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公开(公告)号：US10030250B2
公开(公告)日：2018-07-24
申请号：US12692722
申请日：2010-01-25
摘要： The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylatically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.
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公开(公告)号：US07723570B2
公开(公告)日：2010-05-25
申请号：US11249182
申请日：2005-10-12
IPC分类号： C12N15/82 , A01H5/00 , A61K39/085 , A61K47/00
CPC分类号： C12N15/8258 , A61K39/0005 , A61K39/02 , A61K39/0258 , A61K39/35 , A61K2039/517 , A61K2039/55544 , C12N2710/00088 , Y02A50/469 , Y02A50/474
摘要： The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylatically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.
摘要翻译： 本发明涉及用于人类的转基因大豆，具有农业重要性的动物，宠物和野生动物的疫苗。 这些疫苗用作抗病毒，细菌，真菌，寄生或朊病毒相关疾病，癌症抗原，毒素和自体或自身蛋白的疫苗。 本发明的转基因大豆还可用于诱导对变应原的耐受性或对自身免疫抗原的耐受性，其中个体对所述变应原显示过敏反应或分别对自体或自身蛋白产生自身免疫性。 本发明还涉及在对过敏原显示过敏之前预防性地治疗个体和/或群体。 本发明的其它方面包括使用转基因大豆作为口服避孕药，以及在转基因大豆中表达蛋白佐剂。
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3.发明授权Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin 有权使用大豆产生的重组甲状腺球蛋白检测甲状腺球蛋白的免疫测定公开(公告)号：US09551005B2
公开(公告)日：2017-01-24
申请号：US13254704
申请日：2011-09-02
IPC分类号： C12N15/82 , C07K14/575
CPC分类号： C12N15/8257 , C07K14/575 , C07K2319/21
摘要： The present invention includes novel soybean derived human thyroglobulin, methods of producing human thyroglobulin in plants such as soybean, and novel diagnostic applications for the detection and stratification of endocrine malignancies including thyroid cancer and thyroiditis. The invention also includes the use of soybean-derived human thyroglobulin in affinity matrices to remove autoreactive anti-thyroglobulin antibodies from patient's sera prior to analyses. Moreover, the invention also includes methods and compositions of treating, preventing and or/ameliorating symptoms associated with thyroiditis.
摘要翻译： 本发明包括新型大豆来源的人甲状腺球蛋白，在大豆等植物中产生人甲状腺球蛋白的方法，以及用于检测和分层包括甲状腺癌和甲状腺炎的内分泌恶性肿瘤的新型诊断应用。 本发明还包括使用大豆衍生的人类甲状腺球蛋白在亲和基质中以在分析之前从患者的血清中除去自身反应性的抗甲状腺球蛋白抗体。 此外，本发明还包括治疗，预防和/或改善与甲状腺炎相关的症状的方法和组合物。
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公开(公告)号：US20110135685A1
公开(公告)日：2011-06-09
申请号：US12692722
申请日：2010-01-25
IPC分类号： A61K39/108 , A61K39/07 , A61K39/08 , A61K39/245 , A61K39/285 , A61K39/12 , A61K39/21 , A61K39/215 , A61P31/04 , A61P31/18 , A61P31/22 , A61P31/14
CPC分类号： C12N15/8258 , A61K39/0005 , A61K39/02 , A61K39/0258 , A61K39/35 , A61K2039/517 , A61K2039/55544 , C12N2710/00088 , Y02A50/469 , Y02A50/474
摘要： The present invention relates to vaccines that are made in transgenic soybeans for use in humans, animals of agricultural importance, pets, and wildlife. These vaccines are used as vaccines against viral, bacterial, fungal, parasitic or prion related diseases, cancer antigens, toxins, and autologous or self proteins. The transgenic soybeans of the instant invention also can be used for inducing tolerance to allergens or tolerance to autoimmune antigens, wherein an individual shows hypersensitivity to said allergen or has developed autoimmunity to autologous or self proteins, respectively. The invention also relates to prophylactically treating individuals and/or populations prior to showing hypersensitivity to allergens. Other aspects of the invention include using the transgenic soybeans as an oral contraceptive, and the expression of protein adjuvants in transgenic soybeans.
摘要翻译： 本发明涉及用于人类的转基因大豆，具有农业重要性的动物，宠物和野生动物的疫苗。 这些疫苗用作抗病毒，细菌，真菌，寄生或朊病毒相关疾病，癌症抗原，毒素和自体或自身蛋白的疫苗。 本发明的转基因大豆还可用于诱导对变应原的耐受性或对自身免疫抗原的耐受性，其中个体对所述变应原显示过敏反应或分别对自体或自身蛋白产生自身免疫性。 本发明还涉及在对过敏原显示过敏之前预防性地治疗个体和/或群体。 本发明的其它方面包括使用转基因大豆作为口服避孕药，以及在转基因大豆中表达蛋白佐剂。
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5.发明申请公开(公告)号：US20170233753A1
公开(公告)日：2017-08-17
申请号：US15581151
申请日：2017-04-28
IPC分类号： C12N15/82 , C12N9/02 , C12N9/08 , C12P19/02 , C12N9/24 , C12P7/06 , C12P19/14 , C12N9/04 , C12N9/42
CPC分类号： C12N15/8246 , C12N9/0006 , C12N9/0061 , C12N9/0065 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12N9/2491 , C12N9/2494 , C12N15/8242 , C12N15/8257 , C12P7/06 , C12P19/02 , C12P19/14 , C12Y101/03013 , C12Y110/03002 , C12Y111/01013 , C12Y111/01014 , C12Y111/01016 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01025 , C12Y302/01037 , C12Y302/01074 , C12Y302/01078 , C12Y302/01091 , C12Y302/01151 , Y02E50/17
摘要： A strategy for eliminating or greatly reducing the need for physical/chemical treatments or the use of whole microbes for lignocellulosic biomass and organopollutant degradation is disclosed. The soybean is a practical, cost-efficient and sustainable bioreactor for the production of lignin-degrading and cellulose-degrading enzymes. The use of soybean as a transgenic overexpression platform provides advantages that no other industrial scale enzyme expression system can match. Availability of a battery of related plant biomass degrading enzymes in separate transgenic soybean lines provides unprecedented flexibility in industrial and bioremediation processes. Depending upon the particular application, selected soybean-derived powdered enzyme formulations can be used, and their sequential addition can be orchestrated. Manufacturing enzymes using transgenic soybeans wherein these enzymes are capable of lignocellulose and organopollutant degradation into useful or nontoxic products will dramatically change biomass engineering schemes and environmental remediation practices. This technology has a sum of advantages that other protein expression system cannot duplicate, including the manufacturing of individual enzymes in a cost-effective manner that allows flexibility in cocktail composition, ease of application, and long term storage in the absence of a cold chain.
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6.发明申请Enzymes Manufactured in Transgenic Soybean for Plant Biomass Engineering and Organopollutant Bioremediation 审中-公开用于植物生物量工程和有机污染物生物修复的转基因大豆制造的酶公开(公告)号：US20140356913A1
公开(公告)日：2014-12-04
申请号：US14229880
申请日：2014-03-29
CPC分类号： C12N15/8246 , C12N9/0006 , C12N9/0061 , C12N9/0065 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12N9/2491 , C12N9/2494 , C12N15/8242 , C12N15/8257 , C12P7/06 , C12P19/02 , C12P19/14 , C12Y101/03013 , C12Y110/03002 , C12Y111/01013 , C12Y111/01014 , C12Y111/01016 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01025 , C12Y302/01037 , C12Y302/01074 , C12Y302/01078 , C12Y302/01091 , C12Y302/01151 , Y02E50/17
摘要： A strategy for eliminating or greatly reducing the need for physical/chemical treatments or the use of whole microbes for lignocellulosic biomass and organopollutant degradation is disclosed. The soybean is a practical, cost-efficient and sustainable bioreactor for the production of lignin-degrading and cellulose-degrading enzymes. The use of soybean as a transgenic overexpression platform provides advantages that no other industrial scale enzyme expression system can match. Availability of a battery of related plant biomass degrading enzymes in separate transgenic soybean lines provides unprecedented flexibility in industrial and bioremediation processes. Depending upon the particular application, selected soybean-derived powdered enzyme formulations can be used, and their sequential addition can be orchestrated. Manufacturing enzymes using transgenic soybeans wherein these enzymes are capable of lignocellulose and organopollutant degradation into useful or nontoxic products will dramatically change biomass engineering schemes and environmental remediation practices. This technology has a sum of advantages that other protein expression system cannot duplicate, including the manufacturing of individual enzymes in a cost-effective manner that allows flexibility in cocktail composition, ease of application, and long term storage in the absence of a cold chain.
摘要翻译： 公开了消除或大大减少对物理/化学处理的需要或使用全部微生物用于木质纤维素生物质和有机污染物降解的策略。 大豆是用于生产木质素降解和纤维素降解酶的实用的，经济有效的和可持续的生物反应器。 大豆作为转基因过表达平台的使用提供了没有其他工业规模的酶表达系统可以匹配的优点。 在单独的转基因大豆品系中提供一系列相关植物生物降解酶在工业和生物修复过程中提供了前所未有的灵活性。 根据具体应用，可以使用选择的大豆衍生的粉末状酶制剂，并且可以对其顺序添加进行调配。 使用转基因大豆的制造酶，其中这些酶能够将木素纤维素和有机污染物降解成有用或无毒的产品将显着改变生物质工程方案和环境修复实践。 该技术具有其他蛋白质表达系统不能重复的优点，包括以成本有效的方式制造各种酶，其允许混合物组合的灵活性，易于应用和在没有冷链的情况下长期储存。
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7.发明申请SOYBEAN DERIVED HUMAN THYROGLOBULIN, METHODS OF PRODUCING AND APPLICATIONS THEREOF 审中-公开大豆衍生人THYROGLOBULIN，其生产方法及应用公开(公告)号：US20130243821A1
公开(公告)日：2013-09-19
申请号：US13254704
申请日：2011-09-02
IPC分类号： C07K14/575
CPC分类号： C12N15/8257 , C07K14/575 , C07K2319/21
摘要： The present invention includes novel soybean derived human thyroglobulin, methods of producing human thyroglobulin in plants such as soybean, and novel diagnostic applications for the detection and stratification of endocrine malignancies including thyroid cancer and thyroiditis. The invention also includes the use of soybean-derived human thyroglobulin in affinity matrices to remove autoreactive anti-thyroglobulin antibodies from patient's sera prior to analyses. Moreover, the invention also includes methods and compositons of treating, preventing and or/ameliorating symptoms associated with thyroiditis.
摘要翻译： 本发明包括新型大豆来源的人甲状腺球蛋白，在大豆等植物中产生人甲状腺球蛋白的方法，以及用于检测和分层包括甲状腺癌和甲状腺炎的内分泌恶性肿瘤的新型诊断应用。 本发明还包括使用大豆衍生的人类甲状腺球蛋白在亲和基质中以在分析之前从患者的血清中除去自身反应性的抗甲状腺球蛋白抗体。 此外，本发明还包括治疗，预防和/或改善与甲状腺炎相关的症状的方法和组合物。
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