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公开(公告)号：US20110190727A1
公开(公告)日：2011-08-04
申请号：US13019830
申请日：2011-02-02
CPC分类号： A61F2/958 , A61M25/10 , B23P17/04 , Y10T29/49826
摘要： The present disclosure relates to medical devices and methods, for use in a vascular system. The apparatus includes a balloon catheter having an elongate body, balloon, and fluid control valve for ischemic post-conditioning therapy and/or reperfusion.
摘要翻译： 本公开涉及用于血管系统的医疗装置和方法。 该装置包括具有细长体，球囊和用于缺血后期治疗和/或再灌注的流体控制阀的球囊导管。
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公开(公告)号：US08105261B2
公开(公告)日：2012-01-31
申请号：US11772397
申请日：2007-07-02
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes an implantable occlusive device including a wall member defining an enclosed volume, the wall member can include a semi-permeable membrane. The device can also include a solution comprising a solvent and a solute disposed within the enclosed volume of the wall member. The semi-permeable membrane can be permeable to the solvent and impermeable to the solute. The enclosed volume can be configured to expand and contract in response to changes in the osmolality of a bodily fluid. The device can include a positioning member configured to maintain the position of the implantable occlusive device relative to a lengthwise axis of a lymphatic vessel. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施例中，本发明包括可植入闭塞装置，其包括限定封闭容积的壁构件，所述壁构件可包括半透膜。 该装置还可以包括溶液和溶质，该溶质设置在壁构件的封闭体积内。 半透膜对溶剂是可渗透的，并且对溶质是不可渗透的。 封闭体积可以配置为响应于体液渗透压的变化而膨胀和收缩。 该装置可以包括定位构件，其被配置为相对于淋巴管的纵向轴线保持可植入闭塞装置的位置。 在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。
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公开(公告)号：US20100056858A1
公开(公告)日：2010-03-04
申请号：US12547316
申请日：2009-08-25
申请人： Eric A. Mokelke , Allan C. Shuros
发明人： Eric A. Mokelke , Allan C. Shuros
CPC分类号： A61B17/0218 , A61B17/3207 , A61B2017/0243 , A61B2017/22001 , A61B2017/308 , A61B2090/3784 , A61N1/056 , A61N1/08 , A61N1/3625 , G16H40/63
摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with cardiac catheterization or surgery. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more devices used in the cardiac catheterization or surgery. The pacemaker controls the delivery of the pacing pulses by executing a cardioprotective pacing protocol. In one embodiment, the one or more pacing electrodes are incorporated onto an intravascular ultrasound (IVUS) catheter. In another embodiment, the one or more pacing electrodes are incorporated onto one or more cardiac surgical instruments such as a heart stabilizer and a sternal retractor.
摘要翻译： 应用心脏保护起搏来预防和/或减少与心脏导管插入术或手术相关的心脏损伤。 起搏脉冲从起搏器产生并通过一个或多个起搏电极输送，该起搏电极并入到用于心脏导管插入术或手术中的一个或多个装置上。 起搏器通过执行心脏保护起搏协议来控制起搏脉冲的输送。 在一个实施例中，将一个或多个起搏电极并入到血管内超声（IVUS）导管中。 在另一个实施例中，将一个或多个起搏电极并入一个或多个心脏外科器械，例如心脏稳定器和胸骨牵开器。
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公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译： 描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。 在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。
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公开(公告)号：US08412326B2
公开(公告)日：2013-04-02
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
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公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
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公开(公告)号：US20100249860A1
公开(公告)日：2010-09-30
申请号：US12720246
申请日：2010-03-09
申请人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
发明人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译： 外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。 将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。 经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。
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公开(公告)号：US08942819B2
公开(公告)日：2015-01-27
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译： 各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。 神经刺激输出电路被配置为递送神经刺激。 控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。 包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。 控制器被配置为与传感器电路通信。 存储器具有存储在其中的指令，由控制器电路可操作。 说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数 刺激并提供理想的安全余量以防止对神经组织的损伤。
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公开(公告)号：US08475400B2
公开(公告)日：2013-07-02
申请号：US13346485
申请日：2012-01-09
CPC分类号： A61B17/1219 , A61B17/12031 , A61B17/12036 , A61B17/12099 , A61B17/12136 , A61F2250/0003
摘要： Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施方案涉及用于调节肾功能的装置和方法等。 在一个实施方案中，本发明包括调节患者的肾功能的方法，包括在患者体内植入闭塞装置，所述闭塞装置包括半渗透膜，并且构造成基于穿过所述半透膜的流体通过而膨胀或收缩 不渗透膜。 本文提供了其它方面和实施例。
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公开(公告)号：US08219192B2
公开(公告)日：2012-07-10
申请号：US12496504
申请日：2009-07-01
申请人： Allan C. Shuros , Eric A. Mokelke
发明人： Allan C. Shuros , Eric A. Mokelke
IPC分类号： A61N1/00
CPC分类号： A61N1/36014 , A61N1/046 , A61N1/3625 , A61N1/39
摘要： A transcutaneous cardiac stimulation system delivers pacing pulses according to a cardioprotective pacing protocol. The pacing pulses are delivered through body-surface electrodes attached onto a patient. The cardioprotective pacing protocol specifies pacing parameters selected to augment cardiac stress on the patient's myocardium to a level effecting cardioprotection against ischemic and reperfusion injuries.
摘要翻译： 经皮心脏刺激系统根据心脏保护起搏方案提供起搏脉冲。 起搏脉冲通过附着在患者身上的体表电极传递。 心脏保护起搏方案规定了选择的起搏参数，以增加患者心肌的心脏应激，达到对缺血再灌注损伤的心脏保护作用。
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