13）。 操作伺服阀（11）的压力控制装置（计算机（16））具有作为主回路的压力控制系统，用于反馈控制由压力​​表（14）测量的等温压力容器（13）中的压力，并具有 其中具有用于反馈控制由流量计（12）测量的流量的流入速率控制系统，用于根据流入速率估计来自等温压力容器（13）的流出速率的观测器，以及 通过压力微分器（15）测量的等温压力容器（13）中的压力的​​导数，以及用于将流出量的估计流量提供给流入速率控制系统的模型跟踪控制系统。

    Pressure differentiator
    3.
    发明申请
    Pressure differentiator 失效
    压力微分器

    公开(公告)号：US20060288790A1

    公开(公告)日：2006-12-28

    申请号：US10569197

    申请日：2004-03-29

    申请人： Kenji Kawashima ,  Toshiharu Kagawa

    发明人： Kenji Kawashima ,  Toshiharu Kagawa

    IPC分类号： G01L7/08

    CPC分类号： G01L13/00 ,  G01L11/00

    摘要： An object of the invention is to provide a pressure differentiator capable of improving measurement accuracy. The pressure differentiator of the invention includes an isothermal pressure vessel 1, a narrow tube 3 for connecting an object to be measured to the inside of the vessel 1, and a differential manometer 2 for calculating a differential pressure between the object and the inside of the vessel 1. It is preferable that a flow through the narrow tube 3 during measurement is a laminar flow. The isothermal pressure vessel 1 is fitted with a temperature equalizing material. As the temperature equalizing material, thin metal wires may be used. When the pressure Ps to be measured within a vessel positioned below is changed, the pressure Pc within the isothermal pressure vessel 1 is changed, with a slight lag, through the narrow tube 3. By measuring the differential pressure Pj (=Ps−Pc) at that time, using a diaphragm-type pressure differentiator, the derivative value of the pressure Ps may be calculated.

    摘要翻译： 本发明的目的是提供一种能够提高测量精度的压力微分器。 本发明的压力微分器包括等温压力容器1，用于将待测物体连接到容器1的内部的窄管3和用于计算物体与内部之间的压差的差压计2 优选的是，在测量期间通过窄管3的流动是层流。 等温压力容器1配有温度均衡材料。 作为温度均衡材料，可以使用细金属丝。 当在位于下方的容器内要测量的压力P 改变时，等温压力容器1内的压力P 稍微滞后，通过 通过使用隔膜式压力测量此时的压差P N S（= P P S S P S C C C） 可以计算压力P 的导数值。

    Pressure differentiator fitted with a temperature equalizing material
    4.
    发明授权
    Pressure differentiator fitted with a temperature equalizing material 失效
    压力微分器配有温度均衡材料

    公开(公告)号：US07437910B2

    公开(公告)日：2008-10-21

    申请号：US10569197

    申请日：2004-03-29

    申请人： Kenji Kawashima ,  Toshiharu Kagawa

    发明人： Kenji Kawashima ,  Toshiharu Kagawa

    IPC分类号： G01M3/20 ,  G01M3/02 ,  G01L15/00

    CPC分类号： G01L13/00 ,  G01L11/00

    摘要： An object of the invention is to provide a pressure differentiator capable of improving measurement accuracy.The pressure differentiator of the invention includes an isothermal pressure vessel 1, a narrow tube 3 for connecting an object to be measured to the inside of the vessel 1, and a differential manometer 2 for calculating a differential pressure between the object and the inside of the vessel 1. It is preferable that a flow through the narrow tube 3 during measurement is a laminar flow. The isothermal pressure vessel 1 is fitted with a temperature equalizing material. As the temperature equalizing material, thin metal wires may be used. When the pressure Ps to be measured within a vessel positioned below is changed, the pressure Pc within the isothermal pressure vessel 1 is changed, with a slight lag, through the narrow tube 3. By measuring the differential pressure Pj (=Ps−Pc) at that time, using a diaphragm-type pressure differentiator, the derivative value of the pressure Ps may be calculated.

    摘要翻译： 本发明的目的是提供一种能够提高测量精度的压力微分器。 本发明的压力微分器包括等温压力容器1，用于将待测物体连接到容器1的内部的窄管3和用于计算物体与内部之间的压差的差压计2 优选的是，在测量期间通过窄管3的流动是层流。 等温压力容器1配有温度均衡材料。 作为温度均衡材料，可以使用细金属丝。 当在位于下方的容器内要测量的压力P 改变时，等温压力容器1内的压力P 稍微滞后，通过 通过使用隔膜式压力测量此时的压差P N S（= P P S S P S C C C） 可以计算压力P 的导数值。

    Cyclic compound having pyrimidinylalkylthio group
    5.
    发明授权
    Cyclic compound having pyrimidinylalkylthio group 有权
    具有嘧啶基烷硫基的环状化合物

    公开(公告)号：US08507485B2

    公开(公告)日：2013-08-13

    申请号：US12931072

    申请日：2011-01-24

    申请人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

    发明人： Hisashi Tajima ,  Takahiro Honda ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto

    IPC分类号： A61K31/5377 ,  A61K31/506

    CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/12 ,  C07D409/12

    摘要： A method of treating a disease associated with angiogenesis by administering a therapeutically effective amount of a compound represented by the formula (1) or a salt thereof wherein the ring X represents R1 and R2 independently represent a hydrogen atom, an alkyl, an aryl or an aromatic heterocyclic; R3 represents a hydrogen atom, a halogen atom, a hydroxy, an alkoxy, an aryloxy, an alkyl, an aryl, an amino, an alkylamino, a cycloalkylamino, an arylamino, an alkylcarbonylamino, an arylcarbonylamino, a mercapto, an alkylthio, an arylthio, an alkylsulfinyl or a nonaromatic heterocyclic; A1 represents a sulfur atom, a sulfinyl or a sulfonyl; and A2 represents an alkylene.

    摘要翻译： 通过施用治疗有效量的由式（1）表示的化合物或其盐来治疗与血管生成相关的疾病的方法，其中环X表示R 1和R 2独立地表示氢原子，烷基，芳基或 芳香杂环; R 3表示氢原子，卤素原子，羟基，烷氧基，芳氧基，烷基，芳基，氨基，烷基氨基，环烷基氨基，芳基氨基，烷基羰基氨基，芳基羰基氨基，巯基，烷硫基 芳硫基，烷基亚磺酰基或非芳族杂环; A1表示硫原子，亚磺酰基或磺酰基; A2表示亚烷基。

    1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity
    6.
    发明授权
    1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity 有权
    具有糖皮质激素受体结合活性的1-2-二氢喹啉衍生物

    公开(公告)号：US08017775B2

    公开(公告)日：2011-09-13

    申请号：US11992088

    申请日：2006-09-14

    申请人： Mamoru Matsuda ,  Toshiyuki Mori ,  Kenji Kawashima ,  Masato Nagatsuka ,  Sachiko Kobayashi ,  Minoru Yamamoto ,  Masatomo Kato ,  Miwa Takai ,  Tomoko Oda

    发明人： Mamoru Matsuda ,  Toshiyuki Mori ,  Kenji Kawashima ,  Masato Nagatsuka ,  Sachiko Kobayashi ,  Minoru Yamamoto ,  Masatomo Kato ,  Miwa Takai ,  Tomoko Oda

    IPC分类号： C07D215/38

    CPC分类号： C07D215/14 ,  C07D215/20 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

    摘要： An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S(O)R8 or S(O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.

    摘要翻译： 本发明的目的是研究新型1,2-二氢喹啉衍生物的合成，并找到衍生物的药理作用。 由通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面是有效的。 在该式中，环X表示苯环或吡啶环; R1表示卤素原子，烷基，羟基，烷氧基，氨基等; p表示0〜5的整数， R2表示卤素原子，烷基，羟基等; q表示0〜2的整数， R3表示氢原子，烷基，烯基等; R4和R5表示氢原子等; R6表示氢原子等; A表示亚烷基等; 并且R 7表示OR 8，NR 8 R 9，SR 8，S（O）R 8或S（O）2 R 8，其中R 8表示芳基，杂环基等，R 9表示氢原子等。

    NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP
    7.
    发明申请
    NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP 失效
    新加坡衍生产品有限公司，卡巴集团，乌代组和替代氧化集团

    公开(公告)号：US20110124668A1

    公开(公告)日：2011-05-26

    申请号：US13054041

    申请日：2009-07-14

    申请人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

    发明人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

    IPC分类号： A61K31/404 ,  C07D209/42 ,  C07D403/12 ,  A61K31/506 ,  C07D401/12 ,  A61K31/4439 ,  C07D405/10 ,  A61P29/00 ,  A61P27/06 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  A61P3/00 ,  A61P25/00 ,  A61P37/06 ,  A61P31/00 ,  A61P37/08

    CPC分类号： C07D209/42 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

    摘要： The present invention relates to synthetic studies on novel indole derivatives having a carbamoyl group, a ureido group and a substituted oxy group or a salt thereof, and pharmaceutical actions of the derivatives. The compound and a salt thereof represented by the general formula (1) has an IKKβ inhibitory activity and is useful as a preventive and/or therapeutic agent for diseases considered to be associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group which may have a substituent, a hydroxy group, or a lower alkoxy group which may have a substituent, or the like; R2 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, or a heterocyclic group which may have a substituent, or the like; R3 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or the like; m represents 0, 1, 2, or the like.

    摘要翻译： 本发明涉及具有氨基甲酰基，脲基和取代的氧基或其盐的新型吲哚衍生物的合成研究以及衍生物的药物作用。 由通式（1）表示的化合物及其盐具有IKK＆bgr; 抑制活性，并且可用作被认为与IKK＆bgr相关的疾病的预防和/或治疗剂。 式中，R 1表示氢原子，可以具有取代基的低级烷基，羟基或可具有取代基的低级烷氧基等。 R2表示氢原子，可以具有取代基的低级烷基，可以具有取代基的低级环烷基，可以具有取代基的芳基或可以具有取代基的杂环基等。 R3表示卤原子，可以具有取代基的低级烷基，可以具有取代基的低级烯基，可以具有取代基的低级炔基，可以具有取代基的低级环烷基，可以具有取代基的低级环烷基， 可以具有取代基，可以具有取代基的杂环基等; m表示0,1,2等。