公开(公告)号：US07609809B2

公开(公告)日：2009-10-27

申请号：US11459143

申请日：2006-07-21

申请人： Jeffrey M. Kapatoes ,  Gustavo H. Olivera ,  Eric Schnarr ,  Weiguo Lu ,  Kenneth J. Ruchala ,  Paul J. Reckwerdt ,  John H. Hughes ,  Thomas R. Mackie

发明人： Jeffrey M. Kapatoes ,  Gustavo H. Olivera ,  Eric Schnarr ,  Weiguo Lu ,  Kenneth J. Ruchala ,  Paul J. Reckwerdt ,  John H. Hughes ,  Thomas R. Mackie

IPC分类号： A61N5/10 ,  H05G1/28

CPC分类号： A61N5/103 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1074

摘要： A system and method of defining a new region of interest for an existing region of interest using a dose volume histogram. The method includes the acts of generating a dose volume histogram of radiation dose for a pre-existing region of interest, selecting a subset of the dose volume histogram, and defining a new region of interest that corresponds to the selected subset of the dose volume histogram.

摘要翻译： 使用剂量体积直方图来定义现有感兴趣区域的新感兴趣区域的系统和方法。 该方法包括产生用于预先存在的感兴趣区域的辐射剂量的剂量体积直方图的动作，选择剂量体积直方图的子集，以及定义对应于剂量体积直方图的选定子集的新的感兴趣区域 。

公开(公告)号：US08767917B2

公开(公告)日：2014-07-01

申请号：US11459074

申请日：2006-07-21

申请人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Weiguo Lu ,  Eric Schnarr ,  John H. Hughes ,  Jeffrey M. Kapatoes ,  Thomas R. Mackie ,  Paul J. Reckwerdt

发明人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Weiguo Lu ,  Eric Schnarr ,  John H. Hughes ,  Jeffrey M. Kapatoes ,  Thomas R. Mackie ,  Paul J. Reckwerdt

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1067 ,  A61N2005/1061 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3481 ,  G16H50/50

摘要： A system for and method of delivering radiation therapy to a moving region of interest is disclosed. The method, in one implementation, includes the acts of generating a plurality of treatment plans for providing radiation therapy, delivering radiation therapy to the patient following one of the plurality of treatment plans, monitoring the patient while providing radiation therapy, and changing the treatment plan based at least in part on monitoring the patient.

摘要翻译： 公开了将辐射治疗递送到感兴趣的移动区域的系统和方法。 该方法在一个实施中包括产生用于提供放射治疗的多个治疗计划的动作，在多个治疗计划中的一个治疗计划之后向患者传送放射疗法，在提供放射治疗的同时监测患者，以及改变治疗计划 至少部分地基于监测患者。

公开(公告)号：US07574251B2

公开(公告)日：2009-08-11

申请号：US11459105

申请日：2006-07-21

申请人： Weiguo Lu ,  Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Eric Schnarr ,  Jeffrey M. Kapatoes ,  Thomas R. Mackie ,  Paul J. Reckwerdt

发明人： Weiguo Lu ,  Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Eric Schnarr ,  Jeffrey M. Kapatoes ,  Thomas R. Mackie ,  Paul J. Reckwerdt

IPC分类号： A61B5/05

CPC分类号： A61N5/103 ,  A61N5/1031 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1069 ,  A61N2005/1072 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

摘要： A system and method of adapting a radiation therapy treatment plan. The method includes the acts of preparing a treatment plan for a patient, acquiring images of the patient, performing deformable registration of the images, acquiring data relating to a radiation dose delivered to the patient, applying a biological model relating the radiation dose delivered and a patient effect, and adapting the radiation therapy treatment plan based on the deformable registration and the biological model.

摘要翻译： 适应放射治疗治疗计划的系统和方法。 该方法包括为患者准备治疗计划的动作，获取患者的图像，执行图像的可变形登记，获取与递送给患者的辐射剂量有关的数据，应用与所传送的辐射剂量有关的生物模型和 患者效应，并根据可变形登记和生物模型适应放射治疗计划。

公开(公告)号：US06915005B1

公开(公告)日：2005-07-05

申请号：US10170252

申请日：2002-06-11

申请人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Thomas R. Mackie ,  Jeffrey M. Kapatoes ,  Paul J. Reckwerdt

发明人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Thomas R. Mackie ,  Jeffrey M. Kapatoes ,  Paul J. Reckwerdt

IPC分类号： A61B6/03 ,  A61B6/08 ,  A61N5/10 ,  G06F19/00 ,  G06T1/00 ,  G06T11/00 ,  G06K9/00 ,  G06K9/46 ,  G06K9/40 ,  G06K9/36 ,  G06K9/32

CPC分类号： G06T11/005 ,  A61B6/08 ,  A61B6/508 ,  A61B6/5235 ,  A61N5/1049 ,  G06F19/00

摘要： The present invention provides methods of using current but incomplete data to prepare an approximated complete image of a patient potentially undergoing radiation therapy. A complete image of the patient is fused or aligned with a limited patient image using image registration techniques. The aligned image is converted to sinogram data. This sinogram data is compared to sinogram data corresponding to the limited patient image to determine what data exists beyond the scope of the limited sinogram. Any additional data is added to the limited data sinogram to obtain a complete sinogram. This complete sinogram is then reconstructed into an image that approximates the complete image that would have been taken at the time the limited image was obtained.

摘要翻译： 本发明提供了使用当前但不完整的数据来准备可能经历放射治疗的患者的近似完整图像的方法。 使用图像配准技术将患者的完整图像融合或与有限的患者图像对齐。 对齐的图像转换为正弦图数据。 将该正弦图数据与对应于有限的患者图像的正弦图数据进行比较，以确定在有限的正弦图的范围之外存在什么数据。 任何额外的数据被添加到有限数据正弦图以获得完整的正弦图。 然后，将完整的正弦图重构成近似于在获得有限图像时已经拍摄的完整图像的图像。

公开(公告)号：US09731148B2

公开(公告)日：2017-08-15

申请号：US11459161

申请日：2006-07-21

申请人： Gustavo H. Olivera ,  Thomas R. Mackie ,  Kenneth J. Ruchala ,  Paul J. Reckwerdt ,  John H. Hughes ,  Jeffrey M. Kapatoes ,  Eric Schnarr ,  Weiguo Lu ,  Eric Schloesser ,  Gerald D. Fordyce, II ,  Tim Holzmann

发明人： Gustavo H. Olivera ,  Thomas R. Mackie ,  Kenneth J. Ruchala ,  Paul J. Reckwerdt ,  John H. Hughes ,  Jeffrey M. Kapatoes ,  Eric Schnarr ,  Weiguo Lu ,  Eric Schloesser ,  Gerald D. Fordyce, II ,  Tim Holzmann

IPC分类号： A61B5/00 ,  A61N5/10

CPC分类号： A61N5/1042 ,  A61N5/1049 ,  A61N5/1069

摘要： A system and method of delivering a radiation therapy treatment plan to a patient. The treatment plan is delivered using a radiation therapy system including a moveable support for supporting a patient, a gantry moveable relative to the support and supporting a radiation source and multi-leaf collimator for modulating the radiation source. The support and gantry are moved during delivery of the treatment plan.

公开(公告)号：US08232535B2

公开(公告)日：2012-07-31

申请号：US11431319

申请日：2006-05-10

申请人： Gustavo H. Olivera ,  Thomas R. Mackie ,  Jeffrey M. Kapatoes ,  John H. Hughes ,  Kenneth J. Ruchala ,  Paul J. Reckwerdt

发明人： Gustavo H. Olivera ,  Thomas R. Mackie ,  Jeffrey M. Kapatoes ,  John H. Hughes ,  Kenneth J. Ruchala ,  Paul J. Reckwerdt

IPC分类号： G21G4/00

CPC分类号： A61N5/1042 ,  A61B6/027 ,  A61N5/1049

摘要： A radiation therapy treatment system and method of treating a patient with radiation. The system integrates positioning of the patient, treatment planning, and delivery of the plan. As a result of the integration of imaging capabilities into the treatment apparatus, and efficient processes for contouring and planning, a patient can be treated in approximately 20 minutes or less. The method includes acquiring image data from the patient, defining a target region with one or more predefined shapes, generating a treatment plan based on the defined target region, and delivering radiation to the target region.

摘要翻译： 放射疗法治疗系统和治疗患者放射线的方法。 该系统整合了患者的定位，治疗计划和计划的交付。 作为将成像能力整合到治疗装置中的结果以及用于轮廓和规划的有效过程，可以在大约20分钟或更短时间内对患者进行治疗。 该方法包括从患者获取图像数据，用一个或多个预定形状定义目标区域，基于所定义的目标区域生成治疗计划，以及将辐射传送到目标区域。

公开(公告)号：US07773788B2

公开(公告)日：2010-08-10

申请号：US11459152

申请日：2006-07-21

申请人： Weiguo Lu ,  Gustavo H. Olivera ,  Jeffrey M. Kapatoes ,  Kenneth J. Ruchala ,  Eric Schnarr ,  John H. Hughes ,  Thomas R. Mackie ,  Paul J. Reckwerdt

发明人： Weiguo Lu ,  Gustavo H. Olivera ,  Jeffrey M. Kapatoes ,  Kenneth J. Ruchala ,  Eric Schnarr ,  John H. Hughes ,  Thomas R. Mackie ,  Paul J. Reckwerdt

IPC分类号： G06K9/00

CPC分类号： A61N5/103 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1075

摘要： System and method of evaluating quality assurance criteria related to the delivery of a radiation therapy treatment plan. The method includes the acts of acquiring image data of a patient, generating a treatment plan for the patient based at least in part on the image data, the treatment plan including a calculated radiation dose to be delivered to the patient, acquiring an on-line image of the patient in substantially a treatment position, delivering at least a portion of the calculated radiation dose to the patient, monitoring quality assurance criteria related to the delivery of the treatment plan, calculating the radiation dose received by the patient, and determining whether delivery of the treatment plan occurred as intended based on the quality assurance criteria and the radiation dose received by the patient.

摘要翻译： 评估与放射治疗计划相关的质量保证标准的系统和方法。 该方法包括获取患者的图像数据的动作，至少部分地基于图像数据生成针对患者的治疗计划，治疗计划包括计算出的要递送给患者的辐射剂量，获取在线 将患者的图像基本上处于治疗位置，将计算的辐射剂量的至少一部分递送给患者，监测与治疗计划的递送相关的质量保证标准，计算患者接收的辐射剂量，以及确定是否递送 的治疗计划根据质量保证标准和患者接受的放射剂量进行预期的发生。

公开(公告)号：US07046831B2

公开(公告)日：2006-05-16

申请号：US09802468

申请日：2001-03-09

申请人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Thomas R. Mackie ,  Jeffrey M. Kapatoes ,  Paul J. Reckwerdt

发明人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Thomas R. Mackie ,  Jeffrey M. Kapatoes ,  Paul J. Reckwerdt

IPC分类号： G06K9/00 ,  G06K9/46 ,  G06K9/40 ,  G06K9/36 ,  G06K9/32

CPC分类号： G06T11/005 ,  A61B6/08 ,  A61B6/508 ,  A61B6/5235 ,  A61N5/1049 ,  G06F19/00

摘要： The present invention provides a system and method of using current but incomplete data to prepare an approximated complete image of a patient potentially undergoing radiation therapy. A limited patient image, such as that obtained from a CT scan is fused with a complete image of the same area using image registration techniques. The fused image is converted to sinogram data. This data is compared to sinogram data corresponding to the limited patient image to determine what data exists beyond the scope of the limited sinogram. Any additional data is added to the limited data sinogram to obtain a complete sinogram. This is reconstructed into an image that approximates the complete image that would have been taken at the time the limited image was obtained.

公开(公告)号：US06661870B2

公开(公告)日：2003-12-09

申请号：US09802470

申请日：2001-03-09

申请人： Jeffrey M. Kapatoes ,  Gustavo H. Olivera ,  Paul J. Reckwerdt ,  Thomas R. Mackie ,  Kenneth J. Ruchala

发明人： Jeffrey M. Kapatoes ,  Gustavo H. Olivera ,  Paul J. Reckwerdt ,  Thomas R. Mackie ,  Kenneth J. Ruchala

IPC分类号： A61N510

CPC分类号： A61N5/1042

摘要： A method of compensating for unexpected changes in the size, shape, and/or position of a patient in the delivery of radiation therapy. An image of a patient is used to prepare a treatment plan for the irradiation of a tumor or the like, shown in the image. A second image of a patient includes a visual representation of the tumor and sensitive structures wherein any combination of the size, shape, or position of the tumor or sensitive structures is different from any combination of the size, shape, or position of the visual representation of the tumor or sensitive structures in said first image. The radiation treatment is adjusted to more closely conform the treatment plan to the new size, shape, or position of the tumor as shown in said second image. This adjustment can occur before, during, or after the radiation delivery and can be used to define trade-offs that exist for the delivery. The trade-offs can be assessed and decisions made regarding which fluence adjustment strategy will be acceptable for treatment delivery.

公开(公告)号：US08406844B2

公开(公告)日：2013-03-26

申请号：US10506866

申请日：2003-03-06

申请人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Jeffrey M. Kapatoes ,  Paul J. Reckwerdt ,  Weiguo Lu ,  John H. Hughes

发明人： Kenneth J. Ruchala ,  Gustavo H. Olivera ,  Jeffrey M. Kapatoes ,  Paul J. Reckwerdt ,  Weiguo Lu ,  John H. Hughes

IPC分类号： A61B5/05

CPC分类号： A61N5/103 ,  A61N5/1038 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1069 ,  A61N2005/1061 ,  G06F19/00

摘要： A method of contoured-anatomy dose repositioning (CADR) as a means to automatically reposition a patient to better recover the planned dose distribution without reoptimizinq the treatment plan. CADR utilizes planning CT images, the planned dose distribution, and on-line images for repositioning dose distribution on a given day. Contours are also placed upon the images using manual, automatic, template-based, or other techniques. CADR then optimizes the rigid-body repositioning of the patient so that the daily dose distribution closely matches the planned dose distribution.

摘要翻译： 一种轮廓解剖学剂量重新定位（CADR）的方法，作为自动重新定位患者的手段，以更好地恢复计划的剂量分布，而无需重新计算治疗计划。 CADR利用计划的CT图像，计划的剂量分布和在线图像在给定的一天重新定位剂量分布。 使用手动，自动，基于模板或其他技术的轮廓也被放置在图像上。 然后，CADR优化患者的刚体重新定位，使得日剂量分布与计划的剂量分布密切相关。