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公开(公告)号：US08574896B2
公开(公告)日：2013-11-05
申请号：US12469403
申请日：2009-05-20
IPC分类号： C12M1/34
摘要： The present invention provides a colorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis of the analyte by measuring color produced in the coloring reagent. The enzyme reaction of this method is a single stage reaction, and the color production reaction occurs via the mediator. Therefore, the measurement can be performed in a short time. Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.
摘要翻译： 本发明提供一种可以在短时间内进行简单可靠的分析的比色法。 该方法包括将电子从分析物转移到通过使用氧化还原酶通过介质还原产生颜色的着色剂; 并通过测量着色剂中产生的颜色来对分析物进行定性或定量分析。 该方法的酶反应是单阶段反应，并且通过介体发生颜色产生反应。 因此，可以在短时间内进行测量。 由于该反应既不需要过氧化氢也不需要氧气，因此测量值非常可靠。
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公开(公告)号：US20050014213A1
公开(公告)日：2005-01-20
申请号：US10496453
申请日：2003-01-06
CPC分类号： G01N33/523 , G01N21/78 , G01N33/52 , G01N33/66 , G01N33/92
摘要： The present invention provides a colorimetric method that can perform a simple and reliable analysis in a short time. An aqueous solution including a bipyridyl copper complex and glucose dehydrogenase is prepared. A filter paper is impregnated with the aqueous solution and dried. When a sample such as blood is applied to the filter paper, the bipyridyl copper complex produces reddish brown color in accordance with the glucose concentration, and the color produced in the complex is measured. This reaction is a single reaction and thus occurs in a short time (e.g., 5 seconds or less). Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.
摘要翻译： 本发明提供一种可以在短时间内进行简单可靠的分析的比色法。 制备包含联吡啶铜络合物和葡萄糖脱氢酶的水溶液。 用水溶液浸渍滤纸并干燥。 当将诸如血液的样品施加到滤纸上时，联吡啶铜络合物根据葡萄糖浓度产生红棕色，并测量复合物中产生的颜色。 该反应是单一反应，因此在短时间（例如5秒或更短）内发生。 由于该反应既不需要过氧化氢也不需要氧气，因此测量值非常可靠。
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公开(公告)号：US07550273B2
公开(公告)日：2009-06-23
申请号：US10476298
申请日：2003-01-06
IPC分类号： C12Q1/26
摘要： The present invention provides a calorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring reagent that produces color by reduction via a mediator by using an oxidoreductase; and performing qualitative or quantitative analysis of the analyte by measuring color produced in the coloring reagent. The enzyme reaction of this method is a single stage reaction, and the color production reaction occurs via the mediator. Therefore, the measurement can be performed in a short time. Since this reaction requires neither hydrogen peroxide nor oxygen, the measured values are highly reliable.
摘要翻译： 本发明提供一种能够在短时间内进行简单可靠的分析的量热法。 该方法包括将电子从分析物转移到通过使用氧化还原酶通过介质还原产生颜色的着色剂; 并通过测量着色剂中产生的颜色来对分析物进行定性或定量分析。 该方法的酶反应是单阶段反应，并且通过介体发生颜色产生反应。 因此，可以在短时间内进行测量。 由于该反应既不需要过氧化氢也不需要氧气，因此测量值非常可靠。
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4.发明申请Analyzing tool being reduced in distance of diffusion of reagent and method for manufacture thereof 审中-公开分析试剂扩散距离减小的工具及其制造方法公开(公告)号：US20070053790A1
公开(公告)日：2007-03-08
申请号：US10553336
申请日：2004-04-15
IPC分类号： G01N21/00
CPC分类号： B01L3/502707 , B01L2200/12 , B01L2200/16 , B01L2300/0825 , B01L2300/0838 , B01L2300/0887 , B01L2400/0406
摘要： The present invention relates to an analyzing tool (X1) including a reaction space (4) for allowing a particular component contained in a sample and a reagent to react with each other, and a reagent portion (51, 52) which is arranged in the reaction space (4) and which dissolves when the sample is supplied to the reaction space (4). The reagent portion (51, 52) includes a first part (51) and a second part (52) facing each other at a defining surface defining the reaction space (4).
摘要翻译： 本发明涉及一种分析工具（X 1），其包括用于使包含在样品中的特定成分和试剂彼此反应的反应空间（4）和布置在所述试剂部分中的试剂部分（51,52） 反应空间（4），并且当将样品供应到反应空间（4）时溶解。 试剂部分（51,52）包括在限定反应空间（4）的限定表面处彼此面对的第一部分（51）和第二部分（52）。
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5.发明授权公开(公告)号：US09084831B2
公开(公告)日：2015-07-21
申请号：US13050672
申请日：2011-03-17
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa
IPC分类号： A61K51/08
CPC分类号： A61K51/088 , A61K51/08
摘要： A precursor of a molecular probe for imaging of pancreatic islets is provided. The precursor includes a polypeptide represented by any one of the following formulae (1) to (12), or a polypeptide having a homology with the foregoing polypeptide: *-DLSKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (1) *-LSKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (2) *-SKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (3) *-KQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (4) *-DLSK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (5) *-LSK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (6) *-SK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (7) *-K*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (8) DLSK*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (9) LSK*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (10) SK*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (11) K*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (12)
摘要翻译： 提供了用于胰岛成像的分子探针的前体。 前体包括由下列通式（1）至（12）中的任一个表示的多肽或与前述多肽具有同源性的多肽：* -DLSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（1）* -LSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（ 2）* -SKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（3）* -KQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（4）* -DLSK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（5）* -LSK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（6）* -SK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 7）* -K * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（8）DLSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（9）LSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（10）SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（11）K * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 12）
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6.发明授权Analytical instrument having improved arrangement of reagent section and analytical method 有权具有改进的试剂部分布置和分析方法的分析仪器公开(公告)号：US07780828B2
公开(公告)日：2010-08-24
申请号：US10585295
申请日：2005-01-07
IPC分类号： G01N27/327
CPC分类号： C12Q1/006
摘要： The present invention relates to an analytical instrument (1) which includes a flow path (5) for moving a sample containing blood cells, an introduction port (50) for introducing the sample into the flow path (5), a reagent portion (51) arranged in the flow path (5), and an electron detection medium (52) for obtaining information necessary for analyzing an analysis target component contained in the sample in relation with an amount of electrons transferred. The reagent portion (51) contains an electron mediator for supplying an electron taken from the analysis target component in the sample to the electron detection medium (52), and at least part of the reagent portion is positioned adjacent to the introduction port (50).
摘要翻译： 本发明涉及一种分析仪器（1），其包括用于移动含有血细胞的样品的流路（5），用于将样品引入流路（5）的引入口（50），试剂部分 ）和电子检测介质（52），用于获得与所传送的电子数量相关的用于分析样品中包含的分析对象成分所需的信息。 试剂部（51）包含用于将从样品中的分析对象成分获取的电子供给到电子检测介质（52）的电子介体，并且所述试剂部的至少一部分位于与所述引入口（50）相邻的位置， 。
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7.发明申请公开(公告)号：US20120107239A1
公开(公告)日：2012-05-03
申请号：US13148303
申请日：2010-03-16
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa
IPC分类号： A61K51/04 , C07D209/44
CPC分类号： A61K51/0446
摘要： A precursor of a molecular probe for imaging of pancreatic islets is a compound expressed as the following formula (I): wherein -V-X represents a substituent on a benzene ring, V represents a bond, R1, of OR1, R1 represents a C1-C6 alkylene group, R2 represents H (hydrogen atom), a C1-C6 alkyl group, a C7-C10 aralkyl group, or a protecting group, X represents a OMs group, a OTs group, a OTf group, Br (bromine atom), or I (iodine atom), and carbon marked with * is an asymmetric carbon atom.
摘要翻译： 用于胰岛成像的分子探针的前体是以下式（I）表示的化合物：其中-VX表示苯环上的取代基，V表示OR1的键，R1表示C1-C6 亚烷基，R2表示H（氢原子），C1-C6烷基，C7-C10芳烷基或保护基，X表示OMs基，OTs基，OTf基，Br（溴原子） 或I（碘原子），标有*的碳是不对称碳原子。
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8.发明申请Analytical instrument having improved arrangement of reagent section and analytical method 有权具有改进的试剂部分布置和分析方法的分析仪器公开(公告)号：US20090017483A1
公开(公告)日：2009-01-15
申请号：US10585295
申请日：2005-01-07
CPC分类号： C12Q1/006
摘要： The present invention relates to an analytical instrument (1) which includes a flow path (5) for moving a sample containing blood cells, an introduction port (50) for introducing the sample into the flow path (5), a reagent portion (51) arranged in the flow path (5), and an electron detection medium (52) for obtaining information necessary for analyzing an analysis target component contained in the sample in relation with an amount of electrons transferred. The reagent portion (51) contains an electron mediator for supplying an electron taken from the analysis target component in the sample to the electron detection medium (52), and at least part of the reagent portion is positioned adjacent to the introduction port (50).
摘要翻译： 本发明涉及一种分析仪器（1），其包括用于移动含有血细胞的样品的流路（5），用于将样品引入流路（5）的引入口（50），试剂部分 ）和电子检测介质（52），用于获得与所传送的电子数量相关的用于分析样品中包含的分析对象成分所需的信息。 试剂部（51）包含用于将从样品中的分析对象成分获取的电子供给到电子检测介质（52）的电子介体，并且所述试剂部的至少一部分位于与所述引入口（50）相邻的位置， 。
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公开(公告)号：US08784624B2
公开(公告)日：2014-07-22
申请号：US12309222
申请日：2007-07-11
IPC分类号： G01N27/327
CPC分类号： C12Q1/001
摘要： The present invention relates to an enzyme electrode including: a carbon particle; a metal particle held on the carbon particle, the metal particle having a catalytic activity against a redox reaction; a redox enzyme. The enzyme electrode of the present invention further includes a high-resistance particle enhancing an electrical resistance, the high-resistance particle being chemically stable. The high-resistance particle contains an inorganic substance, for example. The inorganic substance is aluminum oxide or smectite, for example.
摘要翻译： 本发明涉及一种酶电极，包括：碳粒子; 保持在碳粒子上的金属粒子，具有对氧化还原反应的催化活性的金属粒子; 一种氧化还原酶。 本发明的酶电极还包括提高电阻的高电阻粒子，高电阻粒子化学稳定。 高电阻粒子例如含有无机物质。 无机物质例如是氧化铝或绿土。
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10.发明申请公开(公告)号：US20110171129A1
公开(公告)日：2011-07-14
申请号：US13050672
申请日：2011-03-17
申请人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa
发明人： Nobuya Inagaki , Hideo Saji , Kentaro Toyoda , Hiroyuki Kimura , Konomu Hirao , Kenji Nagakawa
CPC分类号： A61K51/088 , A61K51/08
摘要： A precursor of a molecular probe for imaging of pancreatic islets is provided. The precursor includes a polypeptide represented by any one of the following formulae (1) to (12), or a polypeptide having a homology with the foregoing polypeptide: *-DLSKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (1) *-LSKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (2) *-SKQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (3) *-KQMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (4) *-DLSK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (5) *-LSK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (6) *-SK*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (7) *-K*QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 (8) DLSK*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (9) LSK*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (10) SK*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (11) K*QMEEEAVRLFIEWLK*NGGPSSGAPPPS-NH2 (12)
摘要翻译： 提供了用于胰岛成像的分子探针的前体。 前体包括由下列通式（1）至（12）中的任一个表示的多肽或与前述多肽具有同源性的多肽：* -DLSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（1）* -LSKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（ 2）* -SKQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（3）* -KQMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（4）* -DLSK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（5）* -LSK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（6）* -SK * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 7）* -K * QMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2（8）DLSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（9）LSK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（10）SK * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2（11）K * QMEEEAVRLFIEWLK * NGGPSSGAPPPS-NH2 12）
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