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    ACE inhibitor formulation
    2.
    发明申请
    ACE inhibitor formulation 审中-公开
    ACE抑制剂制剂

    公开(公告)号：US20070009591A1

    公开(公告)日：2007-01-11

    申请号：US11176565

    申请日：2005-07-07

    申请人： Jay Trivedi ,  Gaetan Marcoux

    发明人： Jay Trivedi ,  Gaetan Marcoux

    IPC分类号： A61K9/20 ,  B27N3/00

    CPC分类号： A61K9/2072 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/4808

    摘要： A process for preparing pharmaceutical micro-tablets comprises (a) preparing a tableting mix that comprises an ACE inhibitor, for example moexipril hydrochloride, and excipient ingredients that comprise one or more lubricants; and (b) compressing the tableting mix in a tablet press, to form micro-tablets having an average uncoated weight of about 1 to about 40 mg; wherein the process employs means for promoting release of the mirco-tablets from the tablet press, said release promoting means being unnecessary for otherwise similar standard tablets having an average uncoated weight greater than about 50 mg. A plurality of micro-tablets thus prepared, collectively comprising a therapeutically effective amount of the ACE inhibitor, can be filled into a pharmaceutically acceptable capsule shell to provide a dosage form.

    摘要翻译： 制备药物微片剂的方法包括（a）制备包含ACE抑制剂，例如盐酸吗克瑞普的压片混合物和包含一种或多种润滑剂的赋形剂成分; 和（b）在压片机中压制压片混合物，以形成平均未涂布重量为约1至约40mg的微片; 其中所述方法采用促进片剂从片剂释放出的方法，所述释放促进装置对于平均未涂布重量大于约50mg的其它类似标准片剂是不必要的。 这样制备的多个微片剂，共同包含治疗有效量的ACE抑制剂，可以填充到药学上可接受的胶囊壳中以提供剂型。

    Solid dispersions comprising a hygroscopic and/or deliquescent drug
    3.
    发明申请
    Solid dispersions comprising a hygroscopic and/or deliquescent drug 审中-公开
    包含吸湿和/或潮解药物的固体分散体

    公开(公告)号：US20050013856A1

    公开(公告)日：2005-01-20

    申请号：US10741526

    申请日：2003-12-18

    申请人： Jay Trivedi ,  Rajeev Gokhale

    发明人： Jay Trivedi ,  Rajeev Gokhale

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K31/155 ,  A61K9/20

    CPC分类号： A61K9/1623 ,  A61K9/146 ,  A61K9/1611 ,  A61K9/1641 ,  A61K9/1652 ,  A61K31/155

    摘要： A pharmaceutical composition is provided comprising a drug and a carrier medium, wherein the carrier medium comprisese (a) a matrix forming agent selected from the group consisting of hydroxyethylcelluloses, hydroxypropylcelluloses, hydroxypropylmethylcelluloses, hydroxypropylmethylcellulose phthalates, polyvinylpyrrolidones, polyethylene glycols, polyglycolized glycerides, cyclodextrins, carbomers and combinations thereof, and (b) a filler; and wherein the drug is hygroscopic and/or deliquescent and is dispersed in the carrier medium, and wherein the composition is a solid dispersion and is acceptably non-hygroscopic.

    摘要翻译： 提供了包含药物和载体介质的药物组合物，其中载体介质包括（a）选自羟乙基纤维素，羟丙基纤维素，羟丙基甲基纤维素，羟丙基甲基纤维素邻苯二甲酸酯，聚乙烯吡咯烷酮，聚乙二醇，聚乙二醇化甘油酯，环糊精， 卡波姆及其组合，和（b）填料; 并且其中所述药物是吸湿性和/或潮解性的并且分散在所述载体介质中，并且其中所述组合物是固体分散体并且是可接受的非吸湿性的。