公开(公告)号：US4778457A

公开(公告)日：1988-10-18

申请号：US927929

申请日：1986-11-06

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： A61F13/40 ,  A61M35/00

CPC分类号： A61M35/006

摘要： A disposable applicator for treating blepharitis in the human eye includes a handle having at least one mildly abrasive, porous sponge impregnated with at least one antimicrobial agent or antimicrobial agent combined with a soap or detergent such as an antibiotic or PVP-I.

摘要翻译： 用于治疗人眼睑炎的一次性施用器包括具有至少一种温和研磨的多孔海绵的手柄，其浸渍有至少一种抗微生物剂或与肥皂或洗涤剂如抗生素或PVP-1组合的抗微生物剂。

公开(公告)号：US5143080A

公开(公告)日：1992-09-01

申请号：US716980

申请日：1991-06-18

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： A61B5/00 ,  G01N27/06 ,  G01N33/487

CPC分类号： A61B3/101 ,  A61B5/4261 ,  A61B5/4266

摘要： A first exemplary embodiment of an osmometer for the in vivo measurement of the osmolarity of a bodily fluid such as tears or sweat comprises a detachable, preferably disposable, probe in combination with means for measuring the conductivity between two electrodes of the probe. The osmometer further comprises means for converting the measured value of conductivity of the in vivo sample into a corresponding value of osmolarity and display means for displaying a visible representation of that value.In a second exemplary embodiment a sensor of some physical quantity (such as dew point temperature) related to the vapor pressure from a bodily fluid is mounted inside a confining, generally concave shell which is placed adjacent to a portion of the human body for a measurement to be made. For the case of measuring tear osmolarity in the open eye, the confining shell could take the form of a conventional eyecup. The sensor can be a thermocouple or thermistor controlled by a microprocessor to measure vapor pressure by the dew point depression method.

摘要翻译： 用于体内测量体液如泪液或汗液的渗透压的渗透计的第一示例性实施方案包括可拆卸的，优选为一次性的探针，以及用于测量探针的两个电极之间的电导率的装置。 渗透压计还包括用于将体内样品的测量值转换成相应的摩尔渗透压浓度值的装置和用于显示该值的可视表示的显示装置。 在第二示例性实施例中，与来自体液的蒸气压相关的某些物理量（例如露点温度）的传感器安装在与人体的一部分相邻放置以测量的约束的，大体上凹的外壳中 被制造。 对于在眼睛中测量泪液渗透压的情况，限制的外壳可以采取常规眼罩的形式。 传感器可以是由微处理器控制的热电偶或热敏电阻，通过露点抑制法测量蒸气压。

公开(公告)号：US4678422A

公开(公告)日：1987-07-07

申请号：US797228

申请日：1985-11-12

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： B23K26/18 ,  B23K26/40 ,  B29D11/00 ,  B25B17/00

CPC分类号： B29D11/00932 ,  B23K26/18 ,  B23K26/402 ,  B23K2203/42 ,  B29C2791/009

摘要： A system for photoablating a product blank such as a corneal lenticule includes a molding means having a predetermined size and shape to which the finished, molded product should conform. The system includes a source of photoablating light such as an excimer laser, a mechanism for aligning light from the excimer laser with the mold and a blank in the mold. The mold is made of material impervious to photoablating light so that the walls of the mold surrounding the cavity protect the product blank within the cavity when the laser beam is kept parallel to the top surface of the mold, essentially comprising a three-dimensional photoresist. With the moldable product blank held against the inner mold surface, and a portion of the product blank projecting from the mold, photoablating light directed onto the mold and onto the projecting portion removes only the projecting portion, leaving a finished product having a size, shape and conformation substantially identical to the inner mold cavity.

摘要翻译： 用于照射诸如角膜微透镜的产品坯料的系统包括具有预定尺寸和形状的成型装置，成品的成型品应符合该成型装置。 该系统包括诸如准分子激光器的照相光源，用于将来自准分子激光器的光与模具对准的机构和模具中的坯件。 模具由不透光照射的材料制成，使得当激光束保持平行于模具的顶表面时，围绕腔的模具的壁保护腔内的产品坯料，基本上包括三维光致抗蚀剂。 通过将可模制产品坯料固定在内模表面上，并且产品坯料的一部分从模具突出，照射到模具上的照相光和突出部分仅去除突出部分，留下具有尺寸形状的成品 并且构造与内模腔基本相同。

公开(公告)号：US5742426A

公开(公告)日：1998-04-21

申请号：US451016

申请日：1995-05-25

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： G02B27/09 ,  G02B26/08

CPC分类号： G02B26/0875 ,  G02B26/108 ,  G02B27/09

摘要： A laser beam pattern modulator includes a light-transmissive, light-refractive element for rotating and/or linearly displacing the beam such that the refracted beam remains parallel to the incident beam and has the capacity: (a) to minimize a substantial quantity of irregularities in the treatment pattern from hot spots and cold spots in the laser beam; (b) to enlarge and blend the edges of the treatment patterns formed by the beam; and (c) to form an enlarged, multi-zone, aspheric, myopic, hyperopic or astigmatic treatment patterns. A method for treating corneal tissue with laser light, particularly excimer laser light, includes directing a beam of excimer laser light such as a broad beam with variable spot size through a beam modulator such as an anglable, rotatable quartz flat.

摘要翻译： 激光束图案调制器包括透光的光折射元件，用于旋转和/或线性地移动光束，使得折射的光束保持平行于入射光束并且具有以下能力：（a）使大量的不规则性最小化 在激光束的热点和冷点处理图案中; （b）扩大和混合由梁形成的处理图案的边缘; 和（c）形成扩大，多区，非球面，近视，远视或散光治疗模式。 用激光，特别是准分子激光治疗角膜组织的方法包括通过光束调制器例如可旋转的石英平面引导准分子激光束，例如具有可变斑点尺寸的宽束的准分子激光束。

公开(公告)号：US5141506A

公开(公告)日：1992-08-25

申请号：US678883

申请日：1991-03-27

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： A61F9/00 ,  A61B18/20 ,  A61F9/008 ,  A61F9/009 ,  A61F9/01

CPC分类号： A61F9/009 ,  A61F9/00804 ,  A61F9/00817 ,  A61B2018/2025 ,  A61F2009/00872

摘要： A system for photoablating a photoablatable substrate (such as the cornea of a human eye) to create a rounded work surface includes a curved, hollow mirror for reflecting light capable of photoablating such surfaces. The curvature of the mirror determines the shape and curvature of the rounded work surface created. The mirror has an opening of sufficient size and shape to expose the substrate to reflected, photoablating light, and is linked to a mechanism for adjusting mirror tilt and height with respect to the substrate. The system can include a source of photoablating light such as an excimer laser, a mechanism for aligning light from the excimer laser with the mirror surface, a mirror cover for excluding unreflected excimer laser light from desired portions of the substrate, and a high-speed shutter system for controlling the amount and the timing of light transmission from the excimer laser to the reflecting means.

摘要翻译： 用于照射可光化基底（例如人眼角膜）以产生圆形工作表面的系统包括用于反射能够光刻这样表面的光的弯曲的中空反射镜。 镜子的曲率决定了所产生的圆形工作表面的形状和曲率。 反射镜具有足够的尺寸和形状的开口，以使基板暴露于反射的光照光，并且与用于相对于基板调整镜面倾斜和高度的机构相连。 该系统可以包括诸如准分子激光器的照相光源，用于将来自准分子激光器的光与镜面对准的机构，用于从基板的期望部分排除未反射的准分子激光的镜罩，以及高速 快门系统，用于控制从准分子激光器到反射装置的光传输的量和定时。

公开(公告)号：US5061696A

公开(公告)日：1991-10-29

申请号：US353828

申请日：1989-05-18

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： A61K31/715

CPC分类号： A61K31/715 ,  Y10S514/912

摘要： A hypotonic composition for selectively destroying lens cells in humans and other mammals such as lens epithelial cells that would otherwise cause clouding of the lens capsule after removal of the lens from the capsule includes one or more ocularly biocompatible viscoelastic substances that have the capacity for destroying such cells osmotically in small concentrations in hypotonic aqueous solutions, yet are sufficiently viscoelastic to attack only tissues to which they are applied without leaking or otherwise flowing onto the damaging adjacent and neighboring tissue. Such compositions are placed intraocularly in the lens capsule by applying a sufficient quantity of the composition to the epithelial cells to be destroyed to destroy them without damaging or otherwise destroying neighboring eye tissue.

摘要翻译： 用于选择性地破坏人类和其它哺乳动物如晶状体上皮细胞中的晶状体细胞的低渗组合物，否则在从胶囊中除去晶状体之后将导致晶状体囊的混浊包括一种或多种具有破坏能力的眼睛生物相容性粘弹性物质 在低渗水溶液中以小浓度渗透的细胞，但足够的粘弹性仅侵袭它们施用的组织，而不会泄漏或以其他方式流入有害的相邻和相邻组织。 将这样的组合物通过将足量的组合物施用于待破坏的上皮细胞而眼球内放置在晶状体囊中，以破坏它们而不损坏或以其他方式破坏邻近的眼组织。

公开(公告)号：US5008102A

公开(公告)日：1991-04-16

申请号：US137247

申请日：1987-12-23

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： A61F2/00 ,  A61F2/16 ,  A61K9/00 ,  A61K31/07 ,  A61K31/55 ,  A61L27/28 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61K31/55 ,  A61F2/1613 ,  A61K31/07 ,  A61K9/0048 ,  A61L27/28 ,  A61L27/50 ,  A61L27/54 ,  A61F2002/0081 ,  A61L2300/442 ,  A61L2430/16 ,  Y10S514/912 ,  Y10S514/914

摘要： Temporary, light-absorbing, ocularly biocompatible compositions include at least one biocompatible, light-absorbing substance in an amount sufficient to block substantially all light of desired wavelengths and protect susceptible ocular tissues from light induced damage, where the composition is placed introcularly between the light source and ocular tissues susceptible to damage from such light. These compositions can be used to coat or to impregnate intraocular lenses, either before or after insertion of the lenses into the eye, or can be placed intraocularly, in the anterior chamber, over the pupil, in the posterior chamber or in the capsular bag of an eye, as during an ophthalmic procedure. Where the composition includes a viscous, biocompatible, space-maintaining substance such as sodium hyaluronate, chondroitin sulfate, methylcellulose or polyacrylamide, the composition also protects the endothelium, maintains space within the eye, moves tissues, allows focal application of the light-absorbing substance, and permits rapid reversal or pupillary occlusion.

摘要翻译： 临时的，光吸收的，眼睛生物相容的组合物包括至少一种生物相容性的光吸收物质，其量足以阻挡所有波长的所有光，并保护敏感的眼组织免受光诱导的损伤，其中组合物被内部放置在光 源和眼组织对这种光的损伤敏感。 这些组合物可用于在将透镜插入眼睛之前或之后将眼内透镜涂覆或浸渍在眼内，或者可以眼内放置在前房中，在瞳孔，后室或荚膜袋中 眼睛，如在眼科手术期间。 当组合物包含粘性，生物相容性，保持空间的物质如透明质酸钠，硫酸软骨素，甲基纤维素或聚丙烯酰胺时，该组合物还保护内皮，保持眼睛内的空间，移动组织，允许光吸收物质的局部应用 ，并允许快速反转或瞳孔闭塞。

公开(公告)号：US4996993A

公开(公告)日：1991-03-05

申请号：US280984

申请日：1988-12-07

申请人： Kenneth K. York

发明人： Kenneth K. York

IPC分类号： A61B5/00 ,  G01N27/06 ,  G01N33/487

CPC分类号： A61B3/101 ,  A61B5/4261 ,  A61B5/4266

摘要： A first exemplary embodiment of an osmometer for the in vivo measurement of the osmolarity of a bodily fluid such as tears or sweat comprises a detachable, preferably disposable, probe in combination with means for measuring the conductivity between two electrodes of the probe. The osmometer further comprises means for converting the measured value of conductivity of the in vivo sample into a corresponding value of osmolarity and display means for displaying a visible representation of that value.In a second exemplary embodiment a sensor of some physical quantity (such as dew point temperature) related to the vapor pressure from a bodily fluid is mounted inside a confining, generally concave shell which is placed adjacent to a portion of the human body for a measurement to be made. For the case of measuring tear osmolarity in the open eye, the confining shell could take the form of a conventional eyecup. The sensor can be a thermocouple or thermistor controlled by a microprocessor to measure vapor pressure by the dew point depression method.

摘要翻译： 用于体内测量体液如泪液或汗液的渗透压的渗透计的第一示例性实施方案包括可拆卸的，优选为一次性的探针，以及用于测量探针的两个电极之间的电导率的装置。 渗透压计还包括用于将体内样品的测量值转换成相应的摩尔渗透压浓度值的装置和用于显示该值的可视表示的显示装置。 在第二示例性实施例中，与来自体液的蒸气压相关的某些物理量（例如露点温度）的传感器安装在与人体的一部分相邻放置的约束的，大体上凹的壳内，用于测量 被制造。 对于在眼睛中测量泪液渗透压的情况，限制的外壳可以采取常规眼罩的形式。 传感器可以是由微处理器控制的热电偶或热敏电阻，通过露点抑制法测量蒸气压。